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Thomas D. Ryan, MD, PhD

Heart Failure, Transplant, VAD Physician

Academic Affiliations

Assistant Professor, UC Department of Pediatrics

Phone 513-803-2913

Email thomas.ryan@cchmc.org

Clinical & Research Interests
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Clinical

Cardiomyopathy; advanced heart failure; heart transplantation; mechanical circulatory support and transplant

Research

Development of cardiomyopathy in at risk populations, including Duchenne muscular dystrophy and other genetic cardiomyopathies, and anthracycline exposure.

Biography
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Thomas D Ryan, MD, PhD, was born and raised in Wichita, KS and graduated magna cum laude from Wichita State University in 1996 with a BS in biological sciences.

In 1997 he began training in the MD/PhD program at the University of Alabama at Birmingham, and studied the molecular, cellular, and whole organ aspects of cardiac remodeling in a rat model of volume overload. His general pediatrics residency training took place at Cincinnati Children’s Hospital Medical Center from 2006-2009, as did his pediatric cardiology fellowship training from 2009-2012 and advanced fellowship in Pediatric Heart Failure/Transplant from 2012-2013. His clinical and research interests focus on heart failure, cardiomyopathy, cardiac transplantation, and mechanical circulatory support.

Education and Training
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BS: Wichita State University, Wichita, KS, 1996. 

PhD: University of Alabama at Birmingham, Birmingham, AL, 2004.

MD: University of Alabama at Birmingham, Birmingham, AL, 2005.

Residency: Pediatrics, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 2006-2009.

Fellowship: Pediatric Cardiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2009-2012.

Advanced Fellowship: Pediatric Heart Failure/Transplant, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2012-2013.

Certification: American Board of Pediatrics, 2010; American Board of Pediatrics, Sub-board of Pediatric Cardiology, 2012.

Publications
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View PubMed Publications

Ryan TD, Jefferies JL, Chin C, Sticka JJ, Taylor MD, Harris R, Moore J, Goodridge E, Mount L, Bolyard AA, Otto B, Jones A, Shimamura A, Davies S, Myers K. Abnormal circumferential strain measured by echocardiography is present in patients with shwachman-diamond syndrome despite normal shortening fraction. Pediatr Blood Cancer. 2015 Mar 2.

Ryan TD, Jefferies JL, Wilmot I. Managing heart failure in adults with congenital heart disease. Curr Treat Options Cardiovasc Med. 2015 Feb;17(2):376.

Villa CR, Ryan TD, Collins JJ, Taylor MD, Lucky AW, Jefferies JL. Left ventricular non-compaction cardiomyopathy associated with epidermolysis bullosa simplex with muscular dystrophy and PLEC1 mutation. Neuromuscul Disord. 2015 Feb;25(2):165-8.

Dandoy CE, Davies SM, Hirsch R, Chima RS, Paff Z, Cash M, Ryan TD, Lane A, El-Bietar J, Myers KC, Jodele S. Abnormal echocardiography seven days after stem cell transplant may be an early indicator of thrombotic microangiopathy. Biol Blood Marrow Transplant. 2015 Jan;21(1):113-8.

Ryan TD, Jefferies JL, Zafar F, Lorts A, Morales DLSM. The evolving role of the total artificial heart in the management of end-stage congenital heart disease and adolescents. ASAIO Journal. 2015 Jan-Feb;61(1):8-14.

Chin C, Ryan TD, Castleberry CD. Transplantation in the highly sensitized pediatric patient. Circulation. 2014 Jun 3;129:2313-19.

Ryan TD, Jefferies JL, Sawnani H, Wong BL, Gardner A, Del Corral M, Lorts A, Morales DLS. Implantation of the HeartMate II and HeartWare left ventricular assist devices in patients with Duchenne muscular dystrophy: lessons learned from the first applications. ASAIO Journal. 2014 Mar-Apr;60(2):246-8.

Ryan TD, Taylor MD, Wojciech M, Cripe LH, Pratt J, King EC, Lao K, Grenier MA, Jefferies JL, Benson DW, Hor KH. Abnormal circumferential strain is present in young Duchenne muscular dystrophy patients. Pediatric Cardiol. 2013 Jun;34(5):1159-65.

Ryan TD, Ware SM, Lucky AW, Towbin JA, Jefferies JL, Hinton RB. Left ventricular noncompaction cardiomyopathy and aortopathy in a patient with recessive dystrophic epidermolysis bullosa. Circ Heart Fail. 2012 Sep 1;5(5):e81-2.

Ryan TD, Rothstein EC, Aban I, Tallaj JA, Husain A, Lucchesi PA, Dell'Italia LJ. Left ventricular eccentric remodeling and matrix loss are mediated by bradykinin and precede cardiomyocyte elongation in rats with volume overload. J Am Coll Cardiol. 2007 Feb 20;49(7):811-21.

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