Cincinnati Center for Eosinophilic Disorders

December

Eosinophil Researcher Honored as Schmidlapp Woman Scholar
Patricia C. Fulkerson, MD, PhD, assistant professor in the Division of Allergy and Immunology and the Cincinnati Center for Eosinophilic Disorders at Cincinnati Children’s, has been selected as a 2015 Schmidlapp Woman Scholar by the the Fifth Third Bank / Charlotte R. Schmidlapp Women Scholars Program. Learn more about her research in the Fulkerson Lab.

December

Cincinnati Golfers for Charity
Thank you to the Cincinnati Golfers for Charity for supporting our clinical and research efforts in the Cincinnati Center for Eosinophilic Disorders.

November

The Untold Story of a New Asthma Drug
The FDA approved the drug mepolizumab on November 4th to help treat severe asthma, which was an achievement grounded in many years of research and testing by innumerable physicians and scientists, including those at Cincinnati Children's, such as Marc Rothenberg, MD, PhD. Learn more about his research in the Rothenberg Lab.

October 5

Noah Kennedy: Colerain Football's Mightiest Team Member

September 30

Department of Defense Award

Yui-Hsi Wang, PhD was awarded a FY14 Peer Reviewed Medical Research Program (PRMRP) Investigator-Initiated Research Award from the United States Department of Defense for his project "IL-9-Producing Mast Cell Precursors and Food Allergy".

September 23

New Cell Type May Help Explain Why Some People Have Dangerous Food Allergies

Yui-Hsi Wang, PhD and his colleagues report their discovery of a new cell type that appears to drive life-threatening food allergies and may help explain why some people get severe allergic reactions and others do not.

September 1

NIAID R01
Marc Rothenberg, MD, PhD was awarded an R01 by the National Institute of Allergy and Infectious Diseases (NIAID) for his project "Genetic and Immunological Dissection of Eosinophilic Esophagitis". Learn more about his research in the Rothenberg Lab.

August 7

At the faculty "State of the Union" address, Marc Rothenberg, MD, PhD was recognized with the "Most Outstanding Translational Research Achievement between 2010-2015" for his work towards the Nature Genetics publication,"Genome-wide association analysis of eosinophilic esophagitis provides insight into the tissue specificity of this allergic disease” published in Nat Genet. 2014 Aug;46(8):895-900." Learn more about his research in the Rothenberg Lab.

August

EoE in Evolution: The Search Continues for Better Treatments and Diagnostics
Marc Rothenberg, MD, PhD, director of the division and the Cincinnati Center for Eosinophilic Disorders comments in this article about the search for better treatment and diagnostics for eosinophilic esophagitis (EoE). Learn more about his research in the Rothenberg Lab.

June 29

Cincinnati Children's becomes Center of Excellence and an inaugural member of the Food Allergy Research & Education (FARE) Clinical Network. 

June

Digestive Health Center Pilot and Feasibility Award

Ting Wen, PhD, was awarded a Digestive Health Center Pilot and Feasibility Award for his project "Analysis and Function of Esophageal Lymphocytes in Eosinophilic Esophagitis".

June 4

Parent-reported Symptoms Gauge Pathogenic Features of the Food Allergic Disease Eosinophilic Esophagitis in Children

June

Consensus Communication on Early Peanut Introduction and the Prevention of Peanut Allergy in High-Risk Infants

May

NIAID Award

Divisional collaborators Simon P. Hogan, PhD and Yui-Hsi Wang, PhD and national collaborator Rodney Newberry, MD (Washington University in St. Louis) were awarded a multi-principal investigator R01 grant from the National Institute of Allergy and Infectious Diseases (NIAID) for their project "Food Allergy and Goblet Cell Antigen Passages". Learn more about research in the Hogan Lab.

May

CURED Foundation Donates $100,000 For Eosinophilic Disorder Treatment and Research

April

Cincinnati Children's Moms Expand Camp for Kids with Eosinophilic Disorders

March

APFED HOPE Pilot Grant

Ting Wen, PhD was awarded a 2015 APFED HOPE Pilot Grant for his project "Defining Esophageal Lymphocyte Phenotype and Function in Eosinophilic Esophagitis" from the American Partnership for Eosinophilic Disorders (APFED). This award is designed to support the initiation of research that will be the basis of a larger research project within the subspecialty of eosinophilic disorders.

March

FARE Award

Simon P. Hogan, PhD was awarded a 2015 FARE Investigator in Food Allergy Award. This Mid-Career Investigator Award from Food Allergy Research & Education (FARE) will support Hogan in identifying the key proteins and cells that cause the blood vessel fluid leak leading to severe anaphylaxis triggered by foods. Learn more about his research in the Hogan Lab.

March

First-Place Graduate Student Research Forum Poster

Congratulations to Rothenberg Lab member and predoctoral fellow Rahul D'Mello for winning First Place at the 2015 Graduate Student Research Forum poster competition at the University of Cincinnati College of Medicine.

March

ASCI Young Physician-Scientist Award

Patricia C. Fulkerson, MD, PhD was awarded a 2015 Young Physician-Scientist Award by the American Society for Clinical Investigation. The ASCI Council Young Physician-Scientist Awards recognize early-stage physician-scientists who are early in their first faculty appointment and have made notable achievements in their research. This award provides an honorarium for her to present her research at the ASCI/ American Association of Physicians (AAP) Joint Meeting. Learn more about her research in the Fulkerson Lab.

March 3

First-Place DHC Poster

Nurit Azouz, PhD, a research fellow in the Rothenberg Lab, won the first prize for her poster at the 2015 Annual Scientific Symposium by the Digestive Health Center.

February 28

New Patient Contact Registry for Rare Eosinophilic Gastrointestinal Diseases

To coincide with Rare Disease Day® 2015, the Consortium of Eosinophilic Gastrointestinal Disease Researchers (CEGIR) launched a patient contact registry for individuals with eosinophilic gastrointestinal diseases (EGID), a group of rare diseases. Marc Rothenberg, MD, PhD, is the principal investigator of the National Institutes of Health grant that funds the CEGIR (U54 AI117804).

February 25

MicroRNA Potential Biomarker for Esophagitis  

Faculty member Ting Wen, PhD recently commented in an article discussing microRNA as potential biomarkers for esophagitis.

February

Mentoring Achievement Award

One of the faculty researchers of the Cincinnati Center for Eosinophilic Disorders, Simon P. Hogan, PhD, was recognized for his dedicated efforts with the Mentoring Achievement Award in the Fourth Annual Faculty Awards by Cincinnati Children's.

December

Mazda Donation of $6,995.00 to Help Fund Camp CouragEoS!

THANK YOU Mazda Motor of America for your generous support of our Super Hero Campers!

Mazda Nation missions is to unite the Mazda community by bringing together the people and the companies that support it. When you purchase a car from Mazda, you are also helping support the Mazda community! 100% of YOUR contributions go to giving back to the community, and contributing donations to local charities.

Details about the gift: Teagan and his family were asked through our hospital’s “Champions Program” to speak at the “Mazda Dealership Campaign.” They were so moved by Teagan’s story, and experience with the CCED, that collectively the dealerships decided they wanted to combine their individual grant funds so that Camp EoE could be given one large donation. You might recognize Teagan and his mom Kenya because their family also serves on the Board for the Eosinophilic Family Coalition.   

Visit the Eosinophilic Family Coalition, Cincinnati Chapter Facebook page for more information.

November

Goochland Boy Allergic to Nearly All Foods

November

Carina Venter Joins Cincinnati Center for Eosinophilic Disorders

Carina Venter, PhD, RD , will be joining the Division of Allergy and Immunology and Cincinnati Center for Eosinophilic Disorders (CCED) team at Cincinnati Children's as a research associate in February 2015. Dr. Venter is a dietician who was trained in South Africa and completed her postdoctoral studies in food hypersensitivity in the United Kingdom. Her notable accomplishments are many, including being the first and only dietician ever to be invited to act on many of the Advisory Panels for the Food Standards Agency in the United Kingdom. She comes to us from the University of Portsmouth and Isle of Wight, where she serves academically and clinically as a Senior Lecturer and Specialist Allergy Dietitian. Her research endeavors have received funding from the National Institute for Health Research (U.K.) and industry (Danone, Nutricia). In just the past 5 years (2010-2014), Dr. Venter has authored 25 peer-reviewed publications and 3 book chapters and supervised 14 post-graduate students (9 M.Sc. and 5 Ph.D.). Dr. Venter will be a great asset to the division and CCED team, clinic, research, and patients.

November

Coalition of Eosinophil Patient Advocacy Groups (C-EOS)

The Coalition of Eosinophil Patient Advocacy Groups (C-EOS) . C-EOS was established in 2014 to unite organizations representing the interests of patients with eosinophil associated diseases to advance key issues of importance to this population. 

The majority of eosinophil associated diseases lack approved treatments, and there is no cure. By uniting like-minded organizations that support patients with these diseases, we will strengthen support for research and advocacy opportunities.

Learn more about the Coalition . 

October

CURED's RESEARCH DONATION of $85,000

The CURED Foundation continues to make a difference in the lives of those who are affected by EoE.

On behalf of the Cincinnati Center for Eosinophilic Disorders (CCED), Division of Allergy and Immunology, thank you for the grant award in the amount of $85,000.

Words cannot express how truly instrumental your organization has been with propelling our research findings! Our recent publications are landmark in discovery, as we have answered a long-standing question in the field - why is the esophagus the target organ in EoE.

We look forward to applying your generous donation directly back into our research programs. Together, we make a difference!

Most Sincerely,
The CCED Team

October

CCED Receives NIH Grant To Lead Multicenter Consortium on Eosinophilic Disorders

Cincinnati Children's Hospital Medical Center has received a 5-year, $6.25 million grant from the National Institutes of Health to lead a consortium of organizations from around the country that will conduct clinical research into eosinophilic disorders and train investigators in how to conduct clinical research.

Eosinophilic disorders are chronic inflammatory disorders.  These conditions are thought to be triggered by allergic hypersensitivity to certain foods and an over-accumulation in the gastrointestinal tract of white blood cells called eosinophils (part of the body's immune system). Eosinophilic disorders can cause a variety of gastrointestinal complaints including reflux-like symptoms, vomiting, difficulty swallowing, tissue scarring, fibrosis, the formation of strictures, diarrhea, abdominal pain, failure to grow in childhood and other medical complications.

Read more about the grant .

February 28  

Digestive Health Center Pilot and Feasibility Awards   

Joseph D. Sherrill, PhD was awarded a  Digestive Health Center  Pilot and Feasibility Award for his project "Characterization of the Antimicrobial Peptide RNase 7 in Eosinophilic Esophagitis". Additionally,  Simon P. Hogan, PhD  is a co-investigator on another awarded  Digestive Health Center  Pilot and Feasibility Award for the project "Star-related Lipid Transfer (StarD7) in Intestinal Epithelial Barrier Function and Food Sensitization".

February

Digestive Health Center Research Symposium Award 

Julie Caldwell, a research associate in the  Rothenberg Lab , won first for posters at the  Digestive Health Center  Research Symposium for her project "CDH26: a Functional Integrin-Binding Cadherin Involve in Eosinophilic Gastrointestinal Disorders".

January  

ARTrust Grant 

Congratulations to Dave Morris, a clinical fellow in the   Fulkerson Lab , who was awarded a 2014   ARTrust  grant entitled "Characterization of eosinophil progenitors (EoPs) in the peripheral blood of pediatric patients with active eosinophilic esophagitis (EoE)". He is pictured below with Linda Cox, the President of   AAAAI , and Dennis Ledford, the past President of   AAAAI .

November 22-23 Second Annual CURED Patient Research Conference 

The second annual CURED Patient Research Conference was a huge success. There were about 235 in attendance on Friday, and 160 on Saturday. There were 26 states represented and three countries. The attendees heard from the leading experts around the world, including our very own experts from Cincinnati Children's and the Cincinnati Center for Eosinophilic Disorders. CURED's support helps further our mission to find a cure for eosinophilic disorders.

November 11 Discovery by Israeli and American Researchers May Lead to New Treatments for Allergic Diseases (PDF)

September 18 Congratulations to Ting Wen, PhD, a postdoctoral fellow in the Rothenberg Lab for winning the second-place prize at the third annual Ohio River Valley Cytometry Association's Imaging and Cytometry Research Day.

August 12 Interview with the Authors: Mechanism of Siglec-8-Mediated Cell Death

August 5, 2013 Epinephrine: It's Still Our Fail Safe

August 2, 2013 Despite Shots, Peanut Allergy Kills Teen

Simon P. Hogan, PhD was recently appointed as the Director of Research of the Division of Allergy/Immunology. He joins the Division Director, Marc E. Rothenberg, MD, PhD, and Amal H. Assa'ad, MD, the Associate Division Director, in leading the division in its mission to improve the health of children with allergic and immune conditions through innovative research, outstanding clinical care and education of the current and next generation of leaders in healthcare and research. In this new role, Hogan will strengthen the guidance available to division researchers with his hands-on approach and will be an advocate for process improvements that facilitate quality research.

July 31, 2013  A Patch to Treat Peanut Allergies in Works

A recent article in Elle magazine has speculated that GMO (genetically modified organism) corn can promote eosinophil-related diseases. There are statements in this article that are scientifically inaccurate in our opinion.  The magazine article describes the presence of eosinophils in a nasal swab. This finding by itself is not indicative of an eosinophilic disorder.  The presence of eosinophils in a nasal swab specimen is a common finding in patients with hay fever (allergic rhinitis), a disease process that has been well established to be caused by respiratory allergies.  Further, it is our expert opinion that there is not sufficient knowledge or scientific foundation to warrant the claim in this article that eosinophilic disorders arise from GMO corn.  

This statement is released by all of the Cincinnati Children's Hospital doctors mentioned in the article.
Marc E. Rothenberg MD, PhD; Amal H. Assa'ad, MD; Simon P. Hogan, PhD; Karl von Tiehl, MD

June 19, 2013 Mother and Son Plan to Climb Mt. Kilimanjaro for a Cause

March 2013 Patricia C. Fulkerson, MD, PhD, Receives 2013 ARTrust Faculty Development Award Medical School Faculty

November 2nd - 4th, 2012 CURED EGID Symposium

November 1, 2012  CURED Foundation Makes Generous Donation of $150,000 to the Cincinnati Center for Eosinophilic Disorders Research Efforts. This brings the total amount of money donated to the Center by CURED to $2,114,000 in the past 10 years. 

July 25, 2012  CCED and CEFC Annual Interactive Eosinophilic Research Lab Day

May 20, 2012  CURED Foundation Makes Generous Donation of $150,000 to the Cincinnati Center for Eosinophilic Disorders' Research Efforts

May 10, 2012  For Teen With Eosinophils of the Esophagus, Food Is Forbidden

May 9, 2012 Merger of the Food Allergy Initiative (FAI) and the Food Allergy & Anaphylaxis Network (FAAN) Announced

May 2, 2012 Researchers Evaluate Dietary Regimens of Allergic Disease

November 11, 2011 EoE Keynote Presentation at Upcoming Allergy Drug Discovery and Development Conference

November 7, 2011  CURED Foundation Continues Support of Eosinophilic Research

November 2011 Family Finds Support for Severe Allergies

August 3, 2001  Smithfield Girl Undergoing Treatment for Rare Disease

August 1, 2011  Youth Tour and a Special Teen

July 2011  Eosinophilic Esophagitis: Updated Consensus Recommendations For Children and Adults

June 23, 2011 MTV Series True Life: I’m Allergic to Everything

May 18, 2011  Family Building A Community to Deal with Rare Disease

May 18, 2011 Peanut-tainted Blood Triggers Boy's Allergic Reaction

May 15, 2011  A Disease that Hampers Eating

May 13, 2011 Risks: Acid Reflux Drugs Tied to Bone Fractures

April 18, 2011  Imagine a Life with Food? Children Living with EOS Do

April / May 2011 Life Without Food

February 11, 2011  New Pamphlet Guides Patients on Food Allergies. The National Institute of Allergy and Infectious Diseases (NIAID) has released a pamphlet that can be shared with patients, offering a comprehensive overview of food allergies. Download the pamphlet.

December 6, 2010 "Guidelines for Food Allergy Testing Revised." Amal H. Assa'ad, MD comments on the need for consistent follow-up for food allergy in this article about the insufficiency of using skin prick and blood tests alone for food allergy diagnosis. See also Cincinnati Children's summary of this article called Food Allergy Testing: Skin Pricks May Just Scratch the Surface. 

October 2, 2010  Way to Turn Off Immune System's Allergic Reaction Discovered. The findings summarized in this article provide hope that the body can be trained to tolerate food allergies that lead to roughly 300,000 emergency room visits and 100-200 deaths each year.   

July 29, 2010 FDA Drug Safety Communication: Eosinophilic Pneumonia Associated with the Use of Cubicin (daptomycin).

July 22, 2010 Doctor at Cincinnati Children's Receives Prestigious NIH MERIT Award to Extend Research of Eosinophilic Disorders. Marc E. Rothenberg, MD, PhD, director of the Division of Allergy and Immunology at Cincinnati Children’s, has received an NIH MERIT Award to extend funding of his long-standing investigation into “Regulation of Gastrointestinal Eosinophils.” 

July 14, 2010 The NIH expands its food allergy research program: Consortium of Food Allergy Research (CoFAR) renewed with a five-year, $29.9 million grant. 

May 2010 Rare disease makes Scottsdale boy reject food 

May 2010 Myeloid and lymphoid neoplasms with eosinophilia and abnormalities of PDGFRA, PDGFRB or FGFR1.by Barbara J. Bain in Haematologica Editorials and Perspectives.  A recent advancement in screening for PDGFR rearrangement may improve treatment selection for patients with myeloid or lymphoid neoplasms with eosinophilia. This editorial discusses the relation between PDGFR and FGFR1 abnormalities and the cause and treatment of these neoplasms.

March 8, 2010   Gene Site Found for a Children’s Food Allergy. 

April 20, 2007 Marc Rothenberg, MD, PhD, Earns Prestigious E. Mead Johnson Award  

February 21, 2007 Marc Rothenberg, MD, PhD, Named to Prestigious NIH Advisory Panel  

October 17 - 22, 2006 First International Gastrointestinal Eosinophilic Research Symposium  

February 3, 2006 Gene Discovery Linked to Mysterious Chronic Food Allergy: Study offers first molecular insight into eosinophilic esophagitis  

September 16, 2004 Two Studies in Science Point to New Evidence in Asthma Development: Eosinophils Have a Key Role in Asthma  

August 25, 2004 Study In The New England Journal of Medicine Identifies Rapidly Rising Disorder  

January 8, 2004 Study Identifies Breakthrough Treatment For Devastating Blood Disorders  

December 27, 2000 Cincinnati Children's Researcher Uncovers Allergy / Reflux Link: Study Has Significant Treatment Implications  

June 1, 2000 Cincinnati Children's Researchers Uncover Critical Food Allergy Pathway