The Miraldi lab’s focus is mathematical modeling of the immune system from high-dimensional genomics measurements. In close collaboration with experimental immunologists, we seek to learn how diverse immune cells sense and respond to their environment in both health and disease. Our studies leverage new biotechnologies (e.g., chromatin accessibility, single-cell genomics measurements) and often require development of new computational methods. The resulting genome-scale models provide unbiased, experimentally testable hypotheses. Long-term, we would like to use these models to re-engineer immune-cell behavior in the context of autoimmunity, cancer and other diseases. 

In the News

A New Way to Map Cell Regulatory Networks. EurekAlert!, March 5, 2019. 

How Big Data and Genomics are Improving Infectious Disease Research. Healthcare Analytics, Nov. 30, 2017.

Immuno-Engineering from the Numbers. Research Horizons, Spring 2017.

Computational Methods and Biological Systems

Learn more about the methods and systems.

Meet the Lab

Learn more about our current lab members and lab alumni.

Open Lab Positions

The Miraldi Lab seeks talented, motivated individuals at all levels (masters, PhD, postdoc, programmers). Interested parties are invited to submit their CV to Emily via e-mail at emily.miraldi@cchmc.org.