A photo of Joseph Palumbo.

Director, Comprehensive Thrombophilia Center

Co-Director of the Hemostasis Thrombosis Laboratory (HTL)

Professor, UC Department of Pediatrics



Board Certified

"I enjoy connecting with parents and guardians in the care of their children, and I believe that without this critical partnership we can’t deliver the best care."

My Biography & Research


My area of expertise is hematology, and I care for patients with complex disorders of blood clotting and bleeding. Conditions I treat include deep vein thrombosis, pulmonary embolism, von Willebrand disease, platelet dysfunction, as well as other bleeding and clotting disorders.

I became fascinated by the hemostatic system very early in my training. The complexity of this system and the role of blood clotting in so many aspects of health and disease drew me to this area.

I also have loved taking care of children and adolescents since medical school. Many people think of children as fragile, but in fact they are incredibly strong, resilient and adaptable. This age group is constantly changing over time, both physically and mentally, which adds to the challenge and the joy of caring for them.

As pediatric providers, we have to constantly change and adapt our approach as our patients grow. I enjoy connecting with parents and guardians in the care of their children, and I believe that without this critical partnership we can’t deliver the best care.

As a physician/scientist, I strive to combine patient-centered care with the best scientific data available. The fact that we still have so much to learn motivates me to push the knowledge envelope further in my research.

My colleagues and I are seeking a better understanding of the role of the hemostatic system in diseases processes, including cancer and inflammatory diseases. We are working with members of the Cincinnati Children’s Heart Institute to find better ways to prevent bleeding and clotting complications that come with heart surgery and mechanical circulation, such as artificial heart-lung bypass machines.

I’m proud that my peers elected me for inclusion in the Best Doctors in America List I have research funding from the National Institutes of Health and my research has been selected for presentations at numerous national and international symposia. I serve on national and international committees that are part of the American Society of Hematology and the International Society of Thrombosis and Hemostasis.

In my spare time I’m an avid cyclist and enjoy bicycle racing.

Clinical Interests

Bleeding and thrombotic disorders; patients with inherited and acquired thrombophilia; comprehensive testing for rare bleeding and clotting disorders

Research Interests

Defining the role of hemostatic system components in disease pathogenesis, particularly malignancy; examining novel approaches to limit the thrombotic complications associated with mechanical circulation

Academic Affiliation

Professor, UC Department of Pediatrics

Clinical Divisions

Cancer and Blood Diseases, Immune Deficiencies and Histiocytosis, Hemophilia, Thrombosis, Rasopathy, Fontan Management

Research Divisions

Hematology, Cancer and Blood Diseases

Blog Posts

A New Kind of Clot Blocker

Heart and Lung

A New Kind of Clot Blocker

Joseph S. Palumbo, MD, James S. Tweddell, MD6/30/2019

My Locations

My Education

MD: Pennsylvania State University College of Medicine, Hershey, PA, 1993.

Residency: Childrens Hospital Medical Center, Cincinnati, OH, 1997.

Fellowship: Childrens Hospital Medical Center, Cincinnati, OH, 2000.

Subspecialty: Pediatric Hematology / Oncology.

My Publications

Bleeding and thrombotic risk in pregnant women with Fontan physiology. Girnius, A; Zentner, D; Valente, AM; Pieper, PG; Economy, KE; Ladouceur, M; Roos-Hesselink, JW; Warshak, C; Partington, SL; Gao, Z; et al. Heart. 2021; 107:1390-1397.

PAR1 regulation of CXCL1 expression and neutrophil recruitment to the lung in mice infected with influenza A virus. Antoniak, S; Tatsumi, K; Schmedes, CM; Egnatz, GJ; Auriemma, AC; Bharathi, V; Stokol, T; Beck, MA; Griffin, JH; Palumbo, JS; et al. Journal of Thrombosis and Haemostasis. 2021; 19:1103-1111.

Tryptophan metabolism is dysregulated in individuals with Fanconi anemia. Bartlett, AL; Romick-Rosendale, L; Nelson, A; Abdullah, S; Luebbering, N; Bartlett, J; Brusadelli, M; Palumbo, JS; Lake, K; Litts, B; et al. Blood Advances. 2021; 5:250-261.

Host fibrinogen drives antimicrobial function in Staphylococcus aureus peritonitis through bacterial-mediated prothrombin activation. Prasad, JM; Negron, O; Du, X; Mullins, ES; Palumbo, JS; Gilbertie, JM; Hook, M; Grover, SP; Pawlinski, R; Mackman, N; et al. Proceedings of the National Academy of Sciences of the United States of America. 2021; 118.

Safety and efficacy of rivaroxaban in pediatric cerebral venous thrombosis (EINSTEIN-Jr CVT). Connor, P; van Kammen, MS; Lensing, AW A; Chalmers, E; Kállay, K; Hege, K; Simioni, P; Biss, T; Bajolle, F; Bonnet, D; et al. Blood Advances. 2020; 4:6250-6258.

Sustained depletion of FXIII-A by inducing acquired FXIII-B deficiency. Strilchuk, AW; Meixner, SC; Leung, J; Safikhan, NS; Kulkarni, JA; Russell, HM; van der Meel, R; Sutherland, MR; Owens, AP; Palumbo, JS; et al. Blood. 2020; 136:2946-2954.

Safety and efficacy of anticoagulant therapy in pediatric catheter-related venous thrombosis (EINSTEIN-Jr CVC-VTE). Thom, K; Lensing, AW A; Nurmeev, I; Bajolle, F; Bonnet, D; Kenet, G; Patricia Massicotte, M; Karakas, Z; Palumbo, JS; Saracco, P; et al. Blood Advances. 2020; 4:4632-4639.

Extreme Thrombocytosis after Pediatric Pancreatectomy with Islet Autotransplantation Is Unique Compared to Other Postsplenectomy States. Boucher, AA; Luchtman-Jones, L; Palumbo, JS; Cancelas, JA; Abu-El-Haija, M; Jenkins, TM; Lin, TK; Nathan, JD. Journal of Pediatric Surgery. 2020; 55:1645-1650.

Rivaroxaban for treatment of pediatric venous thromboembolism. An Einstein-Jr phase 3 dose-exposure-response evaluation. Young, G; Lensing, AW A; Monagle, P; Male, C; Thelen, K; Willmann, S; Palumbo, JS; Kumar, R; Nurmeev, I; Hege, K; et al. Journal of Thrombosis and Haemostasis. 2020; 18:1672-1685.

Liver fibrosis is driven by protease-activated receptor-1 expressed by hepatic stellate cells in experimental chronic liver injury. Poole, LG; Pant, A; Cline-Fedewa, HM; Williams, KJ; Copple, BL; Palumbo, JS; Luyendyk, JP. Research and Practice in Thrombosis and Haemostasis. 2020; 4:906-917.