Clinical Laboratories
CBDI Clinical Laboratories | Diagnostic Immunology Lab

Diagnostic Immunology Laboratory

The Diagnostic Immunology Laboratories (DIL), consisting of the Clinical Immunology Laboratory and the Research Immunology Laboratory, are committed to providing the highest quality, comprehensive clinical testing available to aid in the detection, diagnosis and treatment of pediatric oncologic, hematologic and immunologic disorders. We're committed to applying scientific advances to promote efficiency, enhance patient care and improve clinical utility.

Our testing is developed to assist in diagnosis and management of rare primary immunodeficiencies and other disorders of the immune system.

Hemophagocytic lymphohistiocytosis (HLH) is a disorder of widespread accumulation of lymphocytes and mature macrophages, sometimes with hemophagocytosis, primarily involving the spleen, lymph nodes, bone marrow, liver and cerebral spinal fluid. HLH can either occur sporadically (secondary HLH), or can be inherited as the autosomal recessive condition known as familial hemophagocytic lymphohistiocytosis (FHL).

We also offer clinical testing for  Wiskott-Aldrich syndrome (WAS), severe combined immunodeficiency (SCID),  X-linked lymphoproliferative disease (XLP) and X-linked immune dysregulation, polyendocrinopathy, enteropathy syndrome (IPEX). 

The Clinical Immunology and Research Immunology Laboratories are integrated in a comprehensive Immunodeficiencies and Histiocytosis Program at Cincinnati Children's Hospital Medical Center. It interfaces with the Molecular Genetics Laboratory as part of the Diagnostic Center for Heritable Immunodeficiencies, as well as with the Bone Marrow Transplantation Program.

Contact Us

Phone: 513-636-4685
Fax: 513-636-3861

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Clinical Laboratory Index

View all tests offered by Cincinnati Children’s.

Customized Volume by ALC

To help calculate the volume of blood to draw, download this chart (.pdf).

CPT Codes, Prices, TAT

For any billing inquiries, email or call 513-636-4685.

For individual test CPT Codes and turn-around times (TAT), visit our Clinical Laboratory Index.

Illustration of involvement of selected primary HLH proteins in cytotoxic lymphocyte degranulation and target cell killing. Antibodies against markers used in selected screening diagnostics are also shown (perforin and CD107a).

Click to view an illustration of the selected primary HLH proteins involved in degranulation and killing.