Gastroenterology, Hepatology and Nutrition
Gandhi Lab

Gandhi Research Lab

Liver Injury Research

The Gandhi laboratory is investigating mechanisms of liver injury with specific focus on hepatic stellate cells (HSCs). HSCs (8-10% of liver cell population) are the major cell type to cause liver fibrosis, but they also have a unique ability to induce acute liver injury directly by producing numerous cytokines and chemokines, and also by modulating characteristics of resident and infiltrating immune and inflammatory cells. The current focus of this program is to delineate precise mechanisms by which HSCs orchestrate inflammatory and immunological responses in the liver using a novel mouse model of HSC depletion (developed in our laboratory) and co-culture techniques.

Steatohepatitis Research

The other research program investigates the mechanisms of steatohepatitis and its sequel (fibrosis, cirrhosis and cancer) due to hepatocyte-specific deficiency of a protein named Augmenter of Liver Regeneration (ALR).  Liver (hepatocyte)-specific ALR-knockout of ALR in mouse was found to induce mitochondrial dysfunction, and progressive nonalcoholic steatohepatitis (NASH) with characteristics very similar to the human NASH. Our group has also observed that the hepatic ALR levels are lower in human NASH. The focus of this research is to discover link between ALR gene polymorphism(s) or anomaly in ALR protein and predisposition to develop aggressive form of NASH. 

Contact Us

Chandrashekhar Gandhi.
Chandrashekhar R. Gandhi, MSc, PhD
Professor, Department of Pediatrics

Mailing address:

Division of Gastroenterology, Hepatology and Nutrition
3333 Burnet Ave. 
MLC 2010 
Cincinnati, OH 45229-3039 

Lab: Location T, Rooms T9.433 and T9.462 

Office: Location T, Suite T9.480

Phone: 513-517-1090