A photo of John Perentesis.

John P. Perentesis, MD, FAAP

  • Director, Division of Oncology
  • Institute Co-Executive Director, Cancer and Blood Diseases Institute
  • Deb Kleisinger Endowed Chair
  • Professor, UC Department of Pediatrics



John P. Perentesis, MD, FAAP, is a nationally recognized expert in the development of new drugs and molecular therapies for pediatric and young adult cancers and leukemia. His laboratory has developed novel anticancer drugs and discovered genes important in the growth of normal and malignant cells. His laboratory is also using tumor patients genomics research for personalizing therapies. In national efforts for new anticancer drug development, he serves in key roles for the National Cancer Institute’s Investigational Drug Steering Committee and the NCI-funded Children’s Oncology Group (COG). The COG is the world's largest children's cancer research entity.

In 2010, Dr. Perentesis was elected by pediatric oncologists from across the country to the national COG Executive Committee. He also serves as vice-chair for the COG Adolescent & Young Adult Cancer Steering Committee and as a member of the Hematology/Oncology and Institutional Performance Monitoring Steering Committees.

Dr. Perentesis has been elected by his peers for inclusion in the Best Doctors in America List since 1998.

MD: University of Michigan, Ann Arbor, MI, 1980.

Residency: University of Minnesota Medical School, Minneapolis, MN, 1983.

Fellowship: University of Minnesota Medical School, Minneapolis, MN, 1986.

Postdoctoral: University of Minnesota Medical School, Minneapolis, MN, 1986.

Certification: Pediatrics, 1989; Hematology/Oncology, 1990.


Young adult cancers; acute myeloid & lymphoid leukemia; Hodgkin lymphoma; new anticancer therapy development

Services and Specialties

Leukemia, Sarcoma, Cancer and Blood Diseases, Young Adult Cancer


Molecular etiology and pharmacogenetics of pediatric cancers; Down syndrome-associated leukemia; new anticancer drug development

Research Areas

Oncology, Cancer and Blood Diseases

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Pilot study of intravenous melphalan combined with continuous infusion L-S,R-buthionine sulfoximine for children with recurrent neuroblastoma. Anderson, CP; Matthay, KK; Perentesis, JP; Neglia, JP; Bailey, HH; Villablanca, JG; Groshen, S; Hasenauer, B; Maris, JM; Seeger, RC; Reynolds, CP. Pediatric Blood and Cancer. 2015; 62:1739-1746.

Impact of Multiple Beams on the FLASH Effect in Soft Tissue and Skin in Mice. Mascia, A; McCauley, S; Speth, J; Nunez, SA; Boivin, G; Vilalta, M; Sharma, RA; Perentesis, JP; Sertorio, M. International Journal of Radiation: Oncology - Biology - Physics. 2024; 118:253-261.

HDAC1 and HDAC6 are essential for driving growth in IDH1 mutant glioma. Garrett, MC; Albano, R; Carnwath, T; Elahi, L; Behrmann, CA; Pemberton, M; Woo, D; O’Brien, E; VanCauwenbergh, B; Perentesis, J; Roskin, K; Kornblum, H; Plas, DR; Lu, QR. Scientific Reports. 2023; 13:12433.

Ultra-high dose-rate proton FLASH improves tumor control. Shukla, S; Saha, T; Rama, N; Acharya, A; Le, T; Bian, F; Donovan, J; Tan, LA; Vatner, R; Kalinichenko, V; Mascia, A; Perentesis, JP; Kalin, TV. Radiotherapy and Oncology. 2023; 186:109741.

Cognitive and behavioral effects of whole brain conventional or high dose rate (FLASH) proton irradiation in a neonatal Sprague Dawley rat model. Williams, M; Sugimoto, C; Regan, S; Pitzer, E; Fritz, A; Sertorio, M; Mascia, A; Vatner, R; Perentesis, J; Vorhees, C. Neurotoxicology and Teratology. 2023; 98:107276.

Radiotherapy for Atypical Teratoid/Rhabdoid Tumor (ATRT) on the Pediatric Proton/Photon Consortium Registry (PPCR). Roehrig, A; Indelicato, DJ; Paulino, AC; Ermoian, R; Hartsell, W; Perentesis, J; Hill-Kayser, C; Lee, JY; Laack, NN; Mangona, V; Gallotto, S; Bajaj, BV M; Aridgides, PD; Yock, TI. Journal of Neuro-Oncology. 2023; 162:353-362.

Use of gemcitabine, oxaliplatin, and anti-CD20 therapy in children and adolescents with non-Hodgkin lymphoma unfit for intensive therapy. Bender, JD; Rubinstein, JD; Mizukawa, B; Perentesis, JP; Pommert, L. Pediatric Blood and Cancer. 2023; 70:e30214.

Barriers to medication adherence among adolescents and young adults with cancer. McGrady, ME; Ketterl, TG; Norris, RE; Perentesis, JP; Pettee, D; Mara, CA; Breen, G; Pai, AL H. Pediatric Blood and Cancer. 2023; 70:e30186.

Data standards in pediatric oncology: Past, present, and future. Wyatt, KD; Noyd, DH; Wood, NM; Phillips, CA; Miller, TP; Rubin, EM; Winestone, LE; Waanders, AJ; Perentesis, JP; Aplenc, R. Pediatric Blood and Cancer. 2023; 70:e30128.

Proton FLASH Radiotherapy for the Treatment of Symptomatic Bone Metastases: The FAST-01 Nonrandomized Trial. Mascia, AE; Daugherty, EC; Zhang, Y; Lee, E; Xiao, Z; Sertorio, M; Woo, J; Backus, LR; McDonald, JM; McCann, C; Bradley, JD; Simone, CB; Perentesis, JP; Breneman, JC. JAMA oncology. 2023; 9:62-69.

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