A photo of Katherine D. Holland.

Katherine D. Holland, MD, PhD

  • Co-Director, Child Neurophysiology Lab
  • Epilepsy Specialist, Division of Neurology
  • Associate Professor, UC Department of Pediatrics



One out of three people with epilepsy have uncontrollable seizures because no therapy has been successful for them. Additionally, the cause is unknown in six out of ten people with epilepsy. As such, researchers need to continue investigating the causes of epilepsy and developing potential treatments.

The research areas I’m interested in include mechanisms of epileptogenesis, epilepsy and ion channels studies. The primary issue my colleagues and I are attempting to solve in our research laboratory is genetic modifiers of epilepsy severity. By understanding modifiers of epilepsy severity, I hope to identify new approaches to therapy.

I've been practicing for more than 20 years. My patient care specialties involve epilepsy and neurophysiology in the pediatrics sector. My family inspired me to become a healthcare provider. All of my parents (mother, father, stepmother and stepfather) researched and worked in the brain sciences field. Much of their work was clinical.

It was ice cream that drew me to pediatrics and treating children. When I was a medical student, a neurologist asked me whether I preferred ice cream or pizza. When I answered ice cream, I was told that this was the mark of a pediatric neurologist.

My research studies have been published in numerous respected journals, such as The New England Journal of Medicine, Neurobiology of Disease, Epilepsy and Behavior, Journal of Neurosurgery: Pediatrics and the Journal of Child Neurology.

MD: Washington University, St. Louis, MO, 1991.

PhD (pharmacology): Washington University, St. Louis, MO, 1991.

Internship: Children's Hospital, Boston, MA.

Residency: St Louis Children's Hospital, St. Louis, MO.

Certification: Neurology with added qualification in pediatric neurology, 2000.

Services and Specialties

Neurology, Epilepsy


Mechanisms of epileptogenesis

Research Areas


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Novel SCN3A variants associated with focal epilepsy in children. Vanoye, CG; Gurnett, CA; Holland, KD; Jr, GA L; Kearney, JA. Neurobiology of Disease. 2014; 62:313-322.


Everolimus for Subependymal Giant-Cell Astrocytomas in Tuberous Sclerosis. Krueger, DA; Care, MM; Holland, K; Agricola, K; Tudor, C; Mangeshkar, P; Wilson, KA; Byars, A; Sahmoud, T; Franz, DN. The New England journal of medicine. 2010; 363:1801-1811.


Mutation of sodium channel SCN3A in a patient with cryptogenic pediatric partial epilepsy. Holland, KD; Kearney, JA; Glauser, TA; Buck, G; Keddache, M; Blankston, JR; Glaaser, IW; Kass, RS; Meisler, MH. Neuroscience Letters. 2008; 433:65-70.


Topiramate or valproate in patients with juvenile myoclonic epilepsy: a randomized open-label comparison. Levisohn, PM; Holland, KD. Epilepsy and Behavior. 2007; 10:547-552.

Early Identification of Candidates for Epilepsy Surgery: A Multicenter, Machine Learning, Prospective Validation Study. Wissel, BD; Greiner, HM; Glauser, TA; Pestian, JP; Ficker, DM; Cavitt, JL; Estofan, L; Holland-Bouley, KD; Mangano, FT; Szczesniak, RD; Dexheimer, JW; Maurer, M; Cohn, D. Neurology. 2024; 102:e208048.

Neuropsychological outcomes after epilepsy surgery: A comparison of stereo electroencephalography and subdural electrodes. Arya, R; Frink, C; Kargol, C; Byars, AW; Huddleston, D; Diedenhofer, DB; Aungaroon, G; Ervin, B; Horn, PS; Ihnen, SK Z; Mangano, FT; Glauser, TA; Greiner, HM; Holland, KD. European Journal of Neurology. 2023; 30:2986-2998.

Automated, machine learning-based alerts increase epilepsy surgery referrals: A randomized controlled trial. Wissel, BD; Greiner, HM; Glauser, TA; Mangano, FT; Holland-Bouley, KD; Zhang, N; Szczesniak, RD; Santel, D; Pestian, JP; Dexheimer, JW. Epilepsia. 2023; 64:1791-1799.

Comparing electrical stimulation functional mapping with subdural electrodes and stereoelectroencephalography. Aungaroon, G; Vedala, K; Byars, AW; Ervin, B; Rozhkov, L; Horn, PS; Ihnen, SK Z; Holland, KD; Tenney, JR; Kremer, K; Leach, JL; Mangano, FT; Greiner, HM; Arya, R. Epilepsia. 2023; 64:1527-1540.

Fatal Epileptic Seizures in Mice Having Compromised Glutathione and Ascorbic Acid Biosynthesis. Chen, Y; Holland, KD; Shertzer, HG; Nebert, DW; Dalton, TP. Antioxidants. 2023; 12:448.

Posterior Quadrant Disconnection Procedure for Intractable Epilepsy: A Case Series of 5 Young Pediatric Patients. Patel, SK; Gibson, JL; Lovha, M; Leach, JL; Arya, R; Tenney, JR; Holland, KD; Aungaroon, G; Greiner, HM; Skoch, J; Mangano, FT. Operative Neurosurgery. 2022; 23:449-456.

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