De Falco Lab

Publications

Li, S; Bhandary, B; Gu, X; DeFalco, T. Perivascular cells support folliculogenesis in the developing ovary. Proceedings of the National Academy of Sciences of USA. 2022; 119:e2213026119.

Heinrich, A; Bhandary, B; Potter, SJ; Ratner, N; DeFalco, T. Cdc42 activity in Sertoli cells is essential for maintenance of spermatogenesis. Cell Reports. 2021; 37:109885.

Li, S; Gu, X; Heinrich, A; Hurley, EG; Capel, B; DeFalco, T. Loss of Mafb and Maf distorts myeloid cell ratios and disrupts fetal mouse testis vascularization and organogenesis†. Biology of Reproduction. 2021; 105:958-975.

Kumar, DL; DeFalco, T. A perivascular niche for multipotent progenitors in the fetal testis. Nature Communications. 2018; 9:4519.

Lin, Y; Barske, L; DeFalco, T; Capel, B. Numb regulates somatic cell lineage commitment during early gonadogenesis in mice. Development (Cambridge). 2017; 144:1607-1618.

DeFalco, T; Potter, SJ; Williams, AV; Waller, B; Kan, MJ; Capel, B. Macrophages Contribute to the Spermatogonial Niche in the Adult Testis. Cell Reports. 2015; 12:1107-1119.

DeFalco, T; Bhattacharya, I; Williams, AV; Sams, DM; Capel, B. Yolk-sac-derived macrophages regulate fetal testis vascularization and morphogenesis. Proceedings of the National Academy of Sciences of USA. 2014; 111:E2384-E2393.

DeFalco, T; Saraswathula, A; Briot, A; Iruela-Arispe, ML; Capel, B. Testosterone levels influence mouse fetal Leydig cell progenitors through notch signaling. Biology of Reproduction. 2013; 88:91.

DeFalco, T; Takahashi, S; Capel, B. Two distinct origins for Leydig cell progenitors in the fetal testis. Developmental Biology. 2011; 352:14-26.

Cool, J; DeFalco, TJ; Capel, B. Vascular-mesenchymal cross-talk through Vegf and Pdgf drives organ patterning. Proceedings of the National Academy of Sciences of USA. 2011; 108:167-172.

Weinhaus, B; Homan, S; Kincaid, M; Tadwalkar, A; Gu, X; Kumar, S; Slaughter, A; Zhang, J; Wu, Q; Kofron, JM; Troutman, TD; DeFalco, T; Lucas, D. Differential regulation of fetal bone marrow and liver hematopoiesis by yolk-sac-derived myeloid cells. Nature Communications. 2025; 16:4427.

Li, S; Kumar, S; Gu, X; DeFalco, T. Testicular immunity. Molecular Aspects of Medicine. 2024; 100:101323.

Matsuyama, S; DeFalco, T. Steroid hormone signaling: multifaceted support of testicular function. Frontiers in Cell and Developmental Biology. 2024; 11:1339385.

Maezawa, S; Yukawa, M; Hasegawa, K; Sugiyama, R; Iizuka, M; Hu, M; Sakashita, A; Vidal, M; Koseki, H; Barski, A; DeFalco, T; Namekawa, SH. PRC1 suppresses a female gene regulatory network to ensure testicular differentiation. Cell Death and Disease. 2023; 14:501.

Gu, X; Heinrich, A; Li, S; DeFalco, T. Testicular macrophages are recruited during a narrow fetal time window and promote organ-specific developmental functions. Nature Communications. 2023; 14:1439.

Li, S; Bhandary, B; Gu, X; DeFalco, T. Perivascular cells support folliculogenesis in the developing ovary. Proceedings of the National Academy of Sciences of USA. 2022; 119:e2213026119.

Gu, X; Li, S; DeFalco, T. Immune and vascular contributions to organogenesis of the testis and ovary. The Federation of European Biochemical Societies (FEBS) Journal. 2022; 289:2386-2408.

Gu, X; Li, S; Matsuyama, S; DeFalco, T. Immune Cells as Critical Regulators of Steroidogenesis in the Testis and Beyond. Frontiers in Endocrinology. 2022; 13:894437.

Gu, X; DeFalco, T. In Vitro Differentiation of Leydig Cells From hiPSCs: A First Step Towards a Cellular Therapy for Hypogonadism?. Endocrinology. 2022; 163:bqab221.

Heinrich, A; Bhandary, B; Potter, SJ; Ratner, N; DeFalco, T. Cdc42 activity in Sertoli cells is essential for maintenance of spermatogenesis. Cell Reports. 2021; 37:109885.

Li, S; Gu, X; Heinrich, A; Hurley, EG; Capel, B; DeFalco, T. Loss of Mafb and Maf distorts myeloid cell ratios and disrupts fetal mouse testis vascularization and organogenesis†. Biology of Reproduction. 2021; 105:958-975.

Kajioka, D; Suzuki, K; Matsushita, S; Hino, S; Sato, T; Takada, S; Isono, K; Takeo, T; Kajimoto, M; Nakagata, N; Nakao, M; Suyama, M; DeFalco, T; Miyagawa, S; Yamada, G. Sexual fate of murine external genitalia development: Conserved transcriptional competency for male-biased genes in both sexes. Proceedings of the National Academy of Sciences of USA. 2021; 118:e2024067118.