Research in the Pang Lab focuses on the function of Fanconi anemia (FA) proteins in hematopoiesis. The process of FA disease progression in the context of hematopoiesis is characterized by bone marrow failure, clonal proliferation of hematopoietic stem and progenitor (HSC/P) cells, and progression to myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). The only curable treatment for this devastating disease is stem cell therapy through bone marrow transplantation. We are studying how the FA proteins function in HSC maintenance and how loss of the FA protein function promotes malignant evolution of HSC/P cells. We are also interested in exploring a novel concept of manipulating the interaction between stem cell and bone marrow microenvironment or niche as a way to improve FA hematopoietic stem cell transplantation.