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Potter, S.J., Kumar, D.L., and DeFalco, T. Origin and Differentiation of Androgen-Producing Cells in the Gonads. In: Piprek R, editor. Molecular Mechanisms of Cell Differentiation in Gonad Development, in the series Results and Problems in Cell Differentiation. Heidelberg, Germany: Springer-Verlag; 2016. In press.

DeFalco, T.*, Potter, S.J., Williams, A.V., Waller, B., Kan, M.J., and Capel, B. Macrophages contribute to the spermatogonial niche in the adult testis**. Cell Rep. 12(7): 1107-19. 2015.
(*corresponding author **Featured Article on the cover of the August 18th issue of Cell Reports, and also highlighted as a Preview in Cell Reports and as a featured article in the “World of Reproductive Biology” in Biology of Reproduction)

Potter, S.J., DeFalco, T. Using ex vivo upright droplet cultures of whole fetal organs to study developmental processes during mouse organogenesis. J. Vis. Exp. 104:e53262. 2015.

DeFalco, T.*, Bhattacharya, I., Williams, A.V., Sams, D.M., and Capel, B.* Yolk-sac-derived macrophages regulate fetal testis vascularization and morphogenesis. Proc. Natl. Acad. Sci. U.S.A. 2014 Jun 10;111(23):E2384-93. (*co-corresponding

DeFalco, T.  DMRT1 keeps masculinity intact . Dev. Cell. 2014 Jun 9;29(5):503-4.

Daikoku, T., Ogawa, Y., Terakawa, J., Ogawa, A., DeFalco, T., and Dey, S.K. Lactoferrin-iCre: a new mouse line to study uterine epithelial gene function. Endocrinology. 2014 Jul;155(7):2718-24.

DEFALCO, T., Saraswathula, A., Briot, A., Iruela-Arispe, M.L., Capel, B. Testosterone levels influence mouse fetal Leydig cell progenitors through Notch signalingBiol. Reprod. 2013 Apr 11;88(4):91. (This article was featured on the cover of the April 2013 issue of Biology of Reproduction

Garcia, T.X., DEFALCO, T., Capel B., and Hofmann, M.C. Constitutive activation of NOTCH1 signaling in Sertoli cells causes gonocyte exit from quiescenceDev. Biol. 2013 May 1;377(1):188-201.

Cool, J.*, DeFalco, T.*, and Capel, B. Testis formation in the fetal mouse: dynamic and complex de novo tubulogenesis. Wiley Interdiscip. Rev. Dev. Biol. 2012 Nov-Dec;1(6):847-59. (*DeFalco, T. and Cool, J. contributed equally to this report)

Jameson, S., Natarajan, A., Cool, J., DeFalco, T., Maatouk, D., Mork, L., Munger, S.C., and Capel, B. Temporal transcriptional profiling of somatic and germ cells reveals biased lineage priming of sexual fate in the fetal mouse gonad. PLoS Genet. 2012;8(3):e1002575.

DeFalco, T., Takahashi, S., and Capel, B. Two distinct origins for Leydig cell progenitors in the fetal testis. Dev. Biol. 2011 Apr 1;352(1):14-26.

Cool, J., DeFalco, T.J., and Capel, B. Vascular-mesenchymal cross-talk through Vegf and Pdgf drives organ patterning. Proc. Natl. Acad. Sci. U.S.A. 2011 Jan 4;108(1):167-72.

DeFalco, T. and Capel, B. Gonad morphogenesis in vertebrates: divergent means to a convergent end. Annu. Rev. Cell Dev. Biol. 2009;25:457-82.

Nanda, S.*, DeFalco, T.J.*, Loh, S.H., Phochanukul, N., Camara, N., Van Doren, M., and Russell, S . Sox100B, a Drosophila group E Sox-domain gene, is required for somatic testis differentiation. Sex. Dev. 2009;3(1):26-37.(*DeFalco, T.J. and Nanda, S. contributed equally to this report).

DeFalco, T., Camara, N., Le Bras, S. and Van Doren M. Nonautonomous sex determination controls sexually dimorphic development of the Drosophila gonadDev. Cell. 2008 Feb;14(2):275-86.

DeFalco, T., Le Bras, S., and Van Doren M. Abdominal-B is essential for proper sexually dimorphic development of the Drosophila gonadMech. Dev. 2004 Nov;121(11):1323-33.

DeFalco, T.J., Verney, G., Jenkins, A.B., McCaffery, J.M., Russell, S., and Van Doren, M. Sex-specific apoptosis regulates sexual dimorphism in the Drosophila embryonic gonadDev. Cell. 2003 Aug;5(2):205-16.

Contact Us

Tony De Falco, PhD
Assistant Professor
UC Department of Pediatrics

Mailing Address:
Division of Reproductive Sciences
3333 Burnet Avenue
MLC 7045
Cincinnati, OH 45229 

Phone: 513-803-3988
Fax: 513-803-1160

Graduate Student and Postdoctoral Training Opportunities

The De Falco Lab is seeking graduate students and postdoctoral fellows to join our team. We use a multi-disciplinary approach to study reproductive biology, with extensive use of mouse genetics, immunofluorescent confocal microscopy, whole organ culture, live imaging, and next generation sequencing techniques. Students and postdoctoral candidates with interests in reproductive or developmental biology should contact Tony De Falco ( to discuss training opportunities.