Numerous studies confirm
the necessity of placental angiogenesis and functional fetal and placental
vascular beds not only for fetal growth but for sustained placental growth in
pregnancies complicated by IUGR have significant impairment in vascular
developmental system. We are assessing quantitatively
and qualitatively uteroplacental vasculature and placental blood flow through a
novel uteroplacental microvasculature imaging, illustrating the impact of IUGR
and treatment on placental blood flow, microvasculature and barrier morphology.
This novel method of placental vasculature visualization allows in-depth
analysis of the fetal and maternal vascular compartments. In this project we
will be able to assess placental vascular development in normal and abnormal
pregnancies as preeclampsia, IUGR and preterm delivery.