Michael A. Helmrath, MD
Department of Pediatrics; Division of General Thoracic Surgery
Description of Research
Dr. Helmrath studies the adaptive response of the intestine following surgical resection. Recent work in his laboratory supports the role of intestinal stem cells sustaining the long-term adaptive response. Ongoing investigation into mechanisms that augment this expansion include the role of IGF-I, GLP-s and Rspondin. In addition, Dr. Helmrath is focusing on protocols to isolate and expand intestinal crypts from both mice and humans. The experimental approach includes the surgical implantation of the tissues in the peritoneal cavity followed by intestinal resection to stimulate tissue growth. In addition, Dr. Helmrath is exploring the application of this model to study the role of molecular signals in the control of intestinal stem cells by applying the surgical implantation model to intestinal organoids derived from human iPS cells developed by investigators (DHC members) at Cincinnati Children's.
Dr. Helmrath collaborates with Drs. Shroyer, Wells, and Zorn to generate expanded intestinal crypts and tissue organoids. Anticipated Core use: Integrative Morphology and Gene and Protein Expression Cores.