A photo of Charles Quinn.

Charles T. Quinn, MD, MS

  • Medical Director, Pediatric Sickle Cell Program
  • Director, Erythrocyte Diagnostic Laboratory
  • Professor, UC Department of Pediatrics



Dr. Quinn conducts patient-oriented and translational research in sickle cell disease and thalassemia. He is the medical director of the Pediatric Sickle Cell Disease Program and the medical director of the Erythrocyte Diagnostic Laboratory at Cincinnati Children’s Hospital. He is also the medical director of the Ohio Department of Health Regional Sickle Cell Services Program – Region 1.

MD: University of Texas Southwestern Medical Center, Dallas, TX, 1994.

MS: University of Texas Southwestern Medical Center, Dallas, TX, 2008.

Residency & Chief Residency: Children's Medical Center Dallas, Dallas, TX; University of Texas Southwestern Medical Center, Dallas, TX, 1998.

Fellowship: Children's Medical Center Dallas, Dallas, TX; University of Texas Southwestern Medical Center, Dallas, TX, 2001.

Certifications: Pediatrics, 1998; Pediatric Hematology-Oncology, 2002.


Sickle cell disease; thalassemia; hemoglobinopathies; genetics of hemoglobinopathies; anemia; autoimmune hemolytic anemia; disorders of red blood cells; iron overload and iron chelation; chronic transfusion therapy; hereditary spherocytosis (HS); hereditary xerocytosis (HX); immune thrombocytopenia (ITP).

Services and Specialties

Cancer and Blood Diseases, Sickle Cell and Hemoglobin Disorders, Cerebrovascular


Identifying the causes of the cardiomyopathy and nephropathy of sickle cell disease and identifying new treatments for these complications; direct measurement of red blood cell turnover (rate of hemolysis); MRI methods for the quantitation of tissue iron; new agents for immune thrombocytopenia (ITP).

Research Areas

Hematology, Cancer and Blood Diseases

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Early initiation of hydroxyurea (hydroxycarbamide) using individualised, pharmacokinetics-guided dosing can produce sustained and nearly pancellular expression of fetal haemoglobin in children with sickle cell anaemia. Quinn, CT; Niss, O; Dong, M; Pfeiffer, A; Korpik, J; Reynaud, M; Bonar, H; Kalfa, TA; Smart, LR; Malik, P; et al. British Journal of Haematology. 2021; 194:617-625.


Left atrial dysfunction in sickle cell anemia is associated with diffuse myocardial fibrosis, increased right ventricular pressure and reduced exercise capacity. Alsaied, T; Niss, O; Tretter, JT; Powell, AW; Chin, C; Fleck, RJ; Cnota, JF; Malik, P; Quinn, CT; Nagueh, SM; et al. Scientific Reports. 2020; 10:1767.


Diastolic dysfunction is associated with exercise impairment in patients with sickle cell anemia. Alsaied, T; Niss, O; Powell, AW; Fleck, RJ; Cnota, JF; Chin, C; Malik, P; Quinn, CT; Taylor, MD. Pediatric Blood and Cancer. 2018; 65:e27113.


Association between diffuse myocardial fibrosis and diastolic dysfunction in sickle cell anemia. Niss, O; Fleck, R; Makue, F; Alsaied, T; Desai, P; Towbin, JA; Malik, P; Taylor, MD; Quinn, CT. Blood. 2017; 130:205-213.


Biochemical surrogate markers of hemolysis do not correlate with directly measured erythrocyte survival in sickle cell anemia. Quinn, CT; Smith, EP; Arbabi, S; Khera, PK; Lindsell, CJ; Niss, O; Joiner, CH; Franco, RS; Cohen, RM. American Journal of Hematology. 2016; 91:1195-1201.


Sickle cell anemia mice develop a unique cardiomyopathy with restrictive physiology. Bakeer, N; James, J; Roy, S; Wansapura, J; Shanmukhappa, SK; Lorenz, JN; Osinska, H; Backer, K; Huby, A; Shrestha, A; et al. Proceedings of the National Academy of Sciences of USA. 2016; 113:E5182-E5191.


Cardiomyopathy With Restrictive Physiology in Sickle Cell Disease. Niss, O; Quinn, CT; Lane, A; Daily, J; Khoury, PR; Bakeer, N; Kimball, TR; Towbin, JA; Malik, P; Taylor, MD. JACC-Cardiovascular Imaging. 2016; 9:243-252.

Feasibility of Electronic Medication Monitoring Among Adolescents and Emerging Adults with Sickle Cell Disease. Hildenbrand, AK; Kidwell, KM; McGrady, ME; Quinn, CT; Crosby, LE; Mara, CA. Patient Preference and Adherence. 2023; 17:3167-3171.

Association between Acute Pain Scores in Children with Sickle Cell Disease and Emergency Department Disposition and Return Visit Rates. Coleman, KD; McKinley, K; Ellison, AM; Alpern, ER; Hariharan, S; Topoz, I; Wurtz, M; Nielsen, B; Cook, LJ; Morris, CR; et al. Blood. 2023; 142:3874.

Patterns of Nonadherence to Hydroxyurea in Pediatric Sickle Cell Disease. Crosby, LE; Lang, A; Mara, C; Quinn, CT; Schultz, CL; Bear, B; Akintobi, TE; Miller, RE; Hildenbrand, AK. Blood. 2023; 142:7198.

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