Alagille syndrome is a rare, inherited disorder. It can affect the liver, heart, eyes, bones, kidneys and nervous system.  This disorder is present at birth, although it may not become apparent until later in life.

Often, patients with Alagille syndrome have a distinctive facial appearance.

Patients may have fewer than normal bile ducts in the liver.

A small number of patients (about 15 percent) go on to develop severe liver disease and require liver transplantation.