A photo of Joseph Palumbo.

Joseph S. Palumbo, MD

  • Director, Comprehensive Thrombophilia Center
  • Co-Director of the Hemostasis Thrombosis Laboratory (HTL)
  • Professor, UC Department of Pediatrics
I enjoy connecting with parents and guardians in the care of their children, and I believe that without this critical partnership we can’t deliver the best care.



My area of expertise is hematology, and I care for patients with complex disorders of blood clotting and bleeding. Conditions I treat include deep vein thrombosis, pulmonary embolism, von Willebrand disease, platelet dysfunction, as well as other bleeding and clotting disorders.

I became fascinated by the hemostatic system very early in my training. The complexity of this system and the role of blood clotting in so many aspects of health and disease drew me to this area.

I also have loved taking care of children and adolescents since medical school. Many people think of children as fragile, but in fact they are incredibly strong, resilient and adaptable. This age group is constantly changing over time, both physically and mentally, which adds to the challenge and the joy of caring for them.

As pediatric providers, we have to constantly change and adapt our approach as our patients grow. I enjoy connecting with parents and guardians in the care of their children, and I believe that without this critical partnership we can’t deliver the best care.

As a physician/scientist, I strive to combine patient-centered care with the best scientific data available. The fact that we still have so much to learn motivates me to push the knowledge envelope further in my research.

My colleagues and I are seeking a better understanding of the role of the hemostatic system in diseases processes, including cancer and inflammatory diseases. We are working with members of the Cincinnati Children’s Heart Institute to find better ways to prevent bleeding and clotting complications that come with heart surgery and mechanical circulation, such as artificial heart-lung bypass machines.

I’m proud that my peers elected me for inclusion in the Best Doctors in America List I have research funding from the National Institutes of Health and my research has been selected for presentations at numerous national and international symposia. I serve on national and international committees that are part of the American Society of Hematology and the International Society of Thrombosis and Hemostasis.

In my spare time I’m an avid cyclist and enjoy bicycle racing.


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Use of thromboelastography in children on extracorporeal membrane oxygenation. Wagner, ML; Johnston, M; Jenkins, T; Palumbo, JS; Rymeski, BA. Journal of Pediatric Surgery. 2022; 57:1056-1061.

Hemostasis and tumor immunity. Cantrell, R; Palumbo, JS. Research and Practice in Thrombosis and Haemostasis. 2022; 6.

Suppression of fibrin(ogen)-driven pathologies in disease models through controlled knockdown by lipid nanoparticle delivery of siRNA. Juang, LJ; Hur, WS; Silva, LM; Strilchuk, AW; Francisco, B; Leung, J; Robertson, MK; Groeneveld, DJ; La Prairie, B; Chun, EM; et al. Blood. 2022; 139:1302-1311.

Thrombin and Fibrinogen Play a Critical Role in Atopic Dermatitis Pathogenesis. Sherenian, M; Filuta, A; Amezcua, P; Ruff, B; Kroner, J; Grashel, B; He, H; Hicks, C; Almasri, C; Biagini, J; et al. Journal of Allergy and Clinical Immunology. 2022; 149.

Cell type-specific roles of PAR1 in Coxsackievirus B3 infection. Bode, MF; Schmedes, CM; Egnatz, GJ; Bharathi, V; Hisada, YM; Martinez, D; Kawano, T; Weithauser, A; Rosenfeldt, L; Rauch, U; et al. Scientific Reports. 2021; 11.

Fibrin(ogen) Promotes Immune Cell Infiltration, Dysbiosis and ROS Production in Experimental Colitis. Sharma, B; Kudira, R; Rosenfeldt, LA; Gourley, BE; Cantrell, R; Watanabe, M; Edwards, O; Romick-Rosendale, LE; Haslam, D; Flick, MJ; et al. Blood. 2021; 138:443-443.

Use of Bivalirudin-Specific Monitoring Assays in Ventricular Assist Device Patients. Engel, E; Losos, M; Martin, J; Palumbo, JS; Lorts, A; Geer, R; Luchtman-Jones, L. Blood. 2021; 138:3236-3236.

Do Family History Questions Improve the Predictive Value of a Standardized Pediatric Bleeding Assessment Tool?. Bajorek, K; Martin, M; Palumbo, JS; Tarango, C; Mullins, ES; Luchtman-Jones, L. Blood. 2021; 138:2111-2111.

Fibrin(ogen) Mechanistically Contributes to Atopic Dermatitis Pathogenesis and Allergic Sensitization. Filuta, A; Amezcua, PK; Ruff, B; He, H; Martin, LJ; Palumbo, JS; Khurana Hershey, GK; Sherenian, MG. Blood. 2021; 138:2097-2097.

Fibrinogen activates focal adhesion kinase (FAK) promoting colorectal adenocarcinoma growth. Sharma, BK; Mureb, D; Murab, S; Rosenfeldt, L; Francisco, B; Cantrell, R; Karns, R; Romick-Rosendale, L; Watanabe-Chailland, M; Mast, J; et al. Journal of Thrombosis and Haemostasis. 2021; 19:2480-2494.

From the Blog

A New Kind of Clot Blocker
Heart and Lung

A New Kind of Clot Blocker

Joseph S. Palumbo, MD, James S. Tweddell, MD6/30/2019

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