Ghandikota, S; Hershey, GKK; Mersha, TB. GENEASE real time bioinformatics tool for multi-omics and disease ontology exploration, analysis and visualization. Bioinformatics. 2018; 34(18):3160-3168.
GENEASE is an efficient web-based tool for real-time exploration and analysis of both coding and non-coding databases. Apart from exploration of genes, pathways and other biological information, it can also be used to perform functional enrichment and overlap analyses of different annotation sources.
Bolcas, PE; Brandt, EB; Zhang, Z; Biagini Myers, JM; Ruff, BP; Khurana Hershey, GK. Vitamin D supplementation attenuates asthma development following traffic-related particulate matter exposure. Journal of Allergy and Clinical Immunology. 2019; 143(1):386-394.e3.
The findings of this paper suggest that early vitamin D supplementation may be an effective preventative strategy for the development of asthma exacerbated by traffic-related air particulate matter (TRAP) exposure.
Murrison, LB; Brandt, EB; Myers, JB; Hershey, GKK. Environmental exposures and mechanisms in allergy and asthma development. Journal of Clinical Investigation. 2019; 129(4):1504-1515.
Environmental exposures in the outdoor, indoor, and human host environment interplay with host factors to contribute to the development, exacerbation, and lifelong progression of allergic disease and asthma. The impact of these environmental factors on allergic disease mechanisms differs based on host genetics, host immunologic milieu, exposure timing, and interactions with other exposures.
Altman, MC; Gill, MA; Whalen, E; Babineau, DC; Shao, B; Liu, AH; Jepson, B; Gruchalla, RS; O'Connor, GT; Pongracic, JA; Kercsmar, CM; Hershey, GKK; Zoratti, EM; Johnson, CC; Teach, SJ; Kattan, M; Bacharier, LB; Beigelman, A; Sigelman, SM; Presnell, S; Gern, JE; Gergen, PJ; Wheatley, LM; Togias, A; Busse, WW; Jackson, DJ. Transcriptome networks identify mechanisms of viral and nonviral asthma exacerbations in children. Nature Immunology. 2019; 20(5):637-651.
This study identifies distinct and novel pathways by which viral and non-viral exacerbations are mediated in children with asthma.
Gern, JE; Jackson, DJ; Lemanske, RF; Seroogy, CM; Tachinardi, U; Craven, M; Hwang, SY; Hamilton, CM; Huggins, W; O'Connor, GT; Gold, DR; Miller, R; Kattan, M; Johnson, CC; Ownby, D; Zoratti, EM; Wood, RA; Visness, CM; Martinez, F; Wright, A; Lynch, S; Ober, C; Khurana Hershey, GK; Ryan, P; Hartert, T; Bacharier, LB. The Childrens Respiratory and Environmental Workgroup CREW birth cohort consortium Design, methods, and study population. Respiratory Research. 2019; 20(1).
This study describes the new Children’s Respiratory and Environmental Workgroup Birth Cohort Consortium, which is part of the Environmental Child Health Outcomes NIH program and includes 11 distinct birth cohorts across the United States.