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Cold Weather Guidelines

We are experiencing some problems with samples arriving frozen or damaged after exposure to cold temperatures. Due to the nature of many of our assays, a sample can become unacceptable for testing due to hemolysis and cellular viability. Try to pack the samples to be as insulated as possible. If you are sending serum or plasma-based tests, we recommend separating the serum / plasma, freezing it and sending it on dry ice. Other whole blood-based tests cannot be frozen. During below-freezing temperatures, we recommend wrapping and shipping specimens in well-insulated material and then using a secondary shipping container in addition to a primary plastic foam pack or box. Packing plastic foam peanuts or uncooled gel / freezer packs in the secondary container is very effective in protecting the specimens. The uncooled gel packs especially will absorb the cold first and provide added protection to the primary container. Call our customer service representatives at 513-636-4685 to discuss shipping and packing options.

The Diagnostic Immunology Laboratories (DIL), consisting of the Clinical Immunology Laboratory and the Research Immunology Laboratory, are committed to providing the highest quality, comprehensive clinical testing available to aid in the detection, diagnosis and treatment of pediatric oncologic, hematologic and immunologic disorders. We're committed to applying scientific advances to promote efficiency, enhance patient care and improve clinical utility.

Our testing is developed to assist in diagnosis and management of rare primary immunodeficiencies and other disorders of the immune system.

Hemophagocytic lymphohistiocytosis (HLH) is a disorder of widespread accumulation of lymphocytes and mature macrophages, sometimes with hemophagocytosis, primarily involving the spleen, lymph nodes, bone marrow, liver and cerebral spinal fluid. HLH can either occur sporadically (secondary HLH), or can be inherited as the autosomal recessive condition known as familial hemophagocytic lymphohistiocytosis (FHL).

We also offer clinical testing for  Wiskott-Aldrich syndrome (WAS), severe combined immunodeficiency (SCID),  X-linked lymphoproliferative disease (XLP) and X-linked immune dysregulation, polyendocrinopathy, enteropathy syndrome (IPEX). 

The Clinical Immunology and Research Immunology Laboratories are integrated in a comprehensive Immunodeficiencies and Histiocytosis Program at Cincinnati Children's Hospital Medical Center. It interfaces with the Molecular Genetics Laboratory as part of the Diagnostic Center for Heritable Immunodeficiencies, as well as with the Bone Marrow Transplantation Program.