Left atrial dysfunction in sickle cell anemia is associated with diffuse myocardial fibrosis, increased right ventricular pressure and reduced exercise capacity.
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Diastolic dysfunction is associated with exercise impairment in patients with sickle cell anemia.
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Biochemical surrogate markers of hemolysis do not correlate with directly measured erythrocyte survival in sickle cell anemia.
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Sickle cell anemia mice develop a unique cardiomyopathy with restrictive physiology.
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