Eosinophilic Disorders

In the News

December

U.S. Senate Passes FASTER Act, Brings Sesame Labeling One Step Closer for Food Allergy Community

November

Transferring Allergies in the Womb
Dr. Rothenberg shares his perspective on a recent article about how maternal mast cells are involved in allergy development in this invited Science Perspective.

Asian Children With Food Allergies More Likely to Experience Quality of Life Challenges

MSSRP Poster Award Winners
Susie Min and Rahul Sandella participated in the 10th Annual Research and Service Symposium at UC on Friday, November 6th. We appreciate UC providing a virtual forum for the MSSRP Program poster judging this year. Susie Min won second place for "Molecular Diagnosis of Eosinophilic Esophagitis from a Single Esophageal Biopsy" with the mentorship of Ting Wen, PhD and Marc Rothenberg, MD, PhD. She will represent us at the annual National Student Research Forum (NSRF) in Galveston, TX (April, 2021). Rahul Sandella won third place for "The Effects of Adiposity on Disease and Symptom Severity in Eosinophilic Esophagitis" with the mentorship of Vincent A. Mukkada, MD and Kara Kliewer, RD, PhD.

October

Grateful Patient with Eosinophilia Thanks Cincinnati Children’s For Improved Life

Anti–Siglec-8 Antibody for Eosinophilic Gastritis and Duodenitis
Patients with eosinophilic gastritis (EG) have limited therapeutic options. The Cincinnati Center for Eosinophilic Disorders is proud to have been an integral part of an important trial, now published in the New England Journal of Medicine, demonstrating that lirentelimab significantly and safely improves symptoms in subjects with EG while eradicating eosinophils. We are hopeful that the Phase 3 trial, which is now enrolling participants, will ultimately confirm these findings so that there are more clinically approved therapeutic options for individuals with this rare disorder.

September

Roots of New Drug for HES Trace Back to Cincinnati Children’s

Cincinnati Children's helps pave way for newly approved use of drug 

What is Eosinophilia?

Treatment for rare esophagus disease deemed breakthrough therapy by FDA: Dupixent shown to reduce esophageal inflammation

FDA Announces Guidance for Industry entitled “Eosinophilic Esophagitis: Developing Drugs for Treatment.”
This guidance is intended to describe the Agency's current thinking and recommended approach for the development of drugs and therapeutic biologics for the treatment of patients with eosinophilic esophagitis.

What it's like to get Palforzia, the first drug to treat peanut allergies in children

August 

How to Read a Food Label

July

Eosinophil responses during COVID-19 infections and coronavirus vaccinations

2020 Virtual Lab Day with the Rothenberg CURED Lab

July

Eosinophil responses during COVID-19 infections and coronavirus vaccinations

May

FDA-Approved Drug Reverses Inflammation in Animal Model of Eosinophilic Esophagitis

Progress Update for Eosinophilic Disorder Research

EGIDExpress Tool Helps Accelerate EoE Research

EOS Network - Your Questions Answered by EOS Network Professionals

Unlocking the Secrets of Eosinophilic Esophagitis: A New Children’s Book

A preliminary report (not peer-reviewed) - Alpha I Antitrypsin is an Inhibitor of the SARS-CoV2-Priming Protease TMPRSS2

The ABCs of EGIDs - online web-based education module

SECURE-EoE/EGID - Coronavirus and EoE/EGID Reporting Database

Research survey for rare disease patients and their families about impacts of COVID-19

February 

RDCRN Spotlight: Patients Power Research in Eosinophilic Gastrointestinal Disorders

Cincinnati Children's Patient Story: Nebraska Family Finds Answers & Food Options for Kids with EoE

EOS Network Website is Live!

Cincinnati Children's Patient Story: Three Matching Shirts, Three Matching Diagnoses

RDCRN Spotlight: NIH's Rare Diseases Clinical Research Network Launches New Logo

January

Research Horizons: New Tests May Help Diagnose Rare Subset of Eosinophilic Disorders

Marc E. Rothenberg was pleased to assist NORD this year in preparation of the Eosinophilic Esophagitis report for the Rare Disease Database!

DECEMBER 4

How to Talk to Party Hosts About Kids' Nut Allergies

NOVEMBER 14

Lawmakers Propose Council to Help People With Rare Diseases

NOVEMBER 13

Nucala (mepolizumab) is the first treatment to show a significant reduction in flares for patients with Hypereosinophilic Syndrome (HES)

NOVEMBER 7-10

5th CURED EGID Research Conference and Patient Education Program and "The CURED" Video

OCTOBER 25

AP-1 activity induced by co-stimulation is rehired for chromatin opening during T cell activation

Marc E. Rothenberg, MD, PhD, shares, "I am pleased to share this research from the Barski Lab. This is an important contribution to the field, defining the epigenetic and transcriptional processes involved in T cell memory. This has direct implications in understanding the immunologic basis of a variety of diseases including allergy."

OCTOBER 23

5th CURED Research Conference and Patient Education Program Begins Nov. 7

OCTOBER 5

Efficacy of Dupilumab in Phase 2 Randomized Trial of Adults with Active Eosinophilic Esophagitis

Marc E. Rothenberg, MD, PhD, shares, "These positive data are good news for the patients, as this is a very promising therapy for eosinophilic esophagitis (EoE). This is also good news for the research field, as these clinical results are based on over a decade of research by the Rothenberg Lab, providing the scientific basis of blocking this pathway in EoE and related eosinophilic gastrointestinal disorders (EGIDs)."

SEPTEMBER 21

Travel Award by Ohio Physiological Society

Rishi Mehta, a student in the Rothenberg Lab, was awarded the AD Instruments Travel Award of the Ohio Physiological Society, which will provide support for him to attend the Experimental Biology 2020 conference. He presented his research in the Rothenberg Lab under the title of "Loss of peptidyl-arginine deiminase 1-mediated citrullination drives esophageal epithelial barrier impairment in allergic inflammation".

AUGUST 5

Phase 2 Randomized, Double-Blind Placebo0Controlled Study in Patients with Eosinophilic Gastritis and/or Eosinophilic Gastroenteritis

Marc E. Rothenberg, MD, PhD, shares, "This is exciting news for the eosinophil gastrointestinal community. This early study met the key endpoints and looks promising for the future treatment of eosinophilic gastrointestinal disease. Here at Cincinnati Children's, we are pleased to have contributed to the preclinical research, design and implementation of this drug and study."

MARCH 12

Dr. Rothenberg received the Paul Ehrlich Lectureship Award

Dr. Rothenberg, the Principal Investigator for the Consortium of Eosinophilic Gastrointestinal Disease Researchers (CEGIR), has been awarded the highest honor bestowed by the International Eosinophil Society for his major contributions to the advancement of our understanding of the eosinophil.

FEBRUARY 19

Can an Antibody Against IL-13 Be Used to Treat Eosinophilic Esophagitis?

JANUARY 31

FOX Cincinnati FARE Interview

Sandy Durrani, MD, discusses the increase of allergies on local Cincinnati FOX News in an interview arranged the by Food Allergy Research and Education (FARE).

JANUARY 16

Knopp Biosciences Expands Research Collaboration with Cincinnati Children's to Characterize Effect of Dexpramipexole in Inflammatory Diseases

Through a previous collaboration with Knopp, Patricia Fulkerson, MD, PhD and her team employed an induced pluripotent stem cell (iPSC) culture system to study the ability of dexpramipexole to inhibit the maturation of eosinophil progenitor cells. Looking forward, Dr. Fulkerson and her team will investigate molecular pathways in eosinophil development and attempt to further elucidate the effect of dexpramipexole on those pathways.

JANUARY

Allergy and Immunology Division: Select Research Advances of 2018 Video

his slideshow highlights notable scientific advances made by The Division of Allergy and Immunology at Cincinnati Children’s in 2018. Their research has advanced the understanding, diagnosis, prevention, and treatment of many rare and common allergic and immunologic diseases, including eosinophilic conditions.

JANUARY

Zuckerman Scholar

Netali Morgenstern-Ben Baruch is a 2018/2019 Zuckerman Israeli Postdoctoral Scholar of the Zuckerman Scholars Program and is investigating an inhibitory receptor, ILT-2, to learn about its role in the type 2 inflammatory disease eosinophilic esophagitis (EoE).

NOVEMBER

Marc Rothenberg, MD, PhD Recognized as a Highly Cited Researcher for 2018

NOVEMBER 22

New Drug Could Be Game-changer For Kids With Severe Peanut Allergies

NOVEMBER 18

Landmark PALISADE Trial of AR101 Published in New England Journal of Medicine - read the open-access journal article

NOVEMBER 9

Anti-IL-13 Phase 2 Trial for Eosinophilic Esophagitis

OCTOBER

Proyecto EoE y Ausencia de Proteina SPINK7:Entrevista al Investigador Principal - see the October issue (pages 8-9) of the AEDESEO newsletter for an interview with Marc Rothenberg, MD, PhD

OCTOBER 24

Scientists Discover Why So Many Children Born With a Defective Esophagus Develop Severe Food Allergies

OCTOBER 18

A revolutionary treatment for allergies to peanuts and other foods is going mainstream--but do the benefits outweigh the risks?

AUGUST 30

Welcome to Dr. Scott Bolton to the CCED

AUGUST 18

2018 CCED Lab Day

JULY 3

Eosinophilic Esophagitis Video: What is EoE?

JUNE 6

Study Finds Absence of Key Protein, SPINK7, May Drive EoE: Replacement Therapy Reversed Effects in Tissue Experiments
A summary of this finding and links to the podcast and journal article are available here. 

MAY 2

Discovery Could Lead to Personalized Medical Therapies for Emerging New Food Allergy Disorder

APRIL 26

Welcome Dr. Vidhya Kunnathur to the CCED

FEBRUARY 6

Aiming for the Highest Summit in EGID Research

FEBRUARY 5

2018 CEGIR Features in Spotlight on Rare Diseases

JANUARY 3

Creating a multi-center rare disease consortium - the Consortium of Eosinophilic Gastrointestinal Disease Researchers
This is a fantastic summary of the formation of CEGIR, the Consortium of Eosinophilic Gastrointestinal Disease Researchers, the first large-scale collaboration between key stakeholders in the field of eosinophilic gastrointestinal disorders, including researchers, patients and the key funding agency, the NIH. CEGIR is dedicated to improving the lives of individuals with eosinophilic gastrointestinal disorders through innovative research, clinical expertise and education via collaborations between scientists, health care providers, patients, and professional organizations.

JANUARY 3

Welcome Hilary Perez

DECEMBER 5

Tips for Hosting a Food-Allergy-Friendly Holiday Party

NOVEMBER 16

Cincinnati Children's Research Paves Way For Newly Approved Asthma Drug

NOVEMBER 8

A Family Journey
The CURED Conference brought together patient families, physicians, and researchers from across the globe to learn from each other. One of the most moving and memorable presentations was a patient perspective from Kara Root, whose story inspires us here at Cincinnati Children’s as well those across the eosinophilic gastrointestinal disorder (EGID) community. You can read more about Kara and her family’s journey on her blog. 

OCTOBER 10

Environmental Factors Could Adjust Risk of Eosinophilic Esophagitis in People with Particular Gene Variants

AUGUST 30

Handy Checklist: Going to College with an Eosinophilic Gastrointestinal Disorder

AUGUST 30

Pushing for Progress in a Rare Eosinophilic Condition: Eosinophilic Gastritis

JULY 17

What's the right time to use an EpiPen?
Amal H. Assa'ad, MD comments about administering epinephrine auto-injectors for anaphylaxis in this news video.

JULY 13

Family Fights For Formula Coverage Despite it Being Illinois Law
In this NCB Chicago news segment, Marc E. Rothenberg, MD, PhD and professional and family colleagues comment about insurance coverage for medical formulas. 

MAY 22

FARE Patient Registry
The FARE Patient Registry launched on May 22, 2017 and is a patient-powered research registry, created with collaboration by FARE’s Medical Advisory Board, members of the Outcomes Research Advisory Board and AltaVoice, a leading registry platform and expert in the field of online protection and privacy.

MAY 17

FDA-approved drug helps treat rare immunologic disease, study finds
The NIH reports on a phase 3 clinical trail that they co-funded and that tested mepolizumab (humanized antibody against IL-5) as an alternative treatment for an eosinophilic syndrome, eosinophilic granulomatosis with polyangiitis (EGPA; previously known as Churg-Strauss syndrome).

JANUARY 17

2016 Division Research Advances Video 
We invite you to watch a short video detailing a few of the Division of Allergy and Immunology’s Research Advances of 2016. Through our sustained commitment to research and clinical excellence for allergic and immunologic conditions, we will continue to change the outcome together.

JANUARY 3

CURED Foundation donates for Eosinophilic Disorder Treatment and Research 
The Campaign Urging Research for Eosinophilic Disease (CURED), a not-for-profit foundation dedicated to those suffering from eosinophilic disorders, has donated $200,000 to the Cincinnati Center for Eosinophilic Disorders (CCED), based at Cincinnati Children’s Hospital Medical Center. The CURED Foundation works extensively in supporting families and raising funds for research. One-hundred percent of funds raised by the CURED Foundation go to research for eosinophilic disorders. To date, CURED has contributed over 4 million dollars to research. 

JANUARY

2017 NIAID Addendum Guidelines for Preventing Peanut Allergy
In 2015, findings from a landmark NIAID-funded clinical trial called the Learning Early About Peanut (LEAP) study showed that introducing peanut-containing foods to infants at high risk for developing peanut allergy was safe and led to an 81% relative reduction in the subsequent development of peanut allergy. Due to the strength of these results, NIAID established a coordinating committee that convened an expert panel to update the 2010 Guidelines to specifically address the prevention of peanut allergy. Amal H. Assa'ad, MD and Carina Venter, PhD, RD contributed to the Addendum Guidelines for the Prevention of Peanut Allergy in the United States that were published in the January 2017 issue of Annals of Allergy and Immunology, along with a guest editorial by Amal H. Assa'ad, MD.

DECEMBER 13

Cincinnati Children’s was recently issued US Patent 9517238 B2 for the work of the inventors Marc E. Rothenberg and Mark Rochman. The invention provides methods of treating allergic inflammatory conditions using an anti-neurotrophin tyrosine kinase receptor 1 (NTRK1)-based therapeutic agent and related compositions and methods. The underlying research for this patent was conducted in the Rothenberg Lab.

DECEMBER 13

Hosting a Food-Allergy-Friendly Holiday Party

NOVEMBER 30

FARE Joins with National Academies of Sciences, Engineering and Medicine in Call for Sweeping Changes to Improve Health, Quality of Life of Individuals With Food Allergies
We would like to mention that this vital work was made possible by so many contributors, including our colleague Carina Venter, PhD, RD, who served as a reviewer and contributor to this 500-page report on food allergy.

NOVEMBER

Trustee Grant Award
Ting Wen, PhD, was awarded a Trustee Grant Award by Cincinnati Children’s to support his research.

NOVEMBER 11

Allergy Guideline Updating Efforts
We are proud of all the dedicated efforts made to move the guidelines for allergen introduction forward. Our colleague Amal H. Assa’ad, MD, comments in this NPR update, and our colleague Carina Venter, PhD, RD, is involved as a member of the scientific panel who are updating the guidelines that will be published in January on the National Institute of Allergy and Infectious Diseases (NIAID) website. Listen to or read the NPR segment (by Patti Neighmond). Read the Reuter's article (by Rob Goodier). Read Dr. Venter's JACI editorial about the LEAP study findings about early allergen consumption.

September 23

5 Tips for Packing a Well-Rounded Nut-free Lunch

AUGUST 29

LEAP Study Editorial
The Journal of Allergy and Clinical Immunology has included the LEAP (Learning Early About Peanut) nutrition study for its readership. Our colleague Carina Venter, PhD, RD, co-authored an editorial about the study findings about early allergen consumption.

AUGUST

CURED Foundation Donates for Eosinophilic Disorder Treatment and Research
The Campaign Urging Research for Eosinophilic Disease (CURED), a not-for-profit foundation dedicated to those suffering from eosinophilic disorders, has donated $100,000 to the Cincinnati Center for Eosinophilic Disorders (CCED), based at Cincinnati Children’s Hospital Medical Center. The CURED Foundation works extensively in supporting families and raising funds for research. One-hundred percent of funds raised by the CURED Foundation go to research for eosinophilic disorders. To date, CURED has contributed over 4 million dollars to research.

July

Infants and Solid Food, an Introductory Course. Carina Venter, PhD, RD, a research associate and dietician at Cincinnati Children's, discusses the transition from formula to solid food in infancy while navigating potential food allergies.

July 22

Darrel E. Goll Award for Scholarly Publication
Our collaborator, Leah C. Kottyan, PhD, received the Darrel E. Goll Award at the FASEB Biology of Calpains in Health and Disease Conference. This award recognizes the most outstanding publication in the field of calpains in the past three years, and we are proud for members of the Rothenberg Lab to have contributed to this outstanding work over the years. Their recent calpain publications include explore the tissue specificity and contribution of calpain 14 in eosinophilic esophagitis.

July 21

NORD Report on Eosinophilic Esophagitis. Marc E. Rothenberg, MD, PhD, assisted in preparing this recent report about eosinophilic esophagitis by the National Organization for Rare Disorders (NORD). Learn more about his research in the Rothenberg Lab.

July 12

Allergy-Friendly On-The-Go Snacks. Carina Venter, PhD, RD, a research associate and dietician at Cincinnati Children's, and Alison Cassin, MS, RD, LD, give helpful ideas for allergy-friendly, on-the-go snacks.

July 9

Harnessing the Power of Big Data. Marc E. Rothenberg, MD, PhD, and Margaret H. Collins, MD, comment about how big data and file sharing among researchers and pathologists in the Consortium of Eosinophil Gastrointestinal Disease Researchers (CEGIR) are having a major impact.

May 17

Marc Rothenberg Receives First Bunning Chair
Cincinnati Children's honored Denise and Dave Bunning for their contributions to the Division of Allergy and Immunology. Cincinnati Children's decided to use this endowment to establish a Chair in Allergy/Immunology that will bear Dave and Denise’s name. Marc E. Rothenberg, MD, PhD, director of the Cincinnati Center for Eosinophilic Disorders, will be the first incumbent of this Chair.

May 16

Scientists Identify Potential Marker of EoE Disease Activity. Patricia C. Fulkerson, MD, PhD, assistant professor in the Division of Allergy and Immunology and the Cincinnati Center for Eosinophilic Disorders at Cincinnati Children’s, led recent, preliminary research suggesting that eosinophil progenitors in the blood may be a potential marker for disease activity of eosinophilic esophagitis in children. Learn more about her research in the Fulkerson Lab.

May 13

Learning to Eat: The Importance of Texture and Food Variety. Carina Venter, PhD, RD, a research associate and dietician at Cincinnati Children's, and Kate Maslin, PhD, RD, an international collaborator, discuss the important of texture and food variety while learning to eat and its potentially life-long effect on food preferences.

April 15

Using Cloud Technology in Rare Disease Research: Interview with CEGIR Principal Investigator

April 7

NIH Study Finds Protein May Be Responsible for Damage in Eosinophilic Esophagitis

March 9

When You're Allergic to Almost Every Food

March 1

EoGenius Diagnostic Test for Eosinophilic Esophagitis
Miraca Life Sciences now offers the EoGenius test, an RNA expression test, designed to help diagnose eosinophilic esophagitis (EoE). This test is founded in research led by Marc E. Rothenberg, MD, PhD and Ting Wen, PhD.

February 19

Research Achievement Award

Our Division Director, Marc E. Rothenberg, MD, PhD, was recognized for his dedicated efforts with a Research Achievement Award in the Fifth Annual Faculty Awards by Cincinnati Children's. Learn more about his research in the Rothenberg Lab.

February 9

Improved Scoring System for the Food Allergic Disease Eosinophilic Esophagitis in Children
Researchers have developed and validated a histologic scoring system to objectively analyze pathologic features of eosinophilic esophagitis (EoE), a severe, often painful food allergy that renders children unable to eat a wide variety of foods. This study was led by researchers in the Division of Allergy and Immunology and the Cincinnati Center for Eosinophilic Disorders at Cincinnati Children’s Hospital Medical Center.

January 1

TOP DOCTOR 2016 List
In Cincinnati magazine, Philip E. Putnam, MD, was named in the TOP DOCTOR 2016 list for Pediatric Gastroenterology subspecialty.

December

Eosinophil Researcher Honored as Schmidlapp Woman Scholar
Patricia C. Fulkerson, MD, PhD, assistant professor in the Division of Allergy and Immunology and the Cincinnati Center for Eosinophilic Disorders at Cincinnati Children’s, has been selected as a 2015 Schmidlapp Woman Scholar by the the Fifth Third Bank / Charlotte R. Schmidlapp Women Scholars Program. Learn more about her research in the .

December

Cincinnati Golfers for Charity
Thank you to the Cincinnati Golfers for Charity for supporting our clinical and research efforts in the Cincinnati Center for Eosinophilic Disorders.

November

The Untold Story of a New Asthma Drug
The FDA approved the drug mepolizumab on November 4th to help treat severe asthma, which was an achievement grounded in many years of research and testing by innumerable physicians and scientists, including those at Cincinnati Children's, such as Marc Rothenberg, MD, PhD. Learn more about his research in the Rothenberg Lab.

October 5

Noah Kennedy: Colerain Football's Mightiest Team Member

September 30

Department of Defense Award

Yui-Hsi Wang, PhD was awarded a FY14 Peer Reviewed Medical Research Program (PRMRP) Investigator-Initiated Research Award from the United States Department of Defense for his project "IL-9-Producing Mast Cell Precursors and Food Allergy".

September 23

New Cell Type May Help Explain Why Some People Have Dangerous Food Allergies

Yui-Hsi Wang, PhD and his colleagues report their discovery of a new cell type that appears to drive life-threatening food allergies and may help explain why some people get severe allergic reactions and others do not.

September 1

NIAID R01
Marc Rothenberg, MD, PhD was awarded an R01 by the National Institute of Allergy and Infectious Diseases (NIAID) for his project "Genetic and Immunological Dissection of Eosinophilic Esophagitis". Learn more about his research in the Rothenberg Lab.

August 7

Most Outstanding Translational Research Achievement between 2010-2015

At the faculty "State of the Union" address, Marc Rothenberg, MD, PhD was recognized with the "Most Outstanding Translational Research Achievement between 2010-2015" for his work towards the Nature Genetics publication,"Genome-wide association analysis of eosinophilic esophagitis provides insight into the tissue specificity of this allergic disease” published in Nat Genet. 2014 Aug;46(8):895-900." Learn more about his research in the Rothenberg Lab.

August

EoE in Evolution: The Search Continues for Better Treatments and Diagnostics
Marc Rothenberg, MD, PhD, director of the division and the Cincinnati Center for Eosinophilic Disorders comments in this article about the search for better treatment and diagnostics for eosinophilic esophagitis (EoE). Learn more about his research in the Rothenberg Lab.

June 29

Cincinnati Children's becomes Center of Excellence and an inaugural member of the Food Allergy Research & Education (FARE) Clinical Network.

June

Digestive Health Center Pilot and Feasibility Award

Ting Wen, PhD, was awarded a Digestive Health Center Pilot and Feasibility Award for his project "Analysis and Function of Esophageal Lymphocytes in Eosinophilic Esophagitis".

June 4

Parent-reported Symptoms Gauge Pathogenic Features of the Food Allergic Disease Eosinophilic Esophagitis in Children

June

Consensus Communication on Early Peanut Introduction and the Prevention of Peanut Allergy in High-Risk Infants

May

NIAID Award

Divisional collaborators Simon P. Hogan, PhD and Yui-Hsi Wang, PhD and national collaborator Rodney Newberry, MD (Washington University in St. Louis) were awarded a multi-principal investigator R01 grant from the National Institute of Allergy and Infectious Diseases (NIAID) for their project "Food Allergy and Goblet Cell Antigen Passages". Learn more about research in the Hogan Lab.

May

CURED Foundation Donates $100,000 For Eosinophilic Disorder Treatment and Research

April

Cincinnati Children's Moms Expand Camp for Kids with Eosinophilic Disorders

March

APFED HOPE Pilot Grant

Ting Wen, PhD was awarded a 2015 APFED HOPE Pilot Grant for his project "Defining Esophageal Lymphocyte Phenotype and Function in Eosinophilic Esophagitis" from the American Partnership for Eosinophilic Disorders (APFED). This award is designed to support the initiation of research that will be the basis of a larger research project within the subspecialty of eosinophilic disorders.

March

FARE Award

Simon P. Hogan, PhD was awarded a 2015 FARE Investigator in Food Allergy Award. This Mid-Career Investigator Award from Food Allergy Research & Education (FARE) will support Hogan in identifying the key proteins and cells that cause the blood vessel fluid leak leading to severe anaphylaxis triggered by foods. Learn more about his research in the .

March

First-Place Graduate Student Research Forum Poster

Congratulations to Rothenberg Lab member and predoctoral fellow Rahul D'Mello for winning First Place at the 2015 Graduate Student Research Forum poster competition at the University of Cincinnati College of Medicine.

March

ASCI Young Physician-Scientist Award

Patricia C. Fulkerson, MD, PhD was awarded a 2015 Young Physician-Scientist Award by the American Society for Clinical Investigation. The ASCI Council Young Physician-Scientist Awards recognize early-stage physician-scientists who are early in their first faculty appointment and have made notable achievements in their research. This award provides an honorarium for her to present her research at the ASCI/ American Association of Physicians (AAP) Joint Meeting. Learn more about her research in the Fulkerson Lab.

March 3

First-Place DHC Poster

Nurit Azouz, PhD, a research fellow in the Rothenberg Lab, won the first prize for her poster at the 2015 Annual Scientific Symposium by the Digestive Health Center.

February 28

New Patient Contact Registry for Rare Eosinophilic Gastrointestinal Diseases

To coincide with Rare Disease Day® 2015, the Consortium of Eosinophilic Gastrointestinal Disease Researchers (CEGIR) launched a patient contact registry for individuals with eosinophilic gastrointestinal diseases (EGID), a group of rare diseases. Marc Rothenberg, MD, PhD, is the principal investigator of the National Institutes of Health grant that funds the CEGIR (U54 AI117804).

February 25

MicroRNA Potential Biomarker for Esophagitis

Faculty member Ting Wen, PhD recently commented in an article discussing microRNA as potential biomarkers for esophagitis.

February

Mentoring Achievement Award

One of the faculty researchers of the Cincinnati Center for Eosinophilic Disorders, Simon P. Hogan, PhD, was recognized for his dedicated efforts with the Mentoring Achievement Award in the Fourth Annual Faculty Awards by Cincinnati Children's.

December

Mazda Donation of $6,995.00 to Help Fund Camp CouragEoS!

THANK YOU Mazda Motor of America for your generous support of our Super Hero Campers!

Mazda Nation missions is to unite the Mazda community by bringing together the people and the companies that support it. When you purchase a car from Mazda, you are also helping support the Mazda community! 100% of YOUR contributions go to giving back to the community, and contributing donations to local charities.

Details about the gift: Teagan and his family were asked through our hospital’s “Champions Program” to speak at the “Mazda Dealership Campaign.” They were so moved by Teagan’s story, and experience with the CCED, that collectively the dealerships decided they wanted to combine their individual grant funds so that Camp EoE could be given one large donation. You might recognize Teagan and his mom Kenya because their family also serves on the Board for the Eosinophilic Family Coalition.

Visit the Eosinophilic Family Coalition, Cincinnati Chapter Facebook page for more information.

November

Goochland Boy Allergic to Nearly All Foods

November

Carina Venter Joins Cincinnati Center for Eosinophilic Disorders

Carina Venter, PhD, RD, will be joining the Division of Allergy and Immunology and Cincinnati Center for Eosinophilic Disorders (CCED) team at Cincinnati Children's as a research associate in February 2015. Dr. Venter is a dietician who was trained in South Africa and completed her postdoctoral studies in food hypersensitivity in the United Kingdom. Her notable accomplishments are many, including being the first and only dietician ever to be invited to act on many of the Advisory Panels for the Food Standards Agency in the United Kingdom. She comes to us from the University of Portsmouth and Isle of Wight, where she serves academically and clinically as a Senior Lecturer and Specialist Allergy Dietitian. Her research endeavors have received funding from the National Institute for Health Research (U.K.) and industry (Danone, Nutricia). In just the past 5 years (2010-2014), Dr. Venter has authored 25 peer-reviewed publications and 3 book chapters and supervised 14 post-graduate students (9 M.Sc. and 5 Ph.D.). Dr. Venter will be a great asset to the division and CCED team, clinic, research, and patients.

November

Coalition of Eosinophil Patient Advocacy Groups (C-EOS)

The Coalition of Eosinophil Patient Advocacy Groups (C-EOS) . C-EOS was established in 2014 to unite organizations representing the interests of patients with eosinophil associated diseases to advance key issues of importance to this population.

The majority of eosinophil associated diseases lack approved treatments, and there is no cure. By uniting like-minded organizations that support patients with these diseases, we will strengthen support for research and advocacy opportunities.

Learn more about the Coalition .

October

CURED's RESEARCH DONATION of $85,000.

The CURED Foundation continues to make a difference in the lives of those who are affected by EoE.

On behalf of the Cincinnati Center for Eosinophilic Disorders (CCED), Division of Allergy and Immunology, thank you for the grant award in the amount of $85,000.
Words cannot express how truly instrumental your organization has been with propelling our research findings! Our recent publications are landmark in discovery, as we have answered a long-standing question in the field - why is the esophagus the target organ in EoE.

We look forward to applying your generous donation directly back into our research programs. Together, we make a difference!

Most Sincerely,
The CCED Team

October

CCED Receives NIH Grant To Lead Multicenter Consortium on Eosinophilic Disorders

Cincinnati Children's Hospital Medical Center has received a 5-year, $6.25 million grant from the National Institutes of Health to lead a consortium of organizations from around the country that will conduct clinical research into eosinophilic disorders and train investigators in how to conduct clinical research.

Eosinophilic disorders are chronic inflammatory disorders. These conditions are thought to be triggered by allergic hypersensitivity to certain foods and an over-accumulation in the gastrointestinal tract of white blood cells called eosinophils (part of the body's immune system). Eosinophilic disorders can cause a variety of gastrointestinal complaints including reflux-like symptoms, vomiting, difficulty swallowing, tissue scarring, fibrosis, the formation of strictures, diarrhea, abdominal pain, failure to grow in childhood and other medical complications.

Read more about the grant .

February 28

Digestive Health Center Pilot and Feasibility Awards

Joseph D. Sherrill, PhD was awarded a Digestive Health Center Pilot and Feasibility Award for his project "Characterization of the Antimicrobial Peptide RNase 7 in Eosinophilic Esophagitis". Additionally, Simon P. Hogan, PhD is a co-investigator on another awarded Digestive Health Center Pilot and Feasibility Award for the project "Star-related Lipid Transfer (StarD7) in Intestinal Epithelial Barrier Function and Food Sensitization".

February

Digestive Health Center Research Symposium Award

Julie Caldwell, a research associate in the Rothenberg Lab , won first for posters at the Digestive Health Center Research Symposium for her project "CDH26: a Functional Integrin-Binding Cadherin Involve in Eosinophilic Gastrointestinal Disorders".

January

ARTrust Grant

Congratulations to Dave Morris, a clinical fellow in the Fulkerson Lab , who was awarded a 2014 ARTrust grant entitled "Characterization of eosinophil progenitors (EoPs) in the peripheral blood of pediatric patients with active eosinophilic esophagitis (EoE)". He is pictured below with Linda Cox, the President of AAAAI , and Dennis Ledford, the past President of AAAAI .

December 17 Discovery of Impaired Barrier Function in Eosinophilic Esophagitis (PDF)

November 27 CURED Foundation Donates $157,000 for Eosinophilic Disorder Treatment and Research (PDF)

November 25 Division Director at Cincinnati Children's Elected AAAS Fellow (PDF)

November 22-23 Second Annual CURED Patient Research Conference

The second annual CURED Patient Research Conference was a huge success. There were about 235 in attendance on Friday, and 160 on Saturday. There were 26 states represented and three countries. The attendees heard from the leading experts around the world, including our very own experts from Cincinnati Children's and the Cincinnati Center for Eosinophilic Disorders. CURED's support helps further our mission to find a cure for eosinophilic disorders.

November 11 Discovery by Israeli and American Researchers May Lead to New Treatments for Allergic Diseases (PDF)

September 18 Congratulations to Ting Wen, PhD, a postdoctoral fellow in the Rothenberg Lab for winning the second-place prize at the third annual Ohio River Valley Cytometry Association's Imaging and Cytometry Research Day.

August 12 Interview with the Authors: Mechanism of Siglec-8-Mediated Cell Death

August 5, 2013 Epinephrine: It's Still Our Fail Safe

August 2, 2013 Despite Shots, Peanut Allergy Kills Teen

July 2013 New Leadership for Division Research Simon P. Hogan, PhD was recently appointed as the Director of Research of the Division of Allergy/Immunology. He joins the Division Director, Marc E. Rothenberg, MD, PhD, and Amal H. Assa'ad, MD, the Associate Division Director, in leading the division in its mission to improve the health of children with allergic and immune conditions through innovative research, outstanding clinical care and education of the current and next generation of leaders in healthcare and research. In this new role, Hogan will strengthen the guidance available to division researchers with his hands-on approach and will be an advocate for process improvements that facilitate quality research.

July 31, 2013 A Patch to Treat Peanut Allergies in Works

July 2013 Faculty Do Not Support Claim that Eosinophilic Disorders are Related to GMO Corn

A recent article in Elle magazine has speculated that GMO (genetically modified organism) corn can promote eosinophil-related diseases. There are statements in this article that are scientifically inaccurate in our opinion. The magazine article describes the presence of eosinophils in a nasal swab. This finding by itself is not indicative of an eosinophilic disorder. The presence of eosinophils in a nasal swab specimen is a common finding in patients with hay fever (allergic rhinitis), a disease process that has been well established to be caused by respiratory allergies. Further, it is our expert opinion that there is not sufficient knowledge or scientific foundation to warrant the claim in this article that eosinophilic disorders arise from GMO corn.

This statement is released by all of the Cincinnati Children's Hospital doctors mentioned in the article. Marc E. Rothenberg MD, PhD; Amal H. Assa'ad, MD; Simon P. Hogan, PhD; Karl von Tiehl, MD

July 2013 A recent research study extends our prior findings about connective tissue disorders and eosinophilic gastrointestinal disorders (Abonia et al.) and provides further rationale for our current Losartan trial.

July 22, 2013 A Bad Alliance: Rare Immune Cells Promote Food-Induced Allergic Inflammation in the Esophagus. The Cincinnati Center for Eosinophilic Disorders' research is opening up new avenues for research by others, as evidenced by this recent Nature Medicine publication by Noti et al. being founded in our work.

June 19, 2013 Mother and Son Plan to Climb Mt. Kilimanjaro for a Cause

March 2013 Patricia C. Fulkerson, MD, PhD, Receives 2013 ARTrust Faculty Development Award Medical School Faculty

March 25, 2013 Grace: Family's Every Meal Must Cater to Rare Disorder

February 2013 Vincent Mukkada Joins the Cincinnati Center for Eosinophilic Disorders

February 2013 Eleanor Garrow Joins the Cincinnati Center for Eosinophilic Disorders

December 2012 Philip E. Putnam, MD, Marc E. Rothenberg, MD, PhD and Kimberly A. Risma, MD, PhD named among Cincy Magazine's list of Best Doctors for 2013

December 12, 2012 Rare Inflammatory Condition Keeps Boy from Eating

November 12, 2012 Leading Food Allergy Organizations Announce Completion of Merger and Introduce New Name

November 5, 2012 Frank Sasinowski, Vice Chair of the Board of Directors for NORD , mentions his work and Keynote speech in the FDA Law Blog.

November 2nd - 4th, 2012 CURED EGID Symposium

November 1, 2012 CURED Foundation Makes Generous Donation of $150,000 to the Cincinnati Center for Eosinophilic Disorders Research Efforts. This brings the total amount of money donated to the Center by CURED to $2,114,000 in the past 10 years.

July 25, 2012 CCED and CEFC Annual Interactive Eosinophilic Research Lab Day

May 20, 2012 CURED Foundation Makes Generous Donation of $150,000 to the Cincinnati Center for Eosinophilic Disorders' Research Efforts

May 17, 2012 In Our Food-Driven Culture, 12-year-old Has to Get by Without Eating

May 13-19, 2012 National Eosinophilic Awareness Week and Food Allergy Awareness Week
Members of the Cincinnati Center for Eosinophilic Disorders were involved in and hosted several activities for this week to increase awareness of both eosinophilic disorders and food allergies, including the second annual Camp CouragEOS. Our main hospital cafeteria also started to sell allergy-free foods.

May 10, 2012 For Teen With Eosinophils of the Esophagus, Food Is Forbidden

May 9, 2012 Merger of the Food Allergy Initiative (FAI) and the Food Allergy & Anaphylaxis Network (FAAN) Announced

May 2, 2012 Researchers Evaluate Dietary Regimens of Allergic Disease

April 18, 2012 CCED Program Director Sean Jameson is awarded the Making A Difference Award (Cincinnati Children's Patient Advisory Council)

April 17, 2012 CCED Nurse M. Jo Ford Nominated for the Florence Nightingale Award (University of Cincinnati College of Nursing)

April 17, 2012 Inability to Eat Enhances Macomb Girl's Taste for Life

March 28, 2012 Researchers Identify New Regulator in Allergic Diseases

March 26, 2012 Passing of Our Friend and Mentor Dr. Leonard I. Bernstein

March 14, 2012 Research! America Honors Food Allergy Initiative (FAI)

March 9, 2012 Genetic Marker for Painful Food Allergy Points to Improved Diagnosis, Treatment

November 11, 2011 EoE Keynote Presentation at Upcoming Allergy Drug Discovery and Development Conference

November 7, 2011 CURED Foundation Continues Support of Eosinophilic Research

November 1, 2011 Mepolizumab Appears Beneficial in Children with Eosinophilic Esophagitis

November 2011 Family Finds Support for Severe Allergies

August 3, 2001 Smithfield Girl Undergoing Treatment for Rare Disease

August 1, 2011 Youth Tour and a Special Teen

July 2011 Eosinophilic Esophagitis: Updated Consensus Recommendations For Children and Adults

June 23, 2011 MTV Series True Life: I’m Allergic to Everything

May 18, 2011 Family Building A Community to Deal with Rare Disease

May 18, 2011 Peanut-tainted Blood Triggers Boy's Allergic Reaction

May 15, 2011 A Disease that Hampers Eating

May 13, 2011 Risks: Acid Reflux Drugs Tied to Bone Fractures

April 18, 2011 Imagine a Life with Food? Children Living with EOS Do

April / May 2011 Life Without Food

February 11, 2011 New Pamphlet Guides Patients on Food Allergies. The National Institute of Allergy and Infectious Diseases (NIAID) has released a pamphlet that can be shared with patients, offering a comprehensive overview of food allergies. Download the pamphlet.

December 6, 2010 "Guidelines for Food Allergy Testing Revised." Amal H. Assa'ad, MD comments on the need for consistent follow-up for food allergy in this article about the insufficiency of using skin prick and blood tests alone for food allergy diagnosis. See also Cincinnati Children's summary of this article called Food Allergy Testing: Skin Pricks May Just Scratch the Surface. 

October 2, 2010  Way to Turn Off Immune System's Allergic Reaction Discovered. The findings summarized in this article provide hope that the body can be trained to tolerate food allergies that lead to roughly 300,000 emergency room visits and 100-200 deaths each year.   

July 29, 2010 FDA Drug Safety Communication: Eosinophilic Pneumonia Associated with the Use of Cubicin (daptomycin).

July 22, 2010 Doctor at Cincinnati Children's Receives Prestigious NIH MERIT Award to Extend Research of Eosinophilic Disorders. Marc E. Rothenberg, MD, PhD, director of the Division of Allergy and Immunology at Cincinnati Children’s, has received an NIH MERIT Award to extend funding of his long-standing investigation into “Regulation of Gastrointestinal Eosinophils.” 

July 14, 2010 The NIH expands its food allergy research program: Consortium of Food Allergy Research (CoFAR) renewed with a five-year, $29.9 million grant. 

May 2010 Rare disease makes Scottsdale boy reject food 

May 2010 Myeloid and lymphoid neoplasms with eosinophilia and abnormalities of PDGFRA, PDGFRB or FGFR1.by Barbara J. Bain in Haematologica Editorials and Perspectives.  A recent advancement in screening for PDGFR rearrangement may improve treatment selection for patients with myeloid or lymphoid neoplasms with eosinophilia. This editorial discusses the relation between PDGFR and FGFR1 abnormalities and the cause and treatment of these neoplasms.

March 8, 2010   Gene Site Found for a Children’s Food Allergy. 

May 14, 2009  Food Allergy & Anaphylaxis Network (FAAN) awards two grants to Cincinnati Children's researchers to fund allergy research.  Learn more about this research that is possible through funds awarded to Dr. Marc Rothenberg and Dr. Simon Hogan.

March 4, 2008  The Wall Street Journal reports on fund raising for CCED  

April 20, 2007 Marc Rothenberg, MD, PhD, Earns Prestigious E. Mead Johnson Award  

February 21, 2007 Marc Rothenberg, MD, PhD, Named to Prestigious NIH Advisory Panel  

October 17 - 22, 2006 First International Gastrointestinal Eosinophilic Research Symposium  

February 3, 2006 Gene Discovery Linked to Mysterious Chronic Food Allergy: Study offers first molecular insight into eosinophilic esophagitis  

 

September 16, 2004 Two Studies in Science Point to New Evidence in Asthma Development: Eosinophils Have a Key Role in Asthma  

August 25, 2004 Study In The New England Journal of Medicine Identifies Rapidly Rising Disorder  

January 8, 2004 Study Identifies Breakthrough Treatment For Devastating Blood Disorders  

 

March 28, 2001 Study Identifies Culprits in Food Allergy Inflammation  

December 27, 2000 Cincinnati Children's Researcher Uncovers Allergy / Reflux Link: Study Has Significant Treatment Implications  

June 1, 2000 Cincinnati Children's Researchers Uncover Critical Food Allergy Pathway