Publications - Original Data

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Ogawa Shibata, A.R., E.J. Troster, and H.R. Wong. Glucocorticoid receptor expression in peripheral white blood cells of critically ill children. Pediatr Criti Care Med. 2015 (in press).

Cvijanovich, N.Z., J.C. King, H.R. Flori, G. Gildengorin, S.A. Vinks, and H.R. Wong. Safety and dose-escalation study of parenteral zinc supplementation in pediatric critical illness. JPEN J Parenter Enteral Nutr. 2015 (in press).

Wong, H.R., K.R. Walley, V. Pettilä, N.J. Meyer, J.A. Russell, S. Karlsson, M.G.S. Shashaty, and C.J. Lindsell. Comparing the prognostic performance of ASSIST to interleukin-6 and procalcitonin in patients with severe sepsis and septic shock. Biomarkers. 2015 (in press).

Wong, H.R., N.Z. Cvijanovich, N. Anas, G.L. Allen, N.J. Thomas, M.T. Bigham, S.L. Weiss, J. Fitzgerald, P.A. Checchia, K. Meyer, T.P. Shanley, M. Quasney, M. Hall, R. Gedeit, R.J. Freishtat, J. Nowak, R.S. Shekhar, S. Gertz, E. Dawson, K. Howard, K. Harmon, E. Beckman, E. Frank, and C.J. Lindsell. Developing a clinically feasible personalized medicine approach to pediatric septic shock. Am J Respir Crit Care Med. 2015 (in press).

Basu, R.K, H.R. Wong, C.D. Krawczeski, D.S. Wheeler, P.B. Manning, L.S. Chawla, P. Devarajan, and S.L. Goldstein. Combining functional and tubular damage biomarkers improves diagnostic precision for acute kidney injury after cardiac surgery. J Am Coll Cardiol. 64:2753-2762, 2014.

Weiss, S.L., N.Z. Cvijanovich, G.L. Allen, N.J. Thomas, R.J. Freishtat, N. Anas, K. Meyer, P.A. Checchia, T.P. Shanley, M.T. Bigham, J. Fitzgerald, S. Banschbach, E. Beckman, K. Howard, E. Frank, K. Harmon, and H.R. Wong. Differential expression of the nuclear-encoded mitochondrial transcriptome in pediatric septic shock. Crit Care. 18:623, 2014.

Atkinson, S.J., N.Z. Cvijanovich, N.J. Thomas, G.L. Allen, N. Anas, M.T. Bigham, M. Hall, R.J. Freishtat, A. Sen, K. Meyer, P.A. Checchia, T.P. Shanley, J. Nowak, M. Quasney, S.L. Weiss, S. Banschbach, E. Beckman, K. Howard, E. Frank, K. Harmon, P. Lahni,  C.J. Lindsell, and H.R. Wong. Corticosteroids and pediatric septic shock:  A risk stratified analysis. PLoS One. 9:e112702, 2014.

Wheeler, D.S., M.T. Bigham, P.M. Lahni, J.S. Giuliano, Jr., D.P. Nelson, P.B. Manning, and H.R. Wong. The extracellular stress response to pediatric cardiopulmonary bypass. J Pediatr Intensive Care. 3:9-16, 2014.

Abulebda, K., N.Z. Cvijanovich, N.J. Thomas, G.L. Allen. N. Anas, M.T. Bigham, M. Hall, R.J. Freishtat, A. Sen, K. Meyer, P.A. Checchia, T.P. Shanley, J. Nowak, M. Quasney, S.L. Weiss, A. Chopra, S. Banschbach, E. Beckman, C.J. Lindsell, and H.R. Wong. Post-intensive care unit admission fluid balance and pediatric septic shock outcomes:  A risk-stratified analysis. Crit Care Med. 42:397-403, 2014.

Wong, H.R., S.L. Weiss, J.S. Giuliano, Jr., M.S. Wainwright, N.Z. Cvijanovich, N.J. Thomas, G.L. Allen, N. Anas, M.T. Bigham, M. Hall, R.J. Freishtat, A. Sen, K. Meyer, P.A. Checchia, T.P. Shanley, J. Nowak, M. Quasney, A. Chopra, J.C. Fitzgerald, R. Gedeit,  S. Banschbach, E. Beckman, P. Lahni, K. Hart, and C.J. Lindsell. Testing the prognostic accuracy of the updated pediatric sepsis biomarker risk model. PLoS One. (9):e86242, 2014.

Basu, R.K., M. Zappitelli, L. Brunner, Y. Wang, H.R. Wong, L.S. Chawla, D.S. Wheeler, and S.L. Goldstein. Derivation and validation of the renal angina index to improve the prediction of acute kidney injury in critically ill children. Kidney Int. 85:659-667, 2014.

Wong, H.R., S.L. Weiss, J.S. Giuliano, Jr., M.S. Wainwright, N.Z. Cvijanovich, N.J. Thomas, G.L. Allen, N. Anas, M.T. Bigham, M. Hall, R.J. Freishtat, A. Sen, K. Meyer, P.A. Checchia, T.P. Shanley, J. Nowak, M. Quasney, A. Chopra, J.C. Fitzgerald, R. Gedeit,  S. Banschbach, E. Beckman, K. Harmon, P. Lahni, and C.J. Lindsell. The temporal version of the pediatric sepsis biomarker risk model. PLoS One. 9:e92121, 2014.

Wong, H.R., C.J. Lindsell, V. Pettilä, N.J. Meyer, S.A. Thair, S. Karlsson, J.A. Russell, C.D. Fjell, J.H. Boyd, E. Ruokonen, M.G.S. Shashaty, J.D. Christie, K.W. Hart. P. Lahni, and K.R. Walley. A multi-biomarker-based outcome risk stratification model for adult septic shock. Crit Care Med. 42:781-789, 2014.

Slinko, S., G. Piraino, P.W. Hake, J.R. Ledford, M. O’Connor, P. Lahni, P.D. Solan, H.R. Wong, and B. Zingarelli. Combined zinc supplementation with proinsulin c-peptide treatment decreases the inflammatory response and morality in murine polymicrobial sepsis. Shock. 41:292-300, 2014.

Basu, R.K., Y. Wang, H.R. Wong, L.S. Chawla, D.S. Wheeler, and S.L. Goldstein. Incorporation of biomarkers with the renal angina index for prediction of severe AKI in critically ill children. Clin J Am Soc Nephrol. 9:654-662, 2014.

Wong, H.R., N.Z. Cvijanovich, G.L. Allen, N.J. Thomas, R.J. Freishtat, N. Anas, K. Meyer, P.A. Checchia, S.L. Weiss, T.P. Shanley, M.T. Bigham, S. Banschbach, E. Beckman, K. Harmon, and J.J. Zimmerman. Corticosteroids are associated with repression of adaptive immunity gene programs in pediatric septic shock. Am J Respir Crit Care Med. 189:940-946, 2014.

Wong, H.R., K.D. Liu, K.N. Kangelaris, P. Lahni, and C.S. Calfee. Performance of interleukin-27 as a sepsis diagnostic biomarker in critically ill adults. J Crit Care. 29:718-722, 2014.

Menon, K., J.D. McNally, K. Choong, R.E. Ward, M. Lawson, T. Ramsay, and H.R. Wong. A survey of physician practices and beliefs on the use of steroids in pediatric fluid and/or vasoactive infusion dependent shock. Pediatr Crit Care Med. 14:462-466, 2013.

Mickiewicz, B., H.J. Vogel, H.R. Wong, and B.W. Winston. Metabolomics as a novel approach for early diagnosis of pediatric septic shock and its mortality. Am J Resp Crit Care Med. 187:967-976, 2013.

Jothimuthu P., R.A. Wilson, J. Herren, X. Pei, W, Kang, R. Daniels, H. Wong, F. Beyette, W.R. Heineman, I. Papautsky. Zinc detection in serum by anodic stripping voltammetry on microfabricated bismuth electrodes. Electroanalysis. 25:401-407, 2013.

Wong, H.R., C.J. Lindsell, P. Lahni, K.W. Hart, and S. Gibot. Interleukin-27 as a sepsis diagnostic biomarker in critically ill adults. Shock. 40:382-386, 2013.

 

Wong H.R., N.Z. Cvijanovich, M. Hall, G.L. Allen, N.J. Thomas, R.J. Freishtat, N. Anas, K. Meyer, P.A. Checchia, R. Lin, M.T. Bigham, A. Sen, J. Nowak, M. Quasney, J.W. Henricksen, A. Chopra, S. Banschbach, E. Beckman, K. Harmon, P. Lahni, and T.P. Shanley. Interleukin-27 is a novel candidate diagnostic biomarker for bacterial infection in critically ill children. Crit Care. 16:R213, 2012.

Wong, H.R., S. Salisbury, Q. Xiao, N.Z. Cvijanovich, M. Hall, G.L. Allen, N.J. Thomas, R.J. Freishtat, N. Anas, K. Meyer, P.A. Checchia, R. Lin, T.P. Shanley, M.T. Bigham, A. Sen, J. Nowak, M. Quasney, J.W. Hendricksen, A. Chopra, S. Banschbach, E. Beckman, K. Harmon, P. Lahni, and C.J. Lindsell. The pediatric sepsis biomarker risk model. Crit Care. 16:R174, 2012.

Nowak, J.E., K. Harmon, C.C. Caldwell, and H.R. Wong. Prophylactic zinc supplementation reduces bacterial load and improves survival in a murine model of sepsis. Pediatr Crit Care Med. 13:e323-329, 2012.

Standage, S.W., C.C. Caldwell, B. Zingarelli, and H.R. Wong. Reduced PPARα expression is associated with decreased survival and increased tissue bacterial load in sepsis. Shock. 37:164-169, 2012.

Standage, S.W., Caldwell, C.C., Zingarelli, B. and Wong, H.R. Reduced PPARα expression is associated with decreased survival and increased tissue bacterial load in sepsis. Shock. 37:164-169, 2012.

Wheeler, D.S.,  Dunsmore, K.E., Denenberg, A.G., Muething, L. , Poynter, S.E. and Wong, H.R. Biological activity of truncated C-terminus human heat shock protein 72. Immunol Lett. 135:173-179, 2011.

Wheeler, D.S., Guiliano, J., Lahni, P., Denenberg, A., Wong, H.R. and Zingarelli, B. The immunomodulatory effects of albumin in vitro and in vivo. Adv Pharmacol Sci. Volume 2011 (2011), Article ID 691928, 7 pages.

Mahabeleshwar, G.H., Kawanami, D., Sharma, N., Takami, Y., Zhou, G., Shi, H., Nayak, L., Jeyaraj, D., Grealy, R., White, M., McManus, R., Ryan, T., Leahy, P., Lin, Z.,  Haldar, S.M., Atkins, G.B., Wong, H.R., Lingrel, J.B. and Jain, M.K. Myeloid KLF2 regulates the host response to polymicrobial infection and endotoxic shock. Immunity. 34:715-728, 2011.

Basu, R.K., Donaworth, E., Wheeler, D.S, Devarajan, P. and Wong, H.R. Antecedent acute kidney injury worsens subsequent endotoxin-induced lung inflammation in a 2-hit mouse model. Am J Physiol Renal Physiol. 301:F597-604, 2011. 

Wong, H.R., Cvijanovich, N.Z., Allen, G.L., Thomas, N.J.,  Freishtat, R.J., Anas, N., Meyer, K., Checchia, P.A., Lin, R.,  Shanley, T.P.,  Bigham, M.T., Wheeler, D.S.,  Doughty, L.A., Tegtmeyer, K., Poynter, S.E., Kaplan, J.M., Chima, R.S., Stalets, E., Basu, R.K., Varisco, B.M. and Barr, F.E. Validation of a gene expression-based subclassification strategy for pediatric septic shock. Crit Care Med. 39:2511-2517, 2011.

Basu, R.K., Standage, S.W., Cvijanovich, N.Z., Allen, G.L., Thomas, N.J., Freishtat, R.J., Anas, N., Meyer, K., Checchia, P.A., Lin, R., Shanley, T.P., Bigham, M.T.,  Wheeler, D.S., Devarajan, P., Goldstein, S.L. and Wong, H.R. Identification of candidate serum biomarkers for severe septic shock-associated kidney injury via microarray. Crit Care. 15:R273, 2011.

Wynn, J.L., Cvijanovich, N.Z., Allen, G.L., Thomas, N.J., Freishtat, R.J., Anas, N.,  Meyer, K., Checchia, P.A., Lin, R.,  Shanley, T.P.,  Bigham, M.T., Banschbach, S., Beckman, E. and Wong, H.R. The influence of developmental age on the early transcriptomic response of children with septic shock. Mol Med. 2011 (in press).

Solan, P.D., Dunsmore, K.E., Denenberg, A.G., Odoms, K., Zingarelli, B. and Wong, H.R. A novel role for matrix metalloproeinase-8 in sepsis. Crit Care Med. 2011 (in press).

Kaplan, J.M., Denenberg, A., Monaco, M., Nowell, M., Wong, H.R. and Zingarelli, B. Changes in peroxisome proliferator-activated receptor-gamma activity in children with septic shock. Intensive Care Med. 36:123-130, 2010.

Nowak, J.E., Wheeler, D.S., Harmon, K.K. and Wong, H.R.Admission chemokine (C-C motif) ligand 4 levels predict survival in pediatric septic shock. Ped Crit Care Med. 11:213-216, 2010.

Wong, H.R., Freishtat, R.J., Monaco, M., Odoms, K. and Shanley, T.P. Leukocyte subset-specific genome-wide expression profiles in pediatric septic shock. Ped Crit Care Med. 11:349-355, 2010.

Calfee, C.S., Thompson, B.T., Parsons, P.E., Ware, L.B., Matthay, M.A. and Wong, H.R. Plasma IL-8 is not an effective risk stratification tool for adults with vasopressor-dependent septic shock. Crit Care Med. 38:1436-1441, 2010.

Wong, H.R., Wheeler, D.S., Tegtmeyer, K., Poynter, S.E., Kaplan, J.M., Chima, R.S., Stalets, E., Basu, R.K. and Doughty, L.A. Toward a clinically feasible gene expression-based sub-classification strategy for septic shock:  proof of concept. Crit Care Med. 38:1955-1961, 2010.

Cvijanovich, N.Z.,  King, J.C., Flori, H.R., Gildengorin, G. and Wong, H.R. Zinc homeostasis in pediatric critical illness. Ped Crit Care Med. 10:29-34, 2009.

Wong, H.R., Shanley, T.P., Cvijanovich, N., Allen, G.L., Lin, R., Anas, N., Meyer, K., Freishtat, R.J., Monaco, M., Odoms, K. and Sakthivel, B. Genome-wide expression profiling across the pediatric SIRS, sepsis, and septic shock spectrum. Crit Care Med. 37:1558-1566, 2009.

Huber, N., Sakai, N., Eismann, T., Shin, T., Kuboki, S., Blanchard, J., Schuster, R.,  Edwards, M.J., Wong, H.R. and Lentsch, A.B. Age-related decrease in proteasome expression contributes to defective NF-kB activation during hepatic ischemia/reperfusion. Hepatology. 49:1718-1728, 2009.

Zingarelli, B., Hake, P.W., O’Connor, M.,  Burroughs, T.J., Wong, H.R., Solomkin, J.S. and Lentsch, A.B. Lung injury after hemorrhage is age dependent:  Role of peroxisome proliferator-activated receptor gamma. Crit Care Med. 37:1978-1987, 2009.

Wong, H.R., Cvijanovich, N., Lin, R., Allen, G.L., Thomas, N.J., Willson, D.F., Freishtat, R.J., Anas, N., Meyer, K., Checchia, P.A., Monaco, M., Odoms, K. and Shanley, T.P.Identification of pediatric septic shock classes based on genome-wide expression profiling. BMC Medicine. 7:34, 2009.

Cobb, J.P., Cairns, C.B., Bulger, E., Wong, H.R., Parsons, P.E., Angus, D.C., Gentile, N.T., Hoyt, D.B., Schwinn, D.A., Wiener-Kronish, J.P. and Upperman, J.S. The United States critical illness and injury trials group. J Trauma. 67:S159-S160, 2009.

Wheeler, D.S., Devarajan, P., Ma, Q., Harmon, K., Monaco, M., Cvijanovich, N. and  Wong, H.R. Serum neutrophil gelatinase-associated lipocalin (NGAL) as a marker of acute kidney injury in critically ill children with septic shock. Crit Care Med. 36:1297-1303, 2008.

Wong, H.R., Odoms, K. and Sakthivel, B. Divergence of canonical danger signals:  The genome-level expression patterns of human mononuclear cells subjected to heat shock or lipopolysaccharide. BMC Immunol. 9:24, 2008.

Cvijanovich, N, Shanley, T.P., Lin, R., Allen, G.L., Thomas, N.J., Checchia, P., Anas, N., Freishtat, R.J., Monaco, M., Odoms, K., Sakthivel, B. and Wong, H.R., for the Genomics of Pediatric SIRS Investigators. Validating the genomic signature of pediatric septic shock. Physiol Genomics. 34:127-134, 2008.

Wong, H.R., Cvijanovich, N., Wheeler, D.S., Bigham, M.T., Monaco, M., Odoms, K., Macias, W.L. and Williams, M.D. Interleukin-8 as a stratification tool for interventional trials involving pediatric septic shock. Am J Respir Crit Care Med. 178:276-282, 2008.

Wong, H.R., Shanley, T.P., Sakthivel, B., Cvijanovich, N., Lin, R., Allen, G.L., Thomas, N.J., Doctor, A., Kalyanaraman, M., Tofil, N.M., Penfil, S., Monaco, M., Tagavilla, M.A., Odoms, K., Dunsmore, K., Barnes, M. and  Aronow, B.J., for the Genomics of Pediatric SIRS Investigators. Genome level expression profiles in pediatric septic shock indicate a role for altered zinc homeostasis in poor outcome. Physiol Genomics. 30:146-155, 2007.

Shanley, T.P., Cvijanovich, N., Lin, R., Allen, G.L., Thomas, N.J., Doctor, A., Kalyanaraman, M., Tofil, N.M., Penfil, S., Monaco, M., Odoms, K., Barnes, M.,  Sakthivel, B.,  Aronow, B.J. and Wong, H.R. Genome-level longitudinal expression of signaling pathways and gene networks in pediatric septic shock. Mol Med. 13:496-508, 2007.

Publications - Invited Review Articles

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Sandquist, M. and H.R. Wong. Biomarkers of sepsis and their potential value in diagnosis, prognosis, and treatment. Expert Rev Clin Immunol. 10:1349-1356, 2014.

Sanquist, M. and H.R. Wong. Micronutrients’ role against sepsis. Chest Physician. 9:1, 2014.

Wynn, J.L., H.R. Wong, T.P. Shanley, M.J. Bizzarro, L. Saiman, and R.A. Polin. Time for a neonatal-specific definition for sepsis. Pediatr Crit Care Med. 15:523-528, 2014.

Alder, M.N., C.J. Lindsell, and H.R. Wong. The pediatric sepsis biomarker risk model:  Potential implications for sepsis therapy and biology. Expert Rev Anti Infect Ther. 12:809-815, 2014.

Maslove, D.M. and H.R. Wong. Gene expression profiling in sepsis:  Timing, tissue, and translational considerations. Trends Mol Med. 20:204-213, 2014.

Hanna, W. and H.R. Wong. Pediatric sepsis:challenges and adjunctive therapies. Crit Care Clin.29:203-222, 2013.

Wong, H.R. Genome-wide expression profiling in pediatric septic shock. Pediatr Res. 73:564-569, 2013.

Samraj, R.S., B. Zingarelli, and H.R. Wong. Role of biomarkers in sepsis care. Shock. 40:358-365, 2013.

Wong, H.R. Sepsis and septic shock:  The potential for gene arrays. Crit Care. 2012.

Wong, H.R. Genetics and genomics in pediatric septic shock. Crit Care Med. 2012.

Standage, S.W. and Wong, H.R. Biomarkers for pediatric sepsis and septic shock. Expert Rev Anti Infect Ther. 1:71-79, 2011.

Kaplan, J.M. and Wong, H.R. Biomarker discovery and development in pediatric critical care medicine. Ped Crit Care Med. 12:165-173, 2011.

Basu, R.K., Devarajan, P., Wong, H.R. and Wheeler, D.S. An update and review of acute kidney injury in pediatrics. Ped Crit Care Med. 12:39-347, 2011.

Wheeler, D.S., Wong, H.R. and Zingarelli, B. Children are not small adults. The Open Inflammation Journal. 4:4-15, 2011.

Giuliano, J.S., Jr., Lahni, P.M., Wong, H.R. and Wheeler, D.S. Extracellular heat shock proteins:  alarmins for the host immune system. The Open Inflammation Journal. 4:49-60, 2011.

Nowak, J.S. and Wong, H.R. Novel therapeutic agents in pediatric sepsis—zinc. The Open Inflammation Journal. 4:110-114, 2011.

Wheeler, D.S., Jeffries, H.E., Zimmerman, J.J., Wong, H.R. and Carcillo, J.A. Sepsis in the pediatric cardiac intensive care unit. World Journal for Pediatric and Congenital Heart Surgery. 2:393-399, 2011.

Wynn, J., Cornell, T.T., Wong, H.R.,  Shanley, T.P. and Wheeler, D.S. The host response to sepsis and developmental impact. Pediatrics. 125:1031-1041, 2010.

Cornell, T.T., Wynn, J.,  Shanley, T.P., Wheeler, D.S. and Wong, H.R. Mechanisms and regulation of the gene expression response to sepsis. Pediatrics. 125:1248-1258, 2010.

Wynn, J.L. and Wong, H.R. Pathophysiology and treatment of septic shock in neonates. Clin Perinatol. 37:439-479, 2010.

Wheeler, D.S., Zingarelli, B., Wheeler, W.J. and Wong, H.R. Novel pharmacologic approaches to the management of sepsis:  targeting the host inflammatory response . Recent Pat Inflamm Allergy Drug Discov. 3:96-112, 2009.