The major goals of these projects are to elucidate gene-environment interactions in allergic disease and responses and to define the epigenetic mechanisms that account for these interactions and their clinical and therapeutic significance.

Epigenetic and Genetic Regulation of the CCL26 locus in Eosinophilic Esophagitis (EoE)

 Epigenetic visual element.

Mechanism of Epigenetic Regulation in Immunity

Mechanism of Epigenetic Regulation in Immunity.

Current Projects

  • Regulation of IL-13-induced EoE-like changes by chromatin remodeling
  • Gene environment interaction involved in development and manifestations of EGID
  • IL-13-induced chromatin landscape in esophageal epithelial cells and fibroblasts
  • Epigenetic mechanism of IL-33-induced responses
  • Role of nuclear IL-33