The broad goals of this research is to understand the cellular, molecular and genetic mechanisms that drive immunologically-mediated disorders.The broad goals of this research is to understand the cellular, molecular and genetic mechanisms that drive immunologically-mediated disorders.

Dysregulated immune responses are of central importance to the pathogenesis and expression of a wide spectrum of disease (HIV, asthma, coronary artery disease, arthritis, cystic fibrosis, cancers) that cause an immense burden of morbidity and mortality in the US and the world at large.



 Theresa Alenghat, PhD. Theresa Alenghat, PhD, Assistant Professor
Molecular mechanisms that mediate intestinal homeostasis and the host-microbiota relationship [Visit the Alenghat Lab]
Artem Barski, PhD. Artem Barski, PhD, Assistant Professor
Epigenomics of immunological memory [Visit the Barski Lab]
Lee Grimes, PhD. Lee Grimes, PhD, Professor
Hematopoiesis, molecular biology, and molecular oncology including mouse modeling of hematopoiesis, myelopoiesis and leukemia. [Visit the Grimes Lab]
John Harley, MD, PhD. John Harley, MD, PhD, Professor
We work to bring the new technologies of genomics to clinical care. We do this for the institution as a service and for our own work in autoimmunity. At the moment we are evaluating the microbiome in blood for systemic lupus erythematosus. [Visit Rheumatology]
Gurjit Khurana Hershey, MD, PhD. Gurjit Khurana Hershey, MD, PhD, Professor
Genetics and the pathogenesis of atopic disorders [Visit the Hershey Lab]
David Hildeman, PhD. David Hildeman, PhD, Professor
Molecular biology of antigen-specific T cells, including mechanisms involved in cell signaling, apoptosis, and sex-based differences in autoimmunity and the T cell response to viral infections [Visit the Hildeman Lab]
 Kenneth Kaufman, PhD. Kenneth Kaufman, PhD, Professor
Utilization of next generation DNA sequencing data to identify variants that cause disease. We are particularly interested in autoimmune diseases such as systemic lupus erythematosus. [Visit CAGE]
Tim Le Cras, PhD. Tim Le Cras, PhD, Associate Professor
Chronic lung diseases: Asthma, Bronchopulmonary dysplasia, Pulmonary fibrosis, Pulmonary hypertension [Visit the Le Cras Lab]
Takahisa Nakamura, PhD. Takahisa Nakamura, PhD, Assistant Professor
Functional analysis of small RNAs and their binding proteins in integrative organ crosstalk in metabolic diseases. [Visit Endocrinology]
Marc Rothenberg, MD, PhD. Marc Rothenberg, MD, PhD, Professor
Eosinophil biology, chemokine receptor signaling pathways [Visit the Rothenberg Lab]
Stephen N. Waggoner, PhD. Stephen N. Waggoner, PhD, Assistant Professor
We are interested in host and viral factors that control disease pathogenesis by regulating development of long-lived immunological memory, generation of potent immune effector cells, and functional repression of immune function during chronic infection. [Visit the Waggoner Lab]
Jeffrey A. Whitsett, MD. Jeffrey A. Whitsett, MD, Professor 
Organ morphogenesis, gene regulation, cell differentiation, respiratory disease [Visit the Whitsett Lab]