A photo of Lee A. Denson.

Director, Schubert-Martin Inflammatory Bowel Disease Center

Professor, UC Department of Pediatrics

513-636-7575

Board Certified

My Biography & Research

Biography

The primary focus of Dr. Lee A. Denson's laboratory is to determine the molecular basis for alterations in growth hormone signaling in inflammatory bowel diseases (IBD).

Normal growth and development are dependent upon the ability of growth hormone to regulate IGF-1 expression. Evidence from studies in children with IBD and mouse models of colitis indicates that inflammatory cytokines which are up regulated in this setting may cause an acquired GH resistance. Consequences may include growth failure, altered body composition and impaired mucosal healing.

We are using complementary experimental and patient-based approaches to investigate regulation of growth hormone signaling in mouse models of colitis and in children with Crohn's disease. These include down regulation of the growth hormone receptor and up regulation of a family of post-receptor inhibitory proteins, the Suppressors of Cytokine Signaling (SOCS). These studies should lead to the development of more effective therapies for children with IBD and other chronic inflammatory conditions.

Clinical Interests

Inflammatory bowel disease; growth failure; celiac disease

Academic Affiliation

Professor, UC Department of Pediatrics

Departments

Gastroenterology GI, Colorectal Disorders, Inflammatory Bowel Disease IBD, Autoimmune Liver Disease, Gastroenterology

Cincinnati Children's Blog

A Promising Early Research Study for IBD Treatment

BlogRare and Complex Conditions

A Promising Early Research Study for IBD Treatment

By Lee A. Denson, MD4/28/2016

My Locations

My Education

MD: Medical College of Virginia, Richmond, VA, 1993.

Residency: Yale-New Haven Hospital, New Haven, CT, 1993-96.

Certification: Pediatrics, 1996 and 2002.

Fellowship: Yale University School of Medicine, New Haven, CT, 1996-99.

My Publications

Characterization of Stool Virome in Children Newly Diagnosed With Moderate to Severe Ulcerative Colitis. Tokarz, R; Hyams, JS; Mack, DR; Boyle, B; Griffiths, AM; LeLeiko, NS; Sauer, CG; Shah, S; Markowitz, J; Baker, SS; et al. Inflammatory Bowel Diseases. 2019; 25:1656-1662.

Single-Cell Analysis of Crohn's Disease Lesions Identifies a Pathogenic Cellular Module Associated with Resistance to Anti-TNF Therapy. Martin, JC; Chang, C; Boschetti, G; Ungaro, R; Giri, M; Grout, JA; Gettler, K; Chuang, L; Nayar, S; Greenstein, AJ; et al. Cell. 2019; 178:1493-1508.e20.

Prioritizing Crohn’s disease genes by integrating association signals with gene expression implicates monocyte subsets. Gettler, K; Giri, M; Kenigsberg, E; Martin, J; Chuang, L; Hsu, N; Denson, LA; Hyams, JS; Griffiths, A; Noe, JD; et al. Genes and Immunity. 2019; 20:577-588.

Association Between Plasma Level of Collagen Type III Alpha 1 Chain and Development of Strictures in Pediatric Patients With Crohn's Disease. Ballengee, CR; Stidham, RW; Liu, C; Kim, M; Prince, J; Mondal, K; Baldassano, R; Dubinsky, M; Markowitz, J; Leleiko, N; et al. Clinical Gastroenterology and Hepatology. 2019; 17:1799-1806.

Improving IBD Transition, Self-management, and Disease Outcomes With an In-clinic Transition Coordinator. Gray, WN; Holbrook, E; Dykes, D; Morgan, PJ; Saeed, SA; Denson, LA. Journal of Pediatric Gastroenterology and Nutrition. 2019; 69:194-199.

Variation in Care in the Management of Children With Crohn's Disease: Data From a Multicenter Inception Cohort Study. Krishnakumar, C; Ballengee, CR; Liu, C; Kim, M; Baker, SS; Baldassano, RN; Cohen, SA; Crandall, WV; Denson, LA; Dubinsky, MC; et al. Inflammatory Bowel Diseases. 2019; 25:1208-1217.

Development of Infliximab Target Concentrations during Induction in Pediatric Crohn Disease Patients. Clarkston, K; Tsai, YT; Jackson, K; Rosen, MJ; Denson, LA; Minar, P. Journal of Pediatric Gastroenterology and Nutrition. 2019; 69:68-74.

Early Onset Granulomatous Colitis Associated with a Mutation in NCF4 Resolved with Hematopoietic Stem Cell Transplantation. Wright, M; Chandrakasan, S; Okou, DT; Yin, H; Jurickova, I; Denson, LA; Kugathasan, S. The Journal of Pediatrics. 2019; 210:220-225.

Development of Infliximab Target Concentrations During Induction in Pediatric Crohn Disease Patients. Clarkston, K; Tsai, Y; Jackson, K; Rosen, MJ; Denson, LA; Minar, P. Journal of Pediatric Gastroenterology and Nutrition. 2019; 69:68-74.

Blood-Derived DNA Methylation Signatures of Crohn's Disease and Severity of Intestinal Inflammation. Somineni, HK; Venkateswaran, S; Kilaru, V; Marigorta, UM; Mo, A; Okou, DT; Kellermayer, R; Mondal, K; Cobb, D; Walters, TD; et al. Gastroenterology. 2019; 156:2254-2265.e3.