Genetics, Genomics & Bioinformatics
Many MDB laboratories use genetics and genomics in their research in a wide variety of ways. The power of next-generation sequencing techniques is often employed in either model systems or directly in clinical populations to gain insight into the mechanisms of development and disease. A major challenge in the current genomics age is to properly interpret these massive datasets and this is an active area of research in the field of bioinformatics.
Faculty
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Theresa Alenghat, PhD, Assistant Professor Molecular mechanisms that mediate intestinal homeostasis and the host-microbiota relationship [Visit the Alenghat Lab ] |
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Bruce Aronow, PhD, Professor Integrative bioinformatics and genomics relevant to human health and disease [Visit the Aronow / Jegga Lab] |
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Artem Barski, PhD, Assistant Professor Epigenomics of immunological memory [Visit the Barski Lab] |
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Cristina Cebrian Ligero, PhD, Assistant Professor The Cebrian lab studies the molecular and cellular mechanisms that drive kidney organogenesis and renal disease. |
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Lee Grimes, PhD, Professor Hematopoiesis, molecular biology, and molecular oncology including mouse modeling of hematopoiesis, myelopoiesis and leukemia. [Visit the Grimes Lab] |
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John Harley, MD, PhD, Professor We work to bring the new technologies of genomics to clinical care. We do this for the institution as a service and for our own work in autoimmunity. At the moment we are evaluating the microbiome in blood for systemic lupus erythematosus. [Visit Rheumatology] |
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Rulang Jiang, PhD, Professor Understanding the genetic basis and molecular mechanisms of major birth defects [Visit the Jiang Lab] |
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Kenneth Kaufman, PhD, Professor Utilization of next generation DNA sequencing data to identify variants that cause disease. We are particularly interested in autoimmune diseases such as systemic lupus erythematosus. [Visit CAGE] |
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Louis Muglia, MD, PhD, Professor Genetic and developmental mechanisms controlling the timing of birth and risk of preterm birth; molecular genetic analysis of the behavioral and neuroendocrine responses to stress. [Visit the Muglia Lab] |
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Joo-Seop Park, PhD, Assistant Professor Gene regulatory networks underlying organogenesis and disease, Kidney development. [Visit Urology] |
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Matt Weirauch, PhD, Assistant Professor My lab uses computational and experimental approaches to study gene regulation, and gene mis-regulation in disease. [Visit the Weirauch Lab] |
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Chunyue Yin, PhD, Assistant Professor The molecular and cellular mechanisms underlying liver development and disease pathogenesis using the zebrafish model organism. [Visit the Yin Lab] |
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Amanda Zacharias, PhD, Assistant Professor Our lab studies how gene expression is regulated by signaling pathways during embryonic development. We use Wnt signaling in the nematode worm, C. elegans, as a model system and utilize a novel time-lapse imaging approach. [Visit the Zacharias Lab] |
