This project focuses on identifying cell signaling pathways which are downstream of epidermal growth factor receptor activation which mediate fibroproliferation. The goal is to identify specific pathways which can be pharmacologically targeted that not only prevent lung fibrosis progression, but augment reversal of existing fibrosis.
NIH/NHLBI including RO1 and P50 grants.
George Thomas, PhD
University of Cincinnati
Department of Cancer and Cell Biology