A photo of Andrew D. Hershey.

Endowed Chair and Director, Division of Neurology

Headache Medicine Specialist, Division of Neurology

Professor, UC Department of Pediatrics



Board Certified

My Biography & Research


As a pediatric neurologist and headache medicine specialist, I combine my clinical interests with my research interests. My clinical interests lie in improving the outcomes for children, adolescents and young adults with headaches, most of which are migraine. My research seeks to understand the clinical and biological characteristics of headaches in order to improve the outcomes of not only the patients and families we see, but of patients everywhere.

My PhD focused on the molecular biology of the Substance P receptor, a neuromodulator of pain pathways. My residency training was in neurology with a special emphasis on child neurology. Combining these two interests naturally led to the study of migraine in children, adolescents and young adults. My career was guided by several mentors along the way, with two of the foremost being Dr. James Krause, my PhD mentor, and Dr. Arthur Prensky, a founder of child neurology who had an interest in headaches.

At Cincinnati Children’s Headache Center, we use a multidisciplinary team approach that incorporates neurology, psychology and nursing to improve the outcomes of these children, adolescents and young adults. A foundation of this approach is a consistent goal of educating the patients on how to manage their disease. Our responsibility is to answer all their questions through a combination of research and education.

We are the only pediatric center in the United States to be recognized as an Advanstar Clinical Center of Excellence in Headache Medicine by Medical Economics. I have received the Seymour Solomon Award from the American Headache Society. I am on multiple national and international committees that have established the treatment and research guidelines for headache medicine.

Cincinnati Children's Headache Center was one of the five founding institutions for the United Council for Neurologic Subspecialties (UCNS)-certified headache medicine training and the only one of the five dedicated to children and adolescents. Our program has been funded consistently by the National Institutes of Health (NIH) since 2003, with our largest grant being $18 million for the Childhood and Adolescent Migraine prevention (CHAMP) study, as reported in New England Journal of Medicine.

Cincinnati Children's Headache Center is an international leader in the treatment, education and research of headaches in children, adolescents and young adults. Our goal is not only to provide the best possible care to our patients but also to help children around the world through our research and education.

Migraine is a genetic condition, but multiple genes contribute to the disease. This results in variable symptoms and risk factors. In our research, we are seeking better disease characterization and learning from our patients, which will help us tease apart these factors. We hope to ultimately improve the lives of our patients and families.

When I’m not helping patients or engaged in research, I like to be out in nature with my family. We enjoy walking, kayaking, hiking and golfing.

Clinical Interests

Headaches; migraines; neurogenetics; neurometabolic disorders

Research Interests

Epidemiology; diagnostic criteria; treatment evaluation; outcome responses; quality of life issues; pharmaceutical trials; and neurogenetics of childhood headaches

Academic Affiliation

Professor, UC Department of Pediatrics

Clinical Divisions

Neurology, Headache Medicine

Research Divisions


Blog Posts

Research from Cincinnati Children’s Leads to New Migraine Treatment Guidelines

Mind Brain Behavior

Research from Cincinnati Children’s Leads to New Migraine Treatment Guidelines

Andrew D. Hershey, MD, PhD, FAHS8/22/2019

CHAMP Study Challenges Medication-Driven Approach to Migraine Care

Mind Brain Behavior

CHAMP Study Challenges Medication-Driven Approach to Migraine Care

Andrew D. Hershey, MD, PhD, FAHS6/30/2019

My Locations

My Education

BS: University of Iowa, Iowa City, IA, 1985.

MD: Washington University, St. Louis, MO, 1992.

PhD: Washington University, St. Louis, MO, 1992.

Residency: St. Louis Childrens Hospital, St. Louis, MO, 1993-1994; Barnes-Jewish Hospital, St. Louis, MO,1994-1995.

Fellowship: St. Louis Childrens Hospital, St. Louis, MO, 1995-1997.

Certification: Neurology with special competence in child neurology, 1998, recertified 2008; Headache Medicine, 2006.

My Publications

Selected Publication

CGRP - The Next Frontier for Migraine. Hershey, AD. The New England journal of medicine. 2017; 377:2190-2191.

Trial of Amitriptyline, Topiramate, and Placebo for Pediatric Migraine. Powers, SW; Coffey, CS; Chamberlin, LA; Ecklund, DJ; Klingner, EA; Yankey, JW; Korbee, LL; Porter, LL; Hershey, AD; Investigators, CH A M P. The New England journal of medicine. 2017; 376:115-124.

The Development of the Medical Transfer Packet for Transition of Care of the Pediatric Patient with Headache. Orr, SL; Gelfand, AA; Hranilovich, J; Irwin, SL; Kabbouche, M; Lagman-Bartolome, AM; Lavell, C; O'Brien, HL; Rajapakse, T; Rao, R; et al. Headache. 2020; 60:2589-2591.

An update on acute and preventive treatments for migraine in children and adolescents. Rao, R; Hershey, AD. Expert Review of Neurotherapeutics: a key contribution to decision making in the treatment of neurologic and neuropsychiatric disorders. 2020; 20:1017-1027.

Clinic-based characterization of continuous headache in children and adolescents: Comparing youth with chronic migraine to those with new daily persistent headache. Reidy, BL; Riddle, EJ; Powers, SW; Slater, SK; Kacperski, J; Kabbouche, MA; Hershey, AD. Cephalalgia: an international journal of headache. 2020; 40:1063-1069.

Identification of neural and psychophysical predictors of headache reduction after cognitive behavioral therapy in adolescents with migraine. Nahman-Averbuch, H; Schneider, VJ; Chamberlin, LA; Kroon Van Diest, AM; Peugh, JL; Lee, GR; Radhakrishnan, R; Hershey, AD; Powers, SW; Coghill, RC; et al. Pain. 2020; Publish Ahead of Print.

Intravenous Migraine Treatment in Children and Adolescents. Werner, KG; Qaiser, S; Kabbouche, MA; Murphy, B; Maconochie, I; Hershey, AD. Current Pain and Headache Reports. 2020; 24.

Digital Therapeutic Self-Management Intervention in Adolescents With Migraine: Feasibility and Preliminary Efficacy of “Migraine Manager”. Hommel, KA; Carmody, J; Hershey, AD; Holbein, C; Kabbouche-Samaha, M; Peugh, J; Powers, S. Headache. 2020; 60:1103-1110.

Alterations in Brain Function After Cognitive Behavioral Therapy for Migraine in Children and Adolescents. Nahman-Averbuch, H; II, SV J; Chamberlin, LA; Van Diest, AM K; Peugh, JL; Lee, GR; Radhakrishnan, R; Hershey, AD; King, CD; Coghill, RC; et al. Headache. 2020; 60:1165-1182.

The Profile and Prognosis of Youth With Status Migrainosus: Results From an Observational Study. Orr, SL; Turner, A; Kabbouche, MA; Horn, PS; O'Brien, HL; Kacperski, J; LeCates, S; White, S; Weberding, J; Miller, MN; et al. Headache. 2020; 60:878-888.