A photo of Gregory Tiao.

Director, Division of General and Thoracic Surgery

Frederick C. Ryckman Chair in Pediatric Surgery

Surgical Director, Liver Transplantation

Associate Director, Pediatric Surgery Fellowship

Professor, UC Department of SurgeryUC Department of Pediatrics

513-636-4371

513-636-7657

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My Biography & Research

Biography

As a pediatric surgeon and a transplant surgeon, Dr. Tiao is involved in the care of children afflicted with biliary atresia from the time of presentation and diagnosis to the initial Kasai portoenterostomy to the liver transplant, when necessary. He sees the many challenges children and their families experience when diagnosed with this life threatening disease process. From that perspective, defining the basis of this disease process such that therapeutic strategies can be developed eliminating these complex interventions is his career goal. His short term goal is to develop an independent research laboratory investigating the pathogenesis of virus induced biliary atresia specifically seeking to determine the mechanistic basis of this disease so that new treatment strategies can be developed to salvage the native liver. 

Dr. Tiao's overarching hypothesis is that biliary atresia results from the infection of cholangiocytes by a virus triggering immune-mediated biliary obstruction. His focus is to determine the mechanisms used by RRV to infect cholangiocytes, how RRV undergoes replication within the cholangiocyte, and how infected cholangiocytes modify the microenvironment, activating the immune system resulting in biliary obstruction. Determination of the mechanistic basis of these inter-related events is essential to understanding the pathogenesis of virus induced BA. By focusing on the basis for the viral insult in the initiation of biliary atresia, he has defined an area of independence from Dr. Jorge Bezerra, his primary research mentor. 

Additional Languages

Mandarin

Clinical Interests

Biliary atresia

Academic Affiliation

Professor, UC Department of SurgeryUC Department of Pediatrics

Departments

Colorectal Disorders, Liver Care, Kidney Transplant, End-Stage Renal Disease, Liver Tumor, Intestinal Disorders, Neurogastroenterology and Motility Disorders, Surgery - General and Thoracic, Pancreas Care, Liver Transplant, Fontan Management, General and Thoracic Surgery

My Locations

My Education

BS: Northwestern University, Evanston, IL, 1986.

MD: University of Illinois, Chicago, IL, 1990.

Residency: Loyola University, Maywood, IL, 1991-1992; Senior Resident, Department of Surgery, University of Cincinnati, Cincinnati, OH, 1995-1997; Chief Resident, Department of Surgery, University of Cincinnati, Cincinnati, OH, 1997-1998.

Fellowships: Research Fellow, University of Cincinnati, Cincinnati, OH, 1992-1995; Transplant Surgery Fellow, University of Cincinnati, Cincinnati, OH, 2000-2002; Pediatric Surgery Fellow, Los Angeles Children's Hospital, Los Angeles, CA, 1998-2000.

Certification: Pediatric Surgeon, 2000; Transplant Surgeon, 2002.

My Publications

Prospective Assessment of Ultrasound Shear Wave Elastography for Discriminating Biliary Atresia from other Causes of Neonatal Cholestasis. Dillman, JR; DiPaola, FW; Smith, SJ; Barth, RA; Asai, A; Lam, S; Campbell, KM; Bezerra, JA; Tiao, GM; Trout, AT. The Journal of Pediatrics. 2019; 212:60-65.e3.

Is anuria prior to pediatric renal transplantation associated with poor allograft outcomes?. Alam, Z; VanderBrink, BA; Brewer, N; Hooper, D; Tiao, G; Alonso, M; Nathan, J; DeFoor, WR; Sheldon, C; Reddy, PP. Pediatric Transplantation. 2019; 23.

Esophageal dysmotility: An intrinsic feature of megacystis, microcolon, hypoperistalsis syndrome (MMIHS). Kocoshis, SA; Goldschmidt, ML; Nathan, JD; El-Chammas, KI; Bondoc, AJ; Tiao, GM; Alonso, MH; Ubesie, AC; Cole, CR; Kaul, A. Journal of Pediatric Surgery. 2019; 54:1303-1307.

Transarterial radioembolization with yttrium-90 of unresectable primary hepatic malignancy in children. Aguado, A; Ristagno, R; Towbin, AJ; Gupta, A; Haberle, S; Qi, Z; Patel, MN; Kukreja, KU; Tiao, GM; Geller, JI. Pediatric Blood and Cancer. 2019; 66:e27510-e27510.

Surgical and anesthetic management for hepatectomy in two pediatric patients with trisomy 18, pulmonary hypertension, and hepatoblastoma. Lucas, DJ; Rubinstein, J; Gosain, A; Tiao, G; Heads, T; Pratap, JN; Williams, R; Helmig, S; Geller, J; Langham, M; et al. Pediatric Blood and Cancer. 2019; 66:e27678-e27678.

Minimal adjuvant chemotherapy for children with hepatoblastoma resected at diagnosis (AHEP0731): a Children's Oncology Group, multicentre, phase 3 trial. Katzenstein, HM D; Langham, MR; Malogolowkin, MH; Krailo, MD; Towbin, AJ; McCarville, MB; Finegold, MJ; Ranganathan, S; Dunn, S; McGahren, ED; et al. The Lancet Oncology. 2019; 20:719-727.

Dose modifications and pharmacokinetics of adjuvant cisplatin monotherapy while on hemodialysis for patients with hepatoblastoma. Boucher, AA; Mizuno, T; Vinks, AA; Goldstein, SL; Tiao, GM; Geller, JI. Pediatric Blood and Cancer. 2019; 66:e27425-e27425.

A rotavirus-induced mouse model to study biliary atresia and neonatal cholestasis. Mohanty, SK; Donnelly, B; Temple, H; Tiao, GM. Methods in molecular biology (Clifton, N.J.). 2019; 1981:259-271.

Hepatoblastoma-The Evolution of Biology, Surgery, and Transplantation. Lim, II P; Bondoc, AJ; Geller, JI; Tiao, GM. Children. 2018; 6:1-1.

Mechanisms of concanavalin A-induced cytokine synthesis by hepatic stellate cells: Distinct roles of interferon regulatory factor-1 in liver injury. Rani, R; Kumar, S; Sharma, A; Mohanty, SK; Donnelly, B; Tiao, GM; Gandhi, CR. The Journal of biological chemistry. 2018; 293:18466-18476.