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A photo of Jack Bleesing.

Co-Director, Diagnostic Immunology Laboratories

Associate Director, Immunodeficiency and Histiocytosis Program

Professor, UC Department of Pediatrics



Board Certified

About Me

Additional Languages

Dutch, German

Clinical Interests

Immunobiology; translational research; immunologic methods development

Research Interests

Clinical investigation of primary immunodeficiency disorders (with emphasis on disorders of immuno dysregulation and B-cell disorders); immuno-reconstitution following blood and marrow transplantation; diagnostic immunology (with emphasis on flow cytometry)

Academic Affiliation

Professor, UC Department of Pediatrics


Cancer and Blood Diseases, Immune Deficiencies and Histiocytosis, Bone Marrow Transplantation BMT, Leukemia, Hemophagocytic lymphohistiocytosisHLH

My Locations

My Education

MD: University of Leiden, Leiden, The Netherlands, 1989.

PhD: University of Leiden, Leiden, The Netherlands, 2002.

Residency: Pediatrics, University of Florida, Gainesville, Florida, 1993.

Fellowship: Allergy/Immunology, Duke University Medical Center, Durham, North Carolina, 1995.

Fellowship: Clinical Laboratory Immunology, National Institutes of Health, Bethesda, Maryland, 2001.

My Publications

Complement blockade for TA-TMA: lessons learned from a large pediatric cohort treated with eculizumab. Jodele, S; Dandoy, CE; Lane, A; Laskin, BL; Laskin, B; Teusink-Cross, A; Myers, KC; Wallace, G; Nelson, AS; Nelson, A; et al. Blood. 2020; 26:S138-S138.

The Value of Chromosome Analysis to Interrogate Variants in DNMT3B Causing Immunodeficiency, Centromeric Instability, and Facial Anomaly Syndrome Type I (ICF1). Kellner, ES; Rathbun, PA; Marshall, GS; Tolusso, LK; Smolarek, TA; Sun, M; Chandra, S; Bleesing, J; Marsh, RA. Journal of Clinical Immunology. 2019; 39:857-859.

Chronic Granulomatous Disease-Associated IBD Resolves and Does Not Adversely Impact Survival Following Allogeneic HCT. Marsh, RA; Leiding, JW; Logan, BR; Griffith, LM; Arnold, DE; Haddad, E; Falcone, EL; Yin, Z; Patel, K; Arbuckle, E; et al. Journal of Clinical Immunology. 2019; 39:653-667.

Current Flow Cytometric Assays for the Screening and Diagnosis of Primary HLH. Chiang, SC C; Bleesing, JJ; Marsh, RA. Frontiers in Immunology. 2019; 10.

Outcomes and Treatment Strategies for Autoimmunity and Hyperinflammation in Patients with RAG Deficiency. Farmer, JR; Foldvari, Z; Ujhazi, B; De Ravin, SS; Chen, K; Bleesing, JJ H; Schuetz, C; Al-Herz, W; Abraham, RS; Joshi, AY; et al. Journal of Allergy and Clinical Immunology-In Practice. 2019; 7:1970-1985.e4.

Two Unique Cases of X-linked SCID: A Diagnostic Challenge in the Era of Newborn Screening. Purswani, P; Meehan, CA; Kuehn, HS; Chang, Y; Dasso, JF; Meyer, AK; Ujhazi, B; Csomos, K; Lindsay, D; Alberdi, T; et al. Frontiers in Pediatrics. 2019; 7.

Successful Bone Marrow Transplantation for XMEN: Hemorrhagic Risk Uncovered. Dimitrova, D; Rose, JJ; Uzel, G; Cohen, JI; Rao, KV; Bleesing, JH; Kanakry, CG; Kanakry, JA. Journal of Clinical Immunology. 2019; 39:1-3.

Loss of GTPase of immunity-associated protein 5 (Gimap5) promotes pathogenic CD4(+) T-cell development and allergic airway disease. Patterson, AR; Bolcas, P; Lampe, K; Cantrell, R; Ruff, B; Lewkowich, I; Hogan, SP; Janssen, EM; Bleesing, J; Hershey, GK K; et al. Journal of Allergy and Clinical Immunology. 2019; 143:245-257.e6.

Gimap5-dependent inactivation of GSK3 beta is required for CD4(+) T cell homeostasis and prevention of immune pathology. Patterson, AR; Endale, M; Lampe, K; Aksoylar, HI; Flagg, A; Woodgett, JR; Hildeman, D; Jordan, MB; Singh, H; Kucuk, Z; et al. Nature Communications. 2018; 9.

Hypogammaglobulinemia with decreased class-switched B-cells and dysregulated T-follicular-helper cells in IPEX syndrome. Shamriz, O; Patel, K; Marsh, RA; Bleesing, J; Joshi, AY; Lucas, L; Prince, C; Pencheva, BB; Kobrynski, L; Chandrakasan, S. Clinical Immunology. 2018; 197:219-223.