Behavior problems, including oppositional defiant behaviors and obsessive compulsive disorder, are common in children with 22Q-VCFS. Many children will be diagnosed with attention deficit hyperactivity disorder (ADHD), often requiring medication. It is also estimated that 25 percent of adults with 22Q-VCFS will be diagnosed with schizophrenia, serious depression, schizoaffective disorder or bipolar illness. There are few long-term studies of children who have developed these disorders, and triggering factors or the effects of early identification are not known.