These projects employ candidate-gene approaches, genome-wide association studies (GWAS), whole-exome sequencing (WES), and other advanced techniques and approaches to identify genetic risk factors for allergic diseases and to gain molecular insight into disease pathogenesis.

Genetic Basis of Allergic Disease visual graphic.

Current Projects

  • Mechanism by which specific genetic susceptibility loci contribute to EoE susceptibility and related responses
  • Deciphering the role of the 2p23 genetic variants, particularly CAPN14 in EoE
  • Deciphering the role of the 5q22 genetic variants, particularly TSLP in EoE
  • Epistasis between CAPN14, TSLP and other genetic risk variants
  • Identification of causative mutations in EoE via Next Generation Sequencing
  • Genetics of Multiplex EoE
  • Interaction between genome, environome and microbiome