A photo of Joseph Palumbo.

Director, Comprehensive Thrombophilia Center

Professor, UC Department of Pediatrics



Board Certified

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My Biography & Research


My area of expertise is hematology, and I care for patients with complex disorders of blood clotting and bleeding. Conditions I treat include deep vein thrombosis, pulmonary embolism, von Willebrand disease, platelet dysfunction, as well as other bleeding and clotting disorders.

I became fascinated by the hemostatic system very early in my training. The complexity of this system and the role of blood clotting in so many aspects of health and disease drew me to this area.

I also have loved taking care of children and adolescents since medical school. Many people think of children as fragile, but in fact they are incredibly strong, resilient and adaptable. This age group is constantly changing over time, both physically and mentally, which adds to the challenge and the joy of caring for them.

As pediatric providers, we have to constantly change and adapt our approach as our patients grow. I enjoy connecting with parents and guardians in the care of their children, and I believe that without this critical partnership we can’t deliver the best care.

As a physician/scientist, I strive to combine patient-centered care with the best scientific data available. The fact that we still have so much to learn motivates me to push the knowledge envelope further in my research.

My colleagues and I are seeking a better understanding of the role of the hemostatic system in diseases processes, including cancer and inflammatory diseases. We are working with members of the Cincinnati Children’s Heart Institute to find better ways to prevent bleeding and clotting complications that come with heart surgery and mechanical circulation, such as artificial heart-lung bypass machines.

I’m proud that my peers elected me for inclusion in the Best Doctors in America List I have research funding from the National Institutes of Health and my research has been selected for presentations at numerous national and international symposia. I serve on national and international committees that are part of the American Society of Hematology and the International Society of Thrombosis and Hemostasis.

In my spare time I’m an avid cyclist and enjoy bicycle racing.

Clinical Interests

Bleeding and thrombotic disorders; patients with inherited and acquired thrombophilia; comprehensive testing for rare bleeding and clotting disorders

Research Interests

Defining the role of hemostatic system components in disease pathogenesis, particularly malignancy; examining novel approaches to limit the thrombotic complications associated with mechanical circulation

Academic Affiliation

Professor, UC Department of Pediatrics


Cancer and Blood Diseases, Immune Deficiencies and Histiocytosis, Hemophilia, Thrombosis, Rasopathy, Fontan Management, Hematology, Cancer and Blood Diseases

Blog Posts

A New Kind of Clot Blocker

Heart and Lung

A New Kind of Clot Blocker

Joseph S. Palumbo, MD, James S. Tweddell, MD6/30/2019

My Locations

My Education

MD: Pennsylvania State University College of Medicine, Hershey, PA, 1993.

Residency: Childrens Hospital Medical Center, Cincinnati, OH, 1997.

Fellowship: Childrens Hospital Medical Center, Cincinnati, OH, 2000.

Subspecialty: Pediatric Hematology / Oncology.

My Publications

Thromboembolic Events Are Independently Associated with Liver Stiffness in Patients with Fontan Circulation. Alsaied, T; Possner, M; Lubert, AM; Trout, AT; Gandhi, JP; Garr, B; Palumbo, JS; Palermo, JJ; Lorts, A; Veldtman, GR; et al. Journal of Clinical Medicine. 2020; 9:418-418.

Cell type-specific mechanisms coupling protease-activated receptor-1 to infectious colitis pathogenesis. Boucher, AA; Rosenfeldt, L; Mureb, D; Shafer, J; Sharma, BK; Lane, A; Crowther, RR; McKell, MC; Whitt, J; Alenghat, T; et al. Journal of Thrombosis and Haemostasis. 2020; 18:91-103.

Von Willebrand factor delays liver repair after acetaminophen-induced acute liver injury in mice. Groeneveld, D; Cline-Fedewa, H; Baker, KS; Williams, KJ; Roth, RA; Mittermeier, K; Lisman, T; Palumbo, JS; Luyendyk, JP. Journal of Hepatology. 2020; 72:146-155.

Rivaroxaban compared with standard anticoagulants for the treatment of acute venous thromboembolism in children: a randomised, controlled, phase 3 trial. Male, C; Lensing, AW A; Palumbo, JS; Kumar, R; Nurmeev, I; Hege, K; Bonnet, D; Connor, P; Hooimeijer, HL; Torres, M; et al. The Lancet Haematology. 2020; 7:e18-e27.

New insights into cancer's exploitation of platelets. Francisco, BJ; Palumbo, JS. Journal of Thrombosis and Haemostasis. 2019; 17:2000-2003.

Antiphospholipid syndrome in pediatric patients. Tarango, C; Palumbo, JS. Current Opinion in Hematology. 2019; 26:366-371.

Cancer-Associated Thrombosis: A Two-Way Street. Sharma, BK; Flick, MJ; Palumbo, JS. Seminars in Thrombosis and Hemostasis. 2019; 45:559-568.

Thrombin Signaling Promotes Pancreatic Adenocarcinoma through PAR-1-Dependent Immune Evasion. Yang, Y; Stange, A; Schweickert, PG; Lanman, NA; Paul, EN; Monia, BP; Revenko, AS; Palumbo, JS; Mullins, ES; Elzey, BD; et al. Cancer Research. 2019; 79:3417-3430.

Randomised Controlled Trial of Rivaroxaban Compared to Standard Anticoagulants for the Treatment of Acute Venous Thromboembolism in Children. Male, C; Lensing, AW A; Palumbo, JS; Kumar, R; Nurmeev, I; Hege, K; Bonnet, D; Connor, P; Hooimeijer, HL; Torres, M; et al. 2019.

Thrombopoietin Contributes to Extreme Thrombocytosis After Pediatric Pancreatectomy With Islet Autotransplantation. Gurria, JP; Boucher, AA; Hornung, L; Palumbo, JS; Badia, P; Luchtman-Jones, L; Abu-El-Haija, M; Lin, TK; Nathan, JD. Pancreas. 2019; 48:652-655.