2016 Research Annual Report
Pathology and Laboratory Medicine

Fig A:  Correlation between urinary concentrations of total 3β -sulfooxy-Δ5-cholen-24-oic acids measured by LC-ESIMS/MS with the concentrations determined by a scoring after FAB-MS analysis for a selection of urine samples from 10 patients with HSD3B7 deficiency before and during bile acid therapy with cholic acid (n=10) and noncholestatic controls (n=5).

Pathology and Laboratory Medicine

Featured Research

Glycocholic Acid Proves Effective Against Newly Identified Amidation Defect

On a regular basis, courier trucks deliver urine samples from around the world to Cincinnati Children’s Mass Spectrometry Lab to be analyzed for signs of cholestatic liver disease caused by genetic defects in bile acid conjugation.

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Division Summary

Research and Training Details
Faculty 21
Research Fellows and Post Docs 4
Total Annual Grant Award Dollars $1,187,121
Total Annual Industry Award Dollars $138,506
Total Publications 76
Clinical Activities and Training
Staff Physicians 1
Clinical Fellows 1