De Falco Lab
Publications

Publications

Li, S-Y; Bhandary, B; Gu, X; Defalco, T. Perivascular cells support folliculogenesis in the developing ovary. Proceedings of the National Academy of Sciences of the United States of America. 2022; 119(41):e2213026119.

Heinrich, A; Bhandary, B; Potter, SJ; Ratner, N; Defalco, T. Cdc42 activity in Sertoli cells is essential for maintenance of spermatogenesis. Cell reports. 2021; 37(4):109885.

Li, S-Y; Gu, X; Heinrich, A; Hurley, EG; Capel, B; Defalco, T. Loss of Mafb and Maf distorts myeloid cell ratios and disrupts fetal mouse testis vascularization and organogenesis†. Biology of Reproduction. 2021; 105(4):958-975.

Kumar, DL; Defalco, T. A perivascular niche for multipotent progenitors in the fetal testis. Nature Communications. 2018; 9(1):4519.

Lin, Y-T; Barske, L; Defalco, T; Capel, B. Numb regulates somatic cell lineage commitment during early gonadogenesis in mice. Development. 2017; 144(9):1607-1618.

Defalco, T; Potter, SJ; Williams, AV; Waller, B; Kan, MJ; Capel, B. Macrophages Contribute to the Spermatogonial Niche in the Adult Testis. Cell reports. 2015; 12(7):1107-1119.

Defalco, T; Bhattacharya, I; Williams, AV; Sams, DM; Capel, B. Yolk-sac-derived macrophages regulate fetal testis vascularization and morphogenesis. Proceedings of the National Academy of Sciences of the United States of America. 2014; 111(23):E2384-E2393.

Defalco, T; Saraswathula, A; Briot, A; Iruela-Arispe, ML; Capel, B. Testosterone levels influence mouse fetal Leydig cell progenitors through notch signaling. Biology of Reproduction. 2013; 88(4):91.

Defalco, T; Takahashi, S; Capel, B. Two distinct origins for Leydig cell progenitors in the fetal testis. Developmental Biology. 2011; 352(1):14-26.

Cool, J; Defalco, TJ; Capel, B. Vascular-mesenchymal cross-talk through Vegf and Pdgf drives organ patterning. Proceedings of the National Academy of Sciences of the United States of America. 2011; 108(1):167-172.

Li, S-Y; Whiteside, S; Li, B; Sun, X; Defalco, T. Mesenchymal-to-epithelial transition of perivascular cells contributes to endometrial re-epithelialization. Nature Communications. 2025; 16(1):10174.

Weinhaus, B; Homan, S; Kincaid, M; Tadwalkar, A; Gu, X; Kumar, S; Slaughter, A; Zhang, J; Wu, Q; Kofron, JM; Troutman, TD; Defalco, T; Lucas, D. Differential regulation of fetal bone marrow and liver hematopoiesis by yolk-sac-derived myeloid cells. Nature Communications. 2025; 16(1):4427.

Matsuyama, S; Defalco, T. Leydig Cell Interaction with Macrophages, Peritubular Cells, and Sertoli Cells. In: Leydig Cells. Springer Nature; 2025:311-336.

Li, S-Y; Kumar, S; Gu, X; Defalco, T. Testicular immunity. Molecular Aspects of Medicine. 2024; 100:101323.

Maezawa, S; Yukawa, M; Hasegawa, K; Sugiyama, R; Iizuka, M; Hu, M; Sakashita, A; Vidal, M; Koseki, H; Barski, A; Defalco, T; Namekawa, SH. PRC1 suppresses a female gene regulatory network to ensure testicular differentiation. Cell Death and Disease. 2023; 14(8):501.

Gu, X; Heinrich, A; Li, S-Y; Defalco, T. Testicular macrophages are recruited during a narrow fetal time window and promote organ-specific developmental functions. Nature Communications. 2023; 14(1):1439.

Matsuyama, S; Defalco, T. Steroid hormone signaling: multifaceted support of testicular function. Frontiers in Cell and Developmental Biology. 2023; 11:1339385.

Li, S-Y; Bhandary, B; Gu, X; Defalco, T. Perivascular cells support folliculogenesis in the developing ovary. Proceedings of the National Academy of Sciences of the United States of America. 2022; 119(41):e2213026119.

Gu, X; Li, S-Y; Defalco, T. Immune and vascular contributions to organogenesis of the testis and ovary. The FEBS Journal. 2022; 289(9):2386-2408.

Gu, X; Defalco, T. In Vitro Differentiation of Leydig Cells From hiPSCs: A First Step Towards a Cellular Therapy for Hypogonadism? Endocrinology. 2022; 163(1).

Gu, X; Li, S-Y; Matsuyama, S; Defalco, T. Immune Cells as Critical Regulators of Steroidogenesis in the Testis and Beyond. Frontiers in Endocrinology. 2022; 13:894437.

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