We recently identified interleukin-27 (IL-27) as a novel biomarker to predict bacterial infection in critically ill children. IL-27 was discovered using our extensive gene expression database, and in our initial derivation cohort it outperformed procalcitonin, which is currently one of the most widely used clinical biomarkers for infection. We have extended these studies to adults in collaboration with investigators in France and the University of California San Francisco.
Wong, H.R., K.D. Liu, K.N. Kangelaris, P. Lahni, and C.S. Calfee. Performance of interleukin-27 as a sepsis diagnostic biomarker in critically ill adults. J Crit Care. 29:718-722, 2014.
Wong, H.R., C.J. Lindsell, P. Lahni, K.W. Hart, and S. Gibot. Interleukin-27 as a sepsis diagnostic biomarker in critically ill adults. Shock. 40:382-386, 2013.
Wong H.R., N.Z. Cvijanovich, M. Hall, G.L. Allen, N.J. Thomas, R.J. Freishtat, N. Anas, K. Meyer, P.A. Checchia, R. Lin, M.T. Bigham, A. Sen, J. Nowak, M. Quasney, J.W. Henricksen, A. Chopra, S. Banschbach, E. Beckman, K. Harmon, P. Lahni, and T.P. Shanley. Interleukin-27 is a novel candidate diagnostic biomarker for bacterial infection in critically ill children. Crit Care. 16:R213, 2012.