A photo of Joseph Palumbo.

Joseph S. Palumbo, MD

  • Director, Comprehensive Thrombophilia Center
  • Co-Director of the Hemostasis Thrombosis Laboratory (HTL)
  • Professor, UC Department of Pediatrics
I enjoy connecting with parents and guardians in the care of their children, and I believe that without this critical partnership we can’t deliver the best care.
Joseph S. Palumbo, MD



My area of expertise is hematology, and I care for patients with complex disorders of blood clotting and bleeding. Conditions I treat include deep vein thrombosis, pulmonary embolism, von Willebrand disease, platelet dysfunction, as well as other bleeding and clotting disorders.

I became fascinated by the hemostatic system very early in my training. The complexity of this system and the role of blood clotting in so many aspects of health and disease drew me to this area.

I also have loved taking care of children and adolescents since medical school. Many people think of children as fragile, but in fact they are incredibly strong, resilient and adaptable. This age group is constantly changing over time, both physically and mentally, which adds to the challenge and the joy of caring for them.

As pediatric providers, we have to constantly change and adapt our approach as our patients grow. I enjoy connecting with parents and guardians in the care of their children, and I believe that without this critical partnership we can’t deliver the best care.

As a physician/scientist, I strive to combine patient-centered care with the best scientific data available. The fact that we still have so much to learn motivates me to push the knowledge envelope further in my research.

My colleagues and I are seeking a better understanding of the role of the hemostatic system in diseases processes, including cancer and inflammatory diseases. We are working with members of the Cincinnati Children’s Heart Institute to find better ways to prevent bleeding and clotting complications that come with heart surgery and mechanical circulation, such as artificial heart-lung bypass machines.

I’m proud that my peers elected me for inclusion in the Best Doctors in America List I have research funding from the National Institutes of Health and my research has been selected for presentations at numerous national and international symposia. I serve on national and international committees that are part of the American Society of Hematology and the International Society of Thrombosis and Hemostasis.

In my spare time I’m an avid cyclist and enjoy bicycle racing.

MD: Pennsylvania State University College of Medicine, Hershey, PA, 1993.

Residency: Childrens Hospital Medical Center, Cincinnati, OH, 1997.

Fellowship: Childrens Hospital Medical Center, Cincinnati, OH, 2000.

Subspecialty: Pediatric Hematology / Oncology.


Bleeding and thrombotic disorders; patients with inherited and acquired thrombophilia; comprehensive testing for rare bleeding and clotting disorders

Services and Specialties

Cancer and Blood Diseases, Immune Deficiencies and Histiocytosis, Hemophilia, Thrombosis, Rasopathy, Fontan Management


Defining the role of hemostatic system components in disease pathogenesis, particularly malignancy; examining novel approaches to limit the thrombotic complications associated with mechanical circulation

Research Areas

Hematology, Cancer and Blood Diseases

Insurance Information

Cincinnati Children's strives to accept a wide variety of health plans. Please contact your health insurance carrier to verify coverage for your specific benefit plan.

View Insurance Information


Thrombin-mediated activation of PAR1 enhances doxorubicin-induced cardiac injury in mice. Grover, SP; Bharathi, V; Posma, JJ; Griffin, JH; Palumbo, JS; Mackman, N; Antoniak, S. Blood Advances. 2023; 7:1945-1953.

Targeting the contact system in a rabbit model of extracorporeal membrane oxygenation. Tweddell, JS; Kharnaf, M; Zafar, F; Riggs, KW; Reagor, JA; Monia, BP; Revenko, A; Leino, DG; Owens, AP; Martin, JK; et al. Blood Advances. 2023; 7:1404-1417.

A Murine Model of Veno-Arterial Extracorporeal Membrane Oxygenation. Kharnaf, M; Hogue, S; Wilkes, Z; Reagor, JA; Leino, DG; Gourley, B; Rosenfeldt, L; Ma, Q; Devarajan, P; Palumbo, JS; et al. ASAIO Journal. 2022; 68:e243-e250.

Anticoagulation in pediatric cancer-associated venous thromboembolism: a subgroup analysis of EINSTEIN-Jr. Palumbo, JS; Lensing, AW A; Brandão, LR; Hooimeijer, HL; Kenet, G; van Ommen, H; Pap, AF; Majumder, M; Kubitza, D; Thelen, K; et al. Blood Advances. 2022; 6:5821-5828.

Anchoring IgG-degrading enzymes to the surface of platelets selectively neutralizes antiplatelet antibodies. Lynch, DR; Stringham, EN; Zhang, B; Balbin-Cuesta, G; Curtis, BR; Palumbo, JS; Greineder, CF; Tourdot, BE. Blood Advances. 2022; 6:4645-4656.

LB1033 Thrombin contributes to atopic dermatitis pathogenesis and staphylococcus aureus skin colonization in children. Filuta, A; Amezcua, PK; Chang, W; Biagini, J; Kroner, J; He, H; Grashel, B; Almasri, C; Martin, L; Palumbo, JS; et al. Journal of Investigative Dermatology. 2022; 142:b36.

Use of thromboelastography in children on extracorporeal membrane oxygenation. Wagner, ML; Johnston, M; Jenkins, T; Palumbo, JS; Rymeski, BA. Journal of Pediatric Surgery. 2022; 57:1056-1061.

Hemostasis and tumor immunity. Cantrell, R; Palumbo, JS. Research and Practice in Thrombosis and Haemostasis. 2022; 6:e12728.

The role of the Thrombin/PAR axis in modulating CD8+ T cell anti-tumor immunity. Cantrell, R; Rosenfeldt, L; Sharma, BK; Gourley, B; Revenko, A; Monia, B; Palumbo, J. Journal of immunology (Baltimore, Md. : 1950). 2022; 208:121.12.

Crosstalk between hemostasis and immunity in cancer pathogenesis. Palumbo, JS. Thrombosis Research. 2022; 213 Suppl 1:S3-S7.

From the Blog

A New Kind of Clot Blocker
Heart and Lung

A New Kind of Clot Blocker

Joseph S. Palumbo, MD6/30/2019

Patient Ratings and Comments

All patient satisfaction ratings and comments are submitted by actual patients and verified by a leading independent patient satisfaction company, NRC Health. Patient identities are withheld to ensure confidentiality and privacy. Only those providers whose satisfaction surveys are administered through Cincinnati Children’s Hospital Medical Center are displayed. Click here to learn more about our survey

Overall Patient Rating