A photo of Bruce Trapnell.

Bruce C. Trapnell, MS, MD


  • Director, Translational Pulmonary Science Center
  • Attending Physician, Pulmonologist - Research, Adult Clinical, Division of Pulmonary Medicine
  • Professor, UC Department of Pediatrics

About

Biography

Dr. Trapnell received his medical degree from the University of Maryland in 1985 and medical residency training at The Ohio State University Hospitals. He completed a fellowship in pulmonary medicine and then served as attending physician and senior attending physician at the Clinical Center of the National Institutes of Health. Subsequently, he served as vice president and director of the Division of Pulmonary and Virology Studies at Genetic Therapy, Incorporated, a subsidiary of Novartis.

In 1997, Dr. Trapnell joined Cincinnati Children’s Hospital Medical Center and is now a professor of Medicine and Pediatrics at the UC College of Medicine. At Cincinnati Children's, he directed Cincinnati’s Cystic Fibrosis Therapeutics Development Network Center for more than a decade and participated in numerous clinical trials as principal investigator including studies leading to FDA-approval of Creon® and Pancreaze®. He established and directs the Rare Lung Diseases Clinical Research Consortium (RLDC) in which a study led by Frank McCormack resulted in FDA approval of Sirolimus® as therapy of Lymphangioleiomyomatosis.

Dr. Trapnell’s research group established that GM-CSF autoantibodies caused the rare lung disease autoimmune pulmonary alveolar proteinosis and established clinical laboratory tests for its diagnosis and identified hereditary pulmonary alveolar proteinosis as a new genetic disease caused by mutations in CSF2RA and CSF2RB. His research group developed a novel type of cell transplantation, pulmonary macrophage transplantation, and is currently translating it for testing as therapy in patients with the disease. The group also contributed to the identification, characterization, and methods for diagnosis of indium-related lung disease.

An ardent patient advocate, Dr. Trapnell has worked with patient foundations for cystic fibrosis (CF), alpha-1-antitrypsin deficiency, pulmonary alveolar proteinosis, lymphangioleiomyomatosis, and childhood interstitial lung diseases. He has served as past scientific director for the Alpha-1 Foundation and as co-founder and current scientific director of the Pulmonary Alveolar Proteinosis Foundation. Since coming to Cincinnati, he has provided training in basic, clinical, and translational research at pre- and post-doctoral levels.

Publications

Two-year follow-up of exposure, engineering controls, respiratory protection and respiratory health among workers at an indium-tin oxide (ITO) production and reclamation facility. Harvey, RR; Virji, MA; Blackley, BH; Stanton, ML; Trapnell, BC; Carey, B; Healey, T; Cummings, KJ. Occupational and Environmental Medicine. 2022; 79:550-556.

Identification of Distinct Inflammatory Programs and Biomarkers in Systemic Juvenile Idiopathic Arthritis and Related Lung Disease by Serum Proteome Analysis. Chen, G; Deutsch, GH; Schulert, GS; Zheng, H; Jang, SR; Trapnell, B; Lee, PY; Macaubas, C; Ho, K; Schneider, C; et al. Arthritis and Rheumatology. 2022; 74:1271-1283.

Signal Transducer and Activator of Transcription 5B Deficiency-associated Lung Disease. Krone, KA; Foley, CL; Fishman, MP; Vargas, SO; Forbes, LR; Vece, TJ; Al-Herz, W; Carey, B; Pai, SY; Hwa, V; et al. American Journal of Respiratory and Critical Care Medicine. 2022; 205:1245-1250.

Autoimmune Pulmonary Alveolar Proteinosis. McCarthy, C; Carey, BC; Trapnell, BC. American Journal of Respiratory and Critical Care Medicine. 2022; 205:1016-1035.

Efficacy and safety of mavrilimumab in giant cell arteritis: a phase 2, randomised, double-blind, placebo-controlled trial. Cid, MC; Unizony, SH; Blockmans, D; Brouwer, E; Dagna, L; Dasgupta, B; Hellmich, B; Molloy, E; Salvarani, C; Trapnell, BC; et al. Annals of the Rheumatic Diseases. 2022; 81:653-661.

A murine model of hereditary pulmonary alveolar proteinosis caused by homozygous Csf2ra gene disruption. Shima, K; Arumugam, P; Sallese, A; Horio, Y; Ma, Y; Trapnell, C; Wessendarp, M; Chalk, C; McCarthy, C; Carey, BC; et al. American Journal of Physiology - Lung Cellular and Molecular Physiology. 2022; 322:L438-L448.

Mavrilimumab in patients with severe COVID-19 pneumonia and systemic hyperinflammation (MASH-COVID): an investigator initiated, multicentre, double-blind, randomised, placebo-controlled trial. Cremer, PC; Abbate, A; Hudock, K; McWilliams, C; Mehta, J; Chang, SY; Sheng, CC; Van Tassell, B; Bonaventura, A; Vecchié, A; et al. The Lancet. Rheumatology. 2021; 3:e410-e418.

Whole-Lung Lavage. Towe, C; Trapnell, B. Diagnostic and Interventional Bronchoscopy in Children. 2021.

Inhaled Molgramostim Therapy in Autoimmune Pulmonary Alveolar Proteinosis. Trapnell, BC; Inoue, Y; Bonella, F; Morgan, C; Jouneau, S; Bendstrup, E; Campo, I; Papiris, SA; Yamaguchi, E; Cetinkaya, E; et al. New England Journal of Medicine. 2020; 383:1635-1644.

GM-CSF blockade with mavrilimumab in severe COVID-19 pneumonia and systemic hyperinflammation: a single-centre, prospective cohort study. De Luca, G; Cavalli, G; Campochiaro, C; Della-Torre, E; Angelillo, P; Tomelleri, A; Boffini, N; Tentori, S; Mette, F; Farina, N; et al. The Lancet. Rheumatology. 2020; 2:e465-e473.

From the Blog


Doctors Find Drug for Lethal Lung Disease After Decades of Trying
Rare Diseases

Doctors Find Drug for Lethal Lung Disease After Decades of Trying

Bruce C. Trapnell, MS, MD9/7/2020

Statins Effective in Treating Pulmonary Alveolar Proteinosis
Heart and Lung

Statins Effective in Treating Pulmonary Alveolar Proteinosis

Bruce C. Trapnell, MS, MD7/1/2019

Macrophage Transplantation Could Take Familial PAP Off the Map
Rare Diseases

Macrophage Transplantation Could Take Familial PAP Off the Map

Bruce C. Trapnell, MS, MD6/28/2019

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