A photo of Thomas D. Ryan.

Director of Clinical Operations, Cardiomyopathy and Advanced Heart Failure

Co-Director, Cardio-Oncology Program

Assistant Professor, UC Department of Pediatrics


Board Certified

About Me


Thomas D. Ryan, MD, PhD, was born and raised in Wichita, KS and graduated magna cum laude from Wichita State University in 1996 with a BS in biological sciences.

In 1997 he began training in the MD/PhD program at the University of Alabama at Birmingham, and studied the molecular, cellular, and whole organ aspects of cardiac remodeling in a rat model of volume overload. His general pediatrics residency training took place at Cincinnati Children’s Hospital Medical Center from 2006-2009, as did his pediatric cardiology fellowship training from 2009-2012 and advanced fellowship in Pediatric Heart Failure/Transplant from 2012-2013. His clinical and research interests focus on heart failure, cardiomyopathy, cardiac transplantation and mechanical circulatory support. He focuses on patients who have developed heart dysfunction as a result of cancer-related therapies.

He is on the Leadership Council of the Cardio-oncology Member Section of the American College of Cardiology and has authored peer-reviewed manuscripts, reviews and textbook chapters on pediatric cardio-oncology.

Clinical Interests

Cardiomyopathy; cardio-oncology; heart transplant; mechanical circulatory support

Research Interests

Cardiomyopathy; cardio-oncology; heart transplant

Academic Affiliation

Assistant Professor, UC Department of Pediatrics


Comprehensive Neuromuscular Center, Cardiomyopathy, Vascular Access Team, Heart Failure and Transplant Program, Rasopathy, Cardio Oncology Program, Heart Institute, Neuromuscular Cardiology

My Locations

My Education

BS: Wichita State University, Wichita, KS, 1996. 

PhD: University of Alabama at Birmingham, Birmingham, AL, 2004.

MD: University of Alabama at Birmingham, Birmingham, AL, 2005.

Residency: Pediatrics, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 2006-2009.

Fellowship: Pediatric Cardiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2009-2012.

Advanced Fellowship: Pediatric Heart Failure/Transplant, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2012-2013.

Certification: American Board of Pediatrics, 2010; American Board of Pediatrics, Sub-board of Pediatric Cardiology, 2012.

My Publications

Ryan TD, Zafar F, Siegel RM, Villa CR, Bryant R III, Chin C. Obesity Class Does Not Further Stratify Outcome in Overweight and Obese Pediatric Patients after Heart Transplantation. Pediatr Transplant. 2018 Mar;22(2).

Powell AW, Nagarajan R, Mays WA, Chin C, Knilans TK, Knecht SK, Amos MA, Gerdes YM, Ryan TD. Cardiopulmonary aerobic fitness assessment during maximal and submaximal exercise testing in pediatric oncology patients after chemotherapy. Am J Clin Oncol. 2018 Jan 19.

Rotz SJ, Dandoy CE, Taylor MD, Jodele S, Jefferies JL, Lane A, El-Bietar JA, Powell AW, Davies SM, Ryan TD. Long-term systolic function in children and young adults after hematopoietic stem cell transplant. Bone Marrow Transplant. 2017 Oct;52(10):1443-1447.

Ryan TD, Parent JJ, Gao Z, Khoury PR, Dupont E, Smith JN, Wong B, Urbina WM, Jefferies JL. Central arterial function measured by non-invasive pulse wave analysis is abnormal in patients with Duchenne muscular dystrophy. Pediatr Cardiol. 2017 Aug;38(6):1269-1276.

Rotz SJ, Ryan TD, Jodele S, Jefferies JL, Lane A, Pate A, Hirsch R, Hlavaty J, Levesque AE, Taylor MD, Cash M, Myers KC, El-Bietar JA, Davies SM, Dandoy CE. The injured heart: early cardiac effects of hematopoietic stem cell transplantation in children and young adults. Bone Marrow Transplant. 2017 Aug;52(8):1171-1179.

Ryan TD, Madueme PC, Jefferies JL, Michelfelder EC, Towbin JA, Woo JG, Sahay RD, King EC, Brown R, Moore RA, Grenier MA, Goldstein BH. Utility of echocardiography in the assessment of left ventricular diastolic function and restrictive physiology in children and young adults with restrictive cardiomyopathy: a comparative echocardiography-catheterization study. Pediatr Cardiol. 2017 Feb;38(2):381-389.

Ryan TD, Lucky AW, King EC, Huang G, Towbin JA, Jefferies JL. Ventricular dysfunction and aortic dilation in patients with recessive dystrophic epidermolysis bullosa. Br J Dermatol. 2016 Mar;174(3):671-3.

Ryan TD, Jefferies JL, Sawnani H, Wong BL, Gardner A, Del Corral M, Lorts A, Morales DLS. Implantation of the HeartMate II and HeartWare left ventricular assist devices in patients with Duchenne muscular dystrophy: lessons learned from the first applications. ASAIO Journal. 2014 Mar-Apr;60(2):246-8.

Ryan TD, Taylor MD, Wojciech M, Cripe LH, Pratt J, King EC, Lao K, Grenier MA, Jefferies JL, Benson DW, Hor KH. Abnormal circumferential strain is present in young Duchenne muscular dystrophy patients. Pediatric Cardiol. 2013 Jun;34(5):1159-65.

Ryan TD, Rothstein EC, Aban I, Tallaj JA, Husain A, Lucchesi PA, Dell'Italia LJ. Left ventricular eccentric remodeling and matrix loss are mediated by bradykinin and precede cardiomyocyte elongation in rats with volume overload. J Am Coll Cardiol. 2007 Feb 20;49(7):811-21.