Rothenberg CURED Lab

Publications from the Rothenberg Lab

These journal article publications are the culmination of our research projects, steps forward in our understanding of biological and diseases processes, a sharing of our findings with others, and a basis for further research.

These steps forward would not be possible without the generous support of many foundations and agencies, such as the Campaign Urging Research for Eosinophilic Disease (CURED) and the National Institutes of Health (NIH).

Publications

Selected Publications

Wen, T; Aronow, BJ; Rochman, Y; Rochman, M; Kiran, KC; Dexheimer, PJ; Putnam, P; Mukkada, V; Foote, H; Rehn, K; et al. Single-cell RNA sequencing identifies inflammatory tissue T cells in eosinophilic esophagitis. Journal of Clinical Investigation. 2019; 129:2014-2028.

Travers, J; Rochman, M; Miracle, CE; Habel, JE; Brusilovsky, M; Caldwell, JM; Rymer, JK; Rothenberg, ME. Chromatin regulates IL-33 release and extracellular cytokine activity. Nature Communications. 2018; 9.

Shoda, T; Wen, T; Aceves, SS; Abonia, JP; Atkins, D; Bonis, PA; Caldwell, JM; Capocelli, KE; Carpenter, CL; Collins, MH; et al. Eosinophilic oesophagitis endotype classification by molecular, clinical, and histopathological analyses: a cross-sectional study. The Lancet Gastroenterology and Hepatology. 2018; 3:477-488.

Azouz, NP; Ynga-Durand, MA; Caldwell, JM; Jain, A; Rochman, M; Fischesser, DM; Ray, LM; Bedard, MC; Mingler, MK; Forney, C; et al. The antiprotease SPINK7 serves as an inhibitory checkpoint for esophageal epithelial inflammatory responses. Science Translational Medicine. 2018; 10:eaap9736-eaap9736.

Martin, LJ; He, H; Collins, MH; Abonia, JP; Myers, JM B; Eby, M; Johansson, H; Kottyan, LC; Hershey, GK K; Rothenberg, ME. Eosinophilic esophagitis (EoE) genetic susceptibility is mediated by synergistic interactions between EoE-specific and general atopic disease loci. Journal of Allergy and Clinical Immunology. 2018; 141:1690-1698.

Caldwell, JM; Collins, MH; Kemme, KA; Sherrill, JD; Wen, T; Rochman, M; Stucke, EM; Amin, L; Tai, H; Putnam, PE; et al. Cadherin 26 is an alpha integrin-binding epithelial receptor regulated during allergic inflammation. Mucosal Immunology. 2017; 10:1190-1201.

Davis, BP; Stucke, EM; Khorki, ME; Litosh, VA; Rymer, JK; Rochman, M; Travers, J; Kottyan, LC; Rothenberg, ME. Eosinophilic esophagitis-linked calpain 14 is an IL-13-induced protease that mediates esophageal epithelial barrier impairment. JCI insight. 2016; 1.

Kottyan, LC; Davis, BP; Sherrill, JD; Liu, K; Rochman, M; Kaufman, K; Weirauch, MT; Vaughn, S; Lazaro, S; Rupert, AM; et al. Genome-wide association analysis of eosinophilic esophagitis provides insight into the tissue specificity of this allergic disease. Nature Genetics. 2014; 46:895-900.

Wen, T; Stucke, EM; Grotjan, TM; Kemme, KA; Abonia, JP; Putnam, PE; Franciosi, JP; Garza, JM; Kaul, A; King, EC; et al. Molecular Diagnosis of Eosinophilic Esophagitis by Gene Expression Profiling. Gastroenterology. 2013; 145:1289-1299.

2020

Chiang, AW T; Duong, LD; Shoda, T; Nhu, QM; Ruffner, M; Hara, T; Aaron, B; Joplin, E; Manresa, M; Abonia, JP; et al. Type 2 Immunity and Age Modify Gene Expression of COVID19 Receptors in Eosinophilic Gastrointestinal Disorders. Journal of Pediatric Gastroenterology and Nutrition. 2020; Publish Ahead of Print.

Roufosse, F; Kahn, JE; Rothenberg, ME; Wardlaw, AJ; Klion, AD; Kirby, SY; Gilson, MJ; Bentley, JH; Bradford, ES; Yancey, SW; et al. Efficacy and safety of mepolizumab in hypereosinophilic syndrome: A phase III, randomized, placebo-controlled trial. Journal of Allergy and Clinical Immunology. 2020; 146:1397-1405.

Rothenberg, ME. Transferring allergies in the womb. Science. 2020; 370:907-908.

Dellon, ES; Peterson, KA; Murray, JA; Falk, GW; Gonsalves, N; Chehade, M; Genta, RM; Leung, J; Khoury, P; Klion, AD; et al. Anti-siglec-8 antibody for eosinophilic gastritis and duodenitis. The New England journal of medicine. 2020; 383:1624-1634.

Azouz, NP; Klingler, AM; Callahan, V; Akhrymuk, IV; Elez, K; Raich, L; Henry, BM; Benoit, JL; Benoit, SW; Noé, F; et al. Alpha 1 Antitrypsin is an Inhibitor of the SARS-CoV-2-Priming Protease TMPRSS2. 2020.

Ben Baruch-Morgenstern, N; Rochman, M; Rothenberg, ME. Pumping mast cells out of allergic inflammation—are proton pump inhibitors taking center stage?. Journal of Allergy and Clinical Immunology. 2020; 146:783-785.

Jensen, ET; Aceves, SS; Bonis, PA; Bray, K; Book, W; Chehade, M; Collins, MH; Dellon, ES; Falk, GW; Gonsalves, N; et al. High Patient Disease Burden in a Cross-sectional, Multicenter Contact Registry Study of Eosinophilic Gastrointestinal Diseases. Journal of Pediatric Gastroenterology and Nutrition. 2020; 71:524-529.

Pesek, RD; Reed, CC; Collins, MH; Muir, AB; Fulkerson, PC; Menard-Katcher, C; Falk, GW; Kuhl, J; Magier, AZ; Ahmed, FN; et al. Association Between Endoscopic and Histologic Findings in a Multicenter Retrospective Cohort of Patients with Non-esophageal Eosinophilic Gastrointestinal Disorders. Digestive Diseases and Sciences. 2020; 65:2024-2035.

Lindsley, AW; Schwartz, JT; Rothenberg, ME. Eosinophil responses during COVID-19 infections and coronavirus vaccination. Journal of Allergy and Clinical Immunology. 2020; 146:1-7.

Brusilovsky, M; Rochman, M; Azouz, NP; Mack, LE; Rothenberg, ME. Uncovering the secretes of allergic inflammation. Journal of Clinical Investigation. 2020; 130:3419-3421.

Dunn, JL M; Shoda, T; Caldwell, JM; Wen, T; Aceves, SS; Collins, MH; Dellon, ES; Falk, GW; Leung, J; Martin, LJ; et al. Esophageal type 2 cytokine expression heterogeneity in eosinophilic esophagitis in a multisite cohort. Journal of Allergy and Clinical Immunology. 2020; 145:1629-1640.e4.

Azouz, NP; Klingler, AM; Pathre, P; Besse, JA; Ben Baruch-Morgenstern, N; Ballaban, AY; Osswald, GA; Brusilovsky, M; Habel, JE; Caldwell, JM; et al. Functional role of kallikrein 5 and proteinase-activated receptor 2 in eosinophilic esophagitis. Science Translational Medicine. 2020; 12:eaaz7773-eaaz7773.

Collins, MH; Martin, LJ; Wen, T; Abonia, JP; Putnam, PE; Mukkada, VA; Rothenberg, ME. Eosinophilic Esophagitis Histology Remission Score: Significant Relations to Measures of Disease Activity and Symptoms. Journal of Pediatric Gastroenterology and Nutrition. 2020; 70:598-603.

Oliva, S; Azouz, NP; Stronati, L; Rothenberg, ME. Recent advances in potential targets for eosinophilic esophagitis treatments. Expert Review of Clinical Immunology. 2020; 16:421-428.

Henderson, A; Magier, A; Schwartz, JT; Martin, LJ; Collins, MH; Putnam, PE; Mukkada, VA; Abonia, JP; Rothenberg, ME; Fulkerson, PC. Monitoring Eosinophilic Esophagitis Disease Activity With Blood Eosinophil Progenitor Levels. Journal of Pediatric Gastroenterology and Nutrition. 2020; 70:482-488.

Applequist, J; Burroughs, C; Jr, RA; Merkel, PA; Rothenberg, ME; Trapnell, B; Desnick, RJ; Sahin, M; Krischer, JP. A novel approach to conducting clinical trials in the community setting: Utilizing patient-driven platforms and social media to drive web-based patient recruitment. BMC Medical Research Methodology. 2020; 20.

Bitton, A; Avlas, S; Reichman, H; Itan, M; Karo-Atar, D; Azouz, NP; Rozenberg, P; Diesendruck, Y; Nahary, L; Rothenberg, ME; et al. A key role for IL-13 signaling via the type 2 IL-4 receptor in experimental atopic dermatitis. Science Immunology. 2020; 5:eaaw2938-eaaw2938.

Hirano, I; Dellon, ES; Hamilton, JD; Collins, MH; Peterson, K; Chehade, M; Schoepfer, AM; Safroneeva, E; Rothenberg, ME; Falk, GW; et al. Efficacy of Dupilumab in a Phase 2 Randomized Trial of Adults With Active Eosinophilic Esophagitis. Gastroenterology. 2020; 158:111-122.e10.

Vanoni, S; Zeng, C; Marella, S; Uddin, J; Wu, D; Arora, K; Ptaschinski, C; Que, J; Noah, T; Waggoner, L; et al. Identification of anoctamin 1 (ANO1) as a key driver of esophageal epithelial proliferation in eosinophilic esophagitis. Journal of Allergy and Clinical Immunology. 2020; 145:239-254.e2.

Pesek, RD; Rothenberg, ME. Eosinophilic gastrointestinal disease below the belt. Journal of Allergy and Clinical Immunology. 2020; 145:87-89.e1.

Shoda, T; Wen, T; Caldwell, JM; Collins, MH; Besse, JA; Osswald, GA; Abonia, JP; Arva, NC; MDd, DA; Capocelli, KE; et al. Molecular, endoscopic, histologic, and circulating biomarker-based diagnosis of eosinophilic gastritis: Multi-site study. Journal of Allergy and Clinical Immunology. 2020; 145:255-269.

Aceves, S; Collins, MH; Rothenberg, ME; Furuta, GT; Gonsalves, N; Abonia, JP; Almonte, S; Andrews, R; Arrington, A; Arva, N; et al. Advancing patient care through the Consortium of Eosinophilic Gastrointestinal Disease Researchers (CEGIR). Journal of Allergy and Clinical Immunology. 2020; 145:28-37.

Kottyan, LC; Parameswaran, S; Weirauch, MT; Rothenberg, ME; Martin, LJ. The genetic etiology of eosinophilic esophagitis. Journal of Allergy and Clinical Immunology. 2020; 145:9-15.

2019

Kurten, RC; Rawson, R; Shoda, T; Duong, LD; Adejumobi, D; Levy, R; Newbury, RO; Rothenberg, ME; Akuthota, P; Wright, BL; et al. Development and Application of a Functional Human Esophageal Mucosa Explant Platform to Eosinophilic Esophagitis. Scientific Reports. 2019; 9.

Klion, AD; Rothenberg, ME. Advances in eosinophilic diseases in 2018. Journal of Allergy and Clinical Immunology. 2019; 144:1490-1494.

Doucet-Ladeveze, R; Holvoet, S; Raymond, F; Foata, F; Hershey, GK K; Sherrill, JD; Rothenberg, ME; Blanchard, C. Transcriptomic Analysis Links Eosinophilic Esophagitis and Atopic Dermatitis. Frontiers in Pediatrics. 2019; 7.

Wen, T; Rothenberg, ME. Cell-by-cell deciphering of T cells in allergic inflammation. Journal of Allergy and Clinical Immunology. 2019; 144:1143-1149.

Lyles, J; Rothenberg, M. Role of genetics, environment, and their interactions in the pathogenesis of eosinophilic esophagitis. Current Opinion in Immunology. 2019; 60:46-53.

Muir, AB; Jensen, ET; Wechsler, JB; Menard-Katcher, P; Falk, GW; Aceves, SS; Furuta, GT; Dellon, ES; Rothenberg, ME; Spergel, JM. Overestimation of the diagnosis of eosinophilic colitis with reliance on billing codes. Journal of Allergy and Clinical Immunology-In Practice. 2019; 7:2434-2436.

Ben Baruch-Morgenstern, N; Shoda, T; Rothenberg, ME. Bagels and LOX in patients with eosinophilic esophagitis. Journal of Allergy and Clinical Immunology. 2019; 144:41-43.

Wheeler, JC; Vanoni, S; Zeng, C; Waggoner, L; Yang, Y; Wu, D; Uddin, J; Karns, R; Kottyan, L; Mukkada, V; et al. 17 beta-Estradiol protects the esophageal epithelium from IL-13-induced barrier dysfunction and remodeling. Journal of Allergy and Clinical Immunology. 2019; 143:2131-2146.

Pesek, RD; Reed, CC; Muir, AB; Fulkerson, PC; Menard-Katcher, C; Falk, GW; Kuhl, J; Martin, EK; Magier, AZ; Ahmed, F; et al. Increasing Rates of Diagnosis, Substantial Co-Occurrence, and Variable Treatment Patterns of Eosinophilic Gastritis, Gastroenteritis, and Colitis Based on 10-Year Data Across a Multicenter Consortium. The American Journal of Gastroenterology (Elsevier). 2019; 114:984-994.

DiTommaso, LA; Rosenberg, CE; Eby, MD; Tasco, A; Collins, MH; Lyles, JL; Putnam, PE; Mukkada, VA; Rothenberg, ME. Prevalence of eosinophilic colitis and the diagnoses associated with colonic eosinophilia. Journal of Allergy and Clinical Immunology. 2019; 143:1928-1930.e3.

Kottyan, LC; Maddox, A; Braxton, JR; Stucke, EM; Mukkada, V; Putnam, PE; Abonia, JP; Chehade, M; Wood, RA; Pesek, RD; et al. Genetic variants at the 16p13 locus confer risk for eosinophilic esophagitis. Genes and Immunity. 2019; 20:281-292.

Krishnan, U; Lijuan, C; Andrew, GJ; Rothenberg, ME; Wen, T. Analysis of eosinophilic esophagitis in children with repaired congenital esophageal atresia. Journal of Allergy and Clinical Immunology. 2019; 143:1455-1464.e2.

Azouz, NP; Rothenberg, ME. Mechanisms of gastrointestinal allergic disorders. Journal of Clinical Investigation. 2019; 129:1419-1430.

Miller, DE; Forney, C; Rochman, M; Cranert, S; Habel, J; Rymer, J; Lynch, A; Schroeder, C; Lee, J; Sauder, A; et al. Genetic, Inflammatory, and Epithelial Cell Differentiation Factors Control Expression of Human Calpain-14. G3-Genes Genomes Genetics. 2019; 9:g3.200901.2018-g3.200901.2018.

Schwartz, JT; Morris, DW; Collins, MH; Rothenberg, ME; Fulkerson, PC. Eosinophil progenitor levels correlate with tissue pathology in pediatric eosinophilic esophagitis. Journal of Allergy and Clinical Immunology. 2019; 143:1221-1224.e3.

Gupta, SK; Falk, GW; Aceves, SS; Chehade, M; Collins, MH; Dellon, ES; Gonsalves, N; Hirano, I; Mukkuda, VA; Peterson, KA; et al. Consortium of Eosinophilic Gastrointestinal Disease Researchers: Advancing the Field of Eosinophilic GI Disorders Through Collaboration Why Was the Consortium of Eosinophilic Gastrointestinal Disease Researchers Established?. Gastroenterology. 2019; 156:838-842.

Hirano, I; Collins, MH; Assouline-Dayan, Y; Evans, L; Gupta, S; Schoepfer, AM; Straumann, A; Safroneeva, E; Grimm, M; Smith, H; et al. RPC4046, a Monoclonal Antibody Against IL13, Reduces Histologic and Endoscopic Activity in Patients With Eosinophilic Esophagitis. Gastroenterology. 2019; 156:592-603.e10.

2018

Ghosh, D; Bernstein, JA; Hershey, GK K; Rothenberg, ME; Mersha, TB. Leveraging Multilayered "Omics " Data for Atopic Dermatitis: A Road Map to Precision Medicine. Frontiers in Immunology. 2018; 9.

Zeng, C; Vanoni, S; Wu, D; Caldwell, JM; Wheeler, JC; Arora, K; Noah, TK; Waggoner, L; Besse, JA; Yamani, AN; et al. Solute carrier family 9, subfamily A, member 3 (SLC9A3)/sodium-hydrogen exchanger member 3 (NHE3) dysregulation and dilated intercellular spaces in patients with eosinophilic esophagitis. Journal of Allergy and Clinical Immunology. 2018; 142:1843-1855.

Syed, M; Ball, JP; Mathis, KW; Hall, ME; Ryan, MJ; Rothenberg, ME; Cardozo, LL Y; Romero, DG. MicroRNA-21 ablation exacerbates aldosterone-mediated cardiac injury, remodeling, and dysfunction. American Journal of Physiology: Endocrinology and Metabolism. 2018; 315:E1154-E1167.

Trisno, SL; Philo, KE D; McCracken, KW; Cata, EM; Ruiz-Torres, S; Rankin, SA; Han, L; Nasr, T; Chaturvedi, P; Rothenberg, ME; et al. Esophageal Organoids from Human Pluripotent Stem Cells Delineate Sox2 Functions during Esophageal Specification. Cell Stem Cell. 2018; 23:501-515.e7.

Hiremath, G; Kodroff, E; Strobel, MJ; Scott, M; Book, W; Reidy, C; Kyle, S; Mack, D; Sable, K; Abonia, P; et al. Individuals affected by eosinophilic gastrointestinal disorders have complex unmet needs and frequently experience unique barriers to care. Clinics and Research in Hepatology and Gastroenterology. 2018; 42:483-493.

Dellon, ES; Liacouras, CA; Molina-Infante, J; Furuta, GT; Spergel, JM; Zevit, N; Spechler, SJ; Attwood, SE; Straumann, A; Aceves, SS; et al. Updated International Consensus Diagnostic Criteria for Eosinophilic Esophagitis: Proceedings of the AGREE Conference. Gastroenterology. 2018; 155:1022-1033.e10.

Rosenberg, CE; Mingler, MK; Caldwell, JM; Collins, MH; Fulkerson, PC; Morris, DW; Mukkada, VA; Putnam, PE; Shoda, T; Wen, T; et al. Esophageal IgG4 levels correlate with histopathologic and transcriptomic features in eosinophilic esophagitis. Allergy: European Journal of Allergy and Clinical Immunology. 2018; 73:1892-1901.

Chehade, M; Jones, SM; Pesek, RD; Burks, AW; Vickery, BP; Wood, RA; Leung, DY M; Furuta, GT; Fleischer, DM; Henning, AK; et al. Phenotypic Characterization of Eosinophilic Esophagitis in a Large Multicenter Patient Population from the Consortium for Food Allergy Research. Journal of Allergy and Clinical Immunology-In Practice. 2018; 6:1534-1544.e5.

Peinhaupt, M; Roula, D; Theiler, A; Sedej, M; Schicho, R; Marsche, G; Sturm, EM; Sabroe, I; Rothenberg, ME; Heinemann, A. DP1 receptor signaling prevents the onset of intrinsic apoptosis in eosinophils and functions as a transcriptional modulator. Journal of Leukocyte Biology. 2018; 104:159-171.

Khoury, P; Akuthota, P; Ackerman, SJ; Arron, JR; Bochner, BS; Collins, MH; Kahn, J; Fulkerson, PC; Gleich, GJ; Gopal-Srivastava, R; et al. Revisiting the NIH Taskforce on the Research needs of Eosinophil-Associated Diseases (RE-TREAD). Journal of Leukocyte Biology. 2018; 104:69-83.

Spergel, JM; Aceves, SS; Kliewer, K; Gonsalves, N; Chehade, M; Wechsler, JB; Groetch, M; Friedlander, J; Dellon, ES; Book, W; et al. New developments in patients with eosinophilic gastrointestinal diseases presented at the CEGIR/TIGERS Symposium at the 2018 American Academy of Allergy, Asthma & Immunology Meeting. Journal of Allergy and Clinical Immunology. 2018; 142:48-53.

Aceves, SS; King, E; Collins, MH; Yang, G; Capocelli, KE; Abonia, JP; Atkins, D; Bonis, PA; Carpenter, CL; Dellon, ES; et al. Alignment of parent- and child-reported outcomes and histology in eosinophilic esophagitis across multiple CEGIR sites. Journal of Allergy and Clinical Immunology. 2018; 142:130-138.e1.

Rochman, M; Azouz, NP; Rothenberg, ME. Epithelial origin of eosinophilic esophagitis. Journal of Allergy and Clinical Immunology. 2018; 142:10-23.

Lynch, MK; Barnes, MJ; Dimmitt, RA; Martin, L; Rothenberg, ME; Goodin, BR. Disease-Related Predictors of Health-Related Quality of Life in Youth With Eosinophilic Esophagitis. Journal of Pediatric Psychology. 2018; 43:464-471.

Sherrill, JD; Kiran, KC; Wang, X; Wen, T; Chamberlin, A; Stucke, EM; Collins, MH; Abonia, JP; Peng, Y; Wu, Q; et al. Whole-exome sequencing uncovers oxidoreductases DHTKD1 and OGDHL as linkers between mitochondrial dysfunction and eosinophilic esophagitis. JCI insight. 2018; 3.

Lu, TX; Rothenberg, ME. MicroRNA. Journal of Allergy and Clinical Immunology. 2018; 141:1202-1207.

Takemura, N; Kurashima, Y; Mori, Y; Okada, K; Ogino, T; Osawa, H; Matsuno, H; Aayam, L; Kaneto, S; Park, EJ; et al. Eosinophil depletion suppresses radiation-induced small intestinal fibrosis. Science Translational Medicine. 2018; 10:eaan0333-eaan0333.

Jensen, ET; Kuhl, JT; Martin, LJ; Langefeld, CD; Dellon, ES; Rothenberg, ME. Early-life environmental exposures interact with genetic susceptibility variants in pediatric patients with eosinophilic esophagitis. Journal of Allergy and Clinical Immunology. 2018; 141:632-637.e5.

Jensen, ET; Kuhl, JT; Martin, LJ; Rothenberg, ME; Dellon, ES. Prenatal, intrapartum, and postnatal factors are associated with pediatric eosinophilic esophagitis. Journal of Allergy and Clinical Immunology. 2018; 141:214-222.

O'Shea, KM; Aceves, SS; Dellon, ES; Gupta, SK; Spergel, JM; Furuta, GT; Rothenberg, ME. Pathophysiology of Eosinophilic Esophagitis. Gastroenterology. 2018; 154:333-345.

Fulkerson, PC; Rothenberg, ME. Eosinophil Development, Disease Involvement, and Therapeutic Suppression. Editor, Alt F. Advances in Immunology. 2018; 138:1-34.

2017

Cheng, K; Gupta, SK; Kantor, S; Kuhl, JT; Aceves, SS; Bonis, PA; Capocelli, KE; Carpenter, C; Chehade, M; Collins, MH; et al. Creating a multi-center rare disease consortium - the Consortium of Eosinophilic Gastrointestinal Disease Researchers (CEGIR). 2017; 2:141-155.

Travers, J; Rochman, M; Caldwell, JM; Besse, JA; Miracle, CE; Rothenberg, ME. IL-33 is induced in undifferentiated, non-dividing esophageal epithelial cells in eosinophilic esophagitis. Scientific Reports. 2017; 7.

Rozenberg, P; Reichman, H; Zab-Bar, I; Itan, M; Pasmanik-Chor, M; Bouffi, C; Qimron, U; Bachelet, I; Fulkerson, PC; Rothenberg, ME; et al. CD300f:IL-5 cross-talk inhibits adipose tissue eosinophil homing and subsequent IL-4 production. Scientific Reports. 2017; 7.

Wen, T; Kuhl, J; Putnam, P; Mukkada, V; Farrell, M; Kaul, A; Cole, C; Rothenberg, ME. A flow cytometry-based diagnosis of eosinophilic esophagitis. Journal of Allergy and Clinical Immunology. 2017; 140:1736-1739.e3.

Rothenberg, ME; Saito, H; Jr, PR S. Advances in mechanisms of allergic disease in 2016. Journal of Allergy and Clinical Immunology. 2017; 140:1622-1631.

Rochman, M; Travers, J; Abonia, JP; Caldwell, JM; Rothenberg, ME. Synaptopodin is upregulated by IL-13 in eosinophilic esophagitis and regulates esophageal epithelial cell motility and barrier integrity. JCI insight. 2017; 2.

Miguel-Hidalgo, JJ; Hall, KO; Bonner, H; Roller, AM; Syed, M; Park, CJ; Ball, JP; Rothenberg, ME; Stockmeier, CA; Romero, DG. MicroRNA-21: Expression in oligodendrocytes and correlation with low myelin mRNAs in depression and alcoholism. Progress in Neuro-Psychopharmacology and Biological Psychiatry. 2017; 79:503-514.

Caldwell, JM; Paul, M; Rothenberg, ME. Novel immunologic mechanisms in eosinophilic esophagitis. Current Opinion in Immunology. 2017; 48:114-121.

Rochman, M; Travers, J; Miracle, CE; Bedard, MC; Wen, T; Azouz, NP; Caldwell, JM; Kiran, KC; Sherrill, JD; Davis, BP; et al. Profound loss of esophageal tissue differentiation in patients with eosinophilic esophagitis. Journal of Allergy and Clinical Immunology. 2017; 140:738-749.e3.

Qin, M; Wang, L; Li, F; Yang, M; Song, L; Tian, F; Yukht, A; Shah, PK; Rothenberg, ME; Sharifi, BG. Oxidized LDL activated eosinophil polarize macrophage phenotype from M2 to M1 through activation of CD36 scavenger receptor. Atherosclerosis. 2017; 263:82-91.

Wen, T; Rothenberg, ME. Clinical Applications of the Eosinophilic Esophagitis Diagnostic Panel. Frontiers in Medicine. 2017; 4.

Litosh, VA; Rochman, M; Rymer, JK; Porollo, A; Kottyan, LC; Rothenberg, ME. Calpain-14 and its association with eosinophilic esophagitis. Journal of Allergy and Clinical Immunology. 2017; 139:1762-1771.e7.

Kottyan, LC; Rothenberg, ME. Genetics of eosinophilic esophagitis. Mucosal Immunology. 2017; 10:580-588.

Goldberg, MR; Elizur, A; Nachshon, L; Appel, MY; Levy, MB; Golobov, K; Goldberg, R; Stein, M; Rothenberg, ME; Katz, Y. Oral immunotherapy-induced gastrointestinal symptoms and peripheral blood eosinophil responses. Journal of Allergy and Clinical Immunology. 2017; 139:1388-1390.e4.

Lyons, JJ; Liu, Y; Ma, CA; Yu, X; O'Connell, MP; Lawrence, MG; Zhang, Y; Karpe, K; Zhao, M; Siegel, AM; et al. ERBIN deficiency links STAT3 and TGF-beta pathway defects with atopy in humans. The Journal of Experimental Medicine. 2017; 214:669-680.

Collins, MH; Martin, LJ; Alexander, ES; Boyd, JT; Sheridan, R; He, H; Pentiuk, S; Putnam, PE; Abonia, JP; Mukkada, VA; et al. Newly developed and validated eosinophilic esophagitis histology scoring system and evidence that it outperforms peak eosinophil count for disease diagnosis and monitoring. Diseases of the Esophagus. 2017; 30:n/a-n/a.

Rothenberg, ME; Bousquet, J. News Beyond Our Pages. Journal of Allergy and Clinical Immunology. 2017; 139:762-763.

Goodman, MA; Manesh, DM; Malik, P; Rothenberg, ME. CRISPR/Cas9 in allergic and immunologic diseases. Expert Review of Clinical Immunology. 2017; 13:5-9.

Verma, AH; Bueter, CL; Rothenberg, ME; Deepe, GS. Eosinophils subvert host resistance to an intracellular pathogen by instigating non-protective IL-4 in CCR2 (-/-) mice. Mucosal Immunology. 2017; 10:194-204.

Wen, T; Rothenberg, ME. The Regulatory Function of Eosinophils. Microbiology Spectrum. 2017; 4:257-269.

Rothenberg, M; Durrani, S. Recent advances in eosinophilic esophagitis. F1000Research. 2017; 6:1775-1775.

2016

Dellon, ES; Collins, MH; Bonis, PA; Leung, J; Capocelli, KE; Dohil, R; Falk, GW; Furuta, GT; Menard-Katcher, C; Gupta, SK; et al. Substantial Variability in Biopsy Practice Patterns Among Gastroenterologists for Suspected Eosinophilic Gastrointestinal Disorders. Clinical Gastroenterology and Hepatology. 2016; 14:1842-1844.

Lyons, JJ; Yu, X; Hughes, JD; Le, QT; Jamil, A; Bai, Y; Ho, N; Zhao, M; Liu, Y; O'Connell, MP; et al. Elevated basal serum tryptase identifies a multisystem disorder associated with increased TPSAB1 copy number. Nature Genetics. 2016; 48:1564-1569.

Loyer, X; Paradis, V; Henique, C; Vion, A; Colnot, N; Guerin, CL; Devue, C; On, S; Scetbun, J; Romain, M; et al. Liver microRNA-21 is overexpressed in non-alcoholic steatohepatitis and contributes to the disease in experimental models by inhibiting PPAR alpha expression. Gut. 2016; 65:1882-1894.

Travers, J; Rochman, M; Miracle, CE; Cohen, JP; Rothenberg, ME. Linking impaired skin barrier function to esophageal allergic inflammation via IL-33. Journal of Allergy and Clinical Immunology. 2016; 138:1381-1383.

Katz, Y; Rothenberg, ME. Infant Feeding: Swinging the Pendulum from Late to Early Introduction of Food. The Israel Medical Association journal : IMAJ. 2016; 18:684-688.

Morris, DW; Stucke, EM; Martin, LJ; Abonia, JP; Mukkada, VA; Putnam, PE; Rothenberg, ME; Fulkerson, PC. Eosinophil progenitor levels are increased in patients with active pediatric eosinophilic esophagitis. Journal of Allergy and Clinical Immunology. 2016; 138:915-918.e5.

Gupta, J; Johansson, E; Bernstein, JA; Chakraborty, R; Hershey, GK K; Rothenberg, ME; Mersha, TB. Resolving the etiology of atopic disorders by using genetic analysis of racial ancestry. Journal of Allergy and Clinical Immunology. 2016; 138:676-699.

Rothenberg, ME. A hidden residential cell in the lung. Journal of Clinical Investigation. 2016; 126:3185-3187.

Ben Baruch-Morgenstern, N; Mingler, MK; Stucke, E; Besse, JA; Wen, T; Reichman, H; Munitz, A; Rothenberg, ME. Paired Ig-like Receptor B Inhibits IL-13-Driven Eosinophil Accumulation and Activation in the Esophagus. Journal of immunology (Baltimore, Md. : 1950). 2016; 197:707-714.

Wawrzyniak, P; Akdis, CA; Finkelman, FD; Rothenberg, ME. Advances and highlights in mechanisms of allergic disease in 2015. Journal of Allergy and Clinical Immunology. 2016; 137:1681-1696.

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Funding Support

Many foundations and agencies, such as the Campaign Urging Research for Eosinophilic Diseases (CURED), generously support our work in the lab to help patients with eosinophilic diseases, including gastrointestinal disorders, asthma and food allergies. Funding Support

CD22 Expression on Gastrointestinal Eosinophils

Reproduction of part of Figure 3, panel B published in The Journal of Immunology (February 1, 2012, vol. 188, p. 1075-1082), showing cell membrane expression of Pan-B cell marker CD22 on gastrointestinal eosinophils of wild type mice by FACS and flow imaging analysis. Copyright 2011. The American Association of Immunologists, Inc. Read More