Publications

Heinrich, A; Bhandary, B; Potter, SJ; Ratner, N; DeFalco, T. Cdc42 activity in Sertoli cells is essential for maintenance of spermatogenesis. Cell Reports. 2021; 37.

Li, S; Gu, X; Heinrich, A; Hurley, EG; Capel, B; DeFalco, T. Loss of Mafb and Maf distorts myeloid cell ratios and disrupts fetal mouse testis vascularization and organogenesis†. Biology of Reproduction. 2021; 105:958-975.

Kumar, DL; DeFalco, T. A perivascular niche for multipotent progenitors in the fetal testis. Nature Communications. 2018; 9.

Lin, Y; Barske, L; DeFalco, T; Capel, B. Numb regulates somatic cell lineage commitment during early gonadogenesis in mice. Development (Cambridge). 2017; 144:1607-1618.

DeFalco, T; Potter, SJ; Williams, AV; Waller, B; Kan, MJ; Capel, B. Macrophages Contribute to the Spermatogonial Niche in the Adult Testis. Cell Reports. 2015; 12:1107-1119.

DeFalco, T; Bhattacharya, I; Williams, AV; Sams, DM; Capel, B. Yolk-sac-derived macrophages regulate fetal testis vascularization and morphogenesis. Proceedings of the National Academy of Sciences of the United States of America. 2014; 111:E2384-E2393.

DeFalco, T; Saraswathula, A; Briot, A; Iruela-Arispe, ML; Capel, B. Testosterone levels influence mouse fetal Leydig cell progenitors through notch signaling. Biology of Reproduction. 2013; 88.

Jameson, SA; Natarajan, A; Cool, J; DeFalco, T; Maatouk, DM; Mork, L; Munger, SC; Capel, B. Temporal transcriptional profiling of somatic and germ cells reveals biased lineage priming of sexual fate in the fetal mouse gonad. PLoS Genetics. 2012; 8.

DeFalco, T; Takahashi, S; Capel, B. Two distinct origins for Leydig cell progenitors in the fetal testis. Developmental Biology. 2011; 352:14-26.

Cool, J; DeFalco, TJ; Capel, B. Vascular-mesenchymal cross-talk through Vegf and Pdgf drives organ patterning. Proceedings of the National Academy of Sciences of the United States of America. 2011; 108:167-172.

Heinrich, A; Bhandary, B; Potter, SJ; Ratner, N; DeFalco, T. Cdc42 activity in Sertoli cells is essential for maintenance of spermatogenesis. Cell Reports. 2021; 37.

Li, S; Gu, X; Heinrich, A; Hurley, EG; Capel, B; DeFalco, T. Loss of Mafb and Maf distorts myeloid cell ratios and disrupts fetal mouse testis vascularization and organogenesis†. Biology of Reproduction. 2021; 105:958-975.

Kajioka, D; Suzuki, K; Matsushita, S; Hino, S; Sato, T; Takada, S; Isono, K; Takeo, T; Kajimoto, M; Nakagata, N; et al. Sexual fate of murine external genitalia development: Conserved transcriptional competency for male-biased genes in both sexes. Proceedings of the National Academy of Sciences of the United States of America. 2021; 118.

Heinrich, A; DeFalco, T. Essential roles of interstitial cells in testicular development and function. Andrology. 2020; 8:903-914.

Nie, Y; Wilson, AF; DeFalco, T; Meetei, AR; Namekawa, SH; Pang, Q. FANCD2 is required for the repression of germline transposable elements. Reviews of Reproduction. 2020; 159:659-668.

Heinrich, A; Potter, SJ; Guo, L; Ratner, N; DeFalco, T. Distinct Roles for Rac1 in Sertoli Cell Function during Testicular Development and Spermatogenesis. Cell Reports. 2020; 31.

Kumar, DL; DeFalco, T. A perivascular niche for multipotent progenitors in the fetal testis. Nature Communications. 2018; 9.

Valiente-Alandi, I; Potter, SJ; Salvador, AM; Schafer, AE; Schips, T; Carrillo-Salinas, F; Gibson, AM; Nieman, ML; Perkins, C; Sargent, MA; et al. Inhibiting Fibronectin Attenuates Fibrosis and Improves Cardiac Function in a Model of Heart Failure. Circulation. 2018; 138:1236-1252.

Hulin, A; Anstine, LJ; Kim, AJ; Potter, SJ; DeFalco, T; Lincoln, J; Yutzey, KE. Macrophage Transitions in Heart Valve Development and Myxomatous Valve Disease. Arteriosclerosis, Thrombosis, and Vascular Biology. 2018; 38:636-644.

Lin, Y; Barske, L; DeFalco, T; Capel, B. Numb regulates somatic cell lineage commitment during early gonadogenesis in mice. Development (Cambridge). 2017; 144:1607-1618.

Contact Us

Tony De Falco, PhD
Associate Professor
UC Department of Pediatrics

Mailing Address:
Reproductive Sciences Center
3333 Burnet Avenue
MLC 7045
Cincinnati, OH 45229 

Phone: 513-803-3988
Fax: 513-803-1160
Email: tony.defalco@cchmc.org

Graduate Student and Postdoctoral Training Opportunities

The De Falco Lab is seeking graduate students and postdoctoral fellows to join our team. We use a multi-disciplinary approach to study reproductive biology, with extensive use of mouse genetics, immunofluorescent confocal microscopy, whole organ culture, live imaging, and next generation sequencing techniques. Students and postdoctoral candidates with interests in reproductive or developmental biology should contact Tony De Falco (tony.defalco@cchmc.org) to discuss training opportunities.