Rothenberg Lab
Rothenberg CURED Lab

Precision and Predictive Medicine

Big data, genomics, and molecular diagnosis

We are translating our research findings to precisely understand individual patients and use these data to make diagnostic, prognostic and therapeutic decisions

Precision medicine.

Current Projects

  • Eosinophilic esophagitis diagnostic panel (EDP)
  • Eosinophilic gastritis diagnostic panel (EoGDP)
  • Other biomarkers
  • Development of non-invasive biomarkers of eosinophilic esophagitis (EoE)
  • Identify biomarkers that predict responsiveness to anti-IL-13 and other therapies

EoE and EG Diagnostic Panels

We developed a molecular diagnostic test called the eosinophilic esophagitis diagnostic panel (EDP), as well as the eosinophilic gastritis diagnostic panel (Shoda et al. JACI, 2020). The EDP uses a high-density Taqman quantitative PCR array to probe biopsy tissue in order to distinguish patients with eosinophilic esophagitis, the disease activity, and exposure to swallowed glucocorticoids. Read More

EGID Diagnostics

We strive to translate our research into clinical utility and practice, as exemplified by our development of diagnostics for eosinophilic gastrointestinal disorders (EGIDs). Read More

PPI-Responsive Esophageal Eosinophilia

Esophageal eosinophilia can be resistant or responsive to proton pump inhibitors (PPI), representing eosinophilic esophagitis (EoE) if it is resistant and PPI-responsive esophageal eosinophilia (PPI-REE) if it is responsive. A recent, collaborative study by the Rothenberg and Wen Labs shows significant molecular overlap between EoE and PPI-REE transcriptomes, suggesting that these conditions have similar underlying mechanisms. A major research question being pursued is how PPIs can reverse esophageal eosinophilia and the pathogenetic relationship between EoE and PPI-REE. Read More
Diagnosing EE.
EoE Diagnosis is Invasive - Read More