Hyper IgE syndrome is an immune deficiency caused by a genetic mutation in either STAT3 (autosomal dominant, also known as Job’s syndrome) or DOCK8 (autosomal recessive). 

There may be other mutations in other genes that are currently not known. 

Patients with either form of hyper IgE syndrome often have trouble fighting harmful bacteria and fungi and may develop serious infections, especially in the skin and lung.