Fellowships / Grants

Katelyn Melgar 2014
Ruth L. Kirschstein National Research Service Award (NRSA) Individual Predoctoral MD/PhD Fellowship.
1F31CA217140-01
Role: PI
Project Title: Novel mechanisms and therapeutic strategies of refractory leukemia 

Jarren Oates 2017  
Provost Graduate Fellowship

Publications

Kopec AK, Abrahams SR, Thornton S, Palumbo JS, Mullins ES, Divanovic S, Weiler H, Owens AP, Mackman N, Goss A, van Ryn J, Luyendyk JP, Flick MJ. Thrombin promotes diet-induced obesity through fibrin-driven inflammation. J Clin Invest. 2017 Aug 1;127(8):3152-3166. PMID: 28737512

Almanan M, Raynor J, Sholl A, Wang M, Chougnet C, Cardin RD, Hildeman DA. Tissue-specific control of latent CMV reactivation by regulatory T cells. PLoS Pathog. 2017 Aug 10;13(8):e1006507. PMID: 28796839

Li KP, Shanmuganad S, Carroll K, Katz JD, Jordan MB, Hildeman DA. Dying to protect: cell death and the control of T-cell homeostasis. Immunol Rev. 2017 May;277(1):21-43. PMID: 28462527

McNally JP, Millen SH, Chaturvedi V, Lakes N, Terrell CE, Elfers EE, Carroll KR, Hogan SP, Andreassen PR3, Kanter J, Allen CE, Henry MM, Greenberg JN, Ladisch S, Hermiston ML, Joyce M, Hildeman DA, Katz JD, Jordan MB. Manipulating DNA damage-response signaling for the treatment of immune-mediated diseases. Proc Natl Acad Sci U S A. 2017 Jun 13;114(24):E4782-E4791. PMID: 28533414

Carey AN, Zhang W, Setchell KDR, Simmons JR, Shi T, Lages CS, Mullen M, Carroll K, Karns R, Bessho K, Sheridan R, Zhao X, Weeber SN, Miethke AG. Hepatic MDR3 expression impacts lipid homeostasis and susceptibility to inflammatory bile duct obstruction in neonates. Pediatr Res. 2017 May 3. doi: 10.1038/pr.2017.78. [Epub ahead of print] PMID: 28355206

Choi K, Komurov K, Fletcher JS, Housma E, Cancelas JA, Wu J, Ratner N.  An inflammatory gene signature distinguishes neurofibroma Schwann cells and macrophages from cells in the normal peripheral nervous system. Sci Rep. 2017 Mar 3;7:43315. doi: 10.1038/srep43315. PMID: 28256556

Vaughn SE, Foley C, Lu X, Patel ZH, Zoller EE, Magnusen AF, Williams AH, Ziegler JT, Comeau ME, Marion MC, Glenn SB, Adler A, Shen N, Nath S, Stevens AM, Freedman BI, Tsao BP, Jacob CO, Kamen DL, Brown EE, Gilkeson GS, Alarcón GS, Reveille JD, Anaya JM, James JA, Moser KL, Criswell LA, Vilá LM, Alarcón-Riquelme ME, Petri M, Scofield RH, Kimberly RP, Ramsey-Goldman R, Binjoo Y, Choi J, Bae SC, Boackle SA, Vyse TJ, Guthridge JM, Namjou B, Gaffney PM, Langefeld CD, Kaufman KM, Kelly JA, Harley IT, Harley JB, Kottyan LC. Lupus risk variants in the PXK locus alter B-cell receptor internalization. Front Genet. 2015 Jan 8;5:450. PMID:25620976

Giles DA, Moreno-Fernandez ME, Stankiewicz TE, Graspeuntner S, Cappelletti M, Wu D, Mukherjee R, Chan CC, Lawson MJ, Klarquist J, Sünderhauf A, Softic S, Kahn CR, Stemmer K, Iwakura Y, Aronow BJ, Karns R, Steinbrecher KA, Karp CL, Sheridan R, Shanmukhappa SK, Reynaud D, Haslam DB, Sina C, Rupp J, Hogan SP, Divanovic S. Thermoneutral housing exacerbates nonalcoholic fatty liver disease in mice and allows for sex-independent disease modeling. Nat Med. 2017 Jul;23(7):829-838. PMID: 28604704

Gonzalez T, Biagini Myers JM, Herr AB, Khurana Hershey GK. Staphylococcal Biofilms in Atopic Dermatitis. Curr Allergy Asthma Rep. 2017 Oct 23;17(12):81.  Review. PMID: 29063212

Horwath M, Bell-Horwath T, Lescano V, Krishnan K, Merino E, Deepe GS. Antifungal Activity of the Lipophilic Antioxidant Ferrostatin-1. Chembiochem. 2017 Aug 7. PMID:  28783875

Li KP, Shanmuganad S, Carroll K, Katz JD, Jordan MB, Hildeman DA. Dying to protect: cell death and the control of T-cell homeostasis. Immunol Rev. 2017 May;277(1):21-43. PMID: 28462527

Rueda CM, Rodriguez- Perea AL, Moreno-Fernandez M, Jackson CM, Melchoir JT, Davidson WS, Chougnet CA. High Density Lipoproteins Selectively Promote the Survival of Human Regulatory T-cells. J Lipid Res. 2017 Apr 4. pii: jlr.M072835. doi: 10.1194/jlr.M072835. [Epub ahead of print] PMID: 28377425

McIntosh LA, Marion MC, Sudman M, Comeau ME, Becker ML, Bohnsack JF, Fingerlin TE, Griffin TA, Haas JP, Lovell DJ, Maier LA, Nigrovic PA, Prahalad S, Punaro M, Rosé CD, Wallace CA, Wise CA; Boston Children's JIA Registry; German Society for Pediatric Rheumatology (GKJR); JIA Gene Expression Studies; NIAMS JIA Genetic Registry; TREAT Study; Understanding TNF Therapy in JIA Project, Moncrieffe H, Howard TD, Langefeld CD, Thompson SD. Genome-wide association meta-analysis reveals novel juvenile idiopathic arthritis susceptibility loci. PMID: 28719732

Wang N, McKell M, Dang A, Yamani A, Waggoner L, Vanoni S, Noah T, Wu D, Kordowski A, Köhl J, Hoebe K, Divanovic S, Hogan SP. Lipopolysaccharide suppresses IgE-mast cell-mediated reactions. Clin Exp Allergy. 2017 Aug 21. PMID: 28833704

Lee N, Rydyznski CE, Rasch MS, Trinh, Maclennan AJ.  Adult ciliary neurotrophic factor receptors help maintain facial motor neuron choline acetyltransferase expression in vivo following nerve crush. J Comp Neurol. 2017 Apr 1;525(5):1206-1215. Epub 2016 Nov 7.  PMID: 27696410

Li KP, Shanmuganad S, Carroll K, Katz JD, Jordan MB, Hildeman DA. Dying to protect: cell death and the control of T-cell homeostasis. Immuno Rev. 2017 May; 277(1):21-43. doi: 10.1111/imr.12538. PMID: 28462527

Wang N, McKell M, Dang A, Yamani A, Waggoner L, Vanoni S, Noah T, Wu D, Kordowski A, Köhl J, Hoebe K, Divanovic S, Hogan SP. Lipopolysaccharide suppresses IgE-mast cell-mediated reactions. Clin Exp Allergy. 2017 Aug 21. PMID: 28833704

Richgels PK, Yamani A, Chougnet CA, Lewkowich IP. Maternal house dust mite exposure during pregnancy enhances severity of house dust mite-induced asthma in murine offspring. J  Allergy Clin Immuol. 2017 Feb 9. pii: S0091-6749(17)30220-8. doi: 10.1016/j.jaci.2016.12.972. [Epub ahead of print] PMID: 28192144

Horwath MC, Bell-Horwath TR, Lescano V, Krishnan K, Merino EJ, Deepe GS Jr. Antifungal Activity of the Lipophilic Antioxidant Ferrostatin-1. Chembiochem. 2017 Oct 18;18(20):2069-2078. doi: 10.1002/cbic.201700105. Epub 2017 Sep 1. PMID:  2878387

Jiang TT, Shao TY, Ang WXG, Kinder JM, Turner LH, Pham G, Whitt J, Alenghat T, Way SS. Commensal Fungi Recapitulate the Protective Benefits of Intestinal Bacteria. Cell Host Microbe. 2017 Dec 13;22(6):809-816.e4. PMID:  29174402

Lange SM, McKell MC, Schmidt SM, Hossfeld AP, Chaturvedi V, Kinder JM, McAlees JW, Lewkowich IP, Way SS, Turner J, Qualls JE. l-Citrulline Metabolism in Mice Augments CD4+ T Cell Proliferation and Cytokine Production In Vitro, and Accumulation in the Mycobacteria-Infected Lung. Front Immunol. 2017 Nov 16;8:1561. PMID: 29201027

McIntosh LA, Marion MC, Sudman M, Comeau ME, Becker ML, Bohnsack JF, Fingerlin TE, Griffin TA, Haas JP, Lovell DJ, Maier LA, Nigrovic PA, Prahalad S, Punaro M, Rosé CD, Wallace CA, Wise CA, Moncrieffe H, Howard TD, Langefeld CD, Thompson SD. Genome-Wide Association Meta-Analysis Reveals Novel Juvenile Idiopathic Arthritis Susceptibility Loci. Arthritis Rheumatol. 2017 Nov;69(11):2222-2232. doi: 10.1002/art.40216. Epub 2017 Oct 12. PMID:28719732

Patterson AR, Endale M, Lampe K, Aksoylar HI, Flagg A, Woodgett JR, Hildeman D, Jordan MB, Singh H, Kucuk Z, Bleesing J, Hoebe K. Gimap5-dependent inactivation of GSK3β is required for CD4+ T cell homeostasis and prevention of immune pathology. Nat Commun. 2018 Jan PMID: 29382851

Jiang TT, Shao TY, Ang WXG, Kinder JM, Turner LH, Pham G, Whitt J, Alenghat T, Way SS. Commensal Fungi Recapitulate the Protective Benefits of Intestinal Bacteria. Cell Host Microbe. 2017 Dec 13;22(6):809-816.e4. PMID:  29174402

Lange SM, McKell MC, Schmidt SM, Hossfeld AP, Chaturvedi V, Kinder JM, McAlees JW, Lewkowich IP, Way SS, Turner J, Qualls JE. l-Citrulline Metabolism in Mice Augments CD4+ T Cell Proliferation and Cytokine Production In Vitro, and Accumulation in the Mycobacteria-Infected Lung. Front Immunol. 2017 Nov 16;8:1561. PMID: 29201027

Travers J, Rochman M, Caldwell JM, Besse JA, Miracle CE, Rothenberg ME. IL-33 is induced in undifferentiated, non-dividing esophageal epithelial cells in eosinophilic esophagitis. Sci Rep. 2017 Dec 14;7(1):17563. PMID:29242581

Rice TC, Pugh AM, Xia BT, Seitz AP, Whitacre BE, Gulbins E, Caldwell CC. Bronchoalveolar Lavage Microvesicles Protect Burn-Injured Mice from Pulmonary Infection. J Am Coll Surg. 2017 Oct;225(4):538-547. PMID:  28690205

Yamani A, Wu D, Waggoner L, Noah T, Koleske AJ, Finkelman F, Hogan SP. The vascular endothelial specific IL-4 receptor alpha-ABL1 kinase signaling axis regulates the severity of IgE-mediated anaphylactic reactions. J Allergy Clin Immunol. 2017 Nov 17. pii: S0091-6749(17)31764-5. PMID:29157947