Brain and Spinal Tumors Research Studies

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DIPG/High Grade Glioma New Diagnosis

ADVL1217: A Phase 1 Study of AZD1775 (MK-1775) Concurrent With Local Radiation Therapy for the Treatment of Newly Diagnosed Children With Diffuse Intrinsic Pontine Gliomas

  • Conditions: Brain Spinal Tumor DIPG New Diagnosis, Adult - Brain Spinal Tumor DIPG New Diagnosis

PURPOSE: This phase I trial studies the side effects and the best dose of WEE1 inhibitor AZD1775 when given together with local radiation therapy in treating patients with newly diagnosed diffuse intrinsic pontine gliomas. WEE1 inhibitor AZD1775 may stop the growth of tumor cells by blocking some of ...More

CA209908: Phase Ib /II Clinical Trial of Nivolumab Monotherapy and Nivolumab in Combination With Ipilimumab in Pediatric Subjects With High Grade Primary CNS Malignancies

  • Conditions: Brain Spinal Tumors Medulloblastoma Relapse, Adult - Brain Spinal Tumors Medulloblastoma Relapse, Brain Spinal Tumor DIPG Relapse, Brain Spinal Tumor DIPG New Diagnosis, Adult - Brain Spinal Tumor DIPG New Diagnosis, Adult - Brain Spinal Tumor DIPG Relapse, Brain and Spinal Tumor Ependymoma Relapse, Adult - Brain and Spinal Tumor Ependymoma Relapse, Brain Spinal Other ATRT, Adult - Brain Spinal Other ATRT, Brain Spinal Other Germ Cell Tumor, Adult - Brain Spinal Other Germ Cell Tumor, Brain Spinal Other Choroid Plexus Tumor, Adult - Brain Spinal Other Choroid Plexus Tumor, Brain Spinal Other All Other, Adult - Brain Spinal Other All Other

PURPOSE: The purpose of this study is to determine the safety and effectiveness of nivolumab alone and in combination with ipilimumab in pediatric patients with high grade primary central nervous system (CNS) malignancies.
 PRIMARY OUTCOME MEASURES: Incidence of dose limiting toxicity ( ...More

LEE RAD17T-MD-1604: A Phase I Study of Ribociclib and Everolimus Following Radiation Therapy in Children With Newly Diagnosed Non-biopsied Diffuse Pontine Gliomas (DIPG) and RB+ Biopsied DIPG and High Grade Gliomas (HGG)

  • Conditions: Brain Spinal Tumor DIPG New Diagnosis, Adult - Brain Spinal Tumor DIPG New Diagnosis

In this research study, we want to learn about the safety of the study drugs, ribociclib and everolimus, when given together at different doses after radiation therapy. We also want to learn about the effects, if any, these drugs have on children and young adults with brain tumors. We are asking peo ...More