Experimental Hematology and Cancer Biology
Pang Lab

Pang Research Lab

Research in the Pang Lab focuses on the function of Fanconi anemia (FA) proteins in hematopoiesis. The process of FA disease progression in the context of hematopoiesis is characterized by bone marrow failure, clonal proliferation of hematopoietic stem and progenitor (HSC/P) cells, and progression to myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). The only curable treatment for this devastating disease is stem cell therapy through bone marrow transplantation. We are studying how the FA proteins function in HSC maintenance and how loss of the FA protein function promotes malignant evolution of HSC/P cells. We are also interested in exploring a novel concept of manipulating the interaction between stem cell and bone marrow microenvironment or niche as a way to improve FA hematopoietic stem cell transplantation.

Publications

Nie, Y; Wilson, AF; DeFalco, T; Meetei, AR; Namekawa, SH; Pang, Q. FANCD2 is required for the repression of germline transposable elements. Reviews of Reproduction. 2020; 159:659-668.

Abe, H; Alavattam, KG; Hu, Y; Pang, Q; Andreassen, PR; Hegde, RS; Namekawa, SH. The Initiation of Meiotic Sex Chromosome Inactivation Sequesters DNA Damage Signaling from Autosomes in Mouse Spermatogenesis. Current Biology. 2020; 30:408-420.e5.

Nie, Y; Li, Y; Li, X; Wilson, AF; Pang, Q. The non-homologous end-joining activity is required for Fanconi anemia fetal HSC maintenance. Stem Cell Research and Therapy. 2019; 10.

Chatla, S; Wilson, AF; Pang, Q. Inactivation of the NHEJ Activity of DNA-PKcs Prevents Fanconi Anemia Pre-Leukemic HSC Expansion. International Journal of Stem Cells. 2019; 12:457-462.

Chatla, S; Du, W; Wilson, AF; Meetei, AR; Pang, Q. Fancd2-deficient hematopoietic stem and progenitor cells depend on augmented mitochondrial translation for survival and proliferation. Stem Cell Research. 2019; 40.

Liu, W; Du, W; Shang, X; Wang, L; Evelyn, C; Florian, MC; Ryan, MA; Rayes, A; Zhao, X; Setchell, K; et al. Rational identification of a Cdc42 inhibitor presents a new regimen for long-term hematopoietic stem cell mobilization. Leukemia. 2019; 33:749-761.

Du, W; Li, X; Wilson, AF; Pang, Q. A small molecule p53 activator attenuates Fanconi anemia leukemic stem cell proliferation. Stem Cell Research and Therapy. 2018; 9.

Du, W; Liu, W; Mizukawa, B; Shang, X; Sipple, J; Wunderlich, M; Geiger, H; Davies, S; Mulloy, J; Pang, Q; et al. A non-myeloablative conditioning approach for long-term engraftment of human and mouse hematopoietic stem cells. Leukemia. 2018; 32:2041-2046.

Amarachintha, S; Pang, Q. Cobblestone Area-forming Cell Assay of Mouse Bone Marrow Hematopoietic Stem Cells. Bio-protocol. 2018; 8.

Contact Us

A photo of Qishen Pang.

Qishen Pang, PhD
 Professor
UC Department of Pediatrics

Phone: 513-636-1152
Fax: 513-636-3768
Email: qishen.pang@cchmc.org

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