Cincinnati Children’s conducts groundbreaking clinical and basic research in hopes of improving the lives and prognosis of childhood cancer survivors.

Our survivorship research in the Cancer and Blood Diseases Institute focuses on:

  • The development of molecular markers to identify which patients are at high risk for late complications or secondary cancers
  • Ways to improve quality of life and function in patients who have bone tumors and sarcomas
  • The causes of early heart and lung disease in cancer survivors
  • New approaches to study fertility issues and improve fertility outcomes
  • New ways to improve adherence to medication regimens in young adults
  • The evaluation and treatment of neurological and psychological side effects
  • New ways to prevent secondary cancers and other complications associated with cancer treatment

Highlights of Ongoing and Recent Research

  • Stella M. Davies, MB BS, PhD, MRCP, serves on the national steering committee for the National Institutes of Health-funded Childhood Cancer Survivor Study. This study uses data from more than 14,000 childhood cancer survivors to understand genetic influences on the risk of cardiac side effects from treatment, the risk of obesity in leukemia survivors and the risk of second cancers in children treated with radiation therapy as well as other issues. In her laboratory, Davies is looking at genetic markers in cancer survivors to determine which genes might predict susceptibility to long-term problems, such as secondary leukemia. Her research will help improve treatments for aging survivors, as well as personalized cancer treatments based on a patient’s genetic profile.
  • Karen C. Burns, MD, MS, is evaluating treatment options for long-term survivors with fertility problems. She is also exploring better ways to prevent long-term fertility issues caused by chemotherapy and radiation.
  • Rajaram Nagarajan, MD, MS, is leading the Limb Function and Quality of Life of Survivors of Pediatric Lower Extremity Bone Tumors project. This study quantifies the limitations encountered by survivors of lower extremity bone tumors by measuring physical function, disability, quality of life, self-concept and body image. The study also seeks to identify features  that may  predict functional and quality-of-life outcomes.