Hyper IgE syndrome is an immune deficiency caused by a genetic mutation in either STAT3 (autosomal dominant, also known as Job’s syndrome) or DOCK8 (autosomal recessive). 

There may be other mutations in other genes that are not known at this time. 

Patients with either form of hyper IgE syndrome often have trouble fighting harmful bacteria and fungi. They may get serious infections. This often happens in the skin and lungs.