Kalinichenko Lab

Ren, X; Ustiyan, V; Guo, M; Wang, G; Bolte, C; Zhang, Y; Xu, Y; Whitsett, JA; Kalin, TV; Kalinichenko, VV. Postnatal Alveologenesis Depends on FOXF1 Signaling in c-KIT+ Endothelial Progenitor Cells. American Journal of Respiratory and Critical Care Medicine. 2019; 200:1164-1176.

Pradhan, A; Dunn, A; Ustiyan, V; Bolte, C; Wang, G; Whitsett, JA; Zhang, Y; Porollo, A; Hu, Y; Xiao, R; et al. The S52F FOXF1 Mutation Inhibits STAT3 Signaling and Causes Alveolar Capillary Dysplasia. American Journal of Respiratory and Critical Care Medicine. 2019; 200:1045-1056.

Sun, L; Ren, X; Wang, I; Pradhan, A; Zhang, Y; Flood, HM; Han, B; Whitsett, JA; Kalin, TV; Kalinichenko, VV. The FOXM1 inhibitor RCM-1 suppresses goblet cell metaplasia and prevents IL-13 and STAT6 signaling in allergen-exposed mice. Science Signaling. 2017; 10.

Cai, Y; Bolte, C; Le, T; Goda, C; Xu, Y; Kalin, TV; Kalinichenko, VV. FOXF1 maintains endothelial barrier function and prevents edema after lung injury. Science Signaling. 2016; 9.

Ren, X; Ustiyan, V; Pradhan, A; Cai, Y; Havrilak, JA; Bolte, CS; Shannon, JM; Kalin, TV; Kalinichenko, VV. FOXF1 transcription factor is required for formation of embryonic vasculature by regulating VEGF signaling in endothelial cells. Circulation Research. 2014; 115:709-720.

Ren, X; Shah, TA; Ustiyan, V; Zhang, Y; Shinn, J; Chen, G; Whitsett, JA; Kalin, TV; Kalinichenko, VV. FOXM1 promotes allergen-induced goblet cell metaplasia and pulmonary inflammation. Molecular and Cellular Biology. 2013; 33:371-386.

Wang, I; Snyder, J; Zhang, Y; Lander, J; Nakafuku, Y; Lin, J; Chen, G; Kalin, TV; Whitsett, JA; Kalinichenko, VV. Foxm1 mediates cross talk between Kras/mitogen-activated protein kinase and canonical Wnt pathways during development of respiratory epithelium. Molecular and Cellular Biology. 2012; 32:3838-3850.

Kalin, TV; Wang, I; Meliton, L; Zhang, Y; Wert, SE; Ren, X; Snyder, J; Bell, SM; Jr, GL; Whitsett, JA; et al. Forkhead Box m1 transcription factor is required for perinatal lung function. Proceedings of the National Academy of Sciences of the United States of America. 2008; 105:19330-19335.

Malin, D; Kim, I; Boetticher, E; Kalin, TV; Ramakrishna, S; Meliton, L; Ustiyan, V; Zhu, X; Kalinichenko, VV. Forkhead box F1 is essential for migration of mesenchymal cells and directly induces integrin-beta3 expression. Molecular and Cellular Biology. 2007; 27:2486-2498.

Reza, AA; Kohram, F; Reza, HA; Kalin, TR; Kannan, PS; Zacharias, WJ; Kalinichenko, VV. FOXF1 Regulates Alveolar Epithelial Morphogenesis Through Transcriptional Activation of Mesenchymal WNT5A. American Journal of Respiratory Cell and Molecular Biology. 2022.

Pradhan, A; Che, L; Ustiyan, V; Reza, AA; Pek, NM; Zhang, Y; Alber, AB; Kalin, TR; Wambach, JA; Gu, M; et al. Novel FOXF1-Stabilizing Compound TanFe Stimulates Lung Angiogenesis in Alveolar Capillary Dysplasia. American Journal of Respiratory and Critical Care Medicine. 2022.

Wang, G; Wen, B; Deng, Z; Zhang, Y; Kolesnichenko, OA; Ustiyan, V; Pradhan, A; Kalin, TV; Kalinichenko, VV. Endothelial progenitor cells stimulate neonatal lung angiogenesis through FOXF1-mediated activation of BMP9/ACVRL1 signaling. Nature Communications. 2022; 13.

Wen, B; Wang, G; Li, E; Kolesnichenko, OA; Tu, Z; Divanovic, S; Kalin, TV; Kalinichenko, VV. In vivo generation of bone marrow from embryonic stem cells in interspecies chimeras. eLife. 2022; 11.

Ribeiro, R; Macedo, JC; Costa, M; Ustiyan, V; Shindyapina, AV; Tyshkovskiy, A; Gomes, RN; Castro, JP; Kalin, TV; Vasques-Nóvoa, F; et al. In vivo cyclic induction of the FOXM1 transcription factor delays natural and progeroid aging phenotypes and extends healthspan. 2022; 2:397-411.

Toth, A; Steinmeyer, S; Kannan, P; Gray, J; Jackson, CM; Mukherjee, S; Demmert, M; Sheak, JR; Benson, D; Kitzmiller, J; et al. Inflammatory blockade prevents injury to the developing pulmonary gas exchange surface in preterm primates. Science Translational Medicine. 2022; 14.

Damianos, A; Xu, K; Kalin, GT; Kalinichenko, VV. Placental tissue stem cells and their role in neonatal diseases. Seminars in Neonatology. 2022; 27.

Sun, X; Perl, AK; Li, R; Bell, SM; Sajti, E; Kalinichenko, VV; Kalin, TV; Misra, RS; Deshmukh, H; Clair, G; et al. A census of the lung: CellCards from LungMAP. Developmental Cell. 2022; 57:112-145.e2.

Kalinichenko, VV; Bolte, CS; Kalin, TV. Transcription Factors: Forkhead Box (FOX) ☆. Encyclopedia of Respiratory Medicine. 2022.

Kolesnichenko, OA; Whitsett, JA; Kalin, TV; Kalinichenko, VV. Therapeutic Potential of Endothelial Progenitor Cells in Pulmonary Diseases. American Journal of Respiratory Cell and Molecular Biology. 2021; 65:473-488.

Deng, Z; Lin, J; Bud’ko, SL; Webster, B; Kalin, TV; Kalinichenko, VV; Shi, D. Dual Targeting with Cell Surface Electrical Charge and Folic Acid via Superparamagnetic Fe3O4@Cu2-xS for Photothermal Cancer Cell Killing. Cancers. 2021; 13.

Sun, F; Wang, G; Pradhan, A; Xu, K; Gomez-Arroyo, J; Zhang, Y; Kalin, GT; Deng, Z; Vagnozzi, RJ; He, H; et al. Nanoparticle Delivery of STAT3 Alleviates Pulmonary Hypertension in a Mouse Model of Alveolar Capillary Dysplasia. Circulation. 2021; 144:539-555.

Wang, G; Wen, B; Ren, X; Li, E; Zhang, Y; Guo, M; Xu, Y; Whitsett, JA; Kalin, TV; Kalinichenko, VV. Generation of Pulmonary Endothelial Progenitor Cells for Cell-based Therapy Using Interspecies Mouse-Rat Chimeras. American Journal of Respiratory and Critical Care Medicine. 2021; 204:326-338.

Li, E; Ustiyan, V; Wen, B; Kalin, GT; Whitsett, JA; Kalin, TV; Kalinichenko, VV. Blastocyst complementation reveals that NKX2-1 establishes the proximal-peripheral boundary of the airway epithelium. Developmental Dynamics. 2021; 250:1001-1020.

Milewski, D; Shukla, S; Gryder, BE; Pradhan, A; Donovan, J; Sudha, P; Vallabh, S; Pyros, A; Xu, Y; Barski, A; et al. FOXF1 is required for the oncogenic properties of PAX3-FOXO1 in rhabdomyosarcoma. Oncogene. 2021; 40:2182-2199.

Deng, Z; Kalin, GT; Shi, D; Kalinichenko, VV. Nanoparticle Delivery Systems with Cell-Specific Targeting for Pulmonary Diseases. American Journal of Respiratory Cell and Molecular Biology. 2021; 64:292-307.

Wen, B; Li, E; Ustiyan, V; Wang, G; Guo, M; Na, CL; Kalin, GT; Galvan, V; Xu, Y; Weaver, TE; et al. In Vivo Generation of Lung and Thyroid Tissues from Embryonic Stem Cells Using Blastocyst Complementation. American Journal of Respiratory and Critical Care Medicine. 2021; 203:471-483.

Nasr, T; Holderbaum, AM; Chaturvedi, P; Agarwal, K; Kinney, JL; Daniels, K; Trisno, SL; Ustiyan, V; Shannon, JM; Wells, JM; et al. Disruption of a hedgehog-foxf1-rspo2 signaling axis leads to tracheomalacia and a loss of sox9+ tracheal chondrocytes. DMM Disease Models and Mechanisms. 2021; 14.

Cappelletti, M; Doll, JR; Stankiewicz, TE; Lawson, MJ; Sauer, V; Wen, B; Kalinichenko, VV; Sun, X; Tilburgs, T; Divanovic, S. Maternal regulation of inflammatory cues is required for induction of preterm birth. JCI insight. 2020; 5.

Pradhan, A; Kalin, TV; Kalinichenko, VV. Genome Editing for Rare Diseases. Current stem cell reports. 2020; 6:41-51.

Bolte, C; Ustiyan, V; Ren, X; Dunn, AW; Pradhan, A; Wang, G; Kolesnichenko, OA; Deng, Z; Zhang, Y; Shi, D; et al. Nanoparticle Delivery of Proangiogenic Transcription Factors into the Neonatal Circulation Inhibits Alveolar Simplification Caused by Hyperoxia. American Journal of Respiratory and Critical Care Medicine. 2020; 202:100-111.

Black, M; Arumugam, P; Shukla, S; Pradhan, A; Ustiyan, V; Milewski, D; Kalinichenko, VV; Kalin, TV. FOXM1 nuclear transcription factor translocates into mitochondria and inhibits oxidative phosphorylation. Molecular Biology of the Cell. 2020; 31:1411-1424.

Goda, C; Balli, D; Black, M; Milewski, D; Le, T; Ustiyan, V; Ren, X; Kalinichenko, VV; Kalin, TV. Loss of FOXM1 in macrophages promotes pulmonary fibrosis by activating p38 MAPK signaling pathway. PLoS Genetics. 2020; 16.

Bolte, C; Kalin, TV; Kalinichenko, VV. Molecular, cellular, and bioengineering approaches to stimulate lung regeneration after injury. Seminars in Cell and Developmental Biology. 2020; 100:101-108.

Kurahashi, T; Yoshida, Y; Ogura, S; Egawa, M; Furuta, K; Hikita, H; Kodama, T; Sakamori, R; Kiso, S; Kamada, Y; et al. Forkhead Box M1 Transcription Factor Drives Liver Inflammation Linking to Hepatocarcinogenesis in Mice. CMGH Cellular and Molecular Gastroenterology and Hepatology. 2020; 9:425-446.

Whitsett, JA; Zacharias, W; Swarr, D; Kalinichenko, VV. Chapter 67 Cell- and tissue-based therapies for lung disease. Principles of Tissue Engineering. 2020.

Hasegawa, T; Kikuta, J; Sudo, T; Matsuura, Y; Matsui, T; Simmons, S; Ebina, K; Hirao, M; Okuzaki, D; Yoshida, Y; et al. Identification of a novel arthritis-associated osteoclast precursor macrophage regulated by FoxM1. Nature Immunology. 2019; 20:1631-1643.

Ren, X; Ustiyan, V; Guo, M; Wang, G; Bolte, C; Zhang, Y; Xu, Y; Whitsett, JA; Kalin, TV; Kalinichenko, VV. Postnatal Alveologenesis Depends on FOXF1 Signaling in c-KIT+ Endothelial Progenitor Cells. American Journal of Respiratory and Critical Care Medicine. 2019; 200:1164-1176.

Pradhan, A; Dunn, A; Ustiyan, V; Bolte, C; Wang, G; Whitsett, JA; Zhang, Y; Porollo, A; Hu, Y; Xiao, R; et al. The S52F FOXF1 Mutation Inhibits STAT3 Signaling and Causes Alveolar Capillary Dysplasia. American Journal of Respiratory and Critical Care Medicine. 2019; 200:1045-1056.

Shukla, S; Milewski, D; Pradhan, A; Rama, N; Rice, K; Le, T; Flick, MJ; Vaz, S; Zhao, X; Setchell, KD; et al. The FOXM1 Inhibitor RCM-1 Decreases Carcinogenesis and Nuclear β-Catenin. Molecular Cancer Therapeutics. 2019; 18:1217-1229.

Flood, HM; Bolte, C; Dasgupta, N; Sharma, A; Zhang, Y; Gandhi, CR; Kalin, TV; Kalinichenko, VV. The Forkhead box F1 transcription factor inhibits collagen deposition and accumulation of myofibroblasts during liver fibrosis. Biology Open. 2019; 8.

Whitsett, JA; Kalin, TV; Xu, Y; Kalinichenko, VV. Building and Regenerating the Lung Cell by Cell. Physiological Reviews. 2019; 99:513-554.

Izumi, T; Imai, J; Yamamoto, J; Kawana, Y; Endo, A; Sugawara, H; Kohata, M; Asai, Y; Takahashi, K; Kodama, S; et al. Vagus-macrophage-hepatocyte link promotes post-injury liver regeneration and whole-body survival through hepatic FoxM1 activation. Nature Communications. 2018; 9.

Dunn, AW; Kalinichenko, VV; Shi, D. Highly Efficient In Vivo Targeting of the Pulmonary Endothelium Using Novel Modifications of Polyethylenimine: An Importance of Charge. Journal of Interconnection Networks. 2018; 7.

Ustiyan, V; Bolte, C; Zhang, Y; Han, L; Xu, Y; Yutzey, KE; Zorn, AM; Kalin, TV; Shannon, JM; Kalinichenko, VV. FOXF1 transcription factor promotes lung morphogenesis by inducing cellular proliferation in fetal lung mesenchyme. Developmental Biology. 2018; 443:50-63.

Black, M; Milewski, D; Le, T; Ren, X; Xu, Y; Kalinichenko, VV; Kalin, TV. FOXF1 Inhibits Pulmonary Fibrosis by Preventing CDH2-CDH11 Cadherin Switch in Myofibroblasts. Cell Reports. 2018; 23:442-458.