Our laboratory is focusing on the following topics:

  • DNA damage response in the young and aged hematopoietic systems
  • Hematopoietic stem cell mobilization: interstrain variation as well as consequences of aging on mobilization proficiency
  • The role of the retinoblastoma tumor suppressor gene in hematopoiesis (interplay between stem cell self-renewal and cell differentiation; involvement in leukemia progression)
  • Aging of hematopoietic stem cells