Oscar F. Lopez-Nunez, MD
- Staff Pathologist, Division of Pathology and Laboratory Medicine
- Director, Pediatric Pathology Fellowship Program
- Assistant Professor, UC Department of Pathology and Laboratory Medicine
- oscar.lopeznunez@cchmc.org
- Board Certified
About
Biography
As a pediatric pathologist, I am aware of the enormous impact my diagnoses could have on children’s lives and the lives of their families. I approach each one of my patients with the same level of empathy and care as I would with my own children.
I was inspired to pursue pathology over many years of training, where I developed a particular interest in studying disease mechanisms. As a pathology trainee, my personal experiences as a father and my fascination with understanding pediatric oncologic diseases helped me realize how deeply I care for children. So, I became a pediatric pathologist.
I consider myself to be an essential part of an interdisciplinary team. By spending quality time at the microscope, providing a comprehensive pathologic assessment in my reports and maintaining continuous communication with my clinical colleagues, I strive to achieve the correct diagnoses and the best care in every case.
Although my little patients and their families probably will not see me, I do see them. To me, every glass slide under my microscope is a small window into a child’s life. I want families to know I’m committed to providing the best care possible every time I render a diagnosis — no matter how simple or complex.
My areas of research include molecular characterization of bone and soft tissue tumors, like sarcomas. Many of these tumors show aggressive biologic behavior and the identification of molecular signatures can be beneficial from a diagnostic and a therapeutic point of view. I am also interested in the pathobiological mechanisms of pediatric eosinophilic disorders and inflammatory gastrointestinal diseases.
I love spending my free time with my wife and son doing outdoor activities, like hiking and biking. I also enjoy gardening outdoors. Among other things, I love freestyle drawing and illustration — a skill that I often use when spending time with my son or while creating online educational content for my peers in pathology.
MD: Universidad Dr. Jose Matias Delgado, Escuela de Medicina, Antiguo Cuscatlan, El Salvador.
Residency: Anatomic and Clinical Pathology, Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA.
Fellowship: Department of Pathology, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA.
Certification: Educational Commission of Foreign Medical Graduates (ECFMG).
Interests
Sarcomas and pediatric soft tissue tumors; pediatric bone tumors; neuroblastoma; inflammatory bowel disease; eosinophilic gastrointestinal disorders; medical education
Services and Specialties
Interests
Pathobiology of pediatric sarcomas and bone tumors; inflammatory bowel disease; eosinophilic esophagitis; artificial intelligence
Research Areas
Publications
Circulating and Magnetic Resonance Imaging Biomarkers of Intestinal Fibrosis in Small Bowel Crohn's Disease. Inflammatory Bowel Diseases. 2025; 31:1380-1391.
Pediatric endoscopic ultrasound-guided liver biopsy: 3-year experience. Journal of Pediatric Gastroenterology and Nutrition. 2025; 80:920-925.
Multifocal Insulinoma as the Unique Presenting Feature of Multiple Endocrine Neoplasia Type 1 in an Adolescent. Hormone Research in Paediatrics: from developmental endocrinology to clinical research. 2025; 98:75-83.
Reappraisal of soft tissue myoepithelial tumors by DNA methylation profiling reveals an epigenetically distinct group of mostly fusion-driven neoplasms. Virchows Archiv: an international journal of pathology. 2025; 486:573-584.
A Case of MIRAGE Syndrome with SAMD9 Mutation and Refractory Infantile Diarrhea: Endoscopic Biopsy Evaluation via Light and Electron Microscopy. Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society. 2025; 28:111-116.
Unveiling distinctive patterns in pediatric PSC-IBD: Time for a tailored histopathologic index?. Journal of Pediatric Gastroenterology and Nutrition. 2025; 80:257-259.
Exploring the Impact and Prospects of Social Media in Advancing Pediatric Pathology. Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society. 2025; 28:3-14.
Transnasal Endoscopy Acquires Esophageal Biopsies Adequate for Comprehensive Pathology Evaluation in Patients With Eosinophilic Esophagitis. Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society. 2024; 27:327-334.
Histopathology of Eosinophilic Esophagitis. Immunology and Allergy Clinics of North America. 2024; 44:205-221.
Histopathology of Eosinophilic Gastrointestinal Diseases Beyond Eosinophilic Esophagitis. Immunology and Allergy Clinics of North America. 2024; 44:369-381.
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