A photo of Lee A. Denson.

Director, Schubert-Martin Inflammatory Bowel Disease Center

Professor, UC Department of Pediatrics

513-636-7575

Board Certified

My Biography & Research

Biography

The primary focus of Dr. Lee A. Denson's laboratory is to determine the molecular basis for alterations in growth hormone signaling in inflammatory bowel diseases (IBD).

Normal growth and development are dependent upon the ability of growth hormone to regulate IGF-1 expression. Evidence from studies in children with IBD and mouse models of colitis indicates that inflammatory cytokines which are up regulated in this setting may cause an acquired GH resistance. Consequences may include growth failure, altered body composition and impaired mucosal healing.

We are using complementary experimental and patient-based approaches to investigate regulation of growth hormone signaling in mouse models of colitis and in children with Crohn's disease. These include down regulation of the growth hormone receptor and up regulation of a family of post-receptor inhibitory proteins, the Suppressors of Cytokine Signaling (SOCS). These studies should lead to the development of more effective therapies for children with IBD and other chronic inflammatory conditions.

Clinical Interests

Inflammatory bowel disease; growth failure; celiac disease

Academic Affiliation

Professor, UC Department of Pediatrics

Divisions

Gastroenterology GI, Colorectal Disorders, Inflammatory Bowel Disease IBD, Autoimmune Liver Disease, Gastroenterology

Cincinnati Children's Blog

A Promising Early Research Study for IBD Treatment

BlogRare and Complex Conditions

A Promising Early Research Study for IBD Treatment

By Lee A. Denson, MD4/28/2016

Science Blog

My Locations

My Education

MD: Medical College of Virginia, Richmond, VA, 1993.

Residency: Yale-New Haven Hospital, New Haven, CT, 1993-96.

Certification: Pediatrics, 1996 and 2002.

Fellowship: Yale University School of Medicine, New Haven, CT, 1996-99.

My Publications

Recommendations for Successful Transition of Adolescents With Inflammatory Bowel Diseases to Adult Care. Shapiro, JM; El-Serag, HB; Gandle, C; Peacock, C; Denson, LA; Fishman, LN; Hernaez, R; Hou, JK. Clinical Gastroenterology and Hepatology. 2020; 18:276-289.e2.

Ulcerative colitis mucosal transcriptomes reveal mitochondriopathy and personalized mechanisms underlying disease severity and treatment response. Haberman, Y; Karns, R; Dexheimer, PJ; Schirmer, M; Somekh, J; Jurickova, I; Braun, T; Novak, E; Bauman, L; Collins, MH; et al. Nature Communications. 2019; 10.

Neutrophil GM-CSF signaling in inflammatory bowel disease patients is influenced by non-coding genetic variants. Venkateswaran, S; Denson, LA; Jurickova, I; Dodd, A; Zwick, ME; Cutler, DJ; Kugathasan, S; Okou, DT. Scientific Reports. 2019; 9.

Study of Environmental Enteropathy and Malnutrition (SEEM) in Pakistan: protocols for biopsy based biomarker discovery and validation. Iqbal, NT; Syed, S; Sadiq, K; Khan, MN; Iqbal, J; Ma, JZ; Umrani, F; Ahmed, S; Maier, EA; Denson, LA; et al. BMC Pediatrics. 2019; 19.

Shared decision making in IBD: A novel approach to trial consent and timing. Schuler, CL; Dodds, C; Hommel, KA; Ittenbach, RF; Denson, LA; Lipstein, EA. Contemporary Clinical Trials Communications. 2019; 16:100447-100447.

Defining the Celiac Disease Transcriptome using Clinical Pathology Specimens Reveals Biologic Pathways and Supports Diagnosis. Loberman-Nachum, N; Sosnovski, K; Di Segni, A; Efroni, G; Braun, T; BenShoshan, M; Anafi, L; Avivi, C; Barshack, I; Shouval, DS; et al. Scientific Reports. 2019; 9.

Evaluation of a Novel Educational Tool in Adolescents With Inflammatory Bowel Disease: The NEAT Study. Vaz, KK H; Carmody, JK; Zhang, Y; Denson, LA; Hommel, KA. Journal of Pediatric Gastroenterology and Nutrition. 2019; 69:564-569.

Serologic, but Not Genetic, Markers Are Associated With Impaired Anthropometrics at Diagnosis of Pediatric Crohn's Disease. Naramore, SK; Jr, BW E; Jiang, G; Kugathasan, S; Denson, LA; Hyams, JS; Steiner, SJ; Grp, PR O-K I I D. Journal of Pediatric Gastroenterology and Nutrition. 2019; 69:e129-e134.

Characterization of Stool Virome in Children Newly Diagnosed with Moderate to Severe Ulcerative Colitis. Tokarz, R; Hyams, JS; Mack, DR; Boyle, B; Griffiths, AM; LeLeiko, NS; Sauer, CG; Shah, S; Markowitz, J; Baker, SS; et al. Inflammatory Bowel Diseases. 2019; 25:1656-1662.

Longitudinal non-adherence predicts treatment escalation in paediatric ulcerative colitis. Carmody, JK; Plevinsky, J; Peugh, JL; Denson, LA; Hyams, JS; Lobato, D; LeLeiko, NS; Hommel, KA. Alimentary Pharmacology and Therapeutics. 2019; 50:911-918.