Projects
Lab Projects (3)
Acute Urticarial Syndrome Disorders in Children Taking Antibiotics
Acute urticarial syndrome disorders in children taking antibiotics present with hives that occur unpredictably after many days of illness caused by an infection. Additional symptoms may include swelling of the face, hands, feet or joints (knees, wrists, ankles). We are doing research to understand why children get allergic symptoms: is it the illness itself or an antibiotic taken for the illness? We might predict the latter, but most of the time, allergy testing shows the medication is safe to use.
Our research hopes to address:
- Can we develop better treatments for hives when we understand mechanisms?
- Can we uncover biomarkers that tell us at the time of hives which children are truly allergic?
Project Collaborators
Grants / Funding Information
$500,000
National Institutes of Health
Acute Infusion/Injection Reactions to Medications
Children with complex illnesses often require life-saving medications delivered by injection. Reactions to injected medications are more frequent and potentially life threatening. Idealized diagnosis and management is lacking; this leads to unnecessary ADR labels and avoidance. There is a dearth of research, so the mechanisms for most reactions are unknown.
Medications we’re studying include IV and injectable antibiotics, anesthesia medications, biologics, blood products, chemotherapy, iron, radiocontrast agents, vaccines and more.
Our research hopes to address:
- Can we develop better treatments for infusion reactions when we understand mechanisms?
- Can we uncover biomarkers that tell us ahead of time which children are at risk?
Severe Cutaneous Adverse Reactions
Children taking medications for infections, seizures or depression/anxiety may be at risk. Reactions are rare, under-recognized, and high morbidity/mortality. Idealized diagnosis and management are lacking. There is a dearth of research.
Our research hopes to address:
- Can we develop better treatments for infusion reactions when we understand mechanisms?
- Can we uncover biomarkers that tell us ahead of time which children are at risk?
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