The Diagnostic Center for Heritable Immunodeficiencies (DCHI) at Cincinnati Children’s is the largest and most specialized center in North America for the diagnosis of rare primary immunodeficiencies, bone marrow failure syndromes and other disorders of the immune system. The DCHI has been recognized as a center of excellence by the Federation of Clinical Immunology Societies and the Jeffrey Modell Foundation.
Enhanced Immunology Exome
Our updated Immunology Exome now includes a total of 394 genes. Our expanded gene list highlights genes associated with immunodeficiencies affecting cellular and humoral immunity, combined immunodeficiencies with associated or syndromic features, predominantly antibody deficiencies, diseases of immune dysregulation, congenital defects of phagocyte number or function, defects in intrinsic and innate immunity, autoinflammatory disorders, complement deficiencies, and phenocopies of inborn errors of immunity.
Immunology Exome | Test Requisition
Next-generation sequencing (NGS) panels
Other disorders for which the DCHI offers rapid screening and genetic diagnostic testing include Wiskott-Aldrich syndrome (WAS), X-linked lymphoproliferative disease (XLP) and X-linked immune dysregulation, polyendocrinopathy enteropathy syndrome (IPEX).
> Visit our HLH Center of Excellence pages for more information about the treatment of hemophagocytic lymphohistiocytosis.