Jacob "Jack" J.H. Bleesing, MD, PhD

A photo of Jack Bleesing.

Co-Director, Diagnostic Immunology Laboratories

Associate Director, Immunodeficiency and Histiocytosis Program

Professor, UC Department of Pediatrics

513-517-2234

513-636-3549

Board Certified

About Me

Additional Languages

Dutch, German

Clinical Interests

Immunobiology; translational research; immunologic methods development

Research Interests

Clinical investigation of primary immunodeficiency disorders (with emphasis on disorders of immuno dysregulation and B-cell disorders); immuno-reconstitution following blood and marrow transplantation; diagnostic immunology (with emphasis on flow cytometry)

Academic Affiliation

Professor, UC Department of Pediatrics

Clinical Divisions

Cancer and Blood Diseases, Immune Deficiencies and Histiocytosis, Bone Marrow Transplantation BMT, Leukemia, Hemophagocytic lymphohistiocytosisHLH

My Education

MD: University of Leiden, Leiden, The Netherlands, 1989.

PhD: University of Leiden, Leiden, The Netherlands, 2002.

Residency: Pediatrics, University of Florida, Gainesville, Florida, 1993.

Fellowship: Allergy/Immunology, Duke University Medical Center, Durham, North Carolina, 1995.

Fellowship: Clinical Laboratory Immunology, National Institutes of Health, Bethesda, Maryland, 2001.

My Publications

Defective FAS-Mediated Apoptosis and Immune Dysregulation in Gaucher Disease. Miano, M; Madeo, A; Cappelli, E; Lanza, F; Lanza, T; Stroppiano, M; Terranova, P; Venè, R; Bleesing, JJ H; Di Rocco, M. Journal of Allergy and Clinical Immunology-In Practice. 2020; 8:3535-3542.

Successful response to treatment with sirolimus in pulmonary sarcoidosis. Gupta, N; Bleesing, JH; McCormack, FX. American Journal of Respiratory and Critical Care Medicine. 2020; 202:E119-E120.

CCR5 inhibitor as novel acute graft versus host disease prophylaxis in children and young adults undergoing allogeneic stem cell transplant: results of the phase II study. Khandelwal, P; Fukuda, T; Teusink-Cross, A; Kashuba, AD M; Lane, A; Mehta, PA; Marsh, RA; Jordan, MB; Grimley, MS; Myers, KC; et al. Bone Marrow Transplantation. 2020; 55:1552-1559.

Excellent outcomes following hematopoietic cell transplantation for Wiskott-Aldrich syndrome: A PIDTC report. Burroughs, LM; Petrovic, A; Brazauskas, R; Liu, X; Griffith, LM; Ochs, HD; Bleesing, JJ; Edwards, S; Dvorak, CC; Chaudhury, S; et al. Blood. 2020; 135:2094-2105.

Successful liver transplantation in short telomere syndromes without bone marrow failure due to DKC1 mutation. del Brio Castillo, R; Bleesing, J; McCormick, T; Squires, JE; Mazariegos, GV; Squires, J; McKiernan, PJ. Pediatric Transplantation. 2020; 24.

Complement blockade for TA-TMA: Lessons learned from a large pediatric cohort treated with eculizumab. Jodele, S; Dandoy, CE; Lane, A; Laskin, BL; Laskin, B; Teusink-Cross, A; Myers, KC; Wallace, G; Nelson, AS; Nelson, A; et al. Blood. 2020; 26:S138-S138.

The Value of Chromosome Analysis to Interrogate Variants in DNMT3B Causing Immunodeficiency, Centromeric Instability, and Facial Anomaly Syndrome Type I (ICF1). Kellner, ES; Rathbun, PA; Marshall, GS; Tolusso, LK; Smolarek, TA; Sun, M; Chandra, S; Bleesing, J; Marsh, RA. Journal of Clinical Immunology. 2019; 39:857-859.

Chronic Granulomatous Disease-Associated IBD Resolves and Does Not Adversely Impact Survival Following Allogeneic HCT. Marsh, RA; Leiding, JW; Logan, BR; Griffith, LM; Arnold, DE; Haddad, E; Falcone, EL; Yin, Z; Patel, K; Arbuckle, E; et al. Journal of Clinical Immunology. 2019; 39:653-667.

Current Flow Cytometric Assays for the Screening and Diagnosis of Primary HLH. Chiang, SC C; Bleesing, JJ; Marsh, RA. Frontiers in Immunology. 2019; 10.

Outcomes and Treatment Strategies for Autoimmunity and Hyperinflammation in Patients with RAG Deficiency. Farmer, JR; Foldvari, Z; Ujhazi, B; De Ravin, SS; Chen, K; Bleesing, JJ H; Schuetz, C; Al-Herz, W; Abraham, RS; Joshi, AY; et al. Journal of Allergy and Clinical Immunology-In Practice. 2019; 7:1970-1985.e4.