Dey Lab

Sun X, Terakawa J, Clevers H, Barker N, Daikoku T, and Dey SK. Ovarian LGR5 is critical for successful pregnancy. FASEB J 28 (5): 2380-9. May 2014.

Haraguchi H, Saito-Fujita T, Hirota Y, Egashira M, Matsumoto L, Matsuo M, Hiraoka T, Koga K, Yamauchi N, Fukayama M, Bartos A, Cha J, Dey SK, Fujii T, Osuga Y. MicroRNA-200a locally attenuates progesterone signaling in the cervix preventing embryo implantation. Mol Endo 28 (7): 1108-17. Jul 2014.

Daikoku T, Ogawa Y, Terakawa J, Ogawa A, DeFalco T, Dey SK. Lactoferrin-iCre: a new mouse line to study uterine epithelial gene function. Endocrinology 155 (7): 2718-24. July 2014.

Cha J, Bartos A, Park C, Sun X, Li Y, Cha SW, Ajima R, Ho HY, Yamaguchi TP, Dey SK. Appropriate Crypt Formation in the Uterus for Embryo Homing and Implantation Requires Wnt5a-ROR Signaling. Cell Report 8(2): 382-92. Jul 24, 2014.

Sun X, Cappelletti M, Li Y, Karp CL, Divanovic S, Dey SK. Cnr2 Deficiency Confers Resistance to Inflammation-Induced Preterm Birth in Mice. Endo. Jul 22, 2014.

Romero R, Dey SK, Fisher SJ. Preterm Labor: one syndrome, many causes. Science 345(6298): 760-765. Aug 15, 2014.  

Cha J, Sun X, Bartos A, Fenelon J, Lefevre P, Daikoku T, Shaw G, Maxson R, Murphy BD, Renfree MB, Dey SK. A new role for muscle segment homeobox genes in mammalian embryonic diapause. Open Biol 3 (4): 130035, April 2013.

Daikoku T, Yoshie M, Xie H, Sun X, Cha J, Ellenson LH, Dey SK. Conditional deletion of Tsc1 in the female reproductive tract impedes normal oviductal and uterine function by enhancing mTORC1 signaling in mice. Mol Hum Reprod 19 (7): 463-72, July 2013.

Raines AM, Adam M, Magella B, Meyer SE, Grimes HL, Dey SK, Potter SS. Recombineering-based dissection of flanking and paralogous Hox gene functions in mouse reproductive tracts. Development 140 (14): 2942-52, July 2013.

Sun X, Bartos A, Whitsett JA, Dey SK. Uterine deletion of gp130 or Stat3 shows implantation failure with increased estrogenic responses. Mole Endo 27 (9): 1492-501. Sept 2013.

Cha J, Bartos A, Egashira M, Haraguchi H, Saito-Fujita T, Leishman E, Bradshaw H, Dey SK, and Hirota Y. Combinatory approaches prevent preterm birth profoundly exacerbated by gene-environment interactions. J Clin Invest 123 (9): 4063-75. Sept 2013.

Lanekoff I, Burnum-Johnson KE, Thomas M, Short J, Carson JP, Cha J, Dey SK, Yang P, Prieto Conaway MC, and Laskin J. High-Speed MS/MS in Situ Imaging by Nanospray Desorption Electrospray Ionization Mass Spectrometry. Anal Chem 85 (20): 9596-603. Oct 15, 2013.

Katoh H, Wang D, Daikoku T, Sun H, Dey SK, and DuBois RN. CXCR2-expressing myeloid-derived suppressor cells are essential to promote colitis-associated tumorigenesis. Cancer Cell 24 (5): 631-44. Nov 11, 2013.

Sun X, Zhang L, Xie H, Wan H, Magella B, Whitsett JA, and Dey SK. Kruppel-like factor 5 (KLF5) is critical for conferring uterine receptivity to implantation . Proc Natl Acad Sci USA 109(4): 1145-50, Jan 2012.

Hirota Y, Burnum KE, Acar N, Rabinovich GA, Daikoku T, and Dey SK. Galectin-1 markedly reduces the incidence of resorptions in mice missing immunophilin FKBP52. Endocrinology 153(5): 2486-93. May 2012.

Burnum KE, Hirota Y, Baker ES, Yoshie M, Ibrahim YM, Monroe ME, Anderson GA, Smith RD, Daikoku T, Dey SK. Uterine Deletion of Trp53 Compromises Antioxidant Responses in the Mouse Decidua. Endocrinology 153 (9): 4568-79, Sept 2012.

Xie H, Sun X, Piao Y, Jegga AG, Handwerger S, Ko MS, Dey SK. Silencing or amplification of endocannabinoid signaling in blastocysts via CB1 compromises trophoblast cell migration . J Biol Chem 287(38): 32288-97, Sept 2012.  

Daikoku T, Jackson L, Besnard V, Whitsett J, Ellenson LH, Dey SK. Cell-specific conditional deletion of Pten in the uterus results in differential phenotypes. Gynecol Oncol. 122, 2: 424-429. Aug, 2011

Lee JE, Oh HA, Song H, Jun JH, Roh CR, Xie H, Dey SK, and Lim HJ. Autophagy regulates embryonic survival during delayed implantation.  Endocrinology 152(5):2067-2075, May 2011.

Hirota Y, Cha J, Yoshie M, Daikoku T, Dey SK. Heightened uterine mammalian target of rapamycin complex 1 (mTORC1) signaling provokes preterm birth in mice. Proc Natl Acad Sci USA 108 (44): 18073-8, Nov 2011.

Daikoku T, Cha J, Sun X, Tranguch S, Xie H, Fujita T, Hirota Y, Lydon J, DeMayo F, Maxson R, Dey SK. Conditional Deletion of MSX Homeobox Genes in the Uterus Inhibits Blastocyst Implantation by Altering Uterine Receptivity. Developmental Cell 21(6): 1014-25, Dec 2011.

Sun X, Xie H, Yang J, Wang H, Bradshaw HB, and Dey SK. Endocannabinoid signaling directs differentiation of trophoblast cell lineages and placentation. Proc Natl Acad Sci USA 107(39):16887-16892, Epub Sept 13 2010.

Hirota Y, Acar N, Tranguch S, Burnum KE, Xie H, Kodama A, Osuga Y, Ustunel I, Friedman DB, Caprioli RM, Daikoku T, Dey SK. Uterine FK506-binding protein 52 (FKBP52)-peroxiredoxin-6 (PRDX6) signaling protects pregnancy from overt oxidative stress. Proc Natl Acad Sci U S A. 107, 35: 15577-15582. Aug, 2010.

Hirota Y, Daikoku T, Tranguch S, Xie H, Bradshaw HB, Dey SK. Uterine-specific p53 deficiency confers premature uterine senescence and promotes preterm birth in mice. J Clin Invest.120(3):803-815. 2010.

Shaw JLV, Dey SK, Critchley HOD, Horne AW. Current knowledge of the aetiology of human tubal ectopic pregnancy. Hum Reprod Update. 16(4): 432-444. 2010.

Daling JR, Doody DR, Sun X, Trabert BL, Weiss NS, Chen C, Biggs ML, Starr JR,  Dey SK, Schwartz SM. Association of marijuana use and the incidence of testicular germ cell tumors. Cancer. 115(6):1215-1223. 2009.

Sun X, Wang H, Okabe M, Mackie K, Kingsley PJ, Marnett L, Cravatt BF, Dey SK. Genetic loss of Faah compromises male fertility in mice. Biol Reprod. 80(2):235-242. 2009.

Zhuge Y, Lagman JA, Ansenberger K, Mahon CJ, Daikoku T, Dey SK, Bahr JM, Hales DB. CYP1B1 expression in ovarian cancer in the laying hen Gallus domesticus. Gynecol Oncol. 112(1):171-178. 2009.

Burnum KE, Cornett DS, Puolitaival SM, Milne SB, Myers DS, Tranguch S, Brown HA, Dey SK, Caprioli RM. Spatial and temporal alterations of phospholipids determined by mass spectrometry during mouse embryo implantation. J Lipid Res.50(11):2290-2298. 2009.

Huang X, Ketova T, Fleming J, Dey SK, Wang H, Litingtung Y, Chiang C. Sonic hedgehog signaling regulates a novel epithelial progenitor domain of the hindbrain choroid plexus. Development. 136:2535-2543. 2009.

Sun X, Jackson L, Dey SK, Daikoku T. In pursuit of Leucine-rich repeat-containing G protein-coupled receptor-5 regulation and function in the uterus. Endocrinology. 150(11):5065-5073. 2009.

Wada M, Saunders TL, Morrow J, Milne GL, Walker KP, Dey SK, Brock TG, Opp MR, Aronoff DM, Smith WL. Two pathways for cyclooxygenase-2 protein degradation in vivo. J Biol Chem. 284(45):30742-30753. 2009.

Lim HJ, Dey SK. HB-EGF: a unique mediator of embryo-uterine interactions during implantation. Exp Cell Res. 315(4); 619-626. 2009.

Xie H, Tranguch S, Jia X, Zhang H, Das SK,  Dey SK, Kuo CJ, Wang H. Inactivation of nuclear Wnt-β-Catenin signaling limits blastocyst competency for implantation. Development.135(4):717-727. 2008.

Backlund MG, Mann JR, Holla VR, Shi Q, Daikoku T, Dey SK, DuBois RN. Repression of 15-hydroxyprostaglandin dehydrogenase involves histone deacetylase 2 and snail in colorectal cancer. Cancer Res. 68(22):9331-9337. 2008.

Daikoku T, Hirota Y, Tranguch S, Joshi AR, DeMayo FJ, Lydon JP, Ellenson LH, Dey SK. Conditional loss of uterine Pten unfailingly and rapidly induces endometrial cancer in mice. Cancer Res. 68(14):5619-5627. 2008.

Wang D, Wang H, Wei N, Backlund M, Dey SK, DuBois RN. Loss of cannabinoid receptor 1 accelerates intestinal tumor growth. Cancer Res. 68(15):6468-6476. 2008.

Wang H, Xie H, Dey SK. Loss of cannabinoid receptor CB1 induces preterm birth. PLoS One. 3(10):e3320. 2008.

VonStetina JR, Cha B, Tranguch S, Dey SK, Lee L, Lee E, Drummond-Barbosa D. alpha-Endosulfine is a conserved protein required for oocyte meiotic maturation in Drosophila. Development. 135(22):3697-706. 2008.

Hirota Y, Tranguch S, Daikoku T, Hasegawa A, Osuga Y, Taketani Y, Dey SK. Deficiency of immunophilin FKBP52 promotes endometriosis. Am J Pathol. 173(6):1747-1757. 2008.

Horne AW, Phillips, JA, Kane N, Lourenco PC, McDonald SE, Williams ARW, Simon C, Dey SK, Critchley HOD. CB1 expression is attenuated in Fallopian tube and decidua of women with ectopic pregnancy. PLoS One. 3(12):e3969. 2008.

Backlund MG, Mann JR, Holla VR, Shi Q, Daikoku T, Dey SK, DuBois RN. Repression of 15-hydroxyprostaglandin dehydrogenase involves histone deacetylase 2 and snail in colorectal cancer. Cancer Res. 68(22):9331-9337. 2008.

Daikoku T, Dey SK. Two faces of PTEN. Nat Med. 14(11):1192-1193. 2008.

Sun X, Dey SK. Aspects of endocannabinoid signaling in periimplantation biology. Mol Cell Endocrinol.286(1-2 Suppl 1):S3-11. 2008.

Wang H, Xie H, Sun X, Kingsley PJ, Marnett LJ, Cravatt BF, Dey SK. Differential regulation of endocannabinoid synthesis and degradation in the uterus during embryo implantation. Prostaglandins Other Lipid Mediat. 83(1-2):62-74. 2007.

Hong J, Kim ST, Tranguch S, Smith DF, Dey SK. Deficiency of co-chaperone immunophilin FKBP52 compromises sperm fertilizing capacity. Reproduction.133(2):395-403. 2007.

Tranguch S, Wang H, Daikoku T, Xie H, Smith D, Dey SK. FKBP52 deficiency-conferred uterine progesterone resistance is genetic background and pregnancy stage specific. J Clin Invest. 117(7):1824-1834. 2007.

Daikoku T, Tranguch S, Chakrabarty A, Wang D, Khabele D, Orsulic S, Morrow JD, DuBois RN, Dey SK. Extracellular signal-regulated kinase is a target of cycloxygenase-1-peroxisome proliferator-activated receptor-delta signaling in epithelial ovarian cancer. Cancer Res.67(11):5285-5292. 2007.

Sadikot RT, Zeng  H,  Azim AC, Joo M, Dey SK, Breyer RM, Peebles RS, Blackwell TS, Christman JW. Bacterial clearance of Pseudomonas aeruginosa is enhanced by the inhibition of COX-2. Eur J Immunol.37(4):1001-1009. 2007.

Tranguch S, Chakrabarty A, Guo Y, Wang H, Dey SK. Maternal pentraxin 3 deficiency compromises implantation in mice. Biol Reprod. 77(3):425-432. 2007.

Ghosh M, Wang H, Ai Y, Romeo E, Luyendyk JP, Peters JM, Mackman N, Dey SK, Hla T. COX-2 suppresses tissue factor expression via endocannabinoid-directed PPARdelta activation. J Exp Med.204(9):2053-2061. 2007.

Chakrabarty A, Tranguch S, Daikoku T, Jensen K, Furneaux H, Dey SK. MicroRNA regulation of cyclooxygenase-2 during embryo implantation. Proc Natl Acad Sci USA.104(38):15144-15149. 2007.

Wang H, Xie H, Sun X, Tranguch S, Zhang H, Jia X, Wang D, Das SK, Desvergne B, Wahli W, DuBois RN, Dey SK. Stage-specific integration of maternal and embryonic peroxisome proliferator-activated receptor delta signaling is critical to pregnancy success. J Biol Chem.282:37770-37782. 2007.

Xie H, Wang H, Tranguch S,  Iwamoto R, Mekada E, DeMayo F, Lydon J, Das SK, Dey SK. Maternal heparin-binding-EGF deficiency limits pregnancy success in mice. Proc Natl Acad Sci USA.104(46):18315-18320. 2007.

Wang H, Dey SK, Maccarrone M. Jekyll and Hyde: Two faces of cannabinoid signaling in male and female fertility. Endocr Rev. 27(5):427-448. 2006.

Wang H, Dey SK. Roadmap to embryo implantation: clues from mouse models. Nat Rev Genet.7:185-199. 2006.

Wang D, Wang  H, Guo Y, Ning W, Katkuri S, Wahli W, Desvergne B, Dey SK, DuBois RN. Crosstalk between peroxisome proliferator-activated receptor delta and VEGF stimulates cancer progression. Proc Natl Acad Sci, USA. 103(50):19069-19074. 2006. 

Wang H, Xie H, Guo Y, Zhang H, Takahashi T, Kingsley PJ, Marnett LJ, Das SK, Cravatt BF, Dey SK. Fatty acid amide hydrolase deficiency limits early pregnancy events. J CIin Invest116(8):2122-2131. 2006.

Tranguch S, Cheung-Flynn J, Daikoku T, Prapapanich V, Cox MB, Xie H,Wang H, Das SK, Smith DF and Dey SK. Cochaperone immunophilin FKBP52 is critical to uterine receptivity for embryo implantation. Proc Natl Acad Sci USA.102(40):14326-14331. 2005.

Wang H, Tranguch S, Xie H, Hanley G, Das SK, Dey SK. Variation in commercial rodent diets induces disparate molecular and physiological changes in the mouse uterus. Proc Natl Acad Sci USA. 102(28): 9960-9965. 2005.

Dey SK, Lim H, Das SK, Reese J, Paria BC, Daikoku T, Wang H. Molecular cues to implantation. Endocr Rev.25(3): 341-373. 2004.

Wang D, Wang H, Shi Q, Katkuri S,Walhi W, Desvergne B, Das SK, Dey SK, DuBois RN. Prostaglandin E(2) promotes colorectal adenoma growth via transactivation of the nuclear peroxisome proliferator-activated receptor delta. Cancer Cell. 6:285-295. 2004.

Wang H, Guo Y, Wang D, Kingsley PJ, Marnett LJ, Das SK,DuBois RN, Dey SK. Aberrant cannabinoid signaling impairs oviductal transport of embryos. Nat Med.10(10):1074-1080. 2004.

Hamatani T, Daikoku T, Wang H, Matsumoto H, Carter MG, Ko MSH, Dey SK. Global gene expression analysis identifies molecular pathways distinguishing blastocyst dormancy and activation. Proc Natl Acad Sci USA.101(28):10326-10331.2004.

Gupta RA, Wang D, Katkuri S, Wang H, Dey SK, DuBois RN. Activation of nuclear hormone receptor peroxisome proliferator-activated receptor-delta accelerates intestinal adenoma growth. Nat Med. 10(3):245-247. 2004.

Wang H, Matsumoto H, Guo Y, Paria BC, Roberts RL, Dey SK. Differential G protein-coupled cannabinoid receptor signaling by anandamide directs blastocyst activation for implantation. Proc Natl Acad Sci USA. 100(25):14914-14919. 2003.

Ma W-G, Song H, Das SK, Paria BC, Dey SK. Estrogen is a critical determinant that specifies the duration of the window of uterine receptivity for implantation. Proc Natl Acad Sci USA. 100(5):2963-2968. 2003.

Brisken C, Heineman A, Nguyen C, Reinhardt F, Jan J, Dey SK, Dotto P, Weinberg RA. IGF-2 is a mediator of prolactin-induced morphogenesis in the breast. Dev Cell. 3(6):877-887. 2002.

Leach RE, Romero R, Kim YM, Chaiworapongsa T, Kilburn B, Das SK, Dey SK, Johnson A, Qureshi F, Jacques S, Armant DR. Pre-eclampsia and expression of heparin-binding EGF-like growth factor. Lancet. 360:1215-1219. 2002.

Paria BC, Reese J, Das SK, Dey SK. Deciphering the cross-talk of implantation: Advances and challenges. Science. 296:2185-2188. 2002.

Paria BC, Ma W, Tan J, Raja S, Das SK, Dey SK, Hogan BLM. Cellular and molecular responses of the uterus to embryo implantation can be elicited by locally applied growth factors. Proc Natl Acad Sci USA. 98(3):1047-1052. 2001.

Gupta RA, Tan J, Krause WF, Radhika A, Wilson TM, Dey SK, DuBois RN. Prostacyclin-mediated activation of peroxisome proliferator-activated receptor delta in colorectal cancer. Proc Natl Acad Sci USA. 97(24):13275-13280. 2000.

Brisken C, Heineman A, Chavarria T, Elenbaas B, Tan J, Dey SK, McMahon JA, McMahon AP, Weinberg RA. Essential function of Wnt-4 in mammary gland development downstream of progesterone signaling. Gene Dev.14(6):650-654. 2000.

Reese J, Paria BC, Brown N, Zhao X, Morrow, JD, Dey SK. Coordinated regulation of fetal and maternal prostaglandins directs successful birth and postnatal adaptation in the mouse. Proc Natl Acad Sci USA. 97(17):9759-9764. 2000.

Williams CL, Shattuck-Brandt RL, Reese J, Dey SK, DuBois RN. Host cyclooxygenase-2 modulates carcinoma growth. J Clin Invest. 105(11):1589-1594. 2000.

Lim H, Gupta RA, Ma WG, Paria BC, Moller DE, Morrow, JD, DuBois RN, Trzaskos JM, Dey SK. Cyclo-oxygenase-2-derived prostacyclin mediates embryo implantation in the mouse via PPARdelta. Gene Dev.13:1561-1574. 1999.

Lim H, Paria BC, Das SK, Dinchuk JE, Langenbach R, Trzaskos JM, Dey SK. Multiple female reproductive failures in cyclooxygenase 2-deficient mice. Cell.91(2):197-208. 1997.

Das SK, Taylor JA, Korach KS, Paria BC, Dey SK, Lubahn DB. Estrogenic responses in estrogen receptor-alpha deficient mice reveal a distinct estrogen signaling pathway. Proc Natl Acad Sci USA. 94(24):12786-12791. 1997.  

Deutsch DG, Goligorski MS, Schmid PC, Krebsbach RJ, Schmid HHO, Das SK, Dey SK, Arreaza, Thorup C, Stefano G, Moore LC. Production and physiological actions of anandamide in the vasculature of the rat kidney. J Clin Invest. 100(6):1538-1546. 1997.

Schmid PC, Paria BC, Krebsbach RJ, Schmid HHO, Dey SK. Changes in anandamide levels in mouse uterus are associated with uterine receptivity for embryo implantation. Proc Natl Acad Sci USA. 94(8):4188-4192. 1997.

Hou Q, Paria BC, Mui C, Dey SK, Gorski J. Immunolocalization of estrogen receptor protein in the mouse blastocyst during normal and delayed implantation. Proc Natl Acad Sci USA.93(6):2376‑2381. 1996.

Paria BC, Das SK, Dey SK. The preimplantation mouse embryo is a target for cannabinoid ligand‑receptor signaling. Proc Natl Acad Sci USA. 92(21):9460‑9464. 1995.

Das SK, Paria BC, Chakraborty I, Dey SK. Cannabinoid ligand‑receptor signaling in the mouse uterus. Proc Natl Acad Sci USA. 92(10):4332‑4336. 1995.

Paria BC, Das SK, Andrews GK, Dey SK. Expression of the epidermal growth factor receptor gene is regulated in mouse blastocysts during delayed implantation. Proc Natl Acad Sci USA. 90(1):55‑59. 1993.

Paria BC, Huet‑Hudson YM, Dey SK. Blastocyst’s state of activity determines the “window” of implantation in the receptive mouse uterus. Proc Natl Acad Sci USA. 90(21):10159‑10162. 1993.

Paria BC, Dey SK, Andrews GK. Antisense c‑myc effects on preimplantation mouse embryo development. Proc Natl Acad Sci USA. 89(21):10051‑10055. 1992.

Paria BC and Dey SK. Preimplantation embryo development in vitro: Cooperative interactions among embryos and role of growth factors. Proc Natl Acad Sci USA.87:4756‑ 4760. 1990.

Dey SK, Villanueva C, Abdou NI. Histamine receptors on rabbit blastocyst and endometrial cell membranes. Nature.278:648-649. 1979.

Dickmann Z, Sen Gupta J, Dey SK. Does “blastocyst estrogen” initiate implantation? Science. 195:687-688. 1977.

Dickmann Z, Dey SK, Sen Gupta J. Steroidogenesis in rabbit preimplantation embryos.  Proc Natl Acad Sci (USA). 72(1):298-300. 1975.