Central to the mission of Cincinnati Children’s Hospital is the development of therapeutics for both childhood and adult diseases. Starting with Albert Sabin’s polio vaccine and Dr. Jeffrey Whitsett’s development of surfactant replacement therapy for premature infants to the development of the oral rotavirus vaccine by Drs. Ward and Bernstein, Cincinnati Children's research has changed the outcome for many patients. Faculty in the Molecular & Developmental Biology Graduate Program are actively engaged in drug target identification and validation, the development of therapeutics through virtual and experimental screening techniques, structure-aided drug design, as well as the development of immuno- and gene therapies. There is a well-developed pipeline to translate these discoveries to clinical trials, with a particular emphasis on pediatric diseases.