Rothenberg Lab
Rothenberg CURED Lab

Publications from the Rothenberg Lab

These journal article publications are the culmination of our research projects, steps forward in our understanding of biological and diseases processes, a sharing of our findings with others, and a basis for further research. 

These steps forward would not be possible without the generous support of many foundations and agencies, such as the Campaign Urging Research for Eosinophilic Disease (CURED) and the National Institutes of Health (NIH). 

Publications

Wen, T; Aronow, BJ; Rochman, Y; Rochman, M; Kiran, KC; Dexheimer, PJ; Putnam, P; Mukkada, V; Foote, H; Rehn, K; et al. Single-cell RNA sequencing identifies inflammatory tissue T cells in eosinophilic esophagitis. Journal of Clinical Investigation. 2019; 129:2014-2028.

Travers, J; Rochman, M; Miracle, CE; Habel, JE; Brusilovsky, M; Caldwell, JM; Rymer, JK; Rothenberg, ME. Chromatin regulates IL-33 release and extracellular cytokine activity. Nature Communications. 2018; 9.

Shoda, T; Wen, T; Aceves, SS; Abonia, JP; Atkins, D; Bonis, PA; Caldwell, JM; Capocelli, KE; Carpenter, CL; Collins, MH; et al. Eosinophilic oesophagitis endotype classification by molecular, clinical, and histopathological analyses: a cross-sectional study. The Lancet Gastroenterology and Hepatology. 2018; 3:477-488.

Azouz, NP; Ynga-Durand, MA; Caldwell, JM; Jain, A; Rochman, M; Fischesser, DM; Ray, LM; Bedard, MC; Mingler, MK; Forney, C; et al. The antiprotease SPINK7 serves as an inhibitory checkpoint for esophageal epithelial inflammatory responses. Science Translational Medicine. 2018; 10.

Martin, LJ; He, H; Collins, MH; Abonia, JP; Myers, JM B; Eby, M; Johansson, H; Kottyan, LC; Hershey, GK K; Rothenberg, ME. Eosinophilic esophagitis (EoE) genetic susceptibility is mediated by synergistic interactions between EoE-specific and general atopic disease loci. Journal of Allergy and Clinical Immunology. 2018; 141:1690-1698.

Caldwell, JM; Collins, MH; Kemme, KA; Sherrill, JD; Wen, T; Rochman, M; Stucke, EM; Amin, L; Tai, H; Putnam, PE; et al. Cadherin 26 is an alpha integrin-binding epithelial receptor regulated during allergic inflammation. Mucosal Immunology. 2017; 10:1190-1201.

Davis, BP; Stucke, EM; Khorki, ME; Litosh, VA; Rymer, JK; Rochman, M; Travers, J; Kottyan, LC; Rothenberg, ME. Eosinophilic esophagitis-linked calpain 14 is an IL-13-induced protease that mediates esophageal epithelial barrier impairment. JCI insight. 2016; 1.

Kottyan, LC; Davis, BP; Sherrill, JD; Liu, K; Rochman, M; Kaufman, K; Weirauch, MT; Vaughn, S; Lazaro, S; Rupert, AM; et al. Genome-wide association analysis of eosinophilic esophagitis provides insight into the tissue specificity of this allergic disease. Nature Genetics. 2014; 46:895-900.

Wen, T; Stucke, EM; Grotjan, TM; Kemme, KA; Abonia, JP; Putnam, PE; Franciosi, JP; Garza, JM; Kaul, A; King, EC; et al. Molecular diagnosis of eosinophilic esophagitis by gene expression profiling. Gastroenterology. 2013; 145:1289-1299.

Hiremath, G; Sun, L; Collins, MH; Bonis, PA; Arva, NC; Capocelli, KE; Chehade, M; Davis, CM; Falk, GW; Gonsalves, N; et al. Esophageal Epithelium and Lamina Propria are Unevenly Involved in Eosinophilic Esophagitis. Clinical Gastroenterology and Hepatology. 2023.

Parsons, ES; Liu, F; Kaushik, A; Lee, A; Schuetz, J; Dunham, D; Seastedt, H; Ogulur, I; Heider, A; Tan, G; et al. Detection of gut and mucosal peptides through TOMAHAQ in healthy individuals. Allergy: European Journal of Allergy and Clinical Immunology. 2023.

Applequist, J; Burroughs, C; Merkel, PA; Rothenberg, M; Trapnell, B; Desnick, R; Sahin, M; Krischer, J. Direct-to-Consumer Recruitment Methods via Traditional and Social Media to Aid in Research Accrual for Clinical Trials for Rare Diseases: Comparative Analysis Study. Journal of Medical Internet Research. 2023; 25.

Dellon, ES; Rothenberg, ME; Bredenoord, AJ. Dupilumab in Patients with Eosinophilic Esophagitis. Reply. New England Journal of Medicine. 2023; 388:956-957.

Furuta, GT; Fillon, SA; Williamson, KM; Robertson, CE; Stevens, MJ; Aceves, SS; Arva, NC; Chehade, M; Collins, MH; Davis, CM; et al. Mucosal Microbiota Associated With Eosinophilic Esophagitis and Eosinophilic Gastritis. Journal of Pediatric Gastroenterology and Nutrition. 2023; 76:347-354.

Hwee, J; Huynh, L; Du, S; Kwon, N; Jakes, RW; Alfonso-Cristancho, R; Baylis, L; Requena, G; Khanal, A; Rothenberg, ME; et al. Hypereosinophilic syndrome in Europe: Retrospective study of treatment patterns, clinical manifestations, and healthcare resource utilization. Annals of Allergy, Asthma and Immunology. 2023.

Sindher, SB; Barshow, S; Tirumalasetty, J; Arasi, S; Atkins, D; Bauer, M; Bégin, P; Collins, MH; Deschildre, A; Doyle, AD; et al. The role of biologics in pediatric food allergy and eosinophilic gastrointestinal disorders. Journal of Allergy and Clinical Immunology. 2023; 151:595-606.

Soh, WT; Zhang, J; Hollenberg, MD; Vliagoftis, H; Rothenberg, ME; Sokol, CL; Robinson, C; Jacquet, A. Protease allergens as initiators-regulators of allergic inflammation. Allergy: European Journal of Allergy and Clinical Immunology. 2023.

Guarnieri, KM; Saba, NK; Schwartz, JT; Devonshire, AL; Bufford, J; Casale, TB; Rothenberg, ME; Andorf, S. Food allergy characteristics associated with co-existing eosinophilic esophagitis in FARE Registry participants. Journal of Allergy and Clinical Immunology: In Practice. 2023.

Bousquet, J; Melén, E; Haahtela, T; Koppelman, GH; Togias, A; Valenta, R; Akdis, CA; Czarlewski, W; Rothenberg, M; Valiulis, A; et al. Rhinitis associated with asthma is distinct from rhinitis alone: The ARIA-MeDALL hypothesis. Allergy: European Journal of Allergy and Clinical Immunology. 2023.

Ben-Baruch Morgenstern, N; Shoda, T; Rochman, Y; Caldwell, JM; Collins, MH; Mukkada, V; Putnam, PE; Bolton, SM; Felton, JM; Rochman, M; et al. Local type 2 immunity in eosinophilic gastritis. Journal of Allergy and Clinical Immunology. 2023.

Avlas, S; Shani, G; Rhone, N; Itan, M; Dolitzky, A; Hazut, I; Grisaru-Tal, S; Gordon, Y; Shoda, T; Ballaban, A; et al. Epithelial cell-expressed type II IL-4 receptor mediates eosinophilic esophagitis. Allergy: European Journal of Allergy and Clinical Immunology. 2023; 78:464-476.

Alvarado, D; Lu, Y; Shoda, T; Caldwell, JM; Keler, T; Rothenberg, ME. Strong association of mast cells with eosinophilic esophagitis-specific signatures. Allergy: European Journal of Allergy and Clinical Immunology. 2023; 78:583-586.

Dellon, ES; Rothenberg, ME; Collins, MH; Hirano, I; Chehade, M; Bredenoord, AJ; Lucendo, AJ; Spergel, JM; Aceves, S; Sun, X; et al. Dupilumab in Adults and Adolescents with Eosinophilic Esophagitis. New England Journal of Medicine. 2022; 387:2317-2330.

Rothenberg, ME. Scientific journey to the first FDA-approved drug for eosinophilic esophagitis. Journal of Allergy and Clinical Immunology. 2022; 150:1325-1332.

Gautam, Y; Caldwell, J; Kottyan, L; Chehade, M; Dellon, ES; Rothenberg, ME; Mersha, TB. Genome-wide admixture and association analysis identifies African ancestry-specific risk loci of eosinophilic esophagitis in African Americans. Journal of Allergy and Clinical Immunology. 2022.

Dellon, ES; Gonsalves, N; Abonia, JP; Alexander, JA; Arva, NC; Atkins, D; Attwood, SE; Auth, MK H; Bailey, DD; Biederman, L; et al. International Consensus Recommendations for Eosinophilic Gastrointestinal Disease Nomenclature. Clinical Gastroenterology and Hepatology. 2022; 20:2474-2484.e3.

Larey, A; Aknin, E; Daniel, N; Osswald, GA; Caldwell, JM; Rochman, M; Wasserman, T; Collins, MH; Arva, NC; Yang, GY; et al. Harnessing artificial intelligence to infer novel spatial biomarkers for the diagnosis of eosinophilic esophagitis. Frontiers in Medicine. 2022; 9.

Schreiner, P; Safroneeva, E; Schoepfer, A; Greuter, T; Biedermann, L; Schlag, C; Labenz, J; Auth, MK H; Bredenoord, AJ; Chang, JW; et al. Management of eosinophilic esophagitis associated food impaction in Europe and the United States. Diseases of the Esophagus. 2022; 35.

Rothenberg, ME; Roufosse, F; Faguer, S; Gleich, GJ; Steinfeld, J; Yancey, SW; Mavropoulou, E; Kwon, N; García, GR; Sosso, A; et al. Mepolizumab Reduces Hypereosinophilic Syndrome Flares Irrespective of Blood Eosinophil Count and Interleukin-5. Journal of Allergy and Clinical Immunology: In Practice. 2022; 10:2367-2374.e3.

Grisaru-Tal, S; Rothenberg, ME; Munitz, A. Eosinophil-lymphocyte interactions in the tumor microenvironment and cancer immunotherapy. Nature Immunology. 2022; 23:1309-1316.

Brusilovsky, M; Rochman, M; Shoda, T; Kotliar, M; Caldwell, JM; Mack, LE; Besse, JA; Chen, X; Weirauch, MT; Barski, A; et al. Vitamin D receptor and STAT6 interactome governs oesophageal epithelial barrier responses to IL-13 signalling. Gut. 2022.

McNaught, E; Treasure, J; Pollard, N. Overview. Eating Disorders. 2022.

Seibold, MA; Moore, CM; Everman, JL; Williams, BJ M; Nolin, JD; Fairbanks-Mahnke, A; Plender, EG; Patel, BB; Arbes, SJ; Bacharier, LB; et al. Risk factors for SARS-CoV-2 infection and transmission in households with children with asthma and allergy: A prospective surveillance study. Journal of Allergy and Clinical Immunology. 2022; 150:302-311.

Daniel, N; Larey, A; Aknin, E; Osswald, GA; Caldwell, JM; Rochman, M; Collins, MH; Yang, GY; Arva, NC; Capocelli, KE; et al. (2022) A Deep Multi-Label Segmentation Network For Eosinophilic Esophagitis Whole Slide Biopsy Diagnostics. 2022:3211-3217.

Fulkerson, PC; Lussier, SJ; Bendixsen, CG; Castina, SM; Gebretsadik, T; Marlin, JS; Russell, PB; Seibold, MA; Everman, JL; Moore, CM; et al. Human Epidemiology and RespOnse to SARS-CoV-2 (HEROS): Objectives, Design and Enrollment Results of a 12-City Remote Observational Surveillance Study of Households with Children using Direct-to-Participant Methods. 2022.

Droghini, HR; Abonia, JP; Collins, MH; Milner, JD; Lyons, JJ; Freeman, AF; Mukkada, VA; Risma, KA; Rothenberg, ME; Schwartz, JT. Targeted IL-4Rα blockade ameliorates refractory allergic eosinophilic inflammation in a patient with dysregulated TGF-β signaling due to ERBIN deficiency. Journal of Allergy and Clinical Immunology: In Practice. 2022; 10:1903-1906.

Dellon, ES; Khoury, P; Muir, AB; Liacouras, CA; Safroneeva, E; Atkins, D; Collins, MH; Gonsalves, N; Falk, GW; Spergel, JM; et al. A Clinical Severity Index for Eosinophilic Esophagitis: Development, Consensus, and Future Directions. Gastroenterology. 2022; 163:59-76.

Dellon, ES; Khoury, P; Muir, AB; Liacouras, CA; Safroneeva, E; Atkins, D; Collins, MH; Gonsalves, N; Falk, GW; Spergel, JM; et al. A Clinical Severity Index for Eosinophilic Esophagitis: Development, Consensus, and Future Directions. Journal of Allergy and Clinical Immunology. 2022; 150:33-47.

Tanzer, J; Meng, D; Ohsaki, A; Caldwell, JM; Mingler, MK; Rothenberg, ME; Oyoshi, MK. Laundry detergent promotes allergic skin inflammation and esophageal eosinophilia in mice. PLoS ONE. 2022; 17.

Rochman, M; Wen, T; Kotliar, M; Dexheimer, PJ; Morgenstern, NB B; Caldwell, JM; Lim, HW; Rothenberg, ME. Single-cell RNA-Seq of human esophageal epithelium in homeostasis and allergic inflammation. JCI insight. 2022; 7.

Zhang, S; Shoda, T; Aceves, SS; Arva, NC; Chehade, M; Collins, MH; Dellon, ES; Falk, GW; Gonsalves, N; Gupta, SK; et al. Mast cell-pain connection in eosinophilic esophagitis. Allergy: European Journal of Allergy and Clinical Immunology. 2022; 77:1895-1899.

Ben-Baruch Morgenstern, N; Ballaban, AY; Wen, T; Shoda, T; Caldwell, JM; Kliewer, K; Felton, JM; Abonia, JP; Mukkada, VA; Putnam, PE; et al. Single-cell RNA sequencing of mast cells in eosinophilic esophagitis reveals heterogeneity, local proliferation, and activation that persists in remission. Journal of Allergy and Clinical Immunology. 2022; 149:2062-2077.

Eapen, AA; Parameswaran, S; Forney, C; Edsall, LE; Miller, D; Donmez, O; Dunn, K; Lu, X; Granitto, M; Rowden, H; et al. Epigenetic and transcriptional dysregulation in CD4+ T cells in patients with atopic dermatitis. PLoS Genetics. 2022; 18.

Shoda, T; Collins, MH; Rochman, M; Wen, T; Caldwell, JM; Mack, LE; Osswald, GA; Besse, JA; Haberman, Y; Aceves, SS; et al. Evaluating Eosinophilic Colitis as a Unique Disease Using Colonic Molecular Profiles: A Multi-Site Study. Gastroenterology. 2022; 162:1635-1649.

Chen, MM; Roufosse, F; Wang, SA; Verstovsek, S; Durrani, SR; Rothenberg, ME; Pongdee, T; Butterfield, J; Lax, T; Wechsler, ME; et al. An International, Retrospective Study of Off-Label Biologic Use in the Treatment of Hypereosinophilic Syndromes. Journal of Allergy and Clinical Immunology: In Practice. 2022; 10:1217-1228.e3.

Rothenberg, ME. The climate change hypothesis for the allergy epidemic. Journal of Allergy and Clinical Immunology. 2022; 149:1522-1524.

Ziv, YH; Collins, MH; Gonsalves, N; Katzka, DA; Rothenberg, ME. Eosinophilic esophagitis. Yamada's Atlas of Gastroenterology. 2022.

Safroneeva, E; Pan, Z; King, E; Martin, LJ; Collins, MH; Yang, GY; Capocelli, KE; Arva, NC; Abonia, JP; Atkins, D; et al. Long-Lasting Dissociation of Esophageal Eosinophilia and Symptoms After Dilation in Adults With Eosinophilic Esophagitis. Clinical Gastroenterology and Hepatology. 2022; 20:766-775.e4.

Robida, PA; Rische, CH; Morgenstern, NB B; Janarthanam, R; Cao, Y; Krier-Burris, RA; Korver, W; Xu, A; Luu, T; Schanin, J; et al. Functional and Phenotypic Characterization of Siglec-6 on Human Mast Cells. Cells. 2022; 11.

Dellon, ES; Gonsalves, N; Rothenberg, ME; Hirano, I; Chehade, M; Peterson, KA; Falk, GW; Murray, JA; Gehman, LT; Chang, AT; et al. Determination of Biopsy Yield That Optimally Detects Eosinophilic Gastritis and/or Duodenitis in a Randomized Trial of Lirentelimab. Clinical Gastroenterology and Hepatology. 2022; 20:535-545.e15.

Collins, MH; Alexander, ES; Martin, LJ; Grotjan, TM; Mukkada, VA; Sheil, A; Abonia, JP; Putnam, PE; Rothenberg, ME. Acquired Esophageal Strictures in Children: Morphometric and Immunohistochemical Analyses. Pediatric and Developmental Pathology. 2022; 25:124-133.

Rothenberg, ME; Hottinger, SK B; Gonsalves, N; Furuta, GT; Collins, MH; Talley, NJ; Peterson, K; Menard-Katcher, C; Smith, M; Hirano, I; et al. Impressions and aspirations from the FDA GREAT VI Workshop on Eosinophilic Gastrointestinal Disorders Beyond Eosinophilic Esophagitis and Perspectives for Progress in the Field. Journal of Allergy and Clinical Immunology. 2022; 149:844-853.

Hirano, I; Collins, MH; King, E; Sun, Q; Chehade, M; Abonia, JP; Bonis, PA; Capocelli, KE; Dellon, ES; Falk, GW; et al. Prospective Endoscopic Activity Assessment for Eosinophilic Gastritis in a Multisite Cohort. American Journal of Gastroenterology. 2022; 117:413-423.

Ma, C; Schoepfer, AM; Dellon, ES; Bredenoord, AJ; Chehade, M; Collins, MH; Feagan, BG; Furuta, GT; Gupta, SK; Hirano, I; et al. Development of a core outcome set for therapeutic studies in eosinophilic esophagitis (COREOS). Journal of Allergy and Clinical Immunology. 2022; 149:659-670.

Min, S; Shoda, T; Wen, T; Rothenberg, ME. Diagnostic merits of the Eosinophilic Esophagitis Diagnostic Panel from a single esophageal biopsy. Journal of Allergy and Clinical Immunology. 2022; 149:782-787.e1.

Brusilovsky, M; Bao, R; Rochman, M; Kemter, AM; Nagler, CR; Rothenberg, ME. Host-Microbiota Interactions in the Esophagus During Homeostasis and Allergic Inflammation. Gastroenterology. 2022; 162:521-534.e8.

Shoda, T; Wen, T; Caldwell, JM; Ben-Baruch Morgenstern, N; Osswald, GA; Rochman, M; Mack, LE; Felton, JM; Abonia, JP; Arva, NC; et al. Loss of Endothelial TSPAN12 Promotes Fibrostenotic Eosinophilic Esophagitis via Endothelial Cell-Fibroblast Crosstalk. Gastroenterology. 2022; 162:439-453.

Dunn, JL M; Rothenberg, ME. 2021 year in review: Spotlight on eosinophils. Journal of Allergy and Clinical Immunology. 2022; 149:517-524.

Hiremath, G; Sun, L; Correa, H; Acra, S; Collins, MH; Bonis, P; Arva, NC; Capocelli, KE; Falk, GW; King, E; et al. Development and Validation of Web-Based Tool to Predict Lamina Propria Fibrosis in Eosinophilic Esophagitis. American Journal of Gastroenterology. 2022; 117:272-279.

Rothenberg, ME. Linking the allergy epidemic to climate change. Nature Immunology. 2022; 23.

Gleich, GJ; Roufosse, F; Chupp, G; Faguer, S; Walz, B; Reiter, A; Yancey, SW; Bentley, JH; Steinfeld, J; García, GR; et al. Safety and Efficacy of Mepolizumab in Hypereosinophilic Syndrome: An Open-Label Extension Study. Journal of Allergy and Clinical Immunology: In Practice. 2021; 9:4431-4440.e1.

Shoda, T; Kaufman, KM; Wen, T; Caldwell, JM; Osswald, GA; Purnima, P; Zimmermann, N; Collins, MH; Rehn, K; Foote, H; et al. Desmoplakin and periplakin genetically and functionally contribute to eosinophilic esophagitis. Nature Communications. 2021; 12.

Fox-Fisher, I; Piyanzin, S; Ochana, BL; Klochendler, A; Magenheim, J; Peretz, A; Loyfer, N; Moss, J; Cohen, D; Drori, Y; et al. Remote immune processes revealed by immune-derived circulating cell-free DNA. eLife. 2021; 10.

Felton, JM; Bouffi, C; Schwartz, JT; Schollaert, KL; Malik, A; Vallabh, S; Wronowski, B; Magier, AZ; Merlin, L; Barski, A; et al. Aiolos regulates eosinophil migration into tissues. Mucosal Immunology. 2021; 14:1271-1281.

Grisaru-Tal, S; Dulberg, S; Beck, L; Zhang, C; Itan, M; Hediyeh-Zadeh, S; Caldwell, J; Rozenberg, P; Dolitzky, A; Avlas, S; et al. Metastasis-Entrained Eosinophils Enhance Lymphocyte-Mediated Antitumor Immunity. Cancer Research. 2021; 81:5555-5571.

Mahoney, M; Damalanka, VC; Tartell, MA; Chung, DH; Lourenço, AL; Pwee, D; Mayer Bridwell, AE; Hoffmann, M; Voss, J; Karmakar, P; et al. A novel class of TMPRSS2 inhibitors potently block SARS-CoV-2 and MERS-CoV viral entry and protect human epithelial lung cells. Proceedings of the National Academy of Sciences of the United States of America. 2021; 118.

Jin, K; Bardes, EE; Mitelpunkt, A; Wang, JY; Bhatnagar, S; Sengupta, S; Krummel, DP; Rothenberg, ME; Aronow, BJ. An interactive single cell web portal identifies gene and cell networks in COVID-19 host responses. iScience. 2021; 24.

Brusilovsky, M; Rochman, M; Rochman, Y; Caldwell, JM; Mack, LE; Felton, JM; Habel, JE; Porollo, A; Pasare, C; Rothenberg, ME. Environmental allergens trigger type 2 inflammation through ripoptosome activation. Nature Immunology. 2021; 22:1316-1326.

Hiremath, G; Krischer, JP; Rothenberg, ME; Dellon, ES. Validation of self-reported diagnosis of eosinophilic gastrointestinal disorders patients enrolled in the CEGIR contact registry. Gastroenterologie Clinique et Biologique. 2021; 45.

Dunn, JL M; Caldwell, JM; Ballaban, A; Ben-Baruch Morgenstern, N; Rochman, M; Rothenberg, ME. Bidirectional crosstalk between eosinophils and esophageal epithelial cells regulates inflammatory and remodeling processes. Mucosal Immunology. 2021; 14:1133-1143.

Ma, C; Schoepfer, AM; Safroneeva, E; Dellon, ES; Bredenoord, AJ; Chehade, M; Collins, MH; Feagan, BG; Furuta, GT; Gupta, SK; et al. Development of a Core Outcome Set for Therapeutic Studies in Eosinophilic Esophagitis (COREOS): An International Multidisciplinary Consensus. Gastroenterology. 2021; 161:748-755.

Friedlander, JA; Fleischer, DM; Black, JO; Levy, M; Rothenberg, ME; Smith, C; Nguyen, N; Pan, Z; Furuta, GT. Unsedated transnasal esophagoscopy with virtual reality distraction enables earlier monitoring of dietary therapy in eosinophilic esophagitis. Journal of Allergy and Clinical Immunology: In Practice. 2021; 9:3494-3496.

Ma, C; Schoepfer, AM; Safroneeva, E; Dellon, ES; Bredenoord, AJ; Chehade, M; Collins, MH; Feagan, BG; Furuta, GT; Gupta, SK; et al. (2021) A Summary of the Meetings of the Development of a Core Outcome Set for Therapeutic Studies in Eosinophilic Esophagitis (COREOS) International Multidisciplinary Consensus. 161:778-784.

Felton, JM; Vallabh, S; Parameswaran, S; Edsall, LE; Ernst, K; Wronowski, B; Malik, A; Kotliar, M; Weirauch, MT; Barski, A; et al. Epigenetic Analysis of the Chromatin Landscape Identifies a Repertoire of Murine Eosinophil-Specific PU.1-Bound Enhancers. Journal of Immunology. 2021; 207:1044-1054.

Morgenstern, NB B; Rochman, M; Rothenberg, ME. Zooming in on T cell clones: Are we heading to personalized treatment of allergy?. Science Immunology. 2021; 6.

Czyzewski, T; Daniel, N; Rochman, M; Caldwell, J; Osswald, G; Collins, M; Rothenberg, M; Savir, Y. Machine Learning Approach for Biopsy-Based Identification of Eosinophilic Esophagitis Reveals Importance of Global features. IEEE Open Journal of Engineering in Medicine and Biology. 2021; 2:218-223.

Jin, K; Bardes, EE; Mitelpunkt, A; Wang, JY; Bhatnagar, S; Sengupta, S; Krummel, DP; Rothenberg, ME; Aronow, BJ. Implicating Gene and Cell Networks Responsible for Differential COVID-19 Host Responses via an Interactive Single Cell Web Portal. 2021.

Rothenberg, ME. An Allergic Basis for Abdominal Pain. New England Journal of Medicine. 2021; 384:2156-2158.

Sabet, C; Klion, AD; Bailey, D; Jensen, E; Chehade, M; Abonia, JP; Rothenberg, ME; Furuta, GT; Muir, AB. Do rural health disparities affect prevalence data in pediatric eosinophilic esophagitis?. Journal of Allergy and Clinical Immunology: In Practice. 2021; 9:2549-2551.

Rochman, M; Xie, YM; Mack, L; Caldwell, JM; Klingler, AM; Osswald, GA; Azouz, NP; Rothenberg, ME. Broad transcriptional response of the human esophageal epithelium to proton pump inhibitors. Journal of Allergy and Clinical Immunology. 2021; 147:1924-1935.

Chiang, AW T; Duong, LD; Shoda, T; Nhu, QM; Ruffner, M; Hara, T; Aaron, B; Joplin, E; Manresa, MC; Abonia, JP; et al. Type 2 Immunity and Age Modify Gene Expression of Coronavirus-induced Disease 2019 Receptors in Eosinophilic Gastrointestinal Disorders. Journal of Pediatric Gastroenterology and Nutrition. 2021; 72:718-722.

Jacobsen, EA; Jackson, DJ; Heffler, E; Mathur, SK; Bredenoord, AJ; Pavord, ID; Akuthota, P; Roufosse, F; Rothenberg, ME. Eosinophil Knockout Humans: Uncovering the Role of Eosinophils Through Eosinophil-Directed Biological Therapies. Annual Review of Immunology. 2021; 39:719-757.

Azouz, NP; Klingler, AM; Callahan, V; Akhrymuk, IV; Elez, K; Raich, L; Henry, BM; Benoit, JL; Benoit, SW; Noé, F; et al. Alpha 1 Antitrypsin is an Inhibitor of the SARS-CoV-2-Priming Protease TMPRSS2. Pathogens and Immunity. 2021; 6:55-74.

Mersha, TB; Afanador, Y; Johansson, E; Proper, SP; Bernstein, JA; Rothenberg, ME; Hershey, GK K. Resolving Clinical Phenotypes into Endotypes in Allergy: Molecular and Omics Approaches. Clinical Reviews in Allergy and Immunology. 2021; 60:200-219.

Dellon, ES; Collins, MH; Rothenberg, ME; Assouline-Dayan, Y; Evans, L; Gupta, S; Schoepfer, A; Straumann, A; Safroneeva, E; Rodriguez, C; et al. Long-term Efficacy and Tolerability of RPC4046 in an Open-Label Extension Trial of Patients With Eosinophilic Esophagitis. Clinical Gastroenterology and Hepatology. 2021; 19:473-483.e17.

Rothenberg, ME; Bousquet, J. News Beyond Our Pages. Journal of Allergy and Clinical Immunology. 2021; 147:851-852.

Dellon, ES; Shaheen, O; Koutlas, NT; Chang, AO; Martin, LJ; Rothenberg, ME; Jensen, ET. Early life factors are associated with risk for eosinophilic esophagitis diagnosed in adulthood. Diseases of the Esophagus. 2021; 34.

Rothenberg, ME; Bousquet, J. News Beyond Our Pages. Journal of Allergy and Clinical Immunology. 2021; 147:490-491.

Hempel, T; Raich, L; Olsson, S; Azouz, NP; Klingler, AM; Hoffmann, M; Pöhlmann, S; Rothenberg, ME; Noé, F. Molecular mechanism of inhibiting the SARS-CoV-2 cell entry facilitator TMPRSS2 with camostat and nafamostat. Chemical Science. 2021; 12:983-992.

Czyzewski, T; Daniel, N; Rochman, M; Caldwell, J; Osswald, G; Collins, M; Rothenberg, M; Savir, Y. Machine learning approach for biopsy-based identification of eosinophilic esophagitis reveals importance of global features. 2021.

Rothenberg, ME; Bousquet, J. News Beyond Our Pages. Journal of Allergy and Clinical Immunology. 2021; 147:43-44.

O'Shea, KM; Rochman, M; Shoda, T; Zimmermann, N; Caldwell, J; Rothenberg, ME. Eosinophilic esophagitis with extremely high esophageal eosinophil counts. Journal of Allergy and Clinical Immunology. 2021; 147:409-412.e5.

Kottyan, LC; Trimarchi, MP; Lu, X; Caldwell, JM; Maddox, A; Parameswaran, S; Lape, M; D'Mello, RJ; Bonfield, M; Ballaban, A; et al. Replication and meta-analyses nominate numerous eosinophilic esophagitis risk genes. Journal of Allergy and Clinical Immunology. 2021; 147:255-266.

Lyles, JL; Martin, LJ; Shoda, T; Collins, MH; Trimarchi, MP; He, H; Kottyan, LC; Mukkada, VA; Rothenberg, ME. Very early onset eosinophilic esophagitis is common, responds to standard therapy, and demonstrates enrichment for CAPN14 genetic variants. Journal of Allergy and Clinical Immunology. 2021; 147:244-254.e6.

Roufosse, F; Kahn, JE; Rothenberg, ME; Wardlaw, AJ; Klion, AD; Kirby, SY; Gilson, MJ; Bentley, JH; Bradford, ES; Yancey, SW; et al. Efficacy and safety of mepolizumab in hypereosinophilic syndrome: A phase III, randomized, placebo-controlled trial. Journal of Allergy and Clinical Immunology. 2020; 146:1397-1405.

Rothenberg, ME; Bousquet, J. News Beyond Our Pages. Journal of Allergy and Clinical Immunology. 2020; 146:1341-1342.

Rothenberg, ME. Transferring allergies in the womb. Science. 2020; 370:907-908.

Rothenberg, ME; Bousquet, J. News Beyond Our Pages. Journal of Allergy and Clinical Immunology. 2020; 146:993-994.

Dellon, ES; Peterson, KA; Murray, JA; Falk, GW; Gonsalves, N; Chehade, M; Genta, RM; Leung, J; Khoury, P; Klion, AD; et al. Anti-Siglec-8 Antibody for Eosinophilic Gastritis and Duodenitis. New England Journal of Medicine. 2020; 383:1624-1634.

Rothenberg, ME; Bousquet, J. News Beyond Our Pages. Journal of Allergy and Clinical Immunology. 2020; 146:774-775.

Ben Baruch-Morgenstern, N; Rochman, M; Rothenberg, ME. Pumping mast cells out of allergic inflammation-are proton pump inhibitors taking center stage?. Journal of Allergy and Clinical Immunology. 2020; 146:783-785.

Jensen, ET; Aceves, SS; Bonis, PA; Bray, K; Book, W; Chehade, M; Collins, MH; Dellon, ES; Falk, GW; Gonsalves, N; et al. High Patient Disease Burden in a Cross-sectional, Multicenter Contact Registry Study of Eosinophilic Gastrointestinal Diseases. Journal of Pediatric Gastroenterology and Nutrition. 2020; 71:524-529.

Rothenberg, ME; Bousquet, J. News Beyond Our Pages. Journal of Allergy and Clinical Immunology. 2020; 146:507-508.

Rothenberg, ME; Bousquet, J. News Beyond Our Pages. Journal of Allergy and Clinical Immunology. 2020; 146:256-257.

Rothenberg, ME; Bousquet, J. News Beyond Our Pages. Journal of Allergy and Clinical Immunology. 2020; 146:50-51.

Pesek, RD; Reed, CC; Collins, MH; Muir, AB; Fulkerson, PC; Menard-Katcher, C; Falk, GW; Kuhl, J; Magier, AZ; Ahmed, FN; et al. Association Between Endoscopic and Histologic Findings in a Multicenter Retrospective Cohort of Patients with Non-esophageal Eosinophilic Gastrointestinal Disorders. Digestive Diseases and Sciences. 2020; 65:2024-2035.

Lindsley, AW; Schwartz, JT; Rothenberg, ME. Eosinophil responses during COVID-19 infections and coronavirus vaccination. Journal of Allergy and Clinical Immunology. 2020; 146:1-7.

Brusilovsky, M; Rochman, M; Azouz, NP; Mack, LE; Rothenberg, ME. Uncovering the secretes of allergic inflammation. Journal of Clinical Investigation. 2020; 130:3419-3421.

Rothenberg, ME; Bousquet, J. News Beyond Our Pages. Journal of Allergy and Clinical Immunology. 2020; 145:1549-1550.

Dunn, JL M; Shoda, T; Caldwell, JM; Wen, T; Aceves, SS; Collins, MH; Dellon, ES; Falk, GW; Leung, J; Martin, LJ; et al. Esophageal type 2 cytokine expression heterogeneity in eosinophilic esophagitis in a multisite cohort. Journal of Allergy and Clinical Immunology. 2020; 145:1629-1640.e4.

Bousquet, J; Rothenberg, M. News Beyond Our Pages. Journal of Allergy and Clinical Immunology. 2020; 145:1549-1550.

Azouz, NP; Klingler, AM; Pathre, P; Besse, JA; Ben Baruch-Morgenstern, N; Ballaban, AY; Osswald, GA; Brusilovsky, M; Habel, JE; Caldwell, JM; et al. Functional role of kallikrein 5 and proteinase-activated receptor 2 in eosinophilic esophagitis. Science Translational Medicine. 2020; 12.

Collins, MH; Martin, LJ; Wen, T; Abonia, JP; Putnam, PE; Mukkada, VA; Rothenberg, ME. Eosinophilic Esophagitis Histology Remission Score: Significant Relations to Measures of Disease Activity and Symptoms. Journal of Pediatric Gastroenterology and Nutrition. 2020; 70:598-603.

Dellon, ES; Peterson, KA; Murray, JA; Falk, GW; Gonsalves, N; Chehade, M; Leung, J; Genta, RM; Rothenberg, ME; Khoury, P; et al. 932 HISTOLOGIC AND SYMPTOMATIC IMPROVEMENT ACROSS MULTIPLE FORMS OF EOSINOPHILIC GASTROINTESTINAL DISEASES IN ENIGMA, A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL OF ANTOLIMAB (AK002). Gastroenterology. 2020; 158:s-186.

Gupta, SK; Pesek, R; Wang, Y; Foss, K; Bonis, PA; Chehade, M; Collins, MH; Dellon, ES; Falk, GW; Furuta, G; et al. Su1001 CLINICAL CHARACTERISTICS AND DISEASE FEATURES FROM A MULTICENTER LONGITUDINAL COHORT OF EOSINOPHILIC GASTROINTESTINAL DISORDERS MAY INFORM FUTURE STUDIES. Gastroenterology. 2020; 158:s-493.

Hamilton, JD; Lim, WK; Hamon, SC; Rothenberg, ME; Collins, MH; Chehade, M; Harel, S; Wipperman, MF; Hirano, I; Dellon, ES; et al. Mo1228 DUPILUMAB NORMALIZES THE EOSINOPHILIC ESOPHAGITIS DISEASE TRANSCRIPTOME IN ADULT PATIENTS WITH EOSINOPHILIC ESOPHAGITIS. Gastroenterology. 2020; 158:s-835.

Rothenberg, ME; Bousquet, J. News Beyond Our Pages. Journal of Allergy and Clinical Immunology. 2020; 145:1350-1351.

Oliva, S; Azouz, NP; Stronati, L; Rothenberg, ME. Recent advances in potential targets for eosinophilic esophagitis treatments. Expert Review of Clinical Immunology. 2020; 16:421-428.

Henderson, A; Magier, A; Schwartz, JT; Martin, LJ; Collins, MH; Putnam, PE; Mukkada, VA; Abonia, JP; Rothenberg, ME; Fulkerson, PC. Monitoring Eosinophilic Esophagitis Disease Activity With Blood Eosinophil Progenitor Levels. Journal of Pediatric Gastroenterology and Nutrition. 2020; 70:482-488.

Rothenberg, ME; Bousquet, J. News Beyond Our Pages. Journal of Allergy and Clinical Immunology. 2020; 145:1134-1135.

Applequist, J; Burroughs, C; Jr, RA; Merkel, PA; Rothenberg, ME; Trapnell, B; Desnick, RJ; Sahin, M; Krischer, JP. A novel approach to conducting clinical trials in the community setting: utilizing patient-driven platforms and social media to drive web-based patient recruitment. BMC Medical Research Methodology. 2020; 20.

Rothenberg, ME; Bousquet, J. News Beyond Our Pages. Journal of Allergy and Clinical Immunology. 2020; 145:771-772.

Bitton, A; Avlas, S; Reichman, H; Itan, M; Karo-Atar, D; Azouz, NP; Rozenberg, P; Diesendruck, Y; Nahary, L; Rothenberg, ME; et al. A key role for IL-13 signaling via the type 2 IL-4 receptor in experimental atopic dermatitis. Science Immunology. 2020; 5.

Mersha, T; Gautam, Y; Caldwell, J; Rothenberg, M. Genome-wide admixture and association analyses identify novel eosinophilic esophagitis-associated loci in African American ancestry. Journal of Allergy and Clinical Immunology. 2020; 145.

Avlas, S; Itan, M; Dolitzky, A; Varol, C; Rothenberg, M; Munitz, A. Intraesophageal administration of oxazolone to skin-sensitized mice results in experimental eosinophilic esophagitis‏ ‏resembling human disease. Journal of Allergy and Clinical Immunology. 2020; 145.

Munitz, A; Bitton, A; Avlas, S; Reichman, H; Itan, M; Karo-Atar, D; Azouz, N; Rozenberg, P; Nahari, L; Rothenberg, M; et al. A key role for IL-13 signaling via the type 2 IL-4 receptor in atopic dermatitis. Journal of Allergy and Clinical Immunology. 2020; 145.

Rothenberg, ME; Bousquet, J. News Beyond Our Pages. Journal of Allergy and Clinical Immunology. 2020; 145:474-475.

Hirano, I; Dellon, ES; Hamilton, JD; Collins, MH; Peterson, K; Chehade, M; Schoepfer, AM; Safroneeva, E; Rothenberg, ME; Falk, GW; et al. Efficacy of Dupilumab in a Phase 2 Randomized Trial of Adults With Active Eosinophilic Esophagitis. Gastroenterology. 2020; 158:111-122.e10.

Vanoni, S; Zeng, C; Marella, S; Uddin, J; Wu, D; Arora, K; Ptaschinski, C; Que, J; Noah, T; Waggoner, L; et al. Identification of anoctamin 1 (ANO1) as a key driver of esophageal epithelial proliferation in eosinophilic esophagitis. Journal of Allergy and Clinical Immunology. 2020; 145:239-254.e2.

Pesek, RD; Rothenberg, ME. Eosinophilic gastrointestinal disease below the belt. Journal of Allergy and Clinical Immunology. 2020; 145:87-89.e1.

Shoda, T; Wen, T; Caldwell, JM; Collins, MH; Besse, JA; Osswald, GA; Abonia, JP; Arva, NC; MDd, DA; Capocelli, KE; et al. Molecular, endoscopic, histologic, and circulating biomarker-based diagnosis of eosinophilic gastritis: Multi-site study. Journal of Allergy and Clinical Immunology. 2020; 145:255-269.

Aceves, S; Collins, MH; Rothenberg, ME; Furuta, GT; Gonsalves, N; Abonia, JP; Almonte, S; Andrews, R; Arrington, A; Arva, N; et al. Advancing patient care through the Consortium of Eosinophilic Gastrointestinal Disease Researchers (CEGIR). Journal of Allergy and Clinical Immunology. 2020; 145:28-37.

Kottyan, LC; Parameswaran, S; Weirauch, MT; Rothenberg, ME; Martin, LJ. The genetic etiology of eosinophilic esophagitis. Journal of Allergy and Clinical Immunology. 2020; 145:9-15.

Rothenberg, ME; Bousquet, J. News Beyond Our Pages. Journal of Allergy and Clinical Immunology. 2020; 145:85-86.

Kurten, RC; Rawson, R; Shoda, T; Duong, LD; Adejumobi, D; Levy, R; Newbury, RO; Rothenberg, ME; Akuthota, P; Wright, BL; et al. Development and Application of a Functional Human Esophageal Mucosa Explant Platform to Eosinophilic Esophagitis. Scientific Reports. 2019; 9.

Klion, AD; Rothenberg, ME. Advances in eosinophilic diseases in 2018. Journal of Allergy and Clinical Immunology. 2019; 144:1490-1494.

Rothenberg, ME; Bousquet, J. News beyond our pages. Journal of Allergy and Clinical Immunology. 2019; 144:1511-1512.

Doucet-Ladeveze, R; Holvoet, S; Raymond, F; Foata, F; Hershey, GK K; Sherrill, JD; Rothenberg, ME; Blanchard, C. Transcriptomic Analysis Links Eosinophilic Esophagitis and Atopic Dermatitis. Frontiers in Pediatrics. 2019; 7.

Wen, T; Rothenberg, ME. Cell-by-cell deciphering of T cells in allergic inflammation. Journal of Allergy and Clinical Immunology. 2019; 144:1143-1148.

Rothenberg, ME; Bousquet, J. News Beyond Our Pages. Journal of Allergy and Clinical Immunology. 2019; 144:1156-1157.

Lyles, J; Rothenberg, M. Role of genetics, environment, and their interactions in the pathogenesis of eosinophilic esophagitis. Current Opinion in Immunology. 2019; 60:46-53.

Rothenberg, ME; Bousquet, J. News Beyond Our Pages. Journal of Allergy and Clinical Immunology. 2019; 144:924-925.

Muir, AB; Jensen, ET; Wechsler, JB; Menard-Katcher, P; Falk, GW; Aceves, SS; Furuta, GT; Dellon, ES; Rothenberg, ME; Spergel, JM. Overestimation of the diagnosis of eosinophilic colitis with reliance on billing codes. Journal of Allergy and Clinical Immunology: In Practice. 2019; 7:2434-2436.

Rothenberg, ME; Bousquet, J. News beyond our pages. Journal of Allergy and Clinical Immunology. 2019; 144:643-644.

Rothenberg, ME; Bousquet, J. News Beyond Our Pages. Journal of Allergy and Clinical Immunology. 2019; 144:395-396.

Ben Baruch-Morgenstern, N; Shoda, T; Rothenberg, ME. Bagels and LOX in patients with eosinophilic esophagitis. Journal of Allergy and Clinical Immunology. 2019; 144:41-43.

Rothenberg, ME; Bousquet, J. News Beyond Our Pages. Journal of Allergy and Clinical Immunology. 2019; 144:36-37.

Wheeler, JC; Vanoni, S; Zeng, C; Waggoner, L; Yang, Y; Wu, D; Uddin, J; Karns, R; Kottyan, L; Mukkada, V; et al. 17β-Estradiol protects the esophageal epithelium from IL-13-induced barrier dysfunction and remodeling. Journal of Allergy and Clinical Immunology. 2019; 143:2131-2146.

Pesek, RD; Reed, CC; Muir, AB; Fulkerson, PC; Menard-Katcher, C; Falk, GW; Kuhl, J; Martin, EK; Magier, AZ; Ahmed, F; et al. Increasing Rates of Diagnosis, Substantial Co-Occurrence, and Variable Treatment Patterns of Eosinophilic Gastritis, Gastroenteritis, and Colitis Based on 10-Year Data Across a Multicenter Consortium. American Journal of Gastroenterology. 2019; 114:984-994.

Rothenberg, ME; Bousquet, J. News Beyond Our Pages. Journal of Allergy and Clinical Immunology. 2019; 143:2009-2010.

DiTommaso, LA; Rosenberg, CE; Eby, MD; Tasco, A; Collins, MH; Lyles, JL; Putnam, PE; Mukkada, VA; Rothenberg, ME. Prevalence of eosinophilic colitis and the diagnoses associated with colonic eosinophilia. Journal of Allergy and Clinical Immunology. 2019; 143:1928-1930.e3.

Wen, T; Aronow, BJ; Rochman, Y; Rochman, M; Kiran, KC; Dexheimer, PJ; Putnam, P; Mukkada, V; Foote, H; Rehn, K; et al. Single-cell RNA sequencing identifies inflammatory tissue T cells in eosinophilic esophagitis. Journal of Clinical Investigation. 2019; 129:2014-2028.

Jensen, ET; Abonia, JP; Aceves, SS; Bonis, PA; Bray, K; Book, WM; Chehade, M; Collins, MH; Dellon, ES; Falk, GW; et al. Mo1133 – High Patient-Reported Disease Burden for Eosinophilic Gastrointestinal Disorders. Gastroenterology. 2019; 156:s-717.

Dellon, ES; Peterson, KA; Genta, RM; Murray, JA; Gonsalves, N; Chehade, M; Rothenberg, ME; Khoury, P; Bledsoe, AC; Singh, B; et al. Mo1127 – Mast Cells in Addition to Eosinophils are Markedly Elevated At Baseline in Patients with Eosinophilic Gastritis And/Or Gastroenteritis. Gastroenterology. 2019; 156:s-714.

Kliewer, K; Aceves, SS; Atkins, D; Bonis, PA; Chehade, M; Collins, MH; Dellon, ES; Fei, L; Gupta, SK; Kagalwalla, AF; et al. 817 – Efficacy of 1-Food and 4-Food Elimination Diets for Pediatric Eosinophilic Esophagitis in a Randomized Multi-Site Study. Gastroenterology. 2019; 156.

Muir, AB; Jensen, ET; Wechsler, JB; Menard-Katcher, P; Aceves, SS; Falk, GW; Furuta, G; Dellon, ES; Rothenberg, ME; Spergel, J. Su1754 – Overestimation of the Prevalence of Eosinophilic Colitis with Reliance on a Single Billing Code. Gastroenterology. 2019; 156:s-605.

Rothenberg, ME; Bousquet, J. News Beyond Our Pages. Journal of Allergy and Clinical Immunology. 2019; 143:1729-1730.

Kottyan, LC; Maddox, A; Braxton, JR; Stucke, EM; Mukkada, V; Putnam, PE; Abonia, JP; Chehade, M; Wood, RA; Pesek, RD; et al. Genetic variants at the 16p13 locus confer risk for eosinophilic esophagitis. Genes and Immunity. 2019; 20:281-292.

Krishnan, U; Lijuan, C; Andrew, GJ; Rothenberg, ME; Wen, T. Analysis of eosinophilic esophagitis in children with repaired congenital esophageal atresia. Journal of Allergy and Clinical Immunology. 2019; 143:1455-1464.e2.

Rothenberg, ME; Bousquet, J. News Beyond Our Pages. Journal of Allergy and Clinical Immunology. 2019; 143:1334-1335.

Azouz, NP; Rothenberg, ME. Mechanisms of gastrointestinal allergic disorders. Journal of Clinical Investigation. 2019; 129:1419-1430.

Miller, DE; Forney, C; Rochman, M; Cranert, S; Habel, J; Rymer, J; Lynch, A; Schroeder, C; Lee, J; Sauder, A; et al. Genetic, Inflammatory, and Epithelial Cell Differentiation Factors Control Expression of Human Calpain-14. G3: Genes, Genomes, Genetics. 2019; 9:729-736.

Schwartz, JT; Morris, DW; Collins, MH; Rothenberg, ME; Fulkerson, PC. Eosinophil progenitor levels correlate with tissue pathology in pediatric eosinophilic esophagitis. Journal of Allergy and Clinical Immunology. 2019; 143:1221-1224.e3.

Gupta, SK; Falk, GW; Aceves, SS; Chehade, M; Collins, MH; Dellon, ES; Gonsalves, N; Hirano, I; Mukkuda, VA; Peterson, KA; et al. Consortium of Eosinophilic Gastrointestinal Disease Researchers: Advancing the Field of Eosinophilic GI Disorders Through Collaboration. Gastroenterology. 2019; 156:838-842.

Miller, DE; Forney, C; Rochman, M; Cranert, S; Habel, J; Rymer, J; Lynch, A; Schroeder, C; Lee, J; Sauder, A; et al. Genetic, Inflammatory, and Epithelial Cell Differentiation Factors Control Expression of Human Calpain-14. G3: Genes, Genomes, Genetics. 2019; 9:729-736.

Rothenberg, ME; Bousquet, J. News Beyond Our Pages. Journal of Allergy and Clinical Immunology. 2019; 143:921-922.

Hirano, I; Collins, MH; Assouline-Dayan, Y; Evans, L; Gupta, S; Schoepfer, AM; Straumann, A; Safroneeva, E; Grimm, M; Smith, H; et al. RPC4046, a Monoclonal Antibody Against IL13, Reduces Histologic and Endoscopic Activity in Patients With Eosinophilic Esophagitis. Gastroenterology. 2019; 156:592-603.e10.

Rothenberg, ME; Bousquet, J. News Beyond Our Pages. Journal of Allergy and Clinical Immunology. 2019; 143:540-541.

Rothenberg, ME; Bousquet, J. News Beyond Our Pages. Journal of Allergy and Clinical Immunology. 2019; 143:76-77.

Funding Support

Many foundations and agencies, such as the Campaign Urging Research for Eosinophilic Diseases (CURED), generously support our work in the lab to help patients with eosinophilic diseases, including gastrointestinal disorders, asthma and food allergies. Funding Support

CD22 Expression on Gastrointestinal Eosinophils

research-callout1-250-figure 3
Reproduction of part of Figure 3, panel B published in The Journal of Immunology (February 1, 2012, vol. 188, p. 1075-1082), showing cell membrane expression of Pan-B cell marker CD22 on gastrointestinal eosinophils of wild type mice by FACS and flow imaging analysis. Copyright 2011. The American Association of Immunologists, Inc. Read More