The lung epithelial barrier plays an important role in protecting the airways against inhaled particles, allergens and microorganisms. Our recent proteomic analyses of type II epithelial cells identified a subfamily of lipid (phosphatidylcholine) transport proteins (Stard2, Stard7 and Stard10) that appear to be novel inhibitors of allergic disease. We generated knockout mice for Stard7 and Stard10 and demonstrated that these animals display highly exaggerated lung disease when challenged with allergen. Importantly, loss of Stard7 expression was also associated with exaggerated allergic responses in the skin and intestine. The goals of this new project are to identify molecular pathways that underlie the “protective” function of Stard7, Stard10, and/or Stard2 with the long-term goal of uncovering novel therapeutic targets for allergic diseases.