A photo of Bruce Trapnell.

Bruce C. Trapnell, MS, MD

  • Director, Translational Pulmonary Science Center
  • Attending Physician, Pulmonologist - Research, Adult Clinical, Division of Pulmonary Medicine
  • Professor, UC Department of Pediatrics



Dr. Trapnell received his medical degree from the University of Maryland in 1985 and medical residency training at The Ohio State University Hospitals. He completed a fellowship in pulmonary medicine and then served as attending physician and senior attending physician at the Clinical Center of the National Institutes of Health. Subsequently, he served as vice president and director of the Division of Pulmonary and Virology Studies at Genetic Therapy, Incorporated, a subsidiary of Novartis.

In 1997, Dr. Trapnell joined Cincinnati Children’s Hospital Medical Center and is now a professor of Medicine and Pediatrics at the UC College of Medicine. At Cincinnati Children's, he directed Cincinnati’s Cystic Fibrosis Therapeutics Development Network Center for more than a decade and participated in numerous clinical trials as principal investigator including studies leading to FDA-approval of Creon® and Pancreaze®. He established and directs the Rare Lung Diseases Clinical Research Consortium (RLDC) in which a study led by Frank McCormack resulted in FDA approval of Sirolimus® as therapy of Lymphangioleiomyomatosis.

Dr. Trapnell’s research group established that GM-CSF autoantibodies caused the rare lung disease autoimmune pulmonary alveolar proteinosis and established clinical laboratory tests for its diagnosis and identified hereditary pulmonary alveolar proteinosis as a new genetic disease caused by mutations in CSF2RA and CSF2RB. His research group developed a novel type of cell transplantation, pulmonary macrophage transplantation, and is currently translating it for testing as therapy in patients with the disease. The group also contributed to the identification, characterization, and methods for diagnosis of indium-related lung disease.

An ardent patient advocate, Dr. Trapnell has worked with patient foundations for cystic fibrosis (CF), alpha-1-antitrypsin deficiency, pulmonary alveolar proteinosis, lymphangioleiomyomatosis, and childhood interstitial lung diseases. He has served as past scientific director for the Alpha-1 Foundation and as co-founder and current scientific director of the Pulmonary Alveolar Proteinosis Foundation. Since coming to Cincinnati, he has provided training in basic, clinical, and translational research at pre- and post-doctoral levels.

BS: Biochemistry, University of Maryland, College Park, MD, 1978.

MS: Genetics, The George Washington University, Washington, DC, 1981.

MD: University of Maryland School of Medicine, Baltimore, MD, 1984.

Residency: Internal Medicine, The Ohio State University Hospitals, Columbus, OH, 1987.

Fellowship: Pulmonary Medicine, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda, MD, 1989.

Certification: Diplomat in Internal Medicine, American Board of Internal Medicine, 1987; Diplomat, National Board of Medical Examiners, 1987; Diplomat in Pulmonary Medicine, American Board of Internal Medicine, 2000.


Research on rare lung diseases including pulmonary alveolar proteinosis; cystic fibrosis; alpha-1 antitrypsin deficiency; lymphangioleiomyomatosis

Services and Specialties

Pulmonary Medicine, Cystic Fibrosis Center


Alveolar macrophage function; molecular techniques using gene knockout, transgenic and conditional gene expression mouse models and non-human primates, in vitro and in vivo viral gene transfer, and bone marrow transplantation

Research Areas

Pulmonary Biology


Human inherited CCR2 deficiency underlies progressive polycystic lung disease. Neehus, AL; Carey, B; Landekic, M; Panikulam, P; Deutsch, G; Ogishi, M; Arango-Franco, CA; Philippot, Q; Modaresi, M; Mohammadzadeh, I; Aladjidi, N; Trapnell, BC; Casanova, JL; Bustamante, J. Cell. 2024; 187:390-408.e23.

98 Neutrophil extracellular traps disrupt bronchial epithelial junctional integrity and promote infection. Middleton, R; Collins, M; Imbrogno, M; Kramer, E; Brewington, J; Meeker, J; Morgan, H; Ostmann, A; Trapnell, B; Mahajan, S; Wozniak, D; Clancy, J; Hudock, K. Journal of Cystic Fibrosis. 2023; 22:s51.

Interstitial lung disease and mycobacteriosis in children with inherited CCR2 deficiency. Neehus, A; Landekic, M; Rezaei, N; Aladjidi, N; Gros, P; Malo, D; Nogee, L; Trapnell, B; Casanova, J; Bustamante, J. Clinical Immunology. 2023; 250:109360.

Direct-to-Consumer Recruitment Methods via Traditional and Social Media to Aid in Research Accrual for Clinical Trials for Rare Diseases: Comparative Analysis Study. Applequist, J; Burroughs, C; Merkel, PA; Rothenberg, M; Trapnell, B; Desnick, R; Sahin, M; Krischer, J. Journal of Medical Internet Research. 2023; 25:e39262.

Alpha-1 antitrypsin limits neutrophil extracellular trap disruption of airway epithelial barrier function. Hudock, KM; Collins, MS; Imbrogno, MA; Kramer, EL; Brewington, JJ; Ziady, A; Zhang, N; Snowball, J; Xu, Y; Carey, BC; Gollomp, K; Mangalmurti, N; Trapnell, BC; Clancy, JP. Frontiers in Immunology. 2023; 13:1023553.

Pulmonary Alveolar Proteinosis Syndrome. O’Callaghan, M; McCarthy, C; Trapnell, BC. Orphan Lung Diseases. : Springer Nature; Springer Nature; 2023.

A dried blood spot test for diagnosis of autoimmune pulmonary alveolar proteinosis. Carey, B; Chalk, C; Stock, J; Toth, A; Klingler, M; Greenberg, H; Uchida, K; Arumugam, P; Trapnell, BC. Journal of Immunological Methods. 2022; 511:113366.

An exploratory study investigating biomarkers associated with autoimmune pulmonary alveolar proteinosis (aPAP). Campo, I; Meloni, F; Gahlemann, M; Sauter, W; Ittrich, C; Schoelch, C; Trapnell, BC; Gupta, A. Scientific Reports. 2022; 12:8708.

380 Neutrophil extracellular traps disrupt bronchial epithelial barrier function: Alpha-1 antitrypsin to the rescue. Collins, M; Imbrogno, M; Kramer, E; Brewington, J; Zhang, N; Sharon, P; Kopras, E; Meeker, J; Morgan, H; Ostmann, A; O'Grady, S; Trapnell, B; Clancy, J; Hudock, K. Journal of Cystic Fibrosis. 2022; 21:s223.

Two-year follow-up of exposure, engineering controls, respiratory protection and respiratory health among workers at an indium-tin oxide (ITO) production and reclamation facility. Harvey, RR; Virji, MA; Blackley, BH; Stanton, ML; Trapnell, BC; Carey, B; Healey, T; Cummings, KJ. Occupational and Environmental Medicine. 2022; 79:550-556.

From the Blog

Doctors Find Drug for Lethal Lung Disease After Decades of Trying
Rare Diseases

Doctors Find Drug for Lethal Lung Disease After Decades of Trying

Bruce C. Trapnell, MS, MD9/7/2020

Statins Effective in Treating Pulmonary Alveolar Proteinosis
Heart and Lung

Statins Effective in Treating Pulmonary Alveolar Proteinosis

Bruce C. Trapnell, MS, MD7/1/2019

Macrophage Transplantation Could Take Familial PAP Off the Map
Rare Diseases

Macrophage Transplantation Could Take Familial PAP Off the Map

Bruce C. Trapnell, MS, MD6/28/2019

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