A photo of Joseph Palumbo.

Joseph S. Palumbo, MD

  • Director, Comprehensive Thrombophilia Center
  • Co-Director of the Hemostasis Thrombosis Laboratory (HTL)
  • Professor, UC Department of Pediatrics
I enjoy connecting with parents and guardians in the care of their children, and I believe that without this critical partnership we can’t deliver the best care.
Joseph S. Palumbo, MD



My area of expertise is hematology, and I care for patients with complex disorders of blood clotting and bleeding. Conditions I treat include deep vein thrombosis, pulmonary embolism, von Willebrand disease, platelet dysfunction, as well as other bleeding and clotting disorders.

I became fascinated by the hemostatic system very early in my training. The complexity of this system and the role of blood clotting in so many aspects of health and disease drew me to this area.

I also have loved taking care of children and adolescents since medical school. Many people think of children as fragile, but in fact they are incredibly strong, resilient and adaptable. This age group is constantly changing over time, both physically and mentally, which adds to the challenge and the joy of caring for them.

As pediatric providers, we have to constantly change and adapt our approach as our patients grow. I enjoy connecting with parents and guardians in the care of their children, and I believe that without this critical partnership we can’t deliver the best care.

As a physician/scientist, I strive to combine patient-centered care with the best scientific data available. The fact that we still have so much to learn motivates me to push the knowledge envelope further in my research.

My colleagues and I are seeking a better understanding of the role of the hemostatic system in diseases processes, including cancer and inflammatory diseases. We are working with members of the Cincinnati Children’s Heart Institute to find better ways to prevent bleeding and clotting complications that come with heart surgery and mechanical circulation, such as artificial heart-lung bypass machines.

I’m proud that my peers elected me for inclusion in the Best Doctors in America List I have research funding from the National Institutes of Health and my research has been selected for presentations at numerous national and international symposia. I serve on national and international committees that are part of the American Society of Hematology and the International Society of Thrombosis and Hemostasis.

In my spare time I’m an avid cyclist and enjoy bicycle racing.

MD: Pennsylvania State University College of Medicine, Hershey, PA, 1993.

Residency: Childrens Hospital Medical Center, Cincinnati, OH, 1997.

Fellowship: Childrens Hospital Medical Center, Cincinnati, OH, 2000.

Subspecialty: Pediatric Hematology / Oncology.


Bleeding and thrombotic disorders; patients with inherited and acquired thrombophilia; comprehensive testing for rare bleeding and clotting disorders

Services and Specialties

Cancer and Blood Diseases, Immune Deficiencies and Histiocytosis, Hemophilia, Thrombosis, Rasopathy, Fontan Management


Defining the role of hemostatic system components in disease pathogenesis, particularly malignancy; examining novel approaches to limit the thrombotic complications associated with mechanical circulation

Research Areas

Hematology, Cancer and Blood Diseases

Insurance Information

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The key roles of thrombin and fibrinogen in human infant and mice atopic dermatitis models. Filuta, AL; Amezcua, P; Ruff, BP; Biagini, JM; Kroner, J; He, H; Brandt, EB; Martin, LJ; Palumbo, JS; Khurana Hershey, GK; Sherenian, MG. Allergy: European Journal of Allergy and Clinical Immunology. 2024; 79:239-242.

MEK inhibition reduced vascular tumor growth and coagulopathy in a mouse model with hyperactive GNAQ. Schrenk, S; Bischoff, LJ; Goines, J; Cai, Y; Vemaraju, S; Odaka, Y; Good, SR; Palumbo, JS; Szabo, S; Reynaud, D; Van Raamsdonk, CD; Lang, RA; Boscolo, E. Nature Communications. 2023; 14:1929.

S. aureus drives itch and scratch-induced skin damage through a V8 protease-PAR1 axis. Deng, L; Costa, F; Blake, KJ; Choi, S; Chandrabalan, A; Yousuf, MS; Shiers, S; Dubreuil, D; Vega-Mendoza, D; Rolland, C; Price, TJ; Ramachandran, R; Horswill, AR; Chiu, IM. Cell. 2023; 186:5375-5393.e25.

Immune Checkpoint Blockade Promotes Thrombosis Via T-Cell and Neutrophil Activation, and Tumor-Cell Associated Tissue Factor (TF) in a Murine Model of Colorectal Cancer. Shim, YJ; Sharma, BK; Hisada, Y; Mackman, N; Palumbo, JS; Diaz-Montero, C; Khorana, AA; McCrae, KR. Blood. 2023; 142:1192.

APC-PAR1-R46 signaling limits CXCL1 expression during poly IC-induced airway inflammation in mice. Sharma, S; Ursery, LT; Bharathi, V; Miles, SD; Williams, WA; Elzawam, AZ; Schmedes, CM; Egnatz, GJ; Fernandez, JA; Palumbo, JS; Griffin, JH; Mackman, N; Antoniak, S. Journal of Thrombosis and Haemostasis. 2023; 21:3279-3282.

PB0708 The Tissue Factor/Thrombin Axis Limits Spontaneous Lymphatic Metastasis in Mice. Sharma, B; Francisco, B; Rosenfeldt, L; Cantrell, R; Revenko, A; Monia, B; Flick, M; Palumbo, J. Research and Practice in Thrombosis and Haemostasis. 2023; 7:101305.

PB0727 The Role of Thrombin and Thrombin Signaling in Chronic LCMV Infection. Cantrell, R; Feldman, H; Rosenfeldt, L; Ali, A; Sharma, B; Revenko, A; Monia, B; Waggoner, S; Palumbo, J. Research and Practice in Thrombosis and Haemostasis. 2023; 7:101315.

Thrombin-mediated activation of PAR1 enhances doxorubicin-induced cardiac injury in mice. Grover, SP; Bharathi, V; Posma, JJ; Griffin, JH; Palumbo, JS; Mackman, N; Antoniak, S. Blood Advances. 2023; 7:1945-1953.

Targeting the contact system in a rabbit model of extracorporeal membrane oxygenation. Tweddell, JS; Kharnaf, M; Zafar, F; Riggs, KW; Reagor, JA; Monia, BP; Revenko, A; Leino, DG; Owens, AP; Martin, JK; Gourley, B; Rosenfeldt, L; Palumbo, JS. Blood Advances. 2023; 7:1404-1417.

A Murine Model of Veno-Arterial Extracorporeal Membrane Oxygenation. Kharnaf, M; Hogue, S; Wilkes, Z; Reagor, JA; Leino, DG; Gourley, B; Rosenfeldt, L; Ma, Q; Devarajan, P; Palumbo, JS; Tweddell, JS; Zafar, F. ASAIO Journal. 2022; 68:e243-e250.

From the Blog

A New Kind of Clot Blocker
Heart and Lung

A New Kind of Clot Blocker

Joseph S. Palumbo, MD6/30/2019

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