Gastroenterology, Hepatology and Nutrition

Pediatric gastroenterology; hepatology and nutrition with special focus on pancreatic disease and cystic fibrosis.

Biography

Their research is essential to study pediatric pancreatitis etiologies, epidemiology, management protocols and outcomes. This disease was thought to be rare in the pediatric population; however, recent studies have reported increased incidence to be as close as pancreatitis incidence in the adult patient population. Dr. Abu-El-Haija has the knowledge and motivation necessary to complete the proposed research successfully. Her knowledge in pancreatic disease stemmed from a major interest and then was nourished by her expertise in working with pancreatic disease in a cystic fibrosis (CF) pig model. This was a basic science lab work.

During Dr. Abu-El-Haija's fellowship training, she dedicated all her research time to conduct research in this novel cystic fibrosis model to look at the pathways involved in pancreatic destruction. She worked with a great group of collaborators in the world of pancreatic disease, CF and pathology, and this gave her a great deal of knowledge on how to be able to generate novel data in science. She was successful in getting grants that funded her research in the past. Their work has resulted in publications in peer-reviewed journals and hopefully will help advance the care of their patients.

MBBS: Jordan University of Science and Technology (JUST), Jordan, 1997.

Residency: Pediatrics, University of Iowa Hospitals and Clinics, Iowa City, IA, 2009.

Fellowship: Pediatric Gastroenterology, University of Iowa Hospitals and Clinics, Iowa City, IA, 2012.

Ana Catalina (Cata) Arce-Clachar, MD

Abu-El-Haija M, Stasheff S, Atkins DL, Bishop WP. Rheumatic fever in a patient receiving Infliximab therapy for Crohn disease. J Pediatr Gastroenterol Nutr. 2011 Mar;52(3):360-1.

Abu-El-Haija M, Sinkora M, Meyerholz DK, Welsh MJ, McCray PB Jr, Butler J, Uc A. An Activated Immune and Inflammatory Response Targets the Pancreas of Newborn Pigs with Cystic Fibrosis. Pancreatology. 2011 Nov 1;11(5):506-515.

Sánchez-Vargas FM, Abu-El-Haija MA, Gómez-Duarte OG. Salmonella Infections: An Update on Epidemiology, Management, and Prevention. Travel Med Infect Dis. 2011 Nov;9(6):263-77.

Griffin M*, Abu-El-Haija M*, Abu-El-Haija M, Rokhlina T, Uc, A. A Simplified and Versatile Method for Obtaining High Quality RNA From Pancreas. Biotechniques. 2012 May;52(5):332-4. (* contributed equally)

Abu-El-Haija Maisam, Ramachandran Shyam, Meyerholz David, Abu-El-Haija Marwa, Griffin Michelle, Giriyappa Rhadhamma, Welsh Micheal, McCray Paul, Uc Aliye. Pancreatic Damage in a Cystic Fibrosis Pig Model Involves the Activation of Proinflammatory Pathways. Am J Pathol. 2012 Aug;181(2):499-507.

Abu-El-Haija Maisam, Rahhal Riad, Ebach Dawn. Esophageal Squamous Papilloma in a Pediatric Patient. J Gastroint Dig Syst. 2012;2:3.

Aliye Uc, Radhamma Giriyappa, David K. Meyerholz, Michelle Griffin, Marwa Abu-El-Haija, David A. Stoltz, Paula Ludwig, Alejandro Pezzulo, Maisam Abu-El-Haija, Peter Taft, Michael J. Welsh. Pancreatic and Biliary Secretions Differ in Cystic Fibrosis and Wild Type Pigs. Am J Physiol Gastrointest Liver Physiol. 2012 Oct;303(8):G961-8.

Abu-El-Haija Maisam, Ebach Dawn. NASPGHAN pediatric gastroenterology board review, sections: Stomach: anatomy, physiology, pathology. October 2010.

Abu-El-Haija, Maisam, Ebach, Dawn. NASPGHAN pediatric gastroenterology board review, sections Food poisoning and enteric infections. October 2010.

513-303-0353 anacatalina.arce-clachar@cchmc.org

Akihiro Asai, MD, PhD

Akihiro Asai, MD, PhD, investigates disease mechanisms of pediatric cholestatic disorders. The major research focus is pre-clinical and translational research on bile acid transporter defects, known as Progressive Familial Intrahepatic Cholestasis (PFIC).

513-803-1791 akihiro.asai@cchmc.org

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Akihiro Asai, MD, PhD

Academic Affiliations

Instructor, UC Department of Pediatrics

Phone 513-803-1791

Email akihiro.asai@cchmc.org

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Clinical

Pediatric hepatology; pediatric gastroenterology; pediatric liver transplantation

Research

Genetic and metabolic mechanism of pediatric liver diseases

MD: Nagoya University, Nagoya, Japan, 2003.

PhD: Tokyo University, Tokyo, Japan, 2008.

Residency: Pediatrics, Columbia University, New York, NY.

Certification: Pediatrics, 2010.

Fellowship: Pediatric Gastroenterology, Hepatology and Nutrition, Northwestern University, Chicago, IL.

Certification: Pediatric Gastroenterology, Hepatology and Nutrition, 2013.

Fellowship: Advanced/Transplant Hepatology, University of Cincinnati, Cincinnati, OH.

Certification: Advanced/Transplant Hepatology.

Asai A, Kohli R. Familial homozygous hypercholesterolemia: When to turn to transplant? Pediatric Transplantation. 2015;19: 577–579.

Asai A, Miethke A, Bezerra J. Pathogenesis of biliary atresia: defining biology to understand clinical phenotypes. Nat Rev Gastroenterol Hepatol. 2015 Jun;12(6):342-352.

Asai A, Malladi S, Misch J, Pan X, Malladi P, Diehl AM, Whitington PF. Elaboration of tubules with active Hedgehog drives parenchymal fibro genesis in gestational alloimmune liver disease. Human Pathology. 2015 Jan;46(1):84-93.

Asai A, Chou PM, Bu HF, Wang X, Rao MS, Jiang A, DiDonato CJ, Tan XD. Dissociation of hepatic insulin resistance from susceptibility of nonalcoholic fatty liver disease induced by a high-fat and high-carbohydrate diet in mice. Am J Physiol Gastrointest Liver Physiol. 2014 Mar;306(6):G496-504.

Wang X, Bu HF, Zhong W, Asai A, Zhou Z, Tan XD. MFG-E8 and HMGB1 are involved in the mechanism underlying alcohol-induced impairment of macrophage engulfing apoptotic cells. Mol Med. 2013 Jul 24;19:170-82.

Asai A, Sahani N, Kaneki M, Ouchi Y, Martyn JJ, Yasuhara S. Primary Role of Functional Ischemia, Quantitative Evidence of Two-Hit Mechanism, and Phosphodiesterase-5 Inhibitor Therapy in Mouse Muscular Dystrophy. PLoS One. 2007 Aug 29;2(8):e806.

Asai A, Sahani N, Ouchi Y, Martyn JJ, Yasuhara S. In vivo Micro-circulation Measurement in Skeletal Muscle by Intra-vital Microscopy. J Vis Exp. 2007;(4):210.

William F. Balistreri, MD Dorothy M. M. Kersten Professor of Pediatrics

His multicenter studies include assessing the safety and efficacy of new direct acting anti-virals in the treatment of children with chronic hepatitis C and examining the safety and efficacy of these drugs in inducing clearance of HCV and/or HBV (loss of HBeAg) in chronically infected children.

513-636-4594 william.balistreri@cchmc.org

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William F. Balistreri, MD

Dorothy M. M. Kersten Professor of Pediatrics

Director Emeritus, Pediatric Liver Care Center

Medical Director Emeritus, Liver Transplantation

Program Director Emeritus, Fellowship in Transplant Hepatology

Academic Affiliations

Professor, UC Department of Pediatrics

Phone 513-636-4594

Fax 513-636-7805

Email william.balistreri@cchmc.org

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Liver disease (cholestasis, viral hepatitis, metabolic liver disease; liver transplantation); celiac disease.

Biography

Through more than 550 publications, Balistreri has helped to clarify the understanding of many aspects of liver diseases in children.

Balistreri has been editor of The Journal of Pediatrics since 1995. He is the former editor-in-chief of the Journal of Pediatric Gastroenterology and Nutrition, and co-editor, associate editor, guest editor, reviewer and member of numerous editorial boards of several journals. He is co-editor of the prestigious text Liver Disease in Children.

In 2000, Balistreri became the first pediatrician to serve as president of the American Association for the Study of Liver Diseases. He has received numerous awards. These include the Distinguished Leadership Award from the CCFA; the Andrew Sass-Kortsak Memorial Award from the Canadian Liver Foundation and the Canadian Association for the Study of Liver; the Murray Davidson Award from the American Academy of Pediatrics; the prestigious Shwachman Award from the NASPGHAN; the Founder's Award, Cincinnati Pediatric Society; The Distinguished Alumnus Award, University of Buffalo; The Daniel Drake Medal, University of Cincinnati, College of Medicine; the Distinguished Service Award from AASLD; and the Distinguished Educator Award from the American Gastroenterological Association. He received the Outstanding Pediatrician award from the Ohio Chapter of the American Academy of Pediatrics for distinguished achievements in pediatric care and in the education of patients and physicians.

In 2012, NASPGHAN established the William F. Balistreri, MD, Prize for Excellence in Pediatric Gastroenterology, Hepatology and Nutrition. This award will recognize outstanding achievement in an area relevant to the field to be bestowed each year at the annual NASPGHAN meeting.

Balistreri joined Cincinnati Children's in 1978. He served as division director of Pediatric Gastroenterology, Hepatology, and Nutrition for 25 years.

Balistreri has been listed multiple times in Best Doctors in America.

BA: State University of New York at Buffalo, NY, 1966.

MD: University of Buffalo School of Medicine, NY, 1970.

Internship: Cincinnati Children's Hospital Medical Center (University of Cincinnati School of Medicine), Cincinnati, OH, 1970 to 1972.

Residency: Cincinnati Children's Hospital Medical Center (University of Cincinnati School of Medicine), Cincinnati, OH, 1971 to 1972.

Fellowship: Pediatric Gastroenterology and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 1973 to 1974.

Research Fellowship: Gastroenterology, Mayo Foundation, Mayo Clinic, Rochester, MN, 1973 to 1975.

Certification: Pediatrics, 1975 (renewed 1992); Pediatric Gastroenterology and Nutrition, 1990 (certificate #2; renewed 1997, 2004, and 2014).

Subspecialty Certification: 2006, American Board of Pediatrics (certificate #004 Pediatric Transplant Hepatology).

Xanthakos SA, Podberesky DJ, Serai S, Miles L, King EC, Balistreri WF, Kohli R. Use of magnetic resonance elastography to assess hepatic fibrosis in children with chronic liver disease. The Journal of Pediatrics. 2014 Jan;164(1):186-8.

Balistreri WF, Master’s Perspective. Growth and Development of a New Subspecialty: Pediatric Hepatology. HEPATOLOGY. 2013;58:458-476.

Molleston JP, Mellman W, Narkewicz MR, Balistreri WF, Gonzalez-Peralta RP, Jonas M, Lobritto SJ, Mohan P, Murray KF, Rosenthal P, Robuck PR, Barton BA, Schwarz KB, Haber B for the PEDS-C Clinical Research Network. Auto-antibodies and Autoimmune Disease During Treatment of Children with Hepatitis C. J Pediatr Gastroenterol Nutr. 2013;56:304-310.

Jonas MM, Balistreri W, González-Peralta RP, Haber B, Lobritto S, Mohan P, Molleston JP, Murray KF, Narkewicz MR, Rosenthal P, Schwarz KB, Barton BA, Shepherd J, Robuck PR, Mitchell PD, Duggan C. Peginterferon for Chronic Hepatitis C in Children affects growth and body composition: Results from the Pediatric Study of Hepatitis C (PEDS-C) Trial. Hepatology. 2012 Aug;56(2):523-31.

Schwarz KB, Gonzalez-Peralta R, Murray K, Molleston J, Haber B, Jonas M, Mohan P, Balistreri W, Rosenthal P, Narkewicz M, Smith L, Robuck P, Barton B for the PEDS C Clinical Research Network. The combination of ribavirin and peginterferon is superior to perinterferon and placebo for Children and Adolescents with Chronic Hepatitis C: The Peds-C Trial. Gastroenterology. 2011;140:450-458.

Kohli R, Kirby M, Xanthakos SA, Softic S, Feldstein AE, Saxena V, Tang PH, Miles L, Miles MV, Balistreri WF, Woods SC, Seeley RJ. High-fructose, medium chain trans fat diet induces liver fibrosis and elevates plasma coenzyme Q9 in a novel murine model of obesity and nonalcoholic steatohepatitis. Hepatology. 2010 Sep;52(3):934-44.

Kohli R, Kirby M, Setchell KD, Jha P, Klustaitis K, Woollett LA, Pfluger PT, Balistreri WF, Tso P, Jandacek RJ, Woods SC, Heubi JE, Tschoep MH, D'Alessio DA, Shroyer NF, Seeley RJ. Intestinal adaptation after ileal interposition surgery increases bile acid recycling and protects against obesity-related comorbidities. Am J Physiol Gastrointest Liver Physiol. 2010 Sep;299(3):G652-60.

Kohli R, Boyd T, Lake K, Dietrich K, Nicholas L, Balistreri WF, Ebach D, Shashidhar H, Xanthakos SA. Rapid progression of NASH in childhood. J Pediatr Gastroenterol Nutr. 2010 Apr;50(4):453-6.

Leonis MA, Balistreri WF. Evaluation and management of end-stage liver disease in children. Gastroenterology. 2008 May;134(6):1741-51.

Ryckman FC, Bucuvalas JC, Nathan J, Alonso M, Tiao G, Balistreri WF. Outcomes following liver transplantation. Semin Pediatr Surg. 2008 May;17(2):123-30.

John C. Bucuvalas, MD Attending Physician, Division of Gastroenterology, Hepatology and Nutrition

John C. Bucuvalas, MD, seeks to optimize allograft health and minimize complications of immunosuppressive medication. His research integrates clinical correlates & structural characteristics of the allograft with serologies, tissue immunophenotype and tissue transcriptional profiles. Our preliminary data demonstrates distinct cross platform patterns among stable pediatric liver transplant recipient suggesting a path to personalized immunosuppression.

Visit the Bucuvalas Lab.

513-803-1791 john.bucuvalas@cchmc.org

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John C. Bucuvalas, MD

Attending Physician, Division of Gastroenterology, Hepatology and Nutrition

Academic Affiliations

Professor, UC Department of Pediatrics

Phone 513-803-1791

Fax 513-636-7805

Email john.bucuvalas@cchmc.org

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Clinical

Transplant hepatology

Research

Outcomes; operational tolerance in solid organ transplant recipients

Visit the Bucuvalas Lab.

Biography

Dr. Bucuvalas has a broad background in transplant hepatology. He has published broadly on outcomes following liver transplantation and am co-investigator for a study designed to study the Etiopathogenesis and clinical outcome for Medical Adherence in Liver Transplant Recipients. He serves as the protocol chair and have work closely with the PI, Dr. Sandy Feng, in parent study (Immunosuppression Withdrawal for Stable Pediatric Liver Transplant Recipients). He has established strong ties with pediatric solid organ transplant community both internal to Cincinnati Children's and external to Cincinnati Children's thru NIAID, ITN and CTOT. He also has strong ties and collaborations with the liver transplant community thru SPLIT, AST and UNOS.

AB: Harvard College, Cambridge, MA, 1974.

MD: Harvard Medical School, Boston, MA, 1978.

Residency: Pediatrics, Massachusetts General Hospital, Boston, MA, 1978 to 1981.

Chief Residency: Pediatrics, Massachusetts General Hospital, Boston, MA, 1981 to 1982.

Fellowship: Gastroenterology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 1982 to 1986.

Research Scholar: Gastroenterology, Children's Hospital Research Foundation, Cincinnati, OH, 1985 to 1986.

Certification: Pediatrics, 1983; Pediatric Gastroenterology, 1990, re-certified, 1997, 2004; Transplant hepatology (CAQ), 2006.

Gilroy R, Bucuvalas J. Share 35 has us too wary of strangers bearing gifts. Liver Transpl. 2016;22:159–160.

Goldstein SL, Kirkendall E, Nguyen H, Schaffzin JK, Bucuvalas J, Bracke T, Seid M, Ashby M, Foertmeyer N, Brunner L, Lesko A, Barclay C, Lannon C, Muething S. Electronic health record identification of nephrotoxin exposure and associated acute kidney injury. Pediatrics. 2013;132:e756-67.

Bucuvalas J, Filipovich L, Yazigi N, Narkewicz MR, Ng V, Belle SH, Zhang S, Squires RH. Immunophenotype predicts outcome in pediatric acute liver failure. J Pediatr Gastroenterol Nutr. 2013;56:311-5.

Englesbe RM, Kelly B, Goss J, Fecteau A, Mitchell J, Andrews W, Krapohl G, Magee J, Mazariegos G, Horslen S, Bucuvalas J. Reducing Pediatric Liver Transplant Complications: A Potential Roadmap for Transplant Quality Improvement Initiatives within North America. American Journal of Transplantation. 2012;12:2301-2306.

Ng VL, Alonso EM, Bucuvalas JC, et al. Health Status of Children Alive 10 Years after Pediatric Liver Transplantation Performed in the US and Canada: Report of the Studies of Pediatric Liver Transplantation Experience. J Pediatr. 2012;160:820-6.

Campbell K, Ng V, Martin S, Magee J, Goebel J, Anand R, Martz K, Bucuvalas J; SPLIT Renal Function Working Group. Glomerular filtration rate following pediatric liver transplantation--the SPLIT experience. Am J Transplant. 2010 Dec;10(12):2673-82.

Venkat V, Nick T, Wang Y, Bucuvalas JC. An Objective Measure to Identify Pediatric Liver Transplant Recipients at Risk for Late Allograft Rejection Related to Non-Adherence. Pediatric Transplantation. 2007;12:67-72.

Squires R, Shneider BL, Bucuvalas JC, Alonso E, Sokol RJ, Narkewicz MR et al. Acute liver failure in children: the first 348 patients in the pediatric acute liver failure study group. J Pediatr. 2006;148:652-8.

Bucuvalas JC, Frederick FC, Arya G, Andrew B, Lesko A, Cole C, James B, Kotagal U. A Novel Approach to Managing Variation Outpatient Therapeutic Monitoring of Calcineurin Inhibitor Blood Levels in Liver Transplant Recipients. J Pediatrics. 2005;146:744-750.

Bucuvalas JC, Britto M, Krug S, Ryckman FC, Atherton H, Alonso M, Balistreri and Kotagal U. Health-Related Quality Of Life In Pediatric Liver Transplant Recipients: A Single Center Study. Liver Transplantation. 2003;9:62-71.

Kathleen M. Campbell, MD

Kathleen M. Campbell, MD, is interested in the care of patients both before and long after pediatric liver transplantation, with a particular interest in risk factors for, and prevention of, chronic renal dysfunction following transplantation.

513-636-4415 kathleen.campbell@cchmc.org

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Kathleen M. Campbell, MD

Academic Affiliations

Associate Professor, UC Department of Pediatrics

Phone 513-636-4415

Fax 513-636-7805

Email kathleen.campbell@cchmc.org

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Clinical

Diagnosis and management of pediatric liver disease, particularly biliary atresia and other forms of neonatal cholestasis; liver transplantation and post-transplant renal dysfunction.

Research

Clinical and genetic determinants of calcineurin inhibitor induced post-transplant nephrotoxicity; disease modifiers in biliary atresia

Biography

Kathleen M. Campbell, MD, joined the Division of Gastroenterology, Hepatology and Nutrition as a fellow in 2000, after completing her pediatric residency training at Cincinnati Children's Hospital Medical Center. Following the completion of her fellowship, she pursued an additional year of training in pediatric hepatology under the mentoring of Dr. William Balistreri and the physicians and surgeons of the Pediatric Liver Care Center, becoming one of the first in her specialty to obtain focused training in this field.

In 2004, Dr. Campbell was appointed assistant professor of pediatrics in the Division of Gastroenterology, Hepatology and Nutrition and the Pediatric Liver Care Center within the UC Department of Pediatrics. Her clinical and translational research interests include post-transplant renal dysfunction and genetic modifiers of disease in biliary atresia.

MD: University of Tennessee College of Medicine, Memphis, TN, 1997.

Residency: Pediatrics, University of Cincinnati and Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2000.

Fellowship: Pediatric Gastroenterology, Hepatology and Nutrition, University of Cincinnati and Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2003.

Advanced Fellowship: Pediatric Hepatology, University of Cincinnati and Cincinnati Children's Hospital Medical Center, 2004.

Certification: Pediatrics, 2000; Pediatric Gastroenterology, Hepatology and Nutrition, 2003.

Campbell KM, Bucuvalas JC. Renal function in the long term after pediatric liver transplantation: is there a need for protocol kidney biopsies? Curr Opin Organ Transplant. 2010 Oct;15(5):608-13.

Choquette M, Goebel JW, Campbell KM. Nonimmune complications after transplantation. Pediatr Clin North Am. 2010 Apr;57(2):505-21, table of contents. Review.

Pacheco MC, Campbell KM, Bove KE. Ductal plate malformation-like arrays in early explants after a Kasai procedure are independent of splenic malformation complex (heterotaxy). Pediatr Dev Pathol. 2009 Sep-Oct;12(5):355-60.

Calvo-Garcia MA, Campbell KM, O'Hara SM, Khoury P, Mitsnefes MM, Strife CF. Acquired renal cysts after pediatric liver transplantation: association with cyclosporine and renal dysfunction. Pediatr Transplant. 2008 Sep;12(6):666-71.

Campbell KM, Arya G, Ryckman FC, Alonso M, Tiao G, Balistreri WF, Bezerra JA. High prevalence of alpha-1-antitrypsin heterozygosity in children with chronic liver disease. J Pediatr Gastroenterol Nutr. 2007 Jan;44(1):99-103.

Bucuvalas JC, Campbell KM, Cole CR, Guthery SL. Outcomes after liver transplantation: keep the end in mind. J Pediatr Gastroenterol Nutr. 2006 Jul;43 Suppl 1:S41-8.

Campbell KM, Yazigi N, Ryckman FC, Alonso M, Tiao G, Balistreri WF, Atherton H, Bucuvalas JC. High prevalence of renal dysfunction in long-term survivors after pediatric liver transplantation. J Pediatr. 2006 Apr;148(4):475-80.

Shivakumar P, Campbell KM, Sabla GE, Miethke A, Tiao G, McNeal MM, Ward RL, Bezerra JA. Obstruction of extrahepatic bile ducts by lymphocytes is regulated by IFN-gamma in experimental biliary atresia. J Clin Invest. 2004 Aug;114(3):322-9.

Campbell KM, Sabla GE, Bezerra JA. Transcriptional reprogramming in murine liver defines the physiologic consequences of biliary obstruction. J Hepatol. 2004 Jan;40(1):14-23.

Book Chapters

Campbell KM and Balistreri WF. Inflammatory Bowel Disease. Comprehensive Pediatrics. 1st edition. 2001.

Conrad R. Cole, MD, MPH, MSc Clinical Director, Division of Gastroenterology, Hepatology and Nutrition

Conrad R. Cole, MD, MPH, MSc, is interested in intestinal rehabilitation and neonatal nutrition. His research focuses on (1) the prevention of blood stream infections and improving nutritional and developmental outcomes in children with short bowel syndrome and intestinal failure and (2) the epidemiology and prevention of micronutrient malnutrition and its consequences in preschool children especially within minority and low income populations.

513-636-4415 conrad.cole@cchmc.org

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Conrad R. Cole, MD, MPH, MSc

Clinical Director, Division of Gastroenterology, Hepatology and Nutrition

Medical Director, Intestinal Rehabilitation Program

Academic Affiliations

Professor, UC Department of Pediatrics

Phone 513-636-4415

Fax 513-636-7805

Email conrad.cole@cchmc.org

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Clinical

Intestinal failure; short bowel syndrome; growth failure; failure to thrive malabsorption disorders; micronutrient malnutrition

Research

Nutritional and developmental outcomes of infants with intestinal failure and short bowel syndrome; nutritional epidemiology of micronutrient malnutrition in preschool children

Biography

Conrad Cole, MD, is an expert in the management of infants with intestinal failure and short bowel syndrome. He is the clinical director of the Division of Gastroenterology, Hepatology and Nutrition and a professor of pediatrics at the University of Cincinnati College of Medicine.

Dr. Cole's research interest is in the epidemiology of intestinal failure and its complications especially in identifying risk factors associated with worsening prognosis. He is also interested in micronutrient malnutrition specifically zinc and iron and how they impact other micronutrients in intestinal failure patients and preschool children especially from low income minority populations and low income countries (global health).

Prior to joining Cincinnati Children's, Dr. Cole was at Emory University's Schools of Medicine and Public Health. Dr. Cole earned his medical degree from the University of Ibadan, and also completed graduate degrees in public health from Ohio State University and clinical research from Emory University. He received training in nutrition under the mentorship of Fima Lifshitz MD at Maimonides Medical Center and Miami Children's Hospital prior to completing an internship and residency in pediatrics at the Miami Children's Hospital; and a fellowship in pediatric gastroenterology at Cincinnati Children's Hospital Medical Center.

MD: University of Ibadan.

MPH: Ohio State University, Columbus, OH.

MSc: Emory University, Atlanta, GA.

Residency: Miami Children's Hospital, Miami, FL.

Fellowship: Cincinnati Children's Hospital Medical Center, Cincinnati, OH.

Certification: Pediatrics, Pediatric Gastroenterology.

Galloway DP, Troutt ML, Kocoshis SA, Gewirtz AT, Ziegler TR, Cole CR. Increased Anti-Flagellin and Anti-Lipopolysaccharide Immunoglobulins in Pediatric Intestinal Failure: Associations With Fever and Central Line-Associated Bloodstream Infections. JPEN J Parenter Enteral Nutr. 2015 Jul;39(5):562-8.

Ubesie AC, Kocoshis SA, Mezoff AG, Henderson CJ, Helmrath MA, Cole CR. Multiple micronutrient deficiencies among patients with intestinal failure during and after transition to enteral nutrition. J Pediatr. 2013 Dec;163(6):1692-6.

Ubesie AC, Cole CR, Nathan JD, Tiao GM, Alonso MH, Mezoff AG, Henderson CJ, Kocoshis SA. Micronutrient deficiencies in pediatric and young adult intestinal transplant patients. Pediatr Transplant. 2013 Nov;17(7):638-45.

Ubesie AC, Heubi JE, Kocoshis SA, Henderson CJ, Mezoff AG, Rao MB, Cole CR. Vitamin D deficiency and low bone mineral density in pediatric and young adult intestinal failure. J Pediatr Gastroenterol Nutr. 2013 Sep;57(3):372-6.

Cole CR, Grant FK, Swaby-Ellis ED, Smith JL, Jacques A, Northrop-Clewes CA, Caldwell KL, Pfeiffer CM, Ziegler TR. Zinc and iron deficiency and their interrelationship in low-income African American and Hispanic children in Atlanta. American Journal of Clinical Nutrition. 2010;91:1027-1034.

Cole CR, Grant FK, Tangpricha V, Swaby-Ellis ED, Smith JL, Jacques A, Chen HP, Schleicher RL, Ziegler TR. 25-hydroxyvitamin D status of healthy low-income minority children in Atlanta. Pediatrics. 2010;125: 633-639.

Cole C, Freitas A, Clifton MS, Durham MM. Hereditary Multiple Intestinal Atresias: two new cases and review of the literature. Journal of Pediatric Surgery. 2010;45:E21-24.

Frem J, Sarson Y. Sternberg T, Cole CR. Copper supplementation in parenteral nutrition of cholestatic infants. Journal of Pediatric Gastroenterology, Hepatology and Nutrition. 2010;50: 650-654.

Cole CR, Frem JC, Schmotzer B, Gewirtz AT, Meddings JB, Gold BD, Ziegler TR. The rate of bloodstream infection is high in infants with short bowel syndrome: Relationship with small bowel bacterial overgrowth, enteral feeding and inflammatory and immune responses. Journal of Pediatrics. 2010;156: 941-947.e1.

Cole CR, Hansen N, Huggins R, Ziegler TR, Stoll BJ for the NICHD neonatal research network. Very low birth weight preterm infants with surgical short bowel syndrome: incidence, morbidity and mortality and growth outcomes at 18-22 months. Pediatrics. 2008;112:e573-582.

Lee A. Denson, MD Medical Director, Inflammatory Bowel Disease Center

Lee A. Denson, MD, and his research program's goal is to discover mechanisms driving chronic inflammation and mucosal healing in patients with Inflammatory Bowel Disease (IBD). Next generation sequencing (NGS) is being used to define the intestinal microbial community and global pattern of gene expression in large prospective pediatric IBD inception cohorts, in order to inform the development of new diagnostics and therapeutics.
Visit the Denson Lab.

513-636-7575 lee.denson@cchmc.org

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Lee A. Denson, MD

Medical Director, Inflammatory Bowel Disease Center

Academic Affiliations

Professor, UC Department of Pediatrics

Phone 513-636-7575

Email lee.denson@cchmc.org

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Clinical

Inflammatory bowel disease; growth failure; celiac disease

Research

Visit the Denson Lab.

Biography

The primary focus of Dr. Lee A. Denson's laboratory is to determine the molecular basis for alterations in growth hormone signaling in inflammatory bowel diseases (IBD).

Normal growth and development are dependent upon the ability of growth hormone to regulate IGF-1 expression. Evidence from studies in children with IBD and mouse models of colitis indicates that inflammatory cytokines which are up regulated in this setting may cause an acquired GH resistance. Consequences may include growth failure, altered body composition and impaired mucosal healing.

We are using complementary experimental and patient-based approaches to investigate regulation of growth hormone signaling in mouse models of colitis and in children with Crohn's disease. These include down regulation of the growth hormone receptor and up regulation of a family of post-receptor inhibitory proteins, the Suppressors of Cytokine Signaling (SOCS). These studies should lead to the development of more effective therapies for children with IBD and other chronic inflammatory conditions.

MD: Medical College of Virginia, Richmond, VA, 1993.

Residency: Yale-New Haven Hospital, New Haven, CT, 1993-96.

Certification: Pediatrics, 1996 and 2002.

Fellowship: Yale University School of Medicine, New Haven, CT, 1996-99.

Ning K, Gettler K, Zhang W, Ng SM, Bowen BM, Hyams J, Stephens MC, Kugathasan S, Denson LA, Schadt EE, Hoffman GE, Cho JH. Improved integrative framework combining association data with gene expression features to prioritize Crohn's disease genes. Hum Mol Genet. 2015 Jul 15;24(14):4147-57.

Minar P, Haberman Y, Jurickova I, Wen T, Rothenberg ME, Kim MO, Saeed SA, Baldassano RN, Stephens M, Markowitz J, Rosh J, Crandall WV, Heyman MB, Mack DR, Griffiths AM, Baker SS, Hyams JS, Kugathasan S, Denson LA. Utility of neutrophil Fcγ receptor I (CD64) index as a biomarker for mucosal inflammation in pediatric Crohn's disease. Inflamm Bowel Dis. 2014 Jun;20(6):1037-48.

Haberman Y, Tickle TL, Dexheimer PJ, Kim MO, Tang D, Karns R, Baldassano RN, Noe JD, Rosh J, Markowitz J, Heyman MB, Griffiths AM, Crandall WV, Mack DR, Baker SS, Huttenhower C, Keljo DJ, Hyams JS, Kugathasan S, Walters TD, Aronow B, Xavier RJ, Gevers D, Denson LA. Pediatric Crohn disease patients exhibit specific ileal transcriptome and microbiome signature. J Clin Invest. 2014 Aug;124(8):3617-33.

Gevers D, Kugathasan S, Denson LA, Vázquez-Baeza Y, Van Treuren W, Ren B, Schwager E, Knights D, Song SJ, Yassour M, Morgan XC, Kostic AD, Luo C, González A, McDonald D, Haberman Y, Walters T, Baker S, Rosh J, Stephens M, Heyman M, Markowitz J, Baldassano R, Griffiths A, Sylvester F, Mack D, Kim S, Crandall W, Hyams J, Huttenhower C, Knight R, Xavier RJ. The treatment-naïve microbiome in new-onset Crohn’s disease. Cell Host Microbe. 2014 Mar 12;15(3):382-92.

Dykes D, Towbin A, Bonkowski E, Chalk C, Bezold R, Lake K, Kim M, Heubi J, Trapnell B, Podberesky D, Denson L. Increased Prevalence of Luminal Narrowing and Stricturing by Enterography in Pediatric Crohn Disease Patients with Elevated Granulocyte-Macrophage Colony Stimulating Factor Auto-antibodies. Inflamm Bowel Dis. 2013 Sep;19(10):2146-54.

Jurickova I, Collins M, Chalk C, Seese A, Bezold R, Lake K, von Allmen D, Frischer J, Trapnell B, Denson L. Pediatric Crohn Disease Patients with Stricturing Behavior Exhibit Ileal Granulocyte-Macrophage Colony Stimulating Factor Auto-antibody Production and Reduced Neutrophil Bacterial Killing and GM-CSF Bioactivity. Clin Exp Immunol. 2013 Jun;172(3):455-65.

Samson CM, Jurickova I, Molden E, Schreiner W, Colliver J, Bonkowski E, Han X, Trapnell BC, Denson LA. Granulocyte-Macrophage Colony Stimulating Factor Blockade Promotes CCR9+ Lymphocyte Expansion in Nod2 Deficient Mice. Inflamm Bowel Dis. 2011 Dec;17(12):2443-55.

Han X, Uchida K, Jurickova I, Koch D, Willson T, Samson C, Bonkowski E, Trauernicht A, Kim MO, Tomer G, Dubinsky M, Plevy S, Kugathsan S, Trapnell BC, Denson LA. GM-CSF Auto-antibodies in Murine Ileitis and Progressive Ileal Crohn’s Disease. Gastroenterology. 2009 Apr;136(4):1261-71, e1-3.

Denson LA, Kim MO, Bezold R, Carey R, Osuntokun B, Nylund C, Willson T, Bonkowski E, Li D, Ballard E, Collins M, Moyer MS, Klein DJ. A randomized controlled trial of growth hormone in active pediatric Crohn disease. J Pediatr Gastroenterol Nutr. 2010 Aug;51(2):130-9.

Han X, Sosnowska D, Bonkowski E, Denson L. Growth hormone inhibits STAT3 activation and reduces disease activity in murine colitis. Gastroenterology. 2015;129:185-203.

Khalil El-Chammas, MD, MS

513-636-4415 khalil.el-chammas@cchmc.org

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Khalil El-Chammas, MD, MS

Academic Affiliations

Assistant Professor, UC Department of Pediatrics

Phone 513-636-4415

Email khalil.el-chammas@cchmc.org

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Clinical

Pediatric gastroenterology, hepatology and nutrition with a special focus on neuro-gastroenterology and motility disorders.

Research

Pediatric neuro-gastroenterology and motility disorders.

MD: American University of Beirut School of Medicine, Beirut, Lebanon, 2003.

MS: Clinical and Translational Science, Medical College of Wisconsin, Milwaukee, WI, 2012.

Residency: Pediatrics, American University of Beirut Medical Center, Beirut, Lebanon, 2006.

Residency: Pediatrics, Duke University, Durham, NC, 2009.

Fellowship: Pediatric Gastroenterology, Children's Hospital of Wisconsin, Milwaukee, WI, 2012.

Certification: Pediatrics, Pediatric Gastroenterology.

El-Chammas K, Williams SE, Miranda A. Disaccharidase Deficiencies in Children With Chronic Abdominal Pain. JPEN J Parenter Enteral Nutr. 2015 Jul 9.

El-Chammas KI, Rumman N, Goh VL, Quintero D, Goday PS. Rectal prolapse and cystic fibrosis. J Pediatr Gastroenterol Nutr. 2015 Jan;60(1):110-2.

Rumman N, Sultan M, El-Chammas K, Goh V, Salzman N, Quintero D, Werlin S. Calprotectin in cystic fibrosis. BMC Pediatr. 2014 May 29;14:133.

El-Chammas KI, Tipnis NA, Simpson PM, Sood MR. Colon high-resolution manometry: using pressure topography plots to evaluate pediatric colon motility. J Pediatr Gastroenterol Nutr. 2014 Oct;59(4):500-4.

Lerner DG, Li BU, Mamula P, Fishman DS, Kramer R, Goh VL, El-Chammas K, Pentiuk SP, Rothbaum R, Gurrum B, Rahhal RM, Goday PS, Vitola B. Challenges in meeting fellowship procedural guidelines in pediatric therapeutic endoscopy and liver biopsy. J Pediatr Gastroenterol Nutr. 2014 Jan;58(1):27-33.

El-Chammas K, Majeskie A, Simpson P, Sood M, Miranda A. Red flags in children with chronic abdominal pain and Crohn's disease-a single center experience. J Pediatr. 2013 Apr;162(4):783-7.

Vermilyea S, Slicker J, El-Chammas K, Sultan M, Dasgupta M, Hoffmann RG, Wakeham M, Goday PS. Subjective global nutritional assessment in critically ill children. JPEN J Parenter Enteral Nutr. 2013 Sep;37(5):659-66.

El-Chammas KI, Venkatasubramani N, Veith R, Sekhri N, Rhead W, Toriello HV, Goday PS. Pancreatic insufficiency in Toriello-Carey syndrome: report of a second patient. Am J Med Genet A. 2012 May;158A(5):1208-11.

Tipnis NA, El-Chammas KI, Rudolph CD, Werlin SL, Sood MR. Do oro-anal transit markers predict which children would benefit from colonic manometry studies? J Pediatr Gastroenterol Nutr. 2012 Feb;54(2):258-62.

Michael K. Farrell, MD

Michael K. Farrell, MD, is interested in general pediatric gastroenterology problems such as gastroesophageal reflux, chronic abdominal pain, celiac disease and inflammatory bowel disease. He is also interested in all nutritional problems of infants, children and adolescents. A particular interest of Dr. Farrell is providing care as close to their community as possible.

513-636-4415 michael.farrell@cchmc.org

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Michael K. Farrell, MD

Academic Affiliations

Professor, UC Department of Pediatrics

Phone 513-636-4415

Fax 513-636-7805

Email michael.farrell@cchmc.org

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Gastroesophageal reflux; pancreatitis; inflammatory bowel disease; abdominal pain; pediatric nutrition

MD: Jefferson Medical College, Philadelphia, PA, 1970.

Internship: Harrisburg Polyclinic Hospital, Harrisburg, PA, 1970 to 1971.

Residency: Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 1974 to 1976.

Fellowship: Ambulatory Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 1976 to 1977.

Fellowship: Pediatric Gastroenterology and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 1977 to 1979.

Britto MT, Byczkowski TL, Anneken AM, Hausfeld J, Schoettker PJ, Farrell MK, Kotagal UR. Improving access to pediatric subspecialty care: initial failures and lessons learned. Qual Manag Health Care. 2008 Oct-Dec;17(4):320-9.

Stehr W, Farrell MK, Lucky AW, Johnson ND, Racadio JM, Azizkhan RG. Non-endoscopic percutaneous gastrostomy placement in children with recessive dystrophic epidermolysis bullosa. Pediatr Surg Int. 2008 Mar;24(3):349-54.

Azizkhan RG, Stehr W, Cohen AP, Wittkugel E, Farrell MK, Lucky AW, Hammelman BD, Johnson ND, Racadio JM. Esophageal strictures in children with recessive dystrophic epidermolysis bullosa: an 11-year experience with fluoroscopically guided balloon dilatation. J Pediatr Surg. 2006 Jan;41(1):55-60; discussion 55-60.

Noel RJ, Miles L, Putnam PE, Farrell MK. Clinical quiz: rectal prolapse. J Pediatr Gastroenterol Nutr. 2004 Nov;39(5):567, 575.

Pohl JF, Hughes C, Farrell MK. Pathology teach and tell: chronic-onset hereditary tyrosinemia type I. Pediatr Pathol Mol Med. 2001 May-Jun;20(3):241-4.

Perlstein PH, Kotagal UR, Schoettker PJ, Atherton HD, Farrell MK, Gerhardt WE, Alfaro MP. Sustaining the implementation of an evidence-based guideline for bronchiolitis. Arch Pediatr Adolesc Med. 2000 Oct;154(10):1001-7.

Perlstein PH, Kotagal UR, Bolling C, Steele R, Schoettker PJ, Atherton HD, Farrell MK. Evaluation of an evidence-based guideline for bronchiolitis. Pediatrics. 1999 Dec;104(6):1334-41.

Pohl JF, Murarka P, Farrell MK, Bezerra J. Insights. Pylephlebitis. J Pediatr. 1999 Oct;135(4):529.

Dellert SF, Farrell MK, Specker BL, Heubi JE. Bone mineral content in children with short bowel syndrome after discontinuation of parental nutrition. J Pediatr. 1998 Mar;132(3 Pt 1):516-9.

Dellert SF, Nowicki MJ, Farrell MK, Delente J, Heubi JE. The 13C-xylose breath test for the diagnosis of small bowel bacterial overgrowth in children. J Pediatr Gastroenterol Nutr. 1997 Aug;25(2):153-8.

Chandrashekhar R. Gandhi, MSc, PhD

The Gandhi laboratory investigates the mechanisms of acute liver injury of various etiologies and nonalcoholic steatohepatitis (NASH). The goals of these programs are (1) to identify mechanisms by which stellate cells orchestrate inflammatory or immune cell-mediated liver damage, and (2) to discover mechanistic link between augmenter of liver regeneration protein deficiency/anomaly and predisposition to develop aggressive form of NASH.

513-517-1090 shekhar.gandhi@cchmc.org

Chandrashekhar R. Gandhi, MSc, PhD

Academic Affiliations

Professor, UC Department of Surgery

Phone 513-517-1090

Email shekhar.gandhi@cchmc.org

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Research Interests

Mechanisms of liver injury, immunological tolerance and steatohepatitis

Biography

Dr. Gandhi was the first to report the hemodynamic and metabolic effects of a powerful endogenous peptide endothelin in the liver, and increase in its activity during liver injury. Subsequently, his group showed that endothelin receptor antagonism arrests and reverses liver fibrosis/cirrhosis. His laboratory also developed a novel mouse model of hepatic stellate cell depletion and showed that stellate cells play a critical role in acute liver injury and liver’s immunological tolerance. Recently, Dr. Gandhi edited a book entitled “Stellate Cells in Health and Disease” (Elsevier/Academic Press) that covers the entire spectrum of stellate cell biology known to date with contribution from leading experts in stellate cell and liver research.

Another major research program in Dr. Gandhi’s laboratory demonstrated that augmenter of liver regeneration (ALR) protein is a critical intracellular survival factor for hepatocytes, and that secreted ALR exerts important biological effects on nonparenchymal cells. His laboratory developed a novel liver-specific ALR-knockout and heterozygous (ALR+/-) mice. This research has shown, for the first time, that by its mitochondrial function and regulation of lipid and energy metabolism, ALR plays a major role in steatohepatitis. It is apparent that the ALR-deficient mice will be a valuable tool to investigate mechanisms of alcoholic and nonalcoholic steatohepatitis that progress to end-stage liver diseases.

MSc: Biochemistry, Nagpur University, India.

PhD: Biochemistry, Nagpur University, India.

Kumar S, Wang J, Thomson A, Gandhi CR. Hepatic stellate cells increase the immunosuppressive function of natural Foxp3+ regulatory T cells via IDO-induced AhR activation. J Leuko Biol. 2016 Aug 31.

Kumar S, Wang J, Rani S, Gandhi CR. Hepatic deficiency of augmenter of liver regeneration exacerbates alcohol-induced liver injury and promotes fibrosis in mice. PLoS One. 2016 Jan 25;11(1):e0147864.

Gandhi CR, Chaillet JR, Nalesnik MA, Kumar S, Dangi A, Demetris AJ, Ferrell R, Wu T, Divanovic S, Stankeiwicz T, Shaffer B, Stolz DB, Harvey SAK, Wang J, Starzl TE. Liver-specific deletion of augmenter of liver regeneration (ALR) induces accelerated steatohepatitis in mice. Gastroenterology. 2015;148:379-391.

Stewart R, Dangi A, Huang C, Murase N, Kimura S, Stolz DB, Wilson GC, Lentsch AB, Gandhi CR. A novel mouse model of depletion of stellate cells clarifies their role in ischemia/reperfusion- and endotoxin-induced acute liver injury. J Hepatol. 2014;60:298-305.

Dangi A, Sumpter T, Kimura S, Stolz DB, Murase N, Raimondi G, Vodovotz, Huang C, Thomson AW, Gandhi CR. Selective expansion of allogeneic regulatory T cells by hepatic stellate cells: role of endotoxin and implications for allograft tolerance. J Immunol. 2012;188:3667-3677.

Thirunavukkarasu C, Wang LF, Harvey SAK, Watkins SC, Chaillet JR, Starzl, TE, Gandhi CR. Augmenter of liver regeneration: an important intracellular survival factor for hepatocytes. J Hepatology. 2008;48:578-88.

Thirunavukkarasu C, Watkins S, Gandhi CR. Mechanisms of endotoxin-induced nitric oxide, interleukin-6 and tumor necrosis factor-a production in activated rat hepatic stellate cells: role of p38MAPK. Hepatology. 2006;44:389-398.

Thirunavukkarasu C, Uemura T, Wang LF, Watkins S, Gandhi CR. Normal rat hepatic stellate cells respond to endotoxin in LBP-independent manner to produce inhibitor(s) of DNA synthesis in hepatocytes. J Cell Physiol. 2005;204:654-665.

Thirunavukkarasu C, Yang Y, Subbotin VM, Harvey SAK, Fung J, Gandhi CR. Endothelin receptor antagonist TAK-044 arrests and reverses the development of carbon tetrachloride-induced cirrhosis in rats. Gut. 2004;53:1010-1019.

Yang Y, Nemoto E, Harvey SAK, Subbotin VM, Gandhi CR. Increased hepatic expression of platelet-activating factor (PAF) and PAF receptors in carbon tetrachloride induced liver cirrhosis. Gut. 2004;53:877-883.

Grants

Mechanisms of liver failure. Principal Investigator. VA Merit. Oct 2015-Sep 2019.

Mechanisms of nonalcoholic steatohepatitis. Principal Investigator. Department of Defense. Oct 2015-Sep 2018. W81XWH-14-PRMRP-IIRA.

Yael Haberman Ziv, MD, PhD

Yael Haberman Ziv, MD, PhD, uses state-of-the-art sequencing approaches and patients samples to detect the widest range of microbial shifts and changes in host gene expression possible, present in the actual lining of the gut. These analyses are used to better characterize inflammatory bowel disease phenotype and pathogenesis with an ultimate goal to identify key disease driving pathways for future interventions.

513-636-8949 yael.haberman@cchmc.org

High Res

Yael Haberman Ziv, MD, PhD

Academic Affiliation

Adjunct Assistant Professor, UC Department of Pediatrics

Phone 513-636-8949

Email yael.haberman@cchmc.org

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PhD: Tel-Aviv University, Tel-Aviv, Israel, 2006.

MD: Tel-Aviv University, Tel-Aviv, Israel, 2007.

Residency: Pediatrics, Sheba Medical Center, Tel -Hashomer, Israel, 2011.

Fellowship: Pediatric Gastroenterology, Hepatology and Nutrition, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 2014.

Haberman Y, Di Segni A, Loberman-Nachum N, Barel O, Kunik V, Eyal E, Kol N, Hout-Siloni G, Kochavi B, Avivi C, Schvimer M, Rechavi G, Anikster Y, Barshack I, Weiss B. Congenital Sucrase-isomaltase Deficiency: A Novel Compound Heterozygous Mutation Causing Aberrant Protein Localization. J Pediatr Gastroenterol Nutr. 2016 Oct 4.

Dionisi-Vici C, Shteyer E, Niceta M, Rizzo C, Pode-Shakked B, Chillemi G, Bruselles A, Semeraro M, Barel O, Eyal E, Kol N, Haberman Y, Lahad A, Diomedi-Camassei F, Marek-Yagel D, Rechavi G, Tartaglia M, Anikster Y. Expanding the molecular diversity and phenotypic spectrum of glycerol 3-phosphate dehydrogenase 1 deficiency. J Inherit Metab Dis. 2016 Sep;39(5):689-95.

Moshkovits I, Reichman H, Karo-Atar D, Rozenberg P, Zigmond E, Haberman Y, Ben Baruch-Morgenstern N, Lampinen M, Carlson M, Itan M, Denson LA, Varol C, Munitz A. A key requirement for CD300f in innate immune responses of eosinophils in colitis. Mucosal Immunol. 2016 Apr 27.

Stephen J*, Vilboux T*, Haberman Y*, Pri-Chen H, Pode-Shakked B, Marek-Yagel D, Barel O, Di Segni A, Eyal E, Hout-Siloni G, Lahad A, Shalem T, Rechavi G, Malicdan MCV, Weiss B, Gahl WA, Anikster Y. Congenital Protein Losing Enteropathy: An inborn error of lipid metabolism due to DGAT1 mutations. Eur J Hum Genet. 2016 Aug;24(9):1268-73. *Equal contribution.

Arora K, Sinha C, Zhang W, Moon CS, Ren A, Yarlagadda S, Dostmann WR, Adebiyi A, Haberman Y, Denson LA, Wang X, Naren AP. Altered cGMP Dynamics at the Plasma Membrane Contribute to Diarrhea in Ulcerative Colitis. Am J Pathol. 2015 Oct;185(10):2790-804.

Cutler DJ, Zwick ME, Okou DT, Prahalad S, Walters T, Guthery SL, Dubinsky M, Baldassano R, Crandall WV, Rosh J, Markowitz J, Stephens M, Kellermayer R, Pfefferkorn M, Heyman MB, LeLeiko N, Mack D, Moulton D, Kappelman MD, Kumar A, Prince J, Bose P, Mondal K, Ramachandran D, Bohnsack JF, Griffiths AM, Haberman Y, Essers J, Thompson SD, Aronow B, Keljo DJ, Hyams JS, Denson LA; PRO-KIIDS Research Group, Kugathasan S. Dissecting Allele Architecture of Early Onset IBD Using High-Density Genotyping. PLoS One. 2015 Jun 22;10(6).

Haberman Y, Tickle TL, Dexheimer PJ, Kim MO, Tang D, Karns R, Baldassano RN, Noe JD, Rosh J, Markowitz J, Heyman MB, Griffiths AM, Crandall WV, Mack DR, Baker SS, Huttenhower C, Keljo DJ, Hyams JS, Kugathasan S, Walters T, Aronow B, Xavier RJ, Gevers D, Denson LA. Pediatric Crohn disease patients exhibit specific ileal transcriptome and microbiome signature. J Clin Invest. 2014 Aug 1;124(8):3617-33.

Minar P, Haberman Y, Jurickova I, Wen T, Rothenberg ME, Kim MO, Saeed SA, Baldassano RN, Stephens M, Markowitz J, Rosh J, Crandall WV, Heyman MB, Mack DR, Griffiths AM, Baker S, Hyams J, Kugathasan S, Denson LA. Utility of Neutrophil Fcγ Receptor I (CD64) Index as a Biomarker for Mucosal Inflammation in Pediatric Crohn’s Disease. Inflamm Bowel Dis. 2014 Jun;20(6):1037-48.

Gevers D, Kugathasan S*, Denson* LA, Vázquez-Baeza Y, Van Treuren W, Ren B, Schwager E, Knights D, Song SJ, Yassour M, Morgan XC, Kostic AD, Luo C, González A, McDonald D, Haberman Y, Walters T, Baker S, Rosh J, Stephens M, Heyman M, Markowitz J, Baldassano R, Griffiths A, Sylvester F, Mack D, Kim S, Crandall W, Hyams J, Huttenhower C, Knight R, Xavier RJ. The treatment-naive microbiome in new-onset Crohn’s disease. Cell Host Microbe. 2014 Mar 12;15(3):382-92.

Haberman Ziv Y, Burrow T, Kocoshis S, Pentiuk S. Encephalopathy in a short-bowel syndrome patient: case report and discussion of the pathophysiology. JPEN J Parenter Enteral Nutr. 2014 May;38(4):518-20.

Xiaonan Han, PhD

Xiaonan Han, PhD, has a laboratory currently focused on intestinal barrier dysfunction in inflammatory bowel disease (IBD). They have generated intestinal epithelial cell signals transducers and activators of transcription (STAT) 5 deficient mice. Specifically, they are working to identify whether STAT5 signaling in enterocytes protects intestinal epithelial cell (IEC) barrier function in response to gut injury.

513-636-7592 xiaonan.han@cchmc.org

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Xiaonan Han, PhD

Academic Affiliations

Assistant Professor, UC Department of Pediatrics

Phone 513-636-7592

Fax 513-636-5581

Email xiaonan.han@cchmc.org

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Clinical

Signal transducer and activator of transcription (STAT) in inflammatory bowel disease (IBD); gut barrier dysfunction in IBD; drug development in the therapy of IBD.

Research

Visit the Han Lab.

PhD: Chinese Academy of Medical Science (CAMS) & Peking Union Medical College (PUMC), Beijing, China, 2000.

Post-doctoral: University of Pittsburgh Medical School, Pittsburgh, PA, 2003.

Han X, Gilbert S, Groschwitz K, Hogan S, Jurickova I, Trapnell B, Samson C, Gully J. Loss of GM-CSF signalling in non-haematopoietic cells increases NSAID ileal injury. Gut. 2010 Aug;59(8):1066-78.

Munitz A, Cole ET, Beichler A, Groschwitz K, Ahrens R, Steinbrecher K, Willson T, Han X, Denson L, Rothenberg ME, Hogan SP. Paired immunoglobulin-like receptor B (PIR-B) negatively regulates macrophage activation in experimental colitis. Gastroenterology. 2010 Aug;139(2):530-41.

Han X. Intestinal permeability as a clinical surrogate endpoint in the development of future Crohn's disease therapies. Recent Pat Inflamm Allergy Drug Discov. 2010;4(2):159-76. Review.

Groschwitz KR, Ahrens R, Osterfeld H, Gurish MF, Han X, Abrink M, Finkelman FD, Pejler G, Hogan SP. Mast cells regulate homeostatic intestinal epithelial migration and barrier function by a chymase/Mcpt4-dependent mechanism. Proc Natl Acad Sci U S A. 2009 Dec 29;106(52):22381-6.

Han X, Uchida K, Jurickova I, Koch D, Willson T, Samson C, Bonkowski E, Trauernicht A, Kim MO, Tomer G, Dubinsky M, Plevy S, Kugathsan S, Trapnell BC, Denson LA. Granulocyte-macrophage colony-stimulating factor autoantibodies in murine ileitis and progressive ileal Crohn's disease. Gastroenterology. 2009 Apr;136(4):1261-71, e1-3.

Han X, Ren X, Jurickova I, Groschwitz K, Pasternak BA, Xu H, Wilson TA, Hogan SP, Denson LA. Regulation of intestinal barrier function by signal transducer and activator of transcription 5b. Gut. 2009 Jan;58(1):49-58.

Carey R, Jurickova I, Ballard E, Bonkowski E, Han X, Xu H, Denson LA. Activation of an IL-6:STAT3-dependent transcriptome in pediatric-onset inflammatory bowel disease. Inflamm Bowel Dis. 2008 Apr;14(4):446-57.

Han X, Osuntokun B, Benight N, Loesch K, Frank SJ, Denson LA. Signal transducer and activator of transcription 5b promotes mucosal tolerance in pediatric Crohn's disease and murine colitis. Am J Pathol. 2006 Dec;169(6):1999-2013.

Han X, Benight N, Osuntokun B, Loesch K, Frank SJ, Denson LA. Tumour necrosis factor alpha blockade induces an anti-inflammatory growth hormone signalling pathway in experimental colitis. Gut. 2007 Jan;56(1):73-81.

James E. Heubi, MD Director, Center for Clinical and Translational Science and Training

James E. Heubi, MD, has a longstanding interest in pediatric cholestatic liver disease including inborn errors of bile acid metabolism. His research has focused on bile acid and cholesterol absorption and metabolism and fat absorption.

513-636-9776 sandra.geideman@cchmc.org

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James E. Heubi, MD

Director, Center for Clinical and Translational Science and Training

Associate Dean, Clinical and Translational Research

Academic Affiliations

Professor, UC Department of Pediatrics

Phone 513-636-9776

Fax 513-803-1039

Email sandra.geideman@cchmc.org

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Clinical

Pediatric gastroenterology; hepatology and nutrition; pediatric cholestatic liver disease

Research

Pediatric cholestatic liver disease; childhood bone disease; fat malabsorption

Biography

James Heubi, MD, is associate dean for clinical and translational research and professor of pediatrics at the University of Cincinnati College of Medicine. He is the director of the Center for Clinical and Translational Science and Training which is the vehicle by which the University of Cincinnati, Cincinnati Children’s Hospital Medical Center and the Veterans Administration Medical Center administer the NIH-funded, Clinical Translational Science Award and director of the Division of Gastroenterology, Hepatology and Nutrition at the Cincinnati Children’s Hospital Medical Center.

He has been an active clinical investigator with over 195 peer reviewed publications and was the long term program director for the NIH funded General Clinical Research Center. He is the principal investigator and co-investigator on NIH grants and participates is a local principal or co-investigator on two rare disease networks supported by the NIH.

His research interests include cholestatic liver disease in childhood and its complications, inborn errors of bile acid metabolism, bone disease in gastrointestinal and hepatobiliary disorders, fat absorption, and cholesterol absorption and metabolism.

MD: Indiana University School of Medicine, Indianapolis, IN, 1973.

Residency: James Whitcomb Riley Hospital for Children, Indiana University, Indianapolis, IN, 1973 to 1975.

Fellowship: Pediatric Gastroenterology, Children's Hospital Medical Center, Cincinnati, OH, 1979.

Certification: Pediatric Gastroenterology and Nutrition, 1990.

Heubi JE, Setchell KDR, Jha P, Buckley D, Zhang W, Rosenthal P, Potter C, Horslen S, Suskind D. Treatment of bile acid amidation defects with glycocholic acid. Hepatology. 2015 Jan;61(1):268-274.

Setchell KDR, Heubi JE, Shah S, Lavine JE, Suskind D, Al-Edreesi M, Potter C, Russell DW, O’Connell NC, Wolfe B, Jha P, Zhang W, Bove KE, Knisely AS, Hofmann AF, Rosenthal P, Bull LN. Genetic defects in bile acid conjugation cause fat-soluble vitamin deficiency. Gastroenterology. 2013 May;144(5):945-955.

Gonzales E, Gerhardt MF, Fabre M, Setchell KDR, Davit-Spraul A, Vincent I, Heubi JE, Bernard O, Jacquemin E. Oral cholic acid for hereditary defects of primary bile acid synthesis: a safe and effective long-term therapy. Gastroenterology. 2009 Oct;137(4):1310-1320.

Setchell KDR, Heubi JE, Bove KE, O’Connell NC, Brewsaugh T, Steinberg SJ, Moser A, Squires Jr RH. Liver disease caused by failure to racemize trihydroxycholestanocic acid: gene mutation and effect of bile acid therapy. Gastroenterology. 2003 Jan;124(1):217-232.

Oelkers P, Kirby LC, Heubi JE, Dawson PA. Primary bile acid malabsorption caused by mutations in the ileal sodi¬um-de¬pen¬dent bile acid transporter gene (SLC10A2). J Clin Invest. 1997 Apr 15;99(8):1880-1887.

Heubi JE, Hollis BW, Specker B, Tsang RC. Bone disease in chronic childhood cholestasis I. Vitamin D absorption and metabolism. Hepatology. 1989 Feb;9(2):258-264.

Setchell KDR, Suchy FJ, Welsh MB, Zimmer-Nechemias L, Heubi JE, Balistreri WF. Δ4-3-Oxosteroid 5B-reductase deficiency described in identical twins with neonatal hepatitis - A new inborn error in bile acid synthesis. J Clin Invest. 1988 Dec; 82(6):2148-2157.

Heubi JE, Daugherty CC, Partin JS, Partin JC, Schubert WK. Grade l Reye's Syndrome--outcome and predictors of progression to deeper coma grades. N Engl J Med. 1984 Dec 13;311(24):l539-1554.

Lichtenstein PK, Heubi JE, Daugherty CC, Farrell MK, Sokol RJ, Rothbaum RJ, Suchy FJ, Balistreri WF. Grade l Reye's Syndrome. A frequent cause of vomiting and liver dysfunction following varicella and upper respiratory tract infection. N Engl J Med. 1983 Jul;309(3):l33-139.

Heubi JE, Balistreri WF, Fondacaro JD, Partin JC, Schubert WK. Primary bile acid malabsorption: Defective in vitro ileal active bile acid transport. Gastroenterology. 1982 Oct;83(4):804-8ll.

Grants

Cincinnati Center for Clinical and Translational Science and Training. Principal Investigator. National Center for Advancing Translational Sciences/National Institutes of Health. Aug 2015-Mar 2019. UL1 TR000077-05.

Pediatric Gastroenterology and Nutrition Training Grant. Mentor. National Institute of Diabetes and Digestive and Kidney Diseases/ National Institutes of Health. Jul 2005-Jun 2020. T32 DK007727.

Clinical Center of Cholestatic Liver Disease in Children (CHILDREN). Co-Investigator. National Institute of Diabetes and Digestive and Kidney Diseases/ National Institutes of Health. Sep 2009-May 2019. U01 DK062497.

Sterol and Isoprenoid Diseases Consortium. Site Principal Investigator. Eunice Kennedy Shriver National Institute of Child Health and Human Development/National Institutes of Health. Sep 2009-Jul 2019. U54 HD061939.

Bone Mineral Accretion in Young Children. Co-Investigator. Eunice Kennedy Shriver National Institute of Child Health and Human Development/National Institutes of Health. Sep 2013-Jul 2018. R01 HD076321.

Short Term Medical Student Training Grant. Principal Investigator. National Institute of Diabetes and Digestive and Kidney Diseases/National Institutes of Health. Apr 2002-Mar 2019. T35 DK060444-11.

Stacey S. Huppert, PhD

Stacey S. Huppert, PhD, investigates the cellular contribution and molecular factors required for assembly of the three-dimensional hepatic architecture, during liver development, homeostasis and regeneration. Defining the critical elements involved in formation and repair processes of the liver are necessary not only to understand biology, but also to identify the cellular and molecular targets involved in congenital and chronic liver diseases.

Visit the Huppert Lab.

513-803-3871 stacey.huppert@cchmc.org

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Stacey S. Huppert, PhD

Academic Affiliations

Associate Professor, UC Department of Pediatrics

Phone 513-803-3871

Email stacey.huppert@cchmc.org

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Specialties

Hepatic development and regeneration; three-dimensional hepatic architecture; Notch signaling; hepatobiliary disease

Visit the Huppert Lab.

BS: Genetic Biology,Purdue University, West Lafayette, IN, 1992.

PhD: Genetics, Indiana University, Bloomington, IN, 1998.

Postdoctoral Fellow: Developmental Biology, Washington University School of Medicine, St. Louis, MO, 2003.

Instructor: Developmental Biology, Washington University School of Medicine, St. Louis, MO, 2005.

Assistant Professor: Cell and Developmental Biology, Center for Stem Cell Biology, Vanderbilt University Medical Center, Nashville, TN, 2012.

Broadus MR, Chen TW, Neitzel LR, Ng VH, Jodoin JN, Lee LA, Salic A, Robbins DJ, Capobianco AJ, Patton JG, Huppert SS, Lee E. Identification of a Paralog-Specific Notch1 Intracellular Domain Degron. Cell Rep. 2016 May 31;15(9):1920-9.

Poling HM, Mohanty SK, Tiao GM, Huppert SS. A comprehensive analysis of aquaporin and secretory related gene expression in neonate and adult cholangiocytes. Gene Expr Patterns. 2014 Jun 12;15(2):96-103.

Walter TJ, Cast AE, Huppert KA, Huppert SS. Epithelial VEGF signaling is required in the mouse liver for proper sinusoid endothelial cell identity and hepatocyte zonation in vivo. Am J Physiol Gastrointest Liver Physiol. 2014 May 15;306(10):G849-62.

Walter TJ, Vanderpool C, Cast AE, Huppert SS. Intrahepatic bile duct regeneration in mice does not require Hnf6 or Notch signaling through Rbpj. Am J Pathol. 2014 May;184(5):1479-88.

Walter TJ, Sparks EE, Huppert SS. 3-dimensional resin casting and imaging of mouse portal vein or intrahepatic bile duct system. J Vis Exp. 2012 Oct 25;(68):e4272.

Hang BI, Thorne CA, Robbins DJ, Huppert SS, Lee LA, Lee E. Screening for small molecule inhibitors of embryonic pathways: sometimes you gotta crack a few eggs. Bioorg Med Chem. 2012 Mar 15;20(6):1869-77.

Humphreys R, Zheng W, Prince LS, Qu X, Brown C, Loomes K, Huppert SS, Baldwin S, Goudy S. Cranial neural crest ablation of Jagged1 recapitulates the craniofacial phenotype of Alagille syndrome patients. Hum Mol Genet. 2012 Mar 15;21(6):1374-83.

Vanderpool C, Sparks EE, Huppert KA, Gannon M, Means AL, Huppert SS. Genetic interactions between hepatocyte nuclear factor-6 and Notch signaling regulate mouse intrahepatic bile duct development in vivo. Hepatology. 2012 Jan;55(1):233-43.

Sparks EE, Perrien DS, Huppert KA, Peterson TE, Huppert SS. Defects in hepatic Notch signaling result in disruption of the communicating intrahepatic bile duct network in mice. Dis Model Mech. 2011 May;4(3):359-67.

Sparks EE, Huppert KA, Brown MA, Washington MK, Huppert SS. Notch signaling regulates formation of the three-dimensional architecture of intrahepatic bile ducts in mice. Hepatology. 2010 Apr;51(4):1391-400.

Ajay Kaul, MD Director, Neurogastroenterology and Motility Disorders Program

Ajay Kaul, MD, is interested in evaluating gastrointestinal motility disorders especially in children with neurodevelopmental delay. He is currently investigating clinical outcomes after combined endoscopic pyloric Botox injection and balloon dilation in children with gastroparesis and the development of rumination syndrome in this cohort.

513-636-4415 ajay.kaul@cchmc.org

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Ajay Kaul, MD

Director, Neurogastroenterology and Motility Disorders Program

Academic Affiliations

Professor, UC Department of Pediatrics

Phone 513-636-4415

Fax 513-636-7805

Email ajay.kaul@cchmc.org

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Motility disorders; feeding disorders; GI problems in children with special needs

MD: Government Medical College, Jabalpur, India, 1986.

Residency: Children's Hospital of Buffalo, Buffalo, NY; The State University of New York, Albany, NY.

Fellowship: Children's Hospital Medical Center, Cincinnati, OH, 1995-1998.

Certification: Pediatrics, 1995; Pediatric Gastroenterology, 1999.

Kraus D, Wong BL, Horn PS, Kaul A. Constipation in Duchenne Muscular Dystrophy: Prevalence, Diagnosis, and Treatment. J Pediatr. 2016.

Warren M, Kaul A, Bove K. Calretinin-immunoreactive hypoinnervation in Down syndrome (DS): report of an infant with very short-segment Hirschsprung disease (vsHD) and comparison to biopsy findings in 20 normal infants and 11 infants with DS and chronic constipation. Pediatr Dev Pathol. 2015 Jul 31.

Martin LJ, Franciosi JP, Collins MH, Abonia JP, Lee JJ, Hommel KA, Varni JW, Grotjan JT, Eby M, He H, Marsolo K, Putnam PE, Garza JM, Kaul A, Wen T, Rothenberg ME. Pediatric Eosinophilic Esophagitis Symptom Scores (PEESS v2.0) identify histologic and molecular correlates of the key clinical features of disease. J Allergy Clin Immunol. 2015 Jun;135(6):1519-1528.

Sherrill JD, Kiran KC, Blanchard C, Stucke EM, Kemme KA, Collins MH, Abonia JP, Putnam PE, Mukkada VA, Kaul A, Kocoshis SA, Kushner JP, Plassard AJ, Karns RA, Dexheimer PJ, Aronow BJ, Rothenberg ME. Analysis and expansion of the eosinophilic esophagitis transcriptome by RNA sequencing. Genes Immun. 2014 Sep;15(6):361-9.

Alexander ES, Martin LJ, Kaul A, Nadeau KC, Noel RJ, Putnam PE, Rothenberg ME, et. al. Twin and Family Studies Reveal Strong Environmental and Weaker Genetic Cues Explaining Heritability of Eosinophilic Esophagitis. J Allergy Clin Immunol. 2014 Nov;134(5):1084-1092.

Woodley FW, Machado RS, Hayes D Jr, Di Lorenzo C, Kaul A, Skaggs B, McCoy K, Patel A, Mousa H. Children with cystic fibrosis have prolonged chemical clearance of acid reflux compared to symptomatic children without cystic fibrosis. Dig Dis Sci. 2014 Mar;59(3):623-30.

Rayapudi M, Rajavelu P, Zhu X, Kaul A, Mishra A, et al. Invariant natural killer T-Cell Neutralization is a Possible Novel Therapy for Human Eosinophilic Esophagitis. Clin Transl Immunology. Jan 2014;10:3.

Wen T, Stucke EM, Grotjan TM, Kemme KA, Abonia JP, Putnam PE, Franciosi JP, Garza JM, Kaul A, King EC, Collins MH, Kushner JP, Rothenberg ME. Molecular Diagnosis of Eosinophilic Esophagitis by Gene Expression Profiling. Gastroenterology. 2013 Dec;145(6):1289-99.

Abdel-Rahman SM, Amidon GL, Kaul A, Lukacova V, Vinks AA, Knipp GT; Members of the BCS Task Force. Summary of the national institute of child health and human development-best pharmaceuticals for children act pediatric formulation initiatives workshop-pediatric biopharmaceutics classification system working group. Clin Ther. 2012 Nov;34(11):S11-24.

Furuta GT, Williams K, Kooros K, Kaul A, Panzer R, Coury DL, Fuchs G. Management of constipation in children and adolescents with autism spectrum disorders. Pediatrics. 2012 Nov;130 Suppl 2:S98-S105.

Samuel A. Kocoshis, MD Medical Director, Intestinal Care Center

Samuel A. Kocoshis, MD, is investigating ways to minimize intestinal dysfunction following transplantation and also collaborating to better characterize immunologic factors contributing to graft versus host disease and severe acute cellular rejection in intestinal transplantation. Dr. Kocoshis is also interested in identifying biomarkers that predict the development of parenteral nutrition-associated cholestasis.

513-636-4415 samuel.kocoshis@cchmc.org

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Samuel A. Kocoshis, MD

Medical Director, Intestinal Care Center

Medical Director, Small Bowel Transplantation Program

Academic Affiliations

Professor, UC Department of Pediatrics

Phone 513-636-4415

Fax 513-636-7805

Email samuel.kocoshis@cchmc.org

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Clinical

Management of complex intestinal and liver disease; small bowel transplantation; general disorders of the gastrointestinal tract

Research

Altered bile acid metabolism in gastrointestinal disease; small bowel transplantation; inflammatory bowel disease; short bowel syndrome

Biography

Samuel Kocoshis, MD, is an expert in the management of complex intestinal and liver disease at Cincinnati Children's Hospital Medical Center.

Dr. Kocoshis is the director of the Pediatric Nutrition and Intestinal Care Center in the Division of Gastroenterology, Hepatology and Nutrition, and is also the medical director of the Small Intestinal Transplantation Program. In addition, he is professor of pediatrics at the University of Cincinnati College of Medicine.

Dr. Kocoshis' long-standing research interest has been altered bile acid metabolism in gastrointestinal disease. His current clinical research program focuses upon intestinal adaptation following massive small intestinal resection, as well as the immunology of intestinal transplantation.

Prior to joining Cincinnati Children's, Dr. Kocoshis was chief of Pediatric Gastroenterology and co-director of the Intestinal Care Center at Children's Hospital of Pittsburgh, and professor of pediatrics at the University of Pittsburgh School of Medicine.

Dr. Kocoshis earned his bachelor's degree from DePauw University and his medical degree from the Medical College of Wisconsin. He completed an internship in pediatrics at the West Virginia University Medical Center; a residency in pediatrics at Children's Hospital of Pittsburgh; and a clinical fellowship in gastroenterology at Yale University School of Medicine.

BS: DePauw University, Greencastle, IN.

MD: Medical College of Wisconsin, Milwaukee, WI.

Residency: Children's Hospital of Pittsburgh, Pittsburgh, PA.

Fellowship: Yale University School of Medicine, New Haven, CT.

Kocoshis SA. Medical management of pediatric intestinal failure. Semin Pediatr Surg. 2010 Feb;19(1):20-6. Review.

Wessel JJ, Kocoshis SA. Nutritional management of infants with short bowel syndrome. Semin Perinatol. 2007 Apr;31(2):104-11. Review.

Nathan JD, Rudolph JA, Kocoshis SA, Alonso MH, Ryckman FC, Tiao GM. Isolated liver and multivisceral transplantation for total parenteral nutrition-related end-stage liver disease. J Pediatr Surg. 2007 Jan;42(1):143-7.

Kocoshis S. Small Intestinal Failure in Children. Curr Treat Options Gastroenterol. 2001 Oct;4(5):423-432.

Daniel Mallon, MD, MSHPEd Assistant Program Director, Pediatric Residency Training Program

Daniel Mallon investigates best practices in education to support primary-specialty care collaboration and quality improvement. He also conducts Quality Improvement work to improve the care of children with celiac disease, especially those who also have type 1 diabetes.

513-636-4415 daniel.mallon@cchmc.org

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Daniel Mallon, MD, MSHPEd

Assistant Program Director, Pediatric Residency Training Program

Associate Program Director, Gastroenterology, Hepatology and Nutrition Fellowship

Co-Director, Celiac disease/Type 1 Diabetes Clinic

Academic Affiliations

Assistant Professor, UC Department of Pediatrics

Phone 513-636-4415

Email daniel.mallon@cchmc.org

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Clinical

Pediatric gastroenterology; celiac disease; inflammatory bowel disease; constipation; fecal microbiota transplantation; global health education

Research

Health professions education; primary care management of gastrointestinal problems; quality improvement; celiac disease

MD: Indiana University School of Medicine, Indianapolis, IN, 2007.

MS-Health Professions Education: MGH Institute for Health Professions, Boston, MA, 2015.

Residency: Pediatrics, Seattle Children's Hospital/University of Washington School of Medicine, Seattle, WA, 2007-2010.

Chief Resident: Pediatrics, Seattle Children's Hospital, Seattle, WA, 2010-2011.

Fellowship: Pediatric Gastroenterology, Boston Children's Hospital/Harvard Medical School, Boston, MA, 2011-2014.

Mallon D, Leichtner AM. Objective Assessment of Fellows: Doable and Worth Doing. J Pediatr Gastroenterol Nutr. 2016 Sep 16.

Mallon D, Vernacchio L, Leichtner AM, Kerfoot BP. 'Constipation Challenge' game improves guideline knowledge and implementation. Med Educ. 2016 May;50(5):589-90.

Mallon DP, Vernacchio L, Trudell E, Antonelli R, Nurko S, Leichtner AM, Lightdale JR. Shared Care: A Quality Improvement Initiative to Optimize Primary Care Management of Constipation. Pediatrics. 2015;135(5):e1300-1307.

Mallon DP, Suskind DL. Nutrition in Inflammatory Bowel Disease. Nutr Clin Pract 2010;25(4):335-9.

Alexander G. Miethke, MD Medical Director, Liver Transplant Program

Alexander G. Miethke, MD, is interested in susceptibility factors for neonatal liver injury, including biliary atresia. He focuses on the interaction between the maturing adaptive immune system and hepatic immune responses to infectious insults during the early neonatal period.

513-636-8948 alexander.miethke@cchmc.org

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Alexander G. Miethke, MD

Medical Director, Liver Transplant Program

Academic Affiliations

Assistant Professor, UC Department of Pediatrics

Phone 513-636-8948

Email alexander.miethke@cchmc.org

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Clinical

Pediatric liver disease including biliary atresia, inherited liver diseases, autoimmune hepatitis, and primary sclerosing cholangitis; gastrointestinal problems in children with bone marrow failure syndromes

Research

Immune mediated liver injury, specifically the role of regulatory T cells in biliary atresia and primary sclerosing cholangitis; genetic basis for intrahepatic cholestasis in children; acute liver failure in infants with mitochondrial disorders

Biography

Alexander G. Miethke, MD, joined the Division of Gastroenterology, Hepatology and Nutrition as a fellow in 2005, after completing his Pediatric Residency Training at Cincinnati Children's Hospital Medical Center. Following the completion of his fellowship, he pursued an additional year of training in pediatric transplant hepatology under the mentorship of Dr. William Balistreri and the physicians and surgeons of the Pediatric Liver Care Center.

In 2009, Dr. Miethke was appointed assistant professor of pediatrics in the Division of Gastroenterology, Hepatology and Nutrition and the Pediatric Liver Care Center at Cincinnati Children's within the UC Department of Pediatrics. His basic science research interests include the role of regulatory T cells in biliary atresia and other immune mediated liver diseases and the genetic basis of chronic cholestasis syndromes.

MD: Humboldt-University, Berlin, Germany, 2000.

Residency: Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2002-2004.

Fellowship: Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2005-2007.

Advanced Fellowship: Pediatric Transplant Hepatology, University of Cincinnati and Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2009.

Certification: Pediatrics, 2005; Pediatric Gastroenterology, 2009; Pediatric Transplant Hepatology, 2010.

Evason K, Bove KE, Finegold MJ, Knisely AS, Rhee S, Rosenthal P, Miethke AG, Karpen SJ, Ferrell LD, Kim GE. Morphologic findings in progressive familial intrahepatic cholestasis 2 (PFIC2): correlation with genetic and immunohistochemical studies. Am J Surg Pathol. 2011;35:687-96.

Miethke AG, Saxena V, Shivakumar P, Sabla GE, Simmons J, Chougnet CA. Post-natal paucity of regulatory T cells and control of NK cell activation in experimental biliary atresia. J Hepatol. 2010 May;52(5):718-26.

Liu C, Aronow BJ, Jegga AG, Wang N, Miethke A, Mourya R, Bezerra JA. Novel resequencing chip customized to diagnose mutations in patients with inherited syndromes of intrahepatic cholestasis. Gastroenterology. 2007 Jan;132(1):119-26.

Shivakumar P, Campbell KM, Sabla GE, Miethke A, Tiao G, McNeal MM, Ward RL, Bezerra JA. Obstruction of extrahepatic bile ducts by lymphocytes is regulated by IFN-gamma in experimental biliary atresia. J Clin Invest. 2004 Aug;114(3):322-9.

Marialena Mouzaki, MD, MSc Medical Director, Nutrition Service Program

Marialena Mouzaki, MD, MSc, investigates the role of the intestinal microbiota in the development of pediatric non-alcoholic fatty liver disease. In addition, she conducts clinical research in the field of pediatric nutrition.

513-636-6155 elizabeth.hiles@cchmc.org

Joseph J. Palermo, MD, PhD Associate Director, Pancreas Care Center

Joseph J. Palermo, MD, PhD, is interested in focusing on disorders of the bile ducts. He has developed an animal model to investigate the causes of immune mediated cholangiopathies. Additionally, he is exploring the use of decision analytic modeling to improve outcomes for patients with biliary atresia. Dr. Palermo is also investigating how to utilize state of the art imaging techniques to improve the diagnosis and management of cystic fibrosis liver disease.

513-636-4415 joseph.palermo@cchmc.org

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Joseph J. Palermo, MD, PhD

Associate Director, Pancreas Care Center

Academic Affiliations

Assistant Professor, UC Department of Pediatrics

Phone 513-636-4415

Fax 513-636-7805

Email joseph.palermo@cchmc.org

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Clinical

Pancreatic disorders; cystic fibrosis related GI and liver disorders; intestinal polyposis syndromes; general gastroenterology

Research

Acute, recurrent and chronic pancreatitis; cystic fibrosis related liver disease

Biography

Joseph J. Palermo, MD, PhD, obtained his degrees at the University of Cincinnati College of Medicine. He completed his pediatric residency and gastroenterology fellowship at St. Louis Children’s Hospital and Washington University, St. Louis. During fellowship, his research focused on the role of bacterial infections in the development of chronic liver disease and systemic inflammation.

As the medical director of the Pancreas Care Center he is focused on improving the outcomes for patients with a wide variety of pancreatic disorders including pancreatitis, anatomic defects, pancreatic insufficiency and tumors of the pancreas.

In addition, he continues his ongoing research with the Cystic Fibrosis Foundation though the National Institutes of Health funded Cystic Fibrosis Liver Disease Research Consortium and is a member of the multidisciplinary care team for intestinal polyposis syndromes.

MD: University of Cincinnati, Cincinnati, OH, 1997.

PhD: University of Cincinnati, Cincinnati, OH, 1997.

Residency: Pediatrics, St. Louis Children’s Hopsital and Washington University, St. Louis, MO.

Fellowship: Pediatric Gastroenterology, Hepatology and Nutrition, Washington University, St. Louis, MO.

Certification: Pediatric Gastroenterology, 2001.

Palermo J, Szabo F. 50 Years ago in The Journal of Pediatrics: hypoproteinemia and edema in infants with cystic fibrosis of the pancreas. J Pediatr. 2014 Mar 164(3):638.

Bellin MD1, Freeman ML2, Gelrud A3, Slivka A4, Clavel A5, Humar A6, Schwarzenberg SJ7, Lowe ME8, Rickels MR9, Whitcomb DC10, Matthews JB11; PancreasFest Recommendation Conference Participants, Amann S, Andersen DK, Anderson MA, Baillie J, Block G, Brand R, Chari S, Cook M, Cote GA, Dunn T, Frulloni L, Greer JB, Hollingsworth MA, Kim KM, Larson A, Lerch MM, Lin T, Muniraj T, Robertson RP, Sclair S, Singh S, Stopczynski R, Toledo FG, Wilcox CM, Windsor J, Yadav D. Total pancreatectomy and islet autotransplantation in chronic pancreatitis: recommendations from PancreasFest. Pancreatology. 2014 Jan-Feb;14(1):27-35.

Abu-El-Haija M, Lin TK, Palermo J. An Update to the Management of Pediatric Acute Pancreatitis: Highlighting Areas in Need for Research. J Pediatr Gastroenterol Nutr. 2014 Jun;58(6):689-93.

Sundaram SS1, Alonso EM, Haber B, Magee JC, Fredericks E, Kamath B, Kerkar N, Rosenthal P, Shepherd R, Limbers C, Varni JW, Robuck P, Sokol RJ; Childhood Liver Disease Research and Education Network (ChiLDREN), Schwarz K, Anders R, Colombani P, Karnsakul W, Osire SA, Pfeifer K, Wachter L, Whitington P, Alonso E, Bass L, Dunmars K, Jones D, Kelly S, Melin- Aldana H, Rizza D, Superina R, Tkaczyk K, Westfall E, Bezerra J, Bove K, Denlinger J, Heubi J, Jha P, LaGory D, Miethke A, Palermo J, Reed S, Setchell K, Stamper M, Tiao G, Sokol R, Dix M, Faut S, Hines J, Hite M, Jensen J, Karrer F, Lovell M, Mack C, Narkewicz M, Schardt T, Suchy F, Sundaram S, Van Hove J, Arnon R, Boyd M, Chu J, Cohen I, Iyer K, Magid M, Loomes K, Crisci T, Erlichman J, Flake A, Friedman J, Kusemiju O, Leonard L, Piccoli D, Rand E, Russo P, Spinner N, Wu E, Shneider B, Alissa F, Bernard B, Bowen A, Bukauskas K, Hoffmann P, Jaffe R, Lindblad D, Mazariegos G, Ortiz-Iguayo R, Perlmutter D, Scholz S, Sindhi R, Squires R Jr, Venkat V, Vockley J, Zecca D, Rosenthal P, Bull L, Fields S, Fleck S, Heyman M, Hirose S, Hoang V, Kim G, Langlois C, Pech J, Tejeda C, Roberts J, Wang L, Turmelle Y, Dillon P, Guelker S, Harris K, Heuckeroth R, Lowell J, Postma S, Rider J, Rudnick D, Stoll J, Weymann A, White F, Hertel P, Apted Z, Brandt M, Brown J, Carter B, Finegold M, Gibbs R, Harpavat S, Lynds J, McCartney T, Teckman J, Kociela V, Molleston J, Bozic M, Byam B, Haviland V, Klipsch A, Sawyers C, Subbarao G, Wegere J, West K, Murray K, Cooper K, Finn L, Healey P, Horslen S, Jacob S, Miethke A, Palermo J, Reed S, Setchell K, Stamper M, Ng V, Chiu A, Chung C, Day C, DeAngelis M, Fecteau A, Hunt K, Kamath B, Kovaleva T, Langer J, O'Connor C, Quammie C, Shakur L, VanRoestel K, Wang K, Cavallero J, Ford H, Goodhue C, Kerker N, Michail S, Hoang V, Kim G, Langlois C, Pech J, Roberts J, Wang L, Karpen S, Abramowsky C, de la Cruz-Tracy L, Francois-Marcello R, Gupta N, Rhodes J, Ricketts R, Romero R, Scott K, Sekar S, Shehata B, Turner-Green T, Vos M, Robuck P, Doo E, Hoofnagle J, Sherker A, Torrance R, Van Raaphorst R, Magee J, Jones K, Marchant B, Raghunathan T, Spino C, Ye W. Health related quality of life in patients with biliary atresia surviving with their native liver. J Pediatr. 2013 Oct;163(4):1052-7.

Rickels MR1, Bellin M, Toledo FG, Robertson RP, Andersen DK, Chari ST, Brand R, Frulloni L, Anderson MA, Whitcomb DC; PancreasFest Recommendation Conference Participants, Amann S, Baillie J, Belfer I, Criscimanna A, DiMaio C, Gariepy C, Gelrud A, Liang Go V, Humar A, Kim KM, Lambiase L, Lerch MM, Lieb J, Lowe M, Moser A, Mounzer R, Muniraj T, Park W, Rabinovitz M, Schwarzenberg S, Sclair S, Serrano J, Singh S, Wilcox C, Windsor J, Yadav D, Akshintala V, Albers K, Alhabhan S, Berry K, Block G, DO LB, Boggiano S, Boone B, Chauhan S, Chennat J, Cho S, Colatrella A, Cook M, Coronel E, Coté G, Das S, Davis B, Dwyer D, Easler J, Eisses J, Eren D, Esni F, Forsmark C, Freeman M, Friedman S, Gamarra R, Gardner T, Glass L, Goddard A, Gonska T, Greer J, Guda N, Hartigan C, Hartman D, Hollingsworth M, Hongjun W, Hubatch S, Husain S, Jacob J, Jerome-Zapadka K, Kerr K, Krasinskas A, Kumar S, Larson A, LaRusch J, Lee P, Lee K, Lin T, Morinville V, Mullady D, Nagathihalli N, Nawaz H, O'Keefe S, Hee S, Palermo J, Papachristou G, Prabhu A, Purich E, Rhim A, Rolfsmeyer E, Rudert C, Sandhu B, Sevilla W, Singh VP, Slivka A, MS SS, Srinivasan A, Stopczynski R, Tuveson D, Uc A, Umapathy C, Wassef W, Wen Y, Samer A, Wang H. Detection, evaluation and treatment of diabetes mellitus in chronic pancreatitis: recommendations from PancreasFest 2012. Pancreatology. 2013 Jul-Aug;13(4):336-42.

Palermo JJ, Joerger S, Turmelle Y, Putnam P, Garbutt J. Neonatal cholestasis: opportunities to increase early detection. Acad Pediatr. 2012 Jul-Aug12(4):283-7.

Garofalo CK, Hooton TM, Martin SM, Palermo JJ, Gordon JI, Hultgren SJ. Escherichia coli from urine of female patients with urinary tract infections is competent for intracellular bacterial community formation. Infect Immun. 2007 Jan;75(1):52-60.

Anderson GG, Palermo JJ, Schilling JD, Roth R, Heuser J, Hultgren SJ. Intracellular bacterial biofilm-like pods in urinary tract infections. Science. 2003 Jul 4;301(5629):105-7.

Buck SH, Konyn PJ, Palermo J, Robbins J, Moss RL. Altered kinetics of contraction of mouse atrial myocytes expressing ventricular myosin regulatory light chain. Am J Physiol. 1999 Apr;276(4 Pt 2):H1167-71.

Scott P. Pentiuk, MD, MEd Physician, Division of Gastroenterology, Hepatology and Nutrition

Scott P. Pentiuk, MD, MEd, has clinical interests in feeding disorders and general gastroenterology. He is working on outcomes, quality of life, and the use of pureed by gastrostomy tube feedings in children with feeding disorders. Additionally, Dr Pentiuk has a strong interest in medical education and curriculum design for gastroenterology at the resident and fellowship levels.

513-636-4415 scott.pentiuk@cchmc.org

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Scott P. Pentiuk, MD, MEd

Physician, Division of Gastroenterology, Hepatology and Nutrition

Medical Director, A4S

Physician, Interdisciplinary Feeding Team

Academic Affiliations

Associate Professor, UC Department of Pediatrics

Phone 513-636-4415

Email scott.pentiuk@cchmc.org

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Pediatric gastroenterology; feeding disorders; aerodigestive

MD: University of Cincinnati College of Medicine, Cincinnati, OH, 2002.

Residency: Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2005.

Fellowship: Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2008.

Master's of Medical Education: University of Cincinnati, Cincinnati, OH.

Boamah LM, Bohren JR, Pentiuk S, Baker R, Yi M, Moyer MS. Development and testing of a CD-ROM program for improving adolescent knowledge of inflammatory bowel disease. J Pediatr Gastroenterol Nutr. 2010 May;50(5):521-5.

Pentiuk S, Putnam PE, Collins MH, Rothenberg ME. Dissociation between symptoms and histological severity in pediatric eosinophilic esophagitis. J Pediatr Gastroenterol Nutr. 2009 Feb;48(2):152-60.

Pentiuk SP, Miller CK, Kaul A. Eosinophilic esophagitis in infants and toddlers. Dysphagia. 2007 Jan;22(1):44-8.

Philip E. Putnam, MD Director, Endoscopy Services

Philip E. Putnam, MD, is interested in the clinical diagnosis and treatment of eosinophilic gastrointestinal disorders. He is the medical director of the Cincinnati Center for Eosinophilic Disorders. He is also taking part in the Aerodigestive and Sleep Center, a multidisciplinary group including ENT, pulmonary medicine, and pediatric surgery, which evaluates and treats children who have complex disorders involving the airway and gastrointestinal tracts.

513-636-4415 philip.putnam@cchmc.org

Michael J. Rosen, MD, MSCI Associate Director, Schubert-Martin Inflammatory Bowel Disease Center

Michael J. Rosen, MD, MSCI, investigates the role of mucosal type 2 immune response in the pathogenesis of pediatric ulcerative colitis and the interaction between type 2 cytokines and the intestinal epithelium. Dr. Rosen also studies determinants of response to anti-TNF therapy in children with acute severe ulcerative colitis.

513-803-7044 michael.rosen@cchmc.org

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Michael J. Rosen, MD, MSCI

Associate Director, Schubert-Martin Inflammatory Bowel Disease Center

Academic Affiliations

Assistant Professor, UC Department of Pediatrics

Phone 513-803-7044

Email michael.rosen@cchmc.org

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Clinical

Pediatric gastroenterology; pediatric inflammatory bowel disease

Research

Mucosal immunology; epithelial biology; clinical pharmacology

Biography

Michael J. Rosen, MD, MSCI, focuses his career on the clinical care of children with inflammatory bowel disease (IBD), and to research aimed at better understanding the causes of chronic inflammation in childhood IBD. Studies from Dr. Rosen’s laboratory have elucidated the role of the type 2 (Th2) immune responses in regulating the intestinal inflammation and predicting response to therapy in pediatric ulcerative colitis. Dr. Rosen also leads an ongoing multi-center study to identify determinants of response to anti-TNF therapy in children hospitalized with acute severe ulcerative colitis.

Dr. Rosen's research has been funded by the National Institutes of Health, the Crohn's & Colitis Foundation, the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition (NASPGHAN), and the American College of Gastroenterology. Dr. Rosen serves on the editorial board of the journal Inflammatory Bowel Diseases. He is co-chair of the the Pediatric Affairs Committee for the Crohn's and Colitis Foundation and serves on its National Scientific Advisory Committee. His a past recipient of the NASPGHAN Fellow to Faculty Transition Award in IBD and the George Ferry Young Investigator Award.

MD: Harvard Medical School, Boston, MA, 2003.

Residency: Boston Combined Residency Program in Pediatrics (Boston Children's Hospital and Boston Medical Center), Boston, MA, 2003-2006.

Fellowship: Pediatric Gastroenterology, Hepatology, and Nutrition, Vanderbilt University Medical Center and the Monroe Carell, Jr. Children's Hospital at Vanderbilt, Nashville, TN, 2006-2009.

Masters of Science in Clinical Investigation (MSCI): Vanderbilt University School of Medicine, Nashville, TN, 2009.

Certification: Pediatrics, 2007; Pediatric Gastroenterology, Hepatology and Nutrition, 2009.

Rosen MJ, Karns R, Vallance JE, Bezold R, Waddell A, Collins MH, Haberman Y, Minar P, Baldassano RN, Hyams JS, Baker SS, Kellermayer R, Noe J, Griffiths AM, Rosh JR, Crandall WV, Heyman MB, Mack DR, Kappelman MD, Markowitz J, Moulton DE, Leleiko NS, Walters TD, Kugathasan S, Wilson KT, Hogan SP, Denson LA. Mucosal type 2 and type 17 gene expression distinguishes ulcerative colitis from colon-only Crohn’s disease in treatment-naïve pediatric patients. Gastroenterology. 2017;152(6):1345-1357.

Waddell A, Vallance JE, Moore PD, Hummel AT, Shanmukhappa SK, Wu D, Fei L, Washington MK, Minar P, Coburn L, Nakae S, Wilson KT, Denson LA, Hogan SP, Rosen MJ. IL-33 signaling protects from murine oxazolone colitis by supporting intestinal epithelial function. Inflammatory Bowel Diseases. 2015; 21(12):2737-46.

Rosen MJ, Minar P, Vinks AA. Review Article: Applying Pharmacokinetics to Optimize Dosing of Anti-TNF Biologics in Acute Severe Ulcerative Colitis. Alimentary Pharmacology and Therapeutics. 2015;41(11):1094-103.

Rosen MJ, Dhawan A, Saeed SA. Inflammatory Bowel Disease in Children and Adolescents. JAMA Pediatrics. 2015;169(11):1053-60.

Falaiye TO, Mitchell KR, Lu Z, Saville BR, Horst SN, Moulton DE, Schwartz DA, Wilson KT, Rosen MJ. Outcome following infliximab therapy for pediatric patients hospitalized with refractory colitis-predominant inflammatory bowel disease. Journal of Pediatric Gastroenterology and Nutrition. 2014; 58(2):213-9.

Rosen MJ*, Chaturvedi R, Washington MK, Kuhnhein LA, Moore PD, Coggeshall SS, McDonough EM, Weitkamp JH, Singh AB. Coburn LA, Williams CS, Van Kaer L, Peebles RS, Wilson KT. STAT6 activation intensifies disease severity while increasing expression of claudin-2 and Th2-inducing cytokines in murine oxazolone colitis. The Journal of Immunology. 2013; 190(4):1849-1858.

Rosen MJ*, Frey MR, Washington MK, Chaturvedi R, Kuhnhein LA, Matta P, Revetta F, Wilson KT, Polk DB. STAT6 activation in ulcerative colitis: A new target for prevention of IL-13-induced colonic epithelial cell dysfunction. Inflammatory Bowel Diseases. 2011; 17(11):2224-2234.

Rosen MJ, Moulton DE, Koyama T, Morgan WM, Morrow SE, Herline AJ, Muldoon RL, Wise PE, Polk DB, Schwartz DA. Endoscopic Ultrasound to Guide the Combined Medical and Surgical Management of Pediatric Perianal Crohn’s Disease. Inflammatory Bowel Diseases. 2010; 16(3):461-8.

Forcione DG, Rosen MJ, Kisiel JB, Sands BE. Anti-Saccharomyces cerevisiae antibody (ASCA) positivity is associated with increased risk for early surgery in Crohn's disease. Gut. 2004;53:1117-1122.

Sands BE, Arsenault JE, Rosen MJ, et al. Risk of Early Surgery for Crohn's Disease: Implications for Early Treatment Strategies. American Journal of Gastroenterology. 2003;98(12):2712-2718.

Grants

Th2 Cytokines and Signaling in Pediatric Inflammatory Bowel Disease. Principal Investigator. National Institutes of Health/National Institute of Diabetes and Digestive and Kidney Diseases (NIH/NIDDK). Mar 2013-Mar 2018.

Anti-TNF Therapy for Refractory Colitis in Hospitalized Children (ARCH). Principal Investigator. Broad Medical Research Program at the Crohn's & Colitis Foundation of America. Mar 2016–Mar 2019.

Impact of ST2 Signaling and IBD Risk Variants on the Intestinal Epithelium. Principal Investigator. National Institutes of Health/National Institute of Diabetes and Digestive and Kidney Diseases (NIH/NIDDK) R03. Jun 2016–May 2018.

Pranavkumar Shivakumar, PhD

Pranavkumar Shivakumar, PhD, investigates how inflammatory natural killer (NK) and CD8 T-cells work in concert to initiate and propagate acute inflammatory injuries to bile ducts in biliary atresia. He also investigates the role of complement activation in a mouse model of experimental atresia and how complement activation products contribute to epithelial injury and inflammatory cell recruitment.

513-636-3676 pranav.shivakumar@cchmc.org

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Pranavkumar Shivakumar, PhD

Academic Affiliations

Assistant Professor, UC Department of Pediatrics

Phone 513-636-3676

Fax 513-636-5581

Email pranav.shivakumar@cchmc.org

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Research Interests

Dissecting molecular mechanisms and pathways involved in the pathogenesis of biliary atresia

PhD: University of Bombay, Bombay, India, 2002.

MPharm: University of Bombay, Bombay, India, 1997.

Visit the Steinbrecher Lab.

Shivakumar P, Shanmugam RP, Mani CS. Idiopathic granulomatous appendicitis: a rare appendicular pseudo tumor. Trop Gastroenterol. 2010 Apr-Jun;31(2):130-1.

Moyer K, Kaimal V, Pacheco C, Mourya R, Xu H, Shivakumar P, Chakraborty R, Rao M, Magee JC, Bove K, Aronow BJ, Jegga AG, Bezerra JA. Staging of biliary atresia at diagnosis by molecular profiling of the liver. Genome Med. 2010 May 13;2(5):33.

Miethke AG, Saxena V, Shivakumar P, Sabla GE, Simmons J, Chougnet CA. Post-natal paucity of regulatory T cells and control of NK cell activation in experimental biliary atresia. J Hepatol. 2010;52(5):718-26.

Shivakumar P, Krauthammer M. Structural similarity assessment for drug sensitivity prediction in cancer. BMC Bioinformatics. 2009 Sep 17;10 Suppl 9:S17.

Shivakumar P, Sabla G, Whitington P, Chougnet C, Bezerra JA. Neonatal NK cells target the mouse duct epithelium via Nkg2d and drive tissue-specific injury in experimental biliary atresia. J Clin Invest. 2009;119(8):2281-90.

Erickson N, Mohanty SK, Shivakumar P, Sabla G, Chakraborty R, Bezerra JA. Temporal-spatial activation of apoptosis and epithelial injury in murine experimental biliary atresia. Hepatology. 2008;47(5):1567-77.

Shivakumar P, Sabla G, Mohanty S, McNeal M, Ward R, Stringer K, Caldwell C, Chougnet C, Bezerra JA. Effector role of neonatal hepatic CD8+ lymphocytes in epithelial injury and autoimmunity in experimental biliary atresia. Gastroenterology. 2007 Jul;133(1):268-77.

Shanmugam RP, Shivakumar P. A rare complication of jejunal diverticulosis. Trop Gastroenterol. 2006 Jul-Sep;27(3):134-5.

Mohanty SK, Shivakumar P, Sabla G, Bezerra JA. Loss of interleukin-12 modifies the pro-inflammatory response but does not prevent duct obstruction in experimental biliary atresia. BMC Gastroenterol. 2006 Apr 19;6:14.

Carvalho E, Liu C, Shivakumar P, Sabla G, Aronow B, Bezerra JA. Analysis of the biliary transcriptome in experimental biliary atresia. Gastroenterology. 2005 Aug;129(2):713-7.

Kris A. Steinbrecher, PhD

Kris A. Steinbrecher, PhD, is interested in cell signaling events and transcription factors that regulate intestinal epithelial cell responses to infection and inflammation. His laboratory is focused on understanding the role of guanylate cyclase proteins and NF-κB in experimental colitis and enteric bacterial infections.

513-636-4415 kris.steinbrecher@cchmc.org

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Kris A. Steinbrecher, PhD

Academic Affiliations

Assistant Professor, UC Department of Pediatrics

Phone 513-636-4415

Fax 513-636-5581

Email kris.steinbrecher@cchmc.org

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Research Interests

Visit the Steinbrecher Lab.

Inflammatory bowel disease; bacterial infection; signal transduction and gene expression in intestinal epithelial cells

PhD: Molecular and Developmental Biology, University of Cincinnati, Cincinnati, OH, 2001.

Postdoctoral Fellowship: Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, 2001-2005.

Visit the Takebe Lab and Visit the Takebe Lab at Cincinnati Children's Hospital Medical Center.

Begg DP, Steinbrecher KA, Mul JD, Chambers AP, Kohli R, Haller A, Cohen MB, Woods SC, Seeley RJ. Effect of guanylate cyclase-C activity on energy and glucose homeostasis. Diabetes. 2014 Nov;63(11):3798-804.

Xin L, Jiang TT, Chaturvedi V, Kinder JM, Ertelt JM, Rowe JH, Steinbrecher KA, Way SS. Commensal microbes drive intestinal inflammation by IL-17-producing CD4+ T cells through ICOSL and OX40L costimulation in the absence of B7-1 and B7-2.Proc Natl Acad Sci U S A. 2014 Jul 22;111(29):10672-7.

Turpin B, Miller W, Rosenfeldt L, Kombrinck K, Flick MJ, Steinbrecher KA, Harmel-Laws E, Mullins ES, Shaw M, Witte DP, Revenko A, Monia B, Palumbo JS. Thrombin drives tumorigenesis in colitis-associated colon cancer.Cancer Res. 2014 Jun 1;74(11):3020-30.

Steinbrecher KA. The multiple roles of guanylate cyclase C, a heat stable enterotoxin receptor. Curr Opin Gastroenterol. 2014 Jan;30(1):1-6.

Harmel-Laws E, Mann EA, Cohen MB, Steinbrecher KA. Guanylate cyclase C deficiency causes severe inflammation in a murine model of spontaneous colitis.PLoS One. 2013 Nov 11;8(11):e79180.

Elahi S, Ertelt JM, Kinder JM, Jiang TT, Zhang X, Xin L, Chaturvedi V, Strong BS, Qualls JE, Steinbrecher KA, Kalfa TA, Shaaban AF, Way SS. Immunosuppressive CD71+ erythroid cells compromise neonatal host defence against infection. Nature. 2013 Dec 5;504(7478):158-62.

Harley IT, Stankiewicz TE, Giles DA, Softic S, Flick LM, Cappelletti M, Sheridan R, Xanthakos SA, Steinbrecher KA, Sartor RB, Kohli R, Karp CL, Divanovic S. IL-17 signaling accelerates the progression of nonalcoholic fatty liver disease in mice.Hepatology. 2014 May;59(5):1830-9.

Mann EA, Harmel-Laws E, Cohen MB, Steinbrecher KA. Guanylate cyclase C limits systemic dissemination of a murine enteric pathogen. BMC Gastroenterol. 2013 Sep 2;13:135.

Waddell A, Ahrens R, Tsai YT, Sherrill JD, Denson LA, Hogan SP, Steinbrecher KA. Intestinal CCL11 and eosinophilic inflammation is regulated by myeloid cell-specific RelA/p65 in mice. J Immunol. 2013 May 1;190(9):4773-85.

Steinbrecher KA, Harmel-Laws E, Garin-Laflam MP, Mann EA, Bezerra LD, Hogan SP, Cohen MB. Murine guanylate cyclase C regulates colonic injury and inflammation. J Immunol. 2011 Jun 15;186(12):7205-14.

Takanori Takebe, MD

Takanori Takebe, MD, investigates: 1. The deductive development of a complex human organoid model, 2. The multidisciplinary dissection of self-driven mechanisms of organogenesis and 3 The technology prototyping towards drug discovery/transplant applications. Though these efforts, Takebe lab aims to contribute to human health by establishing new therapies especially for treating pediatric intractable disease.

513-803-7807 takanori.takebe@cchmc.org

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Takanori Takebe, MD

Academic Affiliations

Assistant Professor, UC Department of Pediatrics

Associate Professor, Department of Regenerative Medicine, Yokohama City University, Japan

Phone 513-803-7807

Fax 513-636-5581

Email takanori.takebe@cchmc.org

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Visit the Takebe Lab and Visit the Takebe Lab at Cincinnati Children's Hospital Medical Center.

Clinical

Hepatology; transplantation

Research

Organoid; organogenesis; stem cell biology; transplantation; drug development

Biography

Dr. Takebe is an assistant professor at the Cincinnati Children’s Hospital Medical Center. His lab is developing and applying mini-organ technologies from human stem cells – namely organ bud transplants – in patients with a rare congenital metabolic disorder, ultimately expanding the clinical applications to diseases like liver cirrhosis. Also, he holds a joint appointment at the Department of Regenerative Medicine, Yokohama City University in Japan, where he directs a translational program of human induced pluripotent stem cell (iPSC) based liver bud based approach for congenital liver disorders by developing a cGMP manufacturing platform.

Dr. Takebe successfully administered more than six nationally funded projects, awarded number of prestigious awards such as NYSCF robertson investigator award, and produced high impact peer-reviewed publications from each project. His recent associate professor appointment, at the age 26, was one of the youngest recorded in Japan.

MD: Yokohama City University, Japan, 2011.

Shinozawa T, Yoshikawa H-Y, Takebe T*. Reverse Engineering Organ Buds through Self-Driven Condensation and Organization. Developmental Biology. 2016 Jun 27. (*Correspondence)

Takahashi Y, Takebe T*, Taniguchi H*. Engineering pancreatic tissues from stem cells towards therapy. Regenerative Therapy. 2016(3):15-23. (*Joint corresponding authors)

Kagimoto S, Takebe T*, Kobayashi S, Yabuki Y, Hori A, Hirotomi K, Mikami T, Uemura T, Maegawa J, Taniguchi H. Autotransplantation of monkey ear perichondrium-derived progenitor cells for cartilage reconstruction. Cell transplantation. 2016;25(5):951-62. (*Joint corresponding authors)

Takebe T*, Enomura M, Yoshizawa E, Kimura M, Koike H, Ueno Y, Matsuzaki T, Yamazaki T, Toyohara T, Osafune K, Nakauchi H, Yoshikawa H-Y, Taniguchi H. Vascularized And Complex Organ Buds From Diverse Tissues Via Mesenchymal Cell-Driven Condensation. Cell Stem Cell. 2015 Apr;16(5):556-565. (*Corresponding author, Selected as Cover Work)

Selected as Cover Work
Selected as Best of Cell Stem Cell
Previewed in Cell Stem Cell
Featured in Nature Method

Rashid T, Takebe T, Nakauchi H. Novel strategies for liver therapy using stem cells. Gut. 2015;64:1-4.

Zhang RR, Koike H, Takebe T. The visualization of human organogenesis from stem cells by recapitulating multicellular interactions. In Hyper Bio Assembler for 3D Cellular Systems. 2015:275-283.

Takebe T *, Kobayashi S, Suzuki H, Mizuno M, Chang YM, Yoshizawa E, Kimura M, Hori A, Asano J, Maegawa J, Taniguchi H. Transient vascularization of transplanted human adult–derived progenitors promotes self-organizing cartilage. Journal of Clinical Investigation. 2014 Oct;124(10):4325-34. (*Corresponding author)

Takebe T*, Zhang RR, Koike H, Kimura M, Yoshizawa E, Enomura M, Sekine K, Taniguchi H*. Generation of a vascularized and functional human liver from an iPSC-derived organ bud transplant. Nature Protocols. 2014;9:396–409. (*Corresponding author)

Koike H, Ueno Y, Naito T, Shiina T, Ouchi R, Obana Y, Mori M, Sekine K, Takebe T, Zheng YW, Isono K, Koseki H, Taniguchi H. Ring1B Promotes Hepatic Stem/Progenitor Cell Expansion via Simultaneous Suppression of Cdkn1a and Cdkn2a. Hepatology. 2014 Jul;60(1):323-33.

Takebe T*, Sekine K, Enomura M, Koike H, Zhang RR, Ueno Y, Zheng YW, Koike N, Aoyama S, Adachi Y, Taniguch H*: Vascularized and functional human liver from an iPSC-derived organ bud transplant. Nature. 2013;499:481–484. (*Corresponding author)

Selected as Science Breakthrough of the Year
Selected as Word Top5 discovery, Discover Magazine
Featured in Nature, Nature Medicine, Cell Stem Cell, Gastroenterology, Hepatology, Cell Research
Featured in The Economist, New Scientist magazine, Newton, etc

Grants

Robertson Investigator Award. Principal Investigator. New-York Stem Cell Foundation. Jan 2017-Dec 2021.

In vitro human organ generation by reconstituting spatiotemporal control of multiple cellular interactions. Principal Investigator. PRESTO, JST. Oct 2013-Mar 2017.

Cynthia C. Wetzel, PhD Manager, Digestive Health Center

Cynthia C. Wetzel, PhD, is the manager of the Digestive Health Center (DHC) which is one of only 17 Silvio O. Conte Digestive Diseases Research Core Centers in the nation supported by the National Institutes of Diabetes and Digestive and Kidney Diseases. The DHC, located within the Division of Gastroenterology, Hepatology and Nutrition at Cincinnati Children's Hospital Medical Center is the only center dedicated to pediatric digestive diseases research. Visit the DHC website.

513-636-9605 cynthia.wetzel@cchmc.org

Stavra A. Xanthakos, MD, MS Director, Steatohepatitis Center

Stavra A. Xanthakos, MD, MS, is focused on identifying the biologic determinants of non-alcoholic steatohepatitis (NASH), including potential gene-environment interactions with dietary intake during childhood and adolescence. One of her long-term research goals is to develop and apply mechanistically based therapies through clinical trials for NASH in childhood and adolescence.

513-636-4415 stavra.xanthakos@cchmc.org

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Stavra A. Xanthakos, MD, MS

Director, Steatohepatitis Center

Medical Director, Surgical Weight Loss Program for Teens

Associate Director, Gastroenterology Fellowship Program

Academic Affiliations

Associate Professor, UC Department of Pediatrics

Phone 513-636-4415

Fax 513-636-7805

Email stavra.xanthakos@cchmc.org

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Clinical

Non-alcoholic fatty liver disease and steatohepatitis; pediatric obesity; bariatric surgery; nutrition

Research

Prevalence, determinants and outcome of pediatric obesity-related liver disease (Non-alcoholic fatty liver disease and steatohepatitis); bariatric medicine; pediatric obesity and nutrition

Biography

Stavra A. Xanthakos, MD, is an attending physician in the Division of Gastroenterology, Hepatology and Nutrition, the co-director of the Cincinnati Children’s Steatohepatitis Center, and the medical director of the Surgical Weight Loss Program for Teens. She is an assistant professor for the University of Cincinnati College of Medicine. She also partners with physicians and staff in Cincinnati Children’s Center for Better Health and Nutrition in the evaluation and management of pediatric patients suffering from severe pediatric obesity and related complications.

Dr. Xanthakos received her medical degree from Duke University in 1997 and a Master of Science degree in molecular epidemiology from the University of Cincinnati in 2006. Her post-doctoral training, including residency, chief residency and fellowship were completed at Cincinnati Children's and she joined the faculty within the University of Cincinnati College of Medicine in 2005. During her fellowship, Dr. Xanthakos investigated the prevalence and outcome of non-alcoholic fatty liver disease (NAFLD) in young adult women as her master’s thesis in molecular epidemiology. Her current clinical and translational research is focused on identify the predictors and outcome of obesity-related liver disease (nonalcoholic fatty liver disease and steatohepatitis), in obese adolescents undergoing bariatric surgery. She is also a co-investigator in the NIH sponsored Teen LABS, a multicenter consortium investigating bariatric surgery in adolescents and in the NIH-sponsored NASH Clinical Research Network. Additional research interests of Dr. Xanthakos include the treatment and prevention of pediatric obesity, outcomes of bariatric surgery in adolescents, malnutrition in pediatric obesity, as well as identifying genetic and environmental risk factors for pediatric nonalcoholic fatty liver disease to enable better evaluation and treatment options. She also leads clinical quality improvement initiatives in the Steatohepatitis Center, which are aligned with divisional and institutional initiatives to achieve measurable improvements in children’s health and disease outcomes.

Dr. Xanthakos has published extensively in the field of pediatric obesity, bariatric medicine and non-alcoholic fatty liver disease. She regularly is invited to speak about pediatric obesity evaluation and management, particularly bariatric medicine, and pediatric nonalcoholic fatty liver disease.

MD: Duke University, Durham, NC, 1997.

MS: Molecular Epidemiology, University of Cincinnati, 2006.

Residency: Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 1997-2000.

Chief Residency: Cincinnati Children's, Cincinnati, OH, 2000-01.

Clinical Fellowship: Gastroenterology, Hepatology & Nutrition, Cincinnati Children's, Cincinnati, OH, 2001-2004.

Research Fellowship: Molecular Epidemiology in Children's Environmental Health, Masters of Science, 2002-2005.

Certification: Pediatrics, 2008; Pediatric Gastroenterology, 2005.

Carter-Kent C, Alkhouri N, Yerian LM, Brunt EM, Angulo P, Kohli R, Ling SC, Xanthakos SA, Whitington PF, Charatcharoenwitthaya P, Yap J, Lopez R, McCullough AJ and Feldstein AE. The relationship of steatosis grade, zone and type to key histological features in children with nonalcoholic fatty liver disease. Journal of Pediatric Gastroenterology, Hepatology and Nutrition. 2011;52(2):190-7.

Kohli R, Kirby M, Xanthakos SA, Softic S, Feldstein AE, Saxena V, Tang PH, Miles L, Miles MV, Balistreri WF, Woods SC, Seeley RJ. High-fructose, medium chain trans fat diet induces liver fibrosis and elevates plasma coenzyme Q9 in a novel murine model of obesity and nonalcoholic steatohepatitis. Hepatology. 2010 Sep;52(3):934-44.

Kohli R, Boyd T, Lake K, Dietrich K, Nicholas L, Balistreri WF, Ebach D, Shashidhar H, Xanthakos SA. Rapid progression of NASH in childhood. J Pediatr Gastroenterol Nutr. 2010 Apr;50(4):453-6.

Xanthakos SA. Nutritional deficiencies in obesity and after bariatric surgery. Pediatr Clin North Am. 2009 Oct;56(5):1105-21.

Inge TH, Xanthakos S. Sleeve gastrectomy for childhood morbid obesity: why not? Obes Surg. 2010 Jan;20(1):118-20.

Inge TH, Jenkins TM, Zeller M, Dolan L, Daniels SR, Garcia VF, Brandt ML, Bean J, Gamm K, Xanthakos SA. Baseline BMI is a strong predictor of nadir BMI after adolescent gastric bypass. J Pediatr. 2010 Jan;156(1):103-108.

Xanthakos SA. Bariatric surgery for extreme adolescent obesity: Indications, outcomes, and physiologic effects on the gut-brain axis. Pathophysiology. 2008 Aug;15(2):135-46.

Roehrig HR, Xanthakos SA, Sweeney J, Zeller MH, Inge TH. Pregnancy after gastric bypass surgery in adolescents. Obes Surg. 2007 Jul;17(7):873-7.

Miller RJ, Xanthakos SA, Hillard PJ, Inge TH. Bariatric surgery and adolescent gynecology. Curr Opin Obstet Gynecol. 2007 Oct;19(5):427-33.

Inge TH, Xanthakos SA, Zeller MH. Bariatric surgery for pediatric extreme obesity: now or later? Int J Obes (Lond). 2007 Jan;31(1):1-14.

Chunyue Yin, PhD

Chunyue Yin, PhD, studies the cellular and molecular basis of liver development and disease pathogenesis. She focuses on hepatic stellate cells, the key cell type responsible for hepatic fibrogenesis. She utilizes the zebrafish model to investigate the regulation of hepatic stellate cells during liver development and alcoholic liver injury, and their function in liver regeneration. Research in congenital biliary diseases is a second lab focus.

Visit the Yin Lab.

513-803-8096 chunyue.yin@cchmc.org

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Chunyue Yin, PhD

Academic Affiliations

Assistant Professor, UC Department of Pediatrics

Phone 513-803-8096

Email chunyue.yin@cchmc.org

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Specialties

Liver development; hepatic fibrosis and cirrhosis; hepatic stellate cells; stem cells and regeneration; congenital biliary diseases; zebrafish genetics

Visit the Yin Lab.

Biography

Dr. Yin conducted her doctoral research in Dr. Lilianna Solnica-Krezel’s laboratory at Vanderbilt University, where she investigated the molecular regulation of cell movements during zebrafish gastrulation and revealed the impact of gastrulation movements on somite development. In parallel, she participated in a forward genetic screen to identify novel regulators of zebrafish early development. She identified the calamity mutant that exhibits defects in notochord formation and pigmentation. Subsequent positional cloning revealed that a mutation in the atp7a gene, the zebrafish homolog of the human Menkes disease gene, was responsible for the calamity mutant phenotypes.

With a strong interest in building zebrafish models for human diseases, she decided to conduct her postdoctoral research in Dr. Didier Stainier’s laboratory, which is at the forefront of zebrafish digestive organ research. She received a postdoctoral fellowship from the Juvenile Diabetes Research Foundation to study pancreas development in zebrafish hands-off/han mutants that carry a mutation in the transcription factor gene hand2. Her research led to the discovery that the defective pancreatic development in han mutants is due to a failure in asymmetric gut looping. She also showed that gut-looping morphogenesis is dependent on extracellular matrix remodeling and revealed novel roles for Hand2 in this process. This work was published in Developmental Cell in 2010. Her work is now focused on the hepatic stellate cells and hepatic biliary cells. She has developed transgenic lines that mark these cell types and will use them and related reagents to characterize the cellular behaviors of these cells in liver development and disease, as well as the underlying molecular regulations.

BS: Evolution and Ecology, Fudan University, Shanghai, China, 2001.

PhD: Developmental Biology, Vanderbilt University, Nashville, TN, 2007.

Postdoctoral fellow: Developmental Biology, University of California at San Francisco, San Francisco, CA, 2012.