Fig A:  Correlation between urinary concentrations of total 3β -sulfooxy-Δ5-cholen-24-oic acids measured by LC-ESIMS/MS with the concentrations determined by a scoring after FAB-MS analysis for a selection of urine samples from 10 patients with HSD3B7 deficiency before and during bile acid therapy with cholic acid (n=10) and noncholestatic controls (n=5).

Pathology and Laboratory Medicine

Featured Research

Glycocholic Acid Proves Effective Against Newly Identified Amidation Defect

On a regular basis, courier trucks deliver urine samples from around the world to Cincinnati Children’s Mass Spectrometry Lab to be analyzed for signs of cholestatic liver disease caused by genetic defects in bile acid conjugation.

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Research and Training Details

Faculty21
Research Fellows and Post Docs4
Total Annual Grant Award Dollars$1,187,121
Total Annual Industry Award Dollars$138,506
Total Publications76

Clinical Activities and Training

Staff Physicians1
Clinical Fellows1