A photo of Ashish Kumar.

Ashish R. Kumar, MD, PhD


  • Director, Histiocytosis Center
  • Director, Hematology/Oncology Fellowship Program
  • Professor, UC Department of Pediatrics
I try to individualize my delivery of information and care to each patient and their family, while maintaining a high quality of care and treatment.

About

Biography

I've always been fascinated by nature and science. Diseases of the blood and immune system have been called "experiments of nature," which have led to a better understanding of natural biology itself.

As a pediatric hematologist/oncologist, I specialize in histiocyte disorders, primary immune deficiency diseases and bone marrow transplantation. Working with children who have these disorders has provided me valuable lessons about life and medicine. In my practice, I try to individualize my delivery of information and care to each patient and their family, while maintaining a high quality of care and treatment.

Based on research and experience, we have completely changed our approach to treatment for diseases like Langerhans cell histiocytosis (LCH), where we don't use chemotherapy at all. Instead, novel oral inhibitors have revolutionized the outcomes for patients with this condition. We also have a different way of diagnosing patients with hemophagocytic lymphohistiocytosis (HLH), which has resulted in improved outcomes.

In my research, my colleagues and I are looking at two childhood diseases: LCH and infant leukemia. With newer therapies, we have improved outcomes of patients with LCH. However, we still don't have a cure, which would relieve patients of the need to take medications. Infant leukemia remains a largely incurable disease. We are studying the biology of LCH and infant leukemia in the laboratory to develop novel therapies.

One of my most significant honors was participating in the 700 Miles to Hope bike ride, where I rode my bicycle 700 miles over seven days with families of patients affected by HLH. The goal was to raise awareness and funds for HLH research and care, but it ended up doing much more. I learned and discovered so much about people and myself and made many long-lasting friendships.

In my free time, I enjoy traveling, hiking and cooking. I love music, although the only instrument I can play is the air guitar.

Additional Languages

Hindi

Insurance Information

Cincinnati Children's strives to accept a wide variety of health plans. Please contact your health insurance carrier to verify coverage for your specific benefit plan.

View Insurance Information

Publications

Selected

Discrepancies between F-18-FDG PET/CT findings and conventional imaging in Langerhans cell histiocytosis. Ferrell, J; Sharp, S; Kumar, A; Jordan, M; Picarsic, J; Nelson, A. Pediatric Blood and Cancer. 2021; 68.

Selected

High-risk LCH in infants is serially transplantable in a xenograft model but responds durably to targeted therapy. Lee, LH; Krupski, C; Clark, J; Wunderlich, M; Lorsbach, RB; Grimley, MS; Burwinkel, M; Nelson, A; Kumar, AR. Blood Advances. 2020; 4:717-727.

Selected

Challenges in the diagnosis of hemophagocytic lymphohistiocytosis: Recommendations from the North American Consortium for Histiocytosis (NACHO). Jordan, MB; Allen, CE; Greenberg, J; Henry, M; Hermiston, ML; Kumar, A; Hines, M; Eckstein, O; Ladisch, S; Nichols, KE; et al. Pediatric Blood and Cancer. 2019; 66.

Selected

Recommendations for the management of hemophagocytic lymphohistiocytosis in adults. La Rosee, P; Horne, A; Hines, M; Greenwood, TV B; Machowicz, R; Berliner, N; Birndt, S; Gil-Herrera, J; Girschikofsky, M; Jordan, MB; et al. Blood. 2019; 133:2465-2477.

Selected

Limitations of HLH-2004 criteria in distinguishing malignancy-associated hemophagocytic lymphohistiocytosis. Gurunathan, A; Boucher, AA; Mark, M; Prus, KM; O'Brien, MM; Breese, EH; Mizukawa, BE; Absalon, MJ; Nelson, AS; Jordan, MB; et al. Pediatric Blood and Cancer. 2018; 65.

Selected

Real-time genomic profiling of histiocytoses identifies early-kinase domain BRAF alterations while improving treatment outcomes. Lee, LH; Gasilina, A; Roychoudhury, J; McCormack, FX; Pressey, J; Grimley, MS; Lorsbach, R; Ali, S; Bailey, M; Stephens, P; et al. JCI insight. 2017; 2.

LAMP-5 is an essential inflammatory-signaling regulator and novel immunotherapy target for mixed lineage leukemia-rearranged acute leukemia. Gracia-Maldonado, G; Clark, J; Burwinkel, M; Greenslade, B; Wunderlich, M; Salomonis, N; Leone, D; Gatti, E; Pierre, P; Kumar, AR; et al. Haematologica. 2022; 107:803-815.

Ruxolitinib for the Treatment of Chronic GVHD and Overlap Syndrome in Children and Young Adults. Wang, YZ M; Teusink-Cross, A; Elborai, Y; Krupski, MC; Nelson, AS; Grimley, MS; Flannery, A; Mehta, PA; Bleesing, JJ; Chandra, S; et al. Transplantation. 2022; 106:412-419.

ALK-positive histiocytosis: a new clinicopathologic spectrum highlighting neurologic involvement and responses to ALK inhibition. Kemps, PG; Picarsic, J; Durham, BH; Hélias-Rodzewicz, Z; Hiemcke-Jiwa, L; van den Bos, C; van de Wetering, MD; van Noesel, CJ M; van Laar, JA M; Verdijk, RM; et al. Blood. 2022; 139:256-280.

Reduced-Intensity/Reduced-Toxicity Conditioning Approaches Are Tolerated in XIAP Deficiency but Patients Fare Poorly with Acute GVHD. Arnold, DE; Nofal, R; Wakefield, C; Lehmberg, K; Wustrau, K; Albert, MH; Morris, EC; Heimall, JR; Bunin, NJ; Kumar, A; et al. Journal of Clinical Immunology. 2022; 42:36-45.

From the Blog


A Ride For HLH Research
BlogRare and Complex Conditions

A Ride For HLH Research

By Ashish Kumar, MD, PhD1/17/2019

A Message from Dr. Kumar – Learn about HLH, Become a Donor
BlogRare and Complex Conditions

A Message from Dr. Kumar – Learn about HLH, Become a Donor

By Ashish Kumar, MD, PhD9/23/2016

Patient Ratings and Comments

All patient satisfaction ratings and comments are submitted by actual patients and verified by a leading independent patient satisfaction company, NRC Health. Patient identities are withheld to ensure confidentiality and privacy. Only those providers whose satisfaction surveys are administered through Cincinnati Children’s Hospital Medical Center are displayed. Click here to learn more about our survey