A photo of Gregory Tiao.

Director, Division of General and Thoracic Surgery

Frederick C. Ryckman Chair in Pediatric Surgery

Surgical Director, Liver Transplantation

Associate Director, Pediatric Surgery Fellowship

Professor, UC Department of SurgeryUC Department of Pediatrics

513-636-4371

513-636-7657

Board Certified

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My Biography & Research

Biography

As a pediatric surgeon and a transplant surgeon, Dr. Tiao is involved in the care of children afflicted with biliary atresia from the time of presentation and diagnosis to the initial Kasai portoenterostomy to the liver transplant, when necessary. He sees the many challenges children and their families experience when diagnosed with this life threatening disease process. From that perspective, defining the basis of this disease process such that therapeutic strategies can be developed eliminating these complex interventions is his career goal. His short term goal is to develop an independent research laboratory investigating the pathogenesis of virus induced biliary atresia specifically seeking to determine the mechanistic basis of this disease so that new treatment strategies can be developed to salvage the native liver. 

Dr. Tiao's overarching hypothesis is that biliary atresia results from the infection of cholangiocytes by a virus triggering immune-mediated biliary obstruction. His focus is to determine the mechanisms used by RRV to infect cholangiocytes, how RRV undergoes replication within the cholangiocyte, and how infected cholangiocytes modify the microenvironment, activating the immune system resulting in biliary obstruction. Determination of the mechanistic basis of these inter-related events is essential to understanding the pathogenesis of virus induced BA. By focusing on the basis for the viral insult in the initiation of biliary atresia, he has defined an area of independence from Dr. Jorge Bezerra, his primary research mentor. 

Additional Languages

Mandarin

Clinical Interests

Biliary atresia

Academic Affiliation

Professor, UC Department of SurgeryUC Department of Pediatrics

Departments

Colorectal Disorders, General and Thoracic Surgery, Liver Care, Kidney Transplant, End-Stage Renal Disease, Liver Tumor, Intestinal Disorders, Neurogastroenterology and Motility Disorders, Surgery - General and Thoracic, Pancreas Care, Liver Transplant, Best Doctors, Fontan Management

My Locations

My Education

BS: Northwestern University, Evanston, IL, 1986.

MD: University of Illinois, Chicago, IL, 1990.

Residency: Loyola University, Maywood, IL, 1991-1992; Senior Resident, Department of Surgery, University of Cincinnati, Cincinnati, OH, 1995-1997; Chief Resident, Department of Surgery, University of Cincinnati, Cincinnati, OH, 1997-1998.

Fellowships: Research Fellow, University of Cincinnati, Cincinnati, OH, 1992-1995; Transplant Surgery Fellow, University of Cincinnati, Cincinnati, OH, 2000-2002; Pediatric Surgery Fellow, Los Angeles Children's Hospital, Los Angeles, CA, 1998-2000.

Certification: Pediatric Surgeon, 2000; Transplant Surgeon, 2002.

My Publications

Boucher AA, Mizuno T, Vinks AA, Goldstein SL, Tiao GM, Geller JI. Dose modifications and pharmacokinetics of adjuvant cisplatin monotherapy while on hemodialysis for patients with hepatoblastoma. Pediatric Blood & Cancer. 2019;66(1).

Aguado A, Ristagno R, Towbin AJ, Gupta A, Haberle S, Qi Z, Patel MN, Kukreja KU, Tiao GM, Geller JI. Transarterial radioembolization with yttrium-90 of unresectable primary hepatic malignancy in children. Pediatr Blood Cancer. 2018 Nov.

Dunn S, Tiao G, Langham M, McGahren E, Weldon C, Towbin A, Meyer R. Liver Transplant in Upfront Unresectable, Non-Metastatic Hepatoblastoma. Pediatric Blood & Cancer. 2018;65:S13.

Rani R, Kumar S, Sharma A, Mohanty SK, Donnelly B, Tiao GM, Gandhi CR. Mechanisms of concanavalin A-induced cytokine synthesis by hepatic stellate cells: Distinct roles of interferon regulatory factor-1 in liver injury. Journal of Biological Chemistry. 2018;293(48):18466-18476.

D'Souza AM, Shah R, Gupta A, Towbin AJ, Alonso M, Nathan JD, Geller JI. Surgical management of children and adolescents with upfront completely resected hepatocellular carcinoma. Pediatric Blood & Cancer. 2018;65(11).

Ng VL, Sorensen LG, Alonso EM, Fredericks EM, Ye W, Moore J, Karpen SJ, Shneider BL, Molleston JP, Bezerra JA, Murray KF, Loomes KM, Rosenthal P, Squires RH, Wang K, Arnon R, Schwarz KB, Turmelle YP, Haber BH, Sherker AH, Magee JC, Sokol RJ. Childhood Liver Disease Research Network (Heubi JE, Miethke AG, Tiao G). Neurodevelopmental Outcome of Young Children with Biliary Atresia and Native Liver: Results from the ChiLDReN Study. J Pediatr. 2018.

Shneider BL, Spino C, Kamath BM, Magee JC, Bass LM, Setchell KD, Miethke A, Molleston JP, Mack CL, Squires RH, Murray KF, Loomes KM, Rosenthal P, Karpen SJ, Leung DH, Guthery LS, Thomas D, Sherker AH, Sokol RJ. Childhood Liver Disease Research Network (Bezerra JA, Heubi JE, Palermo JJ, Tiao G). Placebo-Controlled Randomized Trial of an intestinal Bile Salt Transport Inhibitor for Pruritus in Alagille Syndrome. Hepatol Commun. 2018;2:1184-1198.

Lobeck IN, Bondoc A, Nolan H, Frischer JS, Campbell KM, Ryan TD, Goldstein L, Nathan JD, Alonso MH, Tiao GM. Extracorporeal Membrane Oxygenation in a Patient with Biliary Atresia: Case and Review of Extracorporeal Life Support Organization Data. ASAIO Journal. 2018 Nov/Dec;64(6).

Goldstein B, Tiao G, Alonso M, Johnson N, Heubi J, Averin K, Bucuvalas J. Transcatheter Relief of Symptomatic Hepatic Venous Outflow Obstruction Following Pediatric Liver Transplantation. American Journal of Transplantation. 2017;17:606.

Wang KS, Tiao G, Bass LM, Hertel PM, Mogul D, Kerkar N, Clifton M, Azen C, Bull L, Rosenthal P, Stewart D, Superina R, Arnon R, Bozic M, Brandt ML, Dillon PA, Fecteau A, Iyer K, Kamath B, Karpen S, Karrer F, Loomes KM, Mack C, Mattei P, Miethke A, Soltys K, Turmelle YP, West K, Zagory J, Goodhue C, Shneider BL; Childhood Liver Disease Research Network (ChilDReN). Analysis of surgical interruption of the enterohepatic circulation as a treatment for pediatric cholestasis. Hepatology. 2017 May;65(5):1645-1654.