Theresa Alenghat, VMD, PhD
Theresa Alenghat, VMD, PhD, investigates central epigenomic pathways that regulate epithelial and immune cell homeostasis in the context of intestinal health and disease. The goal of her research is to provide insight into mechanisms underlying the host-commensal relationship and how this level of regulation affects the development of chronic diseases such as inflammatory bowel disease.
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Jorge A. Bezerra, MD
Director, Division of Gastroenterology, Hepatology and Nutrition
Jorge A. Bezerra, MD, investigates the genetic, cellular and molecular basis of biliary atresia and other cholangiopathies in children. His studies use animal models of disease to identify causes of tissue injury and to develop new therapies to stop progression of liver disease.
Visit the Bezerra Lab.
Jose A. Cancelas Perez, MD, PhD
Director, Research Division and Medical Director for Cell Therapies, Hoxworth Blood Center
Jose A. Cancelas Perez, MD, PhD, focuses on the study of blood-forming cells during the process of adult hematopoiesis. In particular, hematopoietic stem cells (HSC) attract clinical interest because of their potential use in stem cell and gene therapy, and because of their involvement in leukemia.
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Marie-Dominique Filippi, PhD
Member, Division of Experimental Hematology & Cancer Biology
Marie-Dominique Filippi, PhD, is interested in dissecting the molecular mechanism of hematopoietic cell migration. Because hematopoietic cells are utilized for the therapy of multiple blood diseases and neutrophils are responsible for maintaining an immunocompetence status, understanding the molecular mechanism of normal hematopoietic cell functions is of potential therapeutic importance.
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Fred D. Finkelman, MD
Fred D. Finkelman, MD, uses mouse models to study the roles of antibodies and cytokines in health and disease. Particular interests include allergic disorders, parasitic worm infections, and antibody-mediated disorders.
Matthew J. Flick, PhD
Member, Division of Experimental Hematology & Cancer Biology
Matthew J. Flick, PhD, is working to understand how hemostatic factors in the blood that are responsible for clotting also drive inflammation in the context of infection and diseases such as arthritis and fatty liver disease.
H. Leighton (Lee) Grimes, PhD
Director, Cancer Pathology Program, Division of Experimental Hematology & Division of Pathology
H. Leighton (Lee) Grimes, PhD, focuses on the transcriptional control of normal and malignant hematopoiesis. The goal of his research is to understand how normal blood cells are formed, and to use this information to dissect the molecular pathogenesis of marrow failure and leukemia.
Visit the Grimes Lab.
John B. Harley, MD, PhD
Director, Center for Autoimmune Genomics and Etiology (CAGE)
John B. Harley, MD, PhD, is a rheumatologist and biochemist with special clinical and research interests in the genetic etiology of inflammatory diseases. His experimental focus is the many genetic effects and environmental causes of systemic lupus erythematosus (SLE) and related inflammatory diseases. Through this work, nearly 50 genes are known and Epstein Barr virus has been identified to trigger the systemic autoimmunity of lupus. Dr. Harley also builds infrastructure with which to do high throughput genotyping, expression analysis, and epigenetics, which he makes available to his colleagues from around the world. In recent experiments, Dr. Harley organized the logistics of managing >18,000 subjects at >30,000 genetic markers, 3200 subjects at 1.2 million markers, and 10,000 subjects at 196,000 markers. Dr. Harley is committed to all of the steps between association detection through replication and toward identifying the possible functional genetic variants and to pursuing their biology.
David B. Haslam, MD
Director, Antimicrobial Stewardship Program
David B. Haslam, MD, is a pediatric infectious diseases physician who has research programs investigating the host and microbial factors that contribute to disease severity and outcome during Clostridium difficile infection. As medical director of the Antimicrobial Stewardship Program, he is initiating additional research programs on the interplay between antibiotic exposure, the host microbiome, and the molecular epidemiology of antimicrobial resistance.
Andrew B. Herr, PhD
Director of Admissions, Immunology Graduate Program
Andrew B. Herr, PhD, studies protein-protein interactions involved in immune receptor signaling and bacterial pathogenesis. His lab uses X-ray crystallography to solve the atomic structures of proteins along with techniques of biophysical chemistry to understand their interactions in solution. The goal is to understand the molecular basis for autoimmune responses and recurrent bacterial infections, and to develop new therapeutic applications.
Visit the Herr Lab.
Gurjit (Neeru) Khurana Hershey, MD, PhD
Director, Division of Asthma Research
Gurjit (Neeru) Khurana Hershey, MD, PhD, is the principal investigator of a federally funded Asthma and Allergic Diseases Cooperative Research Center which supports, in part, the asthma and allergy-based Greater Cincinnati Pediatric Clinic Repository. She also focuses on elucidating the genetic and environmental factors that contribute to the development of asthma and eczema.
Visit the Khurana Hershey Lab.
David A. Hildeman, PhD
Director, Immunology Graduate Program
David A. Hildeman, PhD, explores the molecular factors that control the decision between tolerance and immunity within T lymphocytes. Using genetic mouse models, viruses, and MHC tetrameric reagents, the lab is focused on the molecular regulation of antigen-specific T cell responses. Dr. Hildeman is also the current director of the Immunology Graduate Program.
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Margaret K. Hostetter, MD
BK Rachford Professor and Chair, Department of Pediatrics
Margaret K. Hostetter, MD, studies the pathogenesis of bloodstream infections caused by the yeast Candida albicans. Her work has highlighted the role of C. albicans in biofilms, activation of human T cells, and evasion of innate immune mechanisms. Her clinical research is focused on the medical evaluation of internationally adopted children.
Shouxiong Huang, PhD
Member, Immunology Graduate Program
investigates the activation and function of innate-like T cells in responses to vitamin-like and lipid antigens using metabolomic and biological approaches. The goal is to discover novel structures and presentation mechanisms of antigens that induce protective T cell responses and ultimately facilitate controlling immune disorders and environmental exposure.
Vivian Hwa, PhD
Basic Research Director, Cincinnati Center for Growth Disorders
Vivian Hwa, PhD, investigates the functional and cellular impacts of genetic defects identified in children with severe growth failure, who often present with a variety of co-morbidities, including immune deficiencies, insulin insensitivities, intellectual impairment, microcephaly. These pathophysiological mutations provide unique opportunities to delineate molecular mechanism(s) of actions and improve understanding of clinical phenotypes.
Visit the Dauber-Hwa Lab.
Michael B. Jordan, MD
Member, Division of Bone Marrow Transplantation and Immune Deficiency
Michael B. Jordan, MD, specializes in caring for children with histiocytic disorders, primary immune deficiencies, or who are undergoing bone marrow transplantation. His laboratory focuses on understanding effector T cell function, immune regulation, and the pathogenesis of hemophagocytic lymphohistiocytosis
. He is also conducting preclinical scientific studies in addition to a translational clinical trial.
Theodosia A. Kalfa, MD, PhD
Co-Director, Erythrocyte Diagnostic Laboratory
Theodosia A. Kalfa, MD, PhD, focuses on the study of intracellular signals in erythropoiesis and mature red blood cells, specifically the signals conducted by Rho GTPases regulating terminal erythroid maturation and enucleation. Her lab also studies the role of Rac GTPases in generation of reactive oxygen species (ROS) within red blood cells from patients and animal models with sickle-cell disease along with the signaling mechanisms and consequences of increased ROS in sickle cells.
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Jonathan D. Katz, PhD
Jonathan D. Katz, PhD, is working to understand the role that autoreactive T lymphocytes play in the Immunopathogenesis of type 1 diabetes, the most common pediatric autoimmune disease. Major focuses include defining: (a) the control of autoreactive T cells via central and peripheral tolerance; (b) the role NKT cells play in regulating autoreactive T cells; and (c) the role dendritic cells play in activating and regulating autoreactive T cells in type 1 diabetes.
Kenneth M. Kaufman, PhD
Kenneth M. Kaufman, PhD, investigates the genetics of complex and rare disorders using genotyping and next-generation DNA technologies. The goal of his research is to identify the underling mechanisms and genetics that lead to complex diseases such as systemic lupus erythematosus.
Raphael Kopan, PhD
Director, Division of Developmental Biology
Raphael Kopan, PhD, and his lab have the long-term goal of organogenesis in vitro. They focus their efforts on Notch signaling as their lead into mechanistic understanding of tissue diversity using genetic engineering, embryology and single cell profiling. They interrogate the mouse embryo to address critical questions regarding the circuit logic of Notch signaling in mammalian organogenesis and its integration in larger signaling context.
Visit the Kopan Lab.
Leah C. Kottyan, PhD
Leah C. Kottyan, PhD, studies the molecular and immunological mechanisms driving the statistical association of genetic variants with systemic lupus erythematosus and eosinophilic esophagitis. The goal of her research is to refine the statistical analysis of genetic data while using analytical and biological tools to predict and confirm genetic variant-dependent differences that affect gene expression, cell function, and disease risk.
Ashish R. Kumar, MD, PhD
Director, Langerhans Cell Histiocytosis Center
Ashish R. Kumar, MD, PhD, is a pediatric hematologist/oncologist whose lab is investigating the biology childhood cancers and blood diseases. The current focus of research in the lab is on infant leukemia and LCH.
Visit the Kumar Lab.
Punam Malik, MD
Director, Cincinnati Comprehensive Sickle Cell Center
Punam Malik, MD, works to correct the gene responsible for sickle cell anemia. One of the lab’s major projects uses gene therapy to treat sickle cell disease. The lab is also interested in gene therapy for other diseases. She has developed various methods for delivering corrective genes to cells, improving methods for gene therapy in general.
Alexander G. Miethke, MD
Medical Director, Liver Transplant Program
Alexander G. Miethke, MD, is interested in susceptibility factors for neonatal liver injury, including biliary atresia. He focuses on the interaction between the maturing adaptive immune system and hepatic immune responses to infectious insults during the early neonatal period.
Emily R. Miraldi, PhD
Dr. Miraldi is a computational and systems biologist who builds mathematical models of the immune system from high-dimensional genomics measurements. Her studies leverage biotechnologies, including chromatin accessibility and single-cell gene expression measurements, and require new computational methods development. Miraldi’s long-term goal is to use these models to reengineer immune-cell behavior in the context of autoimmune and other diseases.
Joseph E. Qualls, PhD
Joseph E. Qualls, PhD, examines the cellular and molecular facets of macrophage biology during health and disease. This white blood cell has an unprecedented role in regulating inflammation, pathogen elimination and maintaining tissue homeostasis. Specifically, Dr. Qualls’ laboratory focuses on amino acid utilization by macrophages, and how this affects the outcome of infection and inflammatory disease.
Nancy Ratner, PhD
Co-Director, Rasopathy Program
Nancy Ratner, PhD, is working to define the interactions between glial cells and axons during nervous system development and how those interactions go awry in disease. Her goal is to develop novel therapies for patients with nervous system diseases.
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Marc E. Rothenberg, MD, PhD
Director, Division of Allergy and Immunology
Marc E. Rothenberg, MD, PhD, is focused on elucidating mechanisms of allergic responses, especially in mucosal tissues such as the lung and the gastrointestinal tract, in order to identify novel pharmaceutical targets for treatment of patients with eosinophilic diseases including eosinophilic gastrointestinal disorders, hypereosinophilic syndromes and asthma and food allergies. His lab has identified and characterized several critical pathways that regulate allergic responses.
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Paul Spearman, MD
Director, Division of Infectious Diseases
Paul Spearman, MD, directs a laboratory engaged in uncovering basic aspects of HIV-host cell interactions and the mechanisms of HIV transmission. We are also developing novel HIV vaccine strategies. Trafficking of the HIV-1 envelope glycoprotein, restriction of HIV spread by BST2/tetherin, and HIV infection of macrophages are areas of active investigation.
Daniel T. Starczynowski, PhD
Member, Experimental Hematology and Cancer Biology
Daniel T. Starczynowski, PhD, is a cancer biologist who has a basic research programs with a translational emphasis in myeloid hematological malignancies. His lab’s major effort is studying the molecular and cellular basis of myelodysplastic syndromes, bone marrow failure syndromes and acute leukemia. The goal is to identify candidate genes and understand their contribution to myeloid malignancies.
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Stephen N. Waggoner, PhD
is a viral immunologist whose lab studies immune regulatory mechanisms that control pathogenesis of disease. The lab uses viruses and bacteria to probe immune functions associated with disease in mice. Interests currently focus on a novel regulatory role of natural killer (NK) cells that influences vaccine efficacy, autoimmune disease, chronic viral infections, and immune dysfunction in the elderly.
Sing Sing Way, MD, PhD
Pauline and Lawson Reed Chair, Division of Infectious Diseases
Sing Sing Way, MD, PhD, is an infectious disease physician-scientist. He cares for infants and children with infection related illness, and provides consultation in the diagnosis and prevention diseases caused by communicable agents. Dr. Way supervises an active basic research laboratory that uses basic immunological approaches to investigate ways to boost host defense and protection against infection. If you have interest in this work, please contact Dr. Way.
Timothy E. Weaver, MS, PhD
Co-Director, Division of Pulmonary Biology
Timothy E. Weaver, MS, PhD, focuses on the identification of cytoprotective pathways that mediate adaptation to genetic and environmental stresses in the pulmonary epithelium. These molecular pathways play a critical role in preventing or slowing the progression of chronic lung disease and may provide novel targets for therapeutic intervention.
Visit the Weaver Lab.
Susanne Wells, PhD
Director, Epithelial Carcinogenesis and Stem Cell Program
Susanne Wells, PhD, focuses on new targets of the HPV E6/E7 oncogenes, and characterizing these as potential risk factors for HPV infection and transformation. Research approaches include bioinformatics; analyses of primary, transformed and 3D cell culture systems; and mouse tumor models to facilitate translational endeavors.
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Yi Zheng, PhD
Director, Experimental Hematology and Cancer Biology
Yi Zheng, PhD, studies the function and signaling mechanism of the Rho family GTPases and the mTor metabolic pathway, particularly in stem cell and cancer stem cell regulation.
Visit the Zheng Lab.