This project focuses on identifying cell signaling pathways which are downstream of epidermal growth factor receptor activation which mediate fibroproliferation. The goal is to identify specific pathways which can be pharmacologically targeted that not only prevent lung fibrosis progression, but augment reversal of existing fibrosis.
NIH/NHLBI including RO1 and P50 grants.
George Thomas, PhD
University of Cincinnati
Department of Cancer and Cell Biology
The goal of this project is to determine the origin of cells which comprise lung fibrosis. A specific focus of this project is to determine the mechanisms and roles of cells originating from the bone marrow that are found in fibrotic lung lesions.
American Heart Association - Grant to Dr. Madala
This project examines the role of interleukin-31(IL-31) in mediating skin and lung fibrosis and the relationship of IL-31 with other TH-2 cytokines and receptors including IL-4 and IL-13.
RO3 grant from the NIH – Pending