Strine, AC; VanderBrink, BA; Riazzi, AC; Schulte, M; Mayes, T; Noh, PH; Jr, DW R; Minevich, E; Sheldon, CA; Reddy, PP. Preoperative nutritional status and use of total parenteral nutrition in pediatric and adolescent patients undergoing continent urinary tract reconstruction. Journal of Pediatric Urology. 2018; 14(6):572.e1-572.e7.
A nutritional assessment is a critical but often neglected aspect of a preoperative evaluation. This retrospective cohort study describes the preoperative nutritional status of pediatric and adolescent patients undergoing continent urinary tract reconstruction and determines the association among malnutrition, use of total parenteral nutrition (TPN), and surgical outcomes.
Marable, SS; Chung, E; Adam, M; Potter, SS; Park, J. Hnf4a deletion in the mouse kidney phenocopies Fanconi renotubular syndrome. JCI insight. 2018; 3(14).
Proximal tubules perform the majority of reabsorption function of the kidney. In this study, researchers presented a mouse model of Fanconi renotubular syndrome that is caused by impaired proximal tubules. They found that loss of Hnf4a in the kidney caused developmental arrest of proximal tubules and that the mutant mice recapitulated the symptoms of Fanconi syndrome patients, showing polyuria, polydipsia, glycosuria, and phosphaturia.
Joshi, RS; Shrivastava, D; Grady, R; Kundu, A; Ramji, J; Reddy, PP; Pippi-Salle, JL; Frazier, JR; Canning, DA; Shukla, AR. A model for sustained collaboration to address the unmet global burden of bladder exstrophy-epispadias complex and penopubic epispadias the international bladder exstrophy consortium. JAMA Surgery. 2018; 153(7):618-624.
International collaboration to alleviate the massive burden of surgical disease is recognized by World Health Organization as an urgent need, yet the surgical mission model to treat reconstructive surgical challenges is often constrained in ensuring adequate patient follow-up, optimal outcomes, and sustainability. This prospective, observational study determined that a unique surgical mission model consisting of an international collaborative, focused on treating the complex diagnoses of bladder exstrophy-epispadias complex and penopubic epispadias, offers outcomes comparable with those in high-income countries, demonstrating a significant patient retention rate and an opportunity to rigorously study outcomes over an accelerated interval owing to the high burden of disease in India.
Moravek, MB; Appiah, LC; Anazodo, A; Burns, KC; Gomez-Lobo, V; Hoefgen, HR; Jaworek Frias, O; Laronda, MM; Levine, J; Meacham, LR; Pavone, ME; Quinn, GP; Rowell, EE; Strine, AC; Woodruff, TK; Nahata, L. Development of a Pediatric Fertility Preservation Program A Report From the Pediatric Initiative Network of the Oncofertility Consortium. Journal of Adolescent Health. 2019; 64(5):563-573.
Structured programs to offer counseling about infertility risk and fertility preservation options are essential in the care of pediatric patients facing fertility-threatening conditions or treatments, yet multiple barriers to program development exist. This report was developed from the institutional experiences of members of the Pediatric Initiative Network of the Oncofertility Consortium, with the intent of providing guidance for health care providers aiming to establish programs at institutions lacking pediatric fertility preservation services.
Neheman, A; Strine, AC; Concodora, CW; Schulte, ME; Noh, PH. Outpatient Robotic Unilateral Extravesical Ureteral Reimplantation in the Pediatric Population Short-Term Assessment of Safety. The Journal of Urology. 2019; 201(3):615-619.
Robotic extravesical ureteral reimplantation has been established as a viable option for surgical management of vesicoureteral reflux. Typically this procedure is associated with a hospital stay for routine postoperative care. In this study, researchers assessed the short-term safety of robotic unilateral extravesical ureteral reimplantation as a scheduled outpatient procedure in a pediatric population. At conclusion, it was determined that robotic unilateral extravesical ureteral reimplantation is safe as an outpatient procedure in the pediatric population, though further evaluation is warranted to assess its short and long-term outcomes on a larger scale.