The Rothenberg Laboratory has several broad research areas and objectives, including:

Epigenetic Basis of Allergic Disease and Responses

  • Identifying epigenetic mechanisms of allergic responses

Genetic Basis of Allergic Disease

  • Identifying genes and key check points that predispose to eosinophilic and other allergic disorders

Immunopathogenesis of Allergic Inflammation

  • Elucidating the cellular and molecular processes involved in allergic responses in the gastrointestinal tract and lung
  • Developing novel models of allergic responses in vivo and in vitro
  • Testing the importance of key molecules including chemokines, cytokines and adhesion molecules in immunity

Impaired Barrier Function

  • Elucidating the role of impaired barrier function in allergic inflammation

Pathogenesis of Eosinophilic Gastrointestinal Disorders

  • Biochemically characterizing the transcriptional programs, regulating molecules and signal transduction mechanisms responsible for eosinophil development and activation
  • Translating bench discoveries into novel therapeutics that treat inflammatory diseases such as eosinophilic esophagitis (EoE) and   hypereosinophilic syndromes (HES).

Precision and Predictive Medicine

  • Conducting big data (genomics, proteonomics) analyses of allergic disease with a focus on eosinophilic esophagitis (EoE)
  • Translating research findings into improved diagnostics (Learn more)

Proteases and Protease Inhibitors in Inflammation

  • Investigating the role of proteases and protease inhibitors in immunity
  • Identifying environmental factors involved in allergic diseases
  • Characterizing microbiome identity and function
  • Elucidating gene-environment interactions